Works matching IS 00912700 AND DT 2021 AND VI 61

Results: 219

Electrophysiological and ECG Effects of Perhexiline, a Mixed Cardiac Ion Channel Inhibitor, Evaluated in Nonclinical Assays and in Healthy Subjects.

Published in:

Journal of Clinical Pharmacology, 2021, v. 61, n. 12, p. 1606, doi. 10.1002/jcph.1934

By:

Midei, Mark G.;
Darpo, Borje;
Ayers, Greg;
Brown, Randy;
Couderc, Jean‐Philippe;
Daly, William;
Ferber, Georg;
Sager, Philip T.;
Camm, A. John

Publication type:

Article

Population Pharmacokinetic Analysis of N‐Acetylcysteine in Pediatric Patients With Inherited Metabolic Disorders Undergoing Hematopoietic Stem Cell Transplant.

Published in:

Journal of Clinical Pharmacology, 2021, v. 61, n. 12, p. 1638, doi. 10.1002/jcph.1943

By:

Sahasrabudhe, Siddhee A.;
Kartha, Reena V.;
Ng, Michelle;
Basso, Lisa M.;
Mishra, Usha;
Cloyd, James C.;
Orchard, Paul J.;
Brundage, Richard C.;
Coles, Lisa D.

Publication type:

Article

Population Pharmacokinetics of Ipatasertib and Its Metabolite in Cancer Patients.

Published in:

Journal of Clinical Pharmacology, 2021, v. 61, n. 12, p. 1579, doi. 10.1002/jcph.1942

By:

Yoshida, Kenta;
Wilkins, Justin;
Winkler, Julia;
Wade, Janet R.;
Kotani, Naoki;
Wang, Nina;
Sane, Rucha;
Chanu, Pascal

Publication type:

Article

Clinical Outcome Data of First Cohort of Chronic Pain Patients Treated With Cannabis‐Based Sublingual Oils in the United Kingdom: Analysis From the UK Medical Cannabis Registry.

Published in:

Journal of Clinical Pharmacology, 2021, v. 61, n. 12, p. 1545, doi. 10.1002/jcph.1961

By:

Kawka, Michal;
Erridge, Simon;
Holvey, Carl;
Coomber, Ross;
Usmani, Azfer;
Sajad, Mohammad;
Platt, Michael W.;
Rucker, James J.;
Sodergren, Mikael H.

Publication type:

Article

Risk of SARS‐CoV‐2 Infection and COVID‐19 Severity Associated With Exposure to Nonsteroidal Anti‐Inflammatory Drugs: Systematic Review and Meta‐Analysis.

Published in:

Journal of Clinical Pharmacology, 2021, v. 61, n. 12, p. 1521, doi. 10.1002/jcph.1949

By:

Prada, Luísa;
D. Santos, Catarina;
Baião, Rita A.;
Costa, João;
Ferreira, Joaquim J.;
Caldeira, Daniel

Publication type:

Article

Efficacy and Safety of Lasmiditan for Acute Treatment of Migraine in Adults: A Meta‐Analysis.

Published in:

Journal of Clinical Pharmacology, 2021, v. 61, n. 12, p. 1534, doi. 10.1002/jcph.1962

By:

Maiti, Rituparna;
Mishra, Archana;
Puliappadamb, Haridas Mundot;
Jena, Monalisa;
Srinivasan, Anand

Publication type:

Article

Population Pharmacokinetics of Viloxazine Extended‐Release Capsules in Pediatric Subjects With Attention Deficit/Hyperactivity Disorder.

Published in:

Journal of Clinical Pharmacology, 2021, v. 61, n. 12, p. 1626, doi. 10.1002/jcph.1940

By:

Nasser, Azmi;
Gomeni, Roberto;
Wang, Zhao;
Kosheleff, Alisa R.;
Xie, Lanyi;
Adeojo, Lilian W.;
Schwabe, Stefan

Publication type:

Article

Population Pharmacokinetic Modeling and Simulations to Evaluate a Potential Dose Regimen of Testosterone Undecanoate in Hypogonadal Males.

Published in:

Journal of Clinical Pharmacology, 2021, v. 61, n. 12, p. 1618, doi. 10.1002/jcph.1939

By:

Pastuszak, Alexander W.;
Bush, Mark;
Curd, Laura;
Vijayan, Saji;
Priestley, Tony;
Xiang, Qinfang;
Hu, Yiqun

Publication type:

Article

Ceftaroline Dosage Optimized for Pediatric Patients With Renal Impairment Using Physiologically Based Pharmacokinetic Modeling.

Published in:

Journal of Clinical Pharmacology, 2021, v. 61, n. 12, p. 1646, doi. 10.1002/jcph.1944

By:

Zhou, Jie;
You, Xiang;
Guo, Guimu;
Ke, Meng;
Xu, Jianwen;
Ye, Lingling;
Wu, Wanhong;
Huang, Pinfang;
Lin, Cuihong

Publication type:

Article

Cisatracurium Continuous Infusion Versus No Neuromuscular Blockade for Acute Respiratory Distress Syndrome on Venovenous Extracorporeal Membrane Oxygenation.

Published in:

Journal of Clinical Pharmacology, 2021, v. 61, n. 11, p. 1415, doi. 10.1002/jcph.1933

By:

Kressin, Christian;
Thompson Bastin, Melissa;
Ather, Ayesha;
Gopinath, Anil;
Srour, Habib;
Schadler, Aric;
Pandya, Komal

Publication type:

Article

Association of ABCC2 Haplotypes to Mycophenolic Acid Pharmacokinetics in Stable Kidney Transplant Recipients.

Published in:

Journal of Clinical Pharmacology, 2021, v. 61, n. 12, p. 1592, doi. 10.1002/jcph.1932

By:

Brazeau, Daniel;
Meaney, Calvin J.;
Consiglio, Joseph D.;
Wilding, Gregory E.;
Cooper, Louise M.;
Venuto, Rocco C.;
Tornatore, Kathleen M.

Publication type:

Article

Prediction of Fluoxetine and Norfluoxetine Pharmacokinetic Profiles Using Physiologically Based Pharmacokinetic Modeling.

Published in:

Journal of Clinical Pharmacology, 2021, v. 61, n. 11, p. 1505, doi. 10.1002/jcph.1927

By:

Jeong, Hyeon‐Cheol;
Chae, Yoon‐Jee;
Lee, Sooyeun;
Kang, Wonku;
Yun, Hwi‐yeol;
Shin, Kwang‐Hee

Publication type:

Article

Issue Information.

Published in:: Journal of Clinical Pharmacology, 2021, v. 61, n. 12, p. 1515, doi. 10.1002/jcph.1465
Publication type:: Article

Risk of Thrombocytopenia With Platelet‐Derived Growth Factor Receptor Kinase Inhibitors in Cancer Patients: A Systematic Review and Meta‐Analysis of Phase 2/3 Randomized, Controlled Trials.

Published in:

Journal of Clinical Pharmacology, 2021, v. 61, n. 11, p. 1397, doi. 10.1002/jcph.1938

By:

Liu, Yuan;
Sun, Wenxia;
Li, Jing

Publication type:

Article

Physiologically Based Pharmacokinetic Modeling for Selumetinib to Evaluate Drug‐Drug Interactions and Pediatric Dose Regimens.

Published in:

Journal of Clinical Pharmacology, 2021, v. 61, n. 11, p. 1493, doi. 10.1002/jcph.1935

By:

Cohen‐Rabbie, Sarit;
Zhou, Li;
Vishwanathan, Karthick;
Wild, Martin;
Xu, Sherrie;
Freshwater, Tomoko;
Jain, Lokesh;
Schalkwijk, Stein;
Tomkinson, Helen;
Zhou, Diansong

Publication type:

Article

Isoniazid Population Pharmacokinetics and Dose Recommendation for Korean Patients With Tuberculosis Based on Target Attainment Analysis.

Published in:

Journal of Clinical Pharmacology, 2021, v. 61, n. 12, p. 1567, doi. 10.1002/jcph.1931

By:

Cho, Yong‐Soon;
Jang, Tae Won;
Kim, Hyo‐Jung;
Oh, Jee Youn;
Lee, Hyun‐Kyung;
Park, Hye Kyeong;
Ghim, Jong‐Lyul;
Long, Nguyen Phuoc;
Park, Yumi;
Choi, Young‐Kyung;
Phuong, Nguyen Thi Thu;
Shin, Jae‐Gook

Publication type:

Article

Pharmacokinetics of Ruxolitinib in HIV Suppressed Individuals on Antiretroviral Agent Therapy from the ACTG A5336 Study.

Published in:

Journal of Clinical Pharmacology, 2021, v. 61, n. 12, p. 1555, doi. 10.1002/jcph.1930

By:

Hurwitz, Selwyn J.;
Tao, Sijia;
Gavegnano, Christina;
Jiang, Yong;
Tressler, Randall L.;
Tsibris, Athe;
del Rio, Carlos;
Overton, Edgar T.;
Lederman, Michael M.;
Kantor, Amy;
Moser, Carlee;
Kohler, James J.;
Lennox, Jeffrey;
Marconi, Vincent C.;
Flexner, Charles W.;
Schinazi, Raymond F.

Publication type:

Article

Pharmacokinetics of Asciminib in Individuals With Hepatic or Renal Impairment.

Published in:

Journal of Clinical Pharmacology, 2021, v. 61, n. 11, p. 1454, doi. 10.1002/jcph.1926

By:

Hoch, Matthias;
Sato, Masahiko;
Zack, Julia;
Quinlan, Michelle;
Sengupta, Tirtha;
Allepuz, Alex;
Aimone, Paola;
Hourcade‐Potelleret, Florence

Publication type:

Article

A Target‐Mediated Drug Disposition Model to Explain Nonlinear Pharmacokinetics of the 11β‐Hydroxysteroid Dehydrogenase Type 1 Inhibitor SPI‐62 in Healthy Adults.

Published in:

Journal of Clinical Pharmacology, 2021, v. 61, n. 11, p. 1442, doi. 10.1002/jcph.1925

By:

Wu, Nan;
Katz, David A.;
An, Guohua

Publication type:

Article

A Clinical Decision Support Tool to Find the Best Initial Intravenous Cyclosporine Regimen in Pediatric Hematopoietic Stem Cell Transplantation.

Published in:

Journal of Clinical Pharmacology, 2021, v. 61, n. 11, p. 1485, doi. 10.1002/jcph.1924

By:

Leclerc, Vincent;
Ducher, Michel;
Ceraulo, Antony;
Bertrand, Yves;
Bleyzac, Nathalie

Publication type:

Article

Ketamine for Refractory Chronic Migraine: An Observational Pilot Study and Metabolite Analysis.

Published in:

Journal of Clinical Pharmacology, 2021, v. 61, n. 11, p. 1421, doi. 10.1002/jcph.1920

By:

Schwenk, Eric S.;
Torjman, Marc C.;
Moaddel, Ruin;
Lovett, Jacqueline;
Katz, Daniel;
Denk, William;
Lauritsen, Clinton;
Silberstein, Stephen D.;
Wainer, Irving W.

Publication type:

Article

Methods for Detecting Pediatric Adverse Drug Reactions From the Electronic Medical Record.

Published in:

Journal of Clinical Pharmacology, 2021, v. 61, n. 11, p. 1479, doi. 10.1002/jcph.1916

By:

Joyner, Lydia M.;
Alicea, Leah A.;
Goldman, Jennifer L.;
Suppes, Sarah L.;
Tillman, Emma M.

Publication type:

Article

Influence of Prednisone on Inflammatory Biomarkers in Community‐Acquired Pneumonia: Secondary Analysis of a Randomized Trial.

Published in:

Journal of Clinical Pharmacology, 2021, v. 61, n. 11, p. 1406, doi. 10.1002/jcph.1914

By:

Raess, Natalie;
Schuetz, Philipp;
Cesana‐Nigro, Nicole;
Winzeler, Bettina;
Urwyler, Sandrine A.;
Schaedelin, Sabine;
Rodondi, Nicolas;
Blum, Manuel R.;
Briel, Matthias;
Mueller, Beat;
Christ‐Crain, Mirjam;
Blum, Claudine A.

Publication type:

Article

Biperiden Challenge Model in Healthy Elderly as Proof‐of‐Pharmacology Tool: A Randomized, Placebo‐Controlled Trial.

Published in:

Journal of Clinical Pharmacology, 2021, v. 61, n. 11, p. 1466, doi. 10.1002/jcph.1913

By:

Bakker, Charlotte;
van Esdonk, Michiel J.;
Stuurman, Rik. E.;
Borghans, Laura G.J.M.;
de Kam, Marieke L.;
van Gerven, Joop M.A.;
Groeneveld, Geert Jan

Publication type:

Article

Population Pharmacokinetics of Olanzapine and Samidorphan When Administered in Combination in Healthy Subjects and Patients With Schizophrenia.

Published in:

Journal of Clinical Pharmacology, 2021, v. 61, n. 11, p. 1430, doi. 10.1002/jcph.1911

By:

Sun, Lei;
Mills, Richard;
Sadler, Brian M.;
Rege, Bhaskar

Publication type:

Article

Issue Information.

Published in:: Journal of Clinical Pharmacology, 2021, v. 61, n. 11, p. 1391, doi. 10.1002/jcph.1464
Publication type:: Article

Corticosteroids in COVID‐19: We Should Be Mindful of Their Acute Toxicities.

Published in:

Journal of Clinical Pharmacology, 2021, v. 61, n. 10, p. 1301, doi. 10.1002/jcph.1936

By:

Karn, Mitesh;
Yonghang, Sapana;
Ghimire, Sadikshya

Publication type:

Article

Is QTc the Right Surrogate in Adequately Assessing the Risk for TdP for Development Compound Candidates? A Call to Investigate.

Published in:: Journal of Clinical Pharmacology, 2021, v. 61, n. 10, p. 1388, doi. 10.1002/jcph.1912
Publication type:: Article

Predictive Performance of Population Pharmacokinetic Models of Levetiracetam in Children and Evaluation of Dosing Regimen.

Published in:

Journal of Clinical Pharmacology, 2021, v. 61, n. 10, p. 1366, doi. 10.1002/jcph.1910

By:

Tauzin, Manon;
Tréluyer, Jean‐Marc;
Nabbout, Rima;
Chemaly, Nicole;
Billette de Villemeur, Thierry;
Desguerre, Isabelle;
Lui, Gabrielle;
Gana, Ines;
Boujaafar, Sana;
Zheng, Yi;
Benaboud, Sihem;
Bouazza, Naim;
Chenevier‐Gobeaux, Camille;
Freihuber, Cécile;
Hirt, Déborah

Publication type:

Article

Gene‐Gene Interactions of Gemcitabine Metabolizing‐Enzyme Genes hCNT3 and WEE1 for Preventing Severe Gemcitabine‐Induced Hematological Toxicity.

Published in:

Journal of Clinical Pharmacology, 2021, v. 61, n. 10, p. 1376, doi. 10.1002/jcph.1909

By:

Li, Juan;
Chen, Bing;
Xi, Wen‐Qi;
Yang, Chen;
Zhang, Wei‐Xia

Publication type:

Article

Concordance of Exposure Changes Because of Renal Impairment Between Results of Dedicated Renal Impairment Studies and Population Pharmacokinetic Predictions.

Published in:

Journal of Clinical Pharmacology, 2021, v. 61, n. 10, p. 1324, doi. 10.1002/jcph.1907

By:

Ahmed, Mariam A.;
Kalaria, Shamir N.;
Younis, Islam R.

Publication type:

Article

Application of Physiologically Based Pharmacokinetic‐Pharmacodynamic Modeling in Preterm Neonates to Guide Gentamicin Dosing Decisions and Predict Antibacterial Effect.

Published in:

Journal of Clinical Pharmacology, 2021, v. 61, n. 10, p. 1356, doi. 10.1002/jcph.1890

By:

Neeli, Harshith;
Hanna, Nazeeh;
Abduljalil, Khaled;
Cusumano, Jaclyn;
Taft, David R.

Publication type:

Article

Anaphylaxis to Subcutaneous Immunoglobulin in a Severe Combined Immunodeficiency Patient.

Published in:

2021

By:

Castano‐Jaramillo, Lina Maria;
Toledo‐Salinas, Carla;
Pardo‐Diaz, Edwin;
Contreras‐Verduzco, Francisco Alberto;
Mendoza‐Hernandez, David Alejandro

Publication type:

Case Study

Population Pharmacokinetic Analysis of Bedaquiline‐Clarithromycin for Dose Selection Against Pulmonary Nontuberculous Mycobacteria Based on a Phase 1, Randomized, Pharmacokinetic Study.

Published in:

Journal of Clinical Pharmacology, 2021, v. 61, n. 10, p. 1344, doi. 10.1002/jcph.1887

By:

Kurosawa, Ken;
Rossenu, Stefaan;
Biewenga, Jeike;
Ouwerkerk‐Mahadevan, Sivi;
Willems, Wouter;
Ernault, Etienne;
Kambili, Chrispin

Publication type:

Article

The New S7B/E14 Question and Answer Draft Guidance for Industry: Contents and Commentary.

Published in:

Journal of Clinical Pharmacology, 2021, v. 61, n. 10, p. 1261, doi. 10.1002/jcph.1880

By:

Darpo, Borje;
Ferber, Georg

Publication type:

Article

Evaluation of the Effect of Mannuronic Acid as a Novel NSAID With Immunosuppressive Properties on Expression of SOCS1, SOCS3, SHIP1, and TRAF6 Genes and Serum Levels of IL‐6 and TNF‐α in Patients With Multiple Sclerosis.

Published in:

Journal of Clinical Pharmacology, 2021, v. 61, n. 10, p. 1303, doi. 10.1002/jcph.1879

By:

Najafi, Soheil;
Saadat, Payam;
Beladi Moghadam, Nahid;
Manoucherinia, Ali;
Aghazadeh, Zahra;
Vali Mohammadi, Anita;
Pashaiefar, Hossein;
Hosseini, Mostafa;
Mirshafiey, Abbas

Publication type:

Article

Pharmacological Predictors of Morbidity and Mortality in COVID‐19.

Published in:

Journal of Clinical Pharmacology, 2021, v. 61, n. 10, p. 1286, doi. 10.1002/jcph.1878

By:

Oddy, Christopher;
McCaul, James;
Keeling, Polly;
Allington, Jonathan;
Senn, Dhanuja;
Soni, Neesha;
Morrison, Hannah;
Mawella, Ruwani;
Samuel, Thomas;
Dixon, John

Publication type:

Article

Baricitinib: From Rheumatoid Arthritis to COVID‐19.

Published in:

Journal of Clinical Pharmacology, 2021, v. 61, n. 10, p. 1274, doi. 10.1002/jcph.1874

By:

Assadiasl, Sara;
Fatahi, Yousef;
Mosharmovahed, Banafsheh;
Mohebbi, Bahareh;
Nicknam, Mohammad Hossein

Publication type:

Article

Pharmacokinetics of Asfotase Alfa in Adult Patients With Pediatric‐Onset Hypophosphatasia.

Published in:

Journal of Clinical Pharmacology, 2021, v. 61, n. 10, p. 1334, doi. 10.1002/jcph.1870

By:

Pan, Wei‐Jian;
Pradhan, Rajendra;
Pelto, Ryan;
Seefried, Lothar

Publication type:

Article

Effects of Hepatic Impairment on the Pharmacokinetics of Abrocitinib and Its Metabolites.

Published in:

Journal of Clinical Pharmacology, 2021, v. 61, n. 10, p. 1311, doi. 10.1002/jcph.1858

By:

Wang, Ellen Q.;
Le, Vu;
O'Gorman, Melissa;
Tripathy, Sakambari;
Dowty, Martin E.;
Wang, Lisy;
Malhotra, Bimal K.

Publication type:

Article

Issue Information.

Published in:: Journal of Clinical Pharmacology, 2021, v. 61, n. 10, p. 1255, doi. 10.1002/jcph.1463
Publication type:: Article

Therapeutic Application of Corticosteroids in COVID‐19: A Focus on Optimum Dose and Duration of Therapy.

Published in:

Journal of Clinical Pharmacology, 2021, v. 61, n. 9, p. 1145, doi. 10.1002/jcph.1929

By:

Khiali, Sajad;
Entezari‐Maleki, Taher

Publication type:

Article

Response to Letter to the Editor From Dr. Cimolai.

Published in:

Journal of Clinical Pharmacology, 2021, v. 61, n. 9, p. 1253, doi. 10.1002/jcph.1893

By:

Fernandez‐Rando, Manuel;
Herrera, Maria Dolores;
Almeida‐González, Carmen V.;
Grilo, Antonio

Publication type:

Article

Population Pharmacokinetic‐Pharmacodynamic Modeling and Covariate Analyses of Neutropenia and Thrombocytopenia in Patients With Solid Tumors Treated With Lurbinectedin.

Published in:

Journal of Clinical Pharmacology, 2021, v. 61, n. 9, p. 1206, doi. 10.1002/jcph.1886

By:

Fernández‐Teruel, Carlos;
Lubomirov, Rubin;
Fudio, Salvador

Publication type:

Article

Risk Factors for Angiotension‐Converting Enzyme Inhibitor–Associated Cough.

Published in:: Journal of Clinical Pharmacology, 2021, v. 61, n. 9, p. 1251, doi. 10.1002/jcph.1883
Publication type:: Article

Relationship Between Apparent Systemic Clearance of Vemurafenib and Toxicity in Patients With Melanoma.

Published in:

Journal of Clinical Pharmacology, 2021, v. 61, n. 9, p. 1243, doi. 10.1002/jcph.1882

By:

Kichenadasse, Ganessan;
Hughes, Jim Henry;
Fahmy, Alia;
Rowland, Andrew;
Sorich, Michael J.;
Hopkins, Ashley H.

Publication type:

Article

Vedolizumab Immunogenicity With Long‐Term or Interrupted Treatment of Patients With Inflammatory Bowel Disease.

Published in:

Journal of Clinical Pharmacology, 2021, v. 61, n. 9, p. 1174, doi. 10.1002/jcph.1877

By:

Wyant, Timothy;
Yang, Lili;
Lirio, Richard A.;
Rosario, Maria

Publication type:

Article

Longitudinal Impact of Acute Spinal Cord Injury on Clinical Pharmacokinetics of Riluzole, a Potential Neuroprotective Agent.

Published in:

Journal of Clinical Pharmacology, 2021, v. 61, n. 9, p. 1232, doi. 10.1002/jcph.1876

By:

Nguyen, Ashley;
Chow, Diana S‐L.;
Wu, Lei;
Teng, Yang;
Sarkar, Mahua;
Toups, Elizabeth G.;
Harrop, James S.;
Schmitt, Karl M.;
Johnson, Michele M.;
Guest, James D.;
Aarabi, Bizhan;
Shaffrey, Christopher I.;
Boakye, Maxwell;
Frankowski, Ralph F.;
Fehlings, Michael G.;
Grossman, Robert G.

Publication type:

Article

A Population Pharmacokinetic Meta‐Analysis of Veliparib, a PARP Inhibitor, Across Phase 1/2/3 Trials in Cancer Patients.

Published in:

Journal of Clinical Pharmacology, 2021, v. 61, n. 9, p. 1195, doi. 10.1002/jcph.1875

By:

Stodtmann, Sven;
Nuthalapati, Silpa;
Eckert, Doerthe;
Kasichayanula, Sreeneeranj;
Joshi, Rujuta;
Bach, Bruce A.;
Mensing, Sven;
Menon, Rajeev;
Xiong, Hao

Publication type:

Article

Pharmacogenomics and Morphine.

Published in:

Journal of Clinical Pharmacology, 2021, v. 61, n. 9, p. 1149, doi. 10.1002/jcph.1873

By:

Ofoegbu, Adaku;
B. Ettienne, Earl

Publication type:

Article