Works matching IS 00778923 AND DT 2000 AND VI 922 AND IP 1

Results: 47

Improvement of Therapeutic Index of Low-Dose Topotecan Delivered per os.

Published in:

Annals of the New York Academy of Sciences, 2000, v. 922, n. 1, p. 330, doi. 10.1111/j.1749-6632.2000.tb07057.x

By:

PRATESI, GRAZIELLA;
CESARE, MICHELANDREA;
ZUNINO, FRANCO

Publication type:

Article

The Homocamptothecin, BN 80927, Is a Potent Topoisomerase I Poison and Topoisomerase II Catalytic Inhibitor.

Published in:

Annals of the New York Academy of Sciences, 2000, v. 922, n. 1, p. 301, doi. 10.1111/j.1749-6632.2000.tb07048.x

By:

DEMARQUAY, DANIÈLE;
COULOMB, HÉLÈNE;
HUCHET, MARION;
LESUEUR-GINOT, LAURENCE;
CAMARA, JOSÉ;
LAVERGNE, OLIVIER;
BIGG, DENNIS

Publication type:

Article

Feasibility, Phase I, and Pharmacological Study of Aerosolized Liposomal 9-Nitro-20(S)-Camptothecin in Patients with Advanced Malignancies in the Lungs.

Published in:

Annals of the New York Academy of Sciences, 2000, v. 922, n. 1, p. 352, doi. 10.1111/j.1749-6632.2000.tb07063.x

By:

VERSCHRAEGEN, C. F.;
GILBERT, B. E.;
HUARINGA, A. J.;
NEWMAN, R.;
HARRIS, N.;
LEYVA, F. J.;
KEUS, L.;
CAMPBELL, K.;
NELSON-TAYLOR, T.;
KNIGHT, V.

Publication type:

Article

Camptothecin Dose, Schedule, and Timing of Administration for Clinical Radiation Sensitization.

Published in:

Annals of the New York Academy of Sciences, 2000, v. 922, n. 1, p. 334, doi. 10.1111/j.1749-6632.2000.tb07058.x

By:

RICH, TYVIN A.;
KIRICHENKO, ALEXANDER V.

Publication type:

Article

DX-8951f: Summary of Phase I Clinical Trials.

Published in:

Annals of the New York Academy of Sciences, 2000, v. 922, n. 1, p. 260, doi. 10.1111/j.1749-6632.2000.tb07044.x

By:

JAGER, R.;
CHEVERTON, P.;
TAMANOI, K.;
COYLE, J.;
DUCHARME, M.;
SAKAMOTO, N.;
SATOMI, M.;
SUZUKI, M.

Publication type:

Article

Phase I Study of 9-Nitro-20(S)-Camptothecin in Combination with Cisplatin for Patients with Advanced Malignancies.

Published in:

Annals of the New York Academy of Sciences, 2000, v. 922, n. 1, p. 345, doi. 10.1111/j.1749-6632.2000.tb07061.x

By:

VERSCHRAEGEN, C. F.;
VINCENT, M.;
ABBRUZZESE, J. L.;
SIEGLER, D.;
KAVANAGH, J. J.;
LOYER, E.;
KUDELKA, A. P.;
RUBIN, E.

Publication type:

Article

In Vitro Antitumor Activity of 9-Nitro-Camptothecin as a Single Agent and in Combination with other Antitumor Drugs.

Published in:

Annals of the New York Academy of Sciences, 2000, v. 922, n. 1, p. 293, doi. 10.1111/j.1749-6632.2000.tb07046.x

By:

BERNACKI, RALPH J.;
PERA, PAULA;
GAMBACORTA, PETER;
BRUN, YSEULT;
GRECO, WILLIAM R.

Publication type:

Article

The Clinical Development of 9-Aminocamptothecin.

Published in:

Annals of the New York Academy of Sciences, 2000, v. 922, n. 1, p. 224, doi. 10.1111/j.1749-6632.2000.tb07041.x

By:

TAKIMOTO, CHRIS H.;
THOMAS, REBECCA

Publication type:

Article

A Spectrophotometric Study of the pH-Dependent and DNA Binding Properties of Topotecan.

Published in:

Annals of the New York Academy of Sciences, 2000, v. 922, n. 1, p. 309, doi. 10.1111/j.1749-6632.2000.tb07051.x

By:

MILLER, STEVEN E.;
PILCH, DANIEL S.

Publication type:

Article

Phase II Study of Intravenous DX-8951f in Patients with Advanced Ovarian, Tubal, or Peritoneal Cancer Refractory to Platinum, Taxane, and Topotecan.

Published in:

Annals of the New York Academy of Sciences, 2000, v. 922, n. 1, p. 349, doi. 10.1111/j.1749-6632.2000.tb07062.x

By:

VERSCHRAEGEN, C. F.;
LEVENBACK, C.;
VINCENT, M.;
WOLF, J.;
BEVERS, M.;
LOYER, E.;
KUDELKA, A. P.;
KAVANAGH, J. J.

Publication type:

Article

Mechanisms of Resistance to Camptothecins.

Published in:

Annals of the New York Academy of Sciences, 2000, v. 922, n. 1, p. 46, doi. 10.1111/j.1749-6632.2000.tb07024.x

By:

SALEEM, AHAMED;
EDWARDS, TROY K.;
RASHEED, ZESHAAN;
RUBIN, ERIC H.

Publication type:

Article

Conjugation of Camptothecins to Poly-(l-Glutamic Acid).

Published in:

Annals of the New York Academy of Sciences, 2000, v. 922, n. 1, p. 136, doi. 10.1111/j.1749-6632.2000.tb07032.x

By:

SINGER, JACK W.;
VRIES, PETER;
BHATT, RAMA;
TULINSKY, JOHN;
KLEIN, PETER;
LI, CHUN;
MILAS, LUKA;
LEWIS, ROBERT A.;
WALLACE, SIDNEY

Publication type:

Article

Rapid Chromatin Reorganization Induced by Topoisomerase I-Mediated DNA Damage.

Published in:

Annals of the New York Academy of Sciences, 2000, v. 922, n. 1, p. 340, doi. 10.1111/j.1749-6632.2000.tb07059.x

By:

SUN, MEI;
DUANN, PU;
LIN, CHIN-TAI;
ZHANG, HUI;
LIU, LEROY F.

Publication type:

Article

Inhibition of DNA Replication in Camptothecin-Treated Cells Is Regulated by Protein Kinases.

Published in:

Annals of the New York Academy of Sciences, 2000, v. 922, n. 1, p. 355, doi. 10.1111/j.1749-6632.2000.tb07064.x

By:

ZHOU, XIANG-YANG;
WANG, YA

Publication type:

Article

Action of Topoisomerase Targeting Drugs on Non-Hodgkin's Lymphoma and Leukemia: Correlation of Clinical and Cell Culture Studies.

Published in:

Annals of the New York Academy of Sciences, 2000, v. 922, n. 1, p. 326, doi. 10.1111/j.1749-6632.2000.tb07056.x

By:

NAIR, J. S.;
KANCHERLA, R.;
SEITER, K.;
TRAGANOS, F.;
TSE-DINH, Y.-C.

Publication type:

Article

Preclinical and Clinical Trials of Topoisomerase Inhibitors.

Published in:

Annals of the New York Academy of Sciences, 2000, v. 922, n. 1, p. 92, doi. 10.1111/j.1749-6632.2000.tb07028.x

By:

SAIJO, NAGAHIRO

Publication type:

Article

Cellular and Molecular Responses to Topoisomerase I Poisons: Exploiting Synergy for Improved Radiotherapy.

Published in:

Annals of the New York Academy of Sciences, 2000, v. 922, n. 1, p. 274, doi. 10.1111/j.1749-6632.2000.tb07045.x

By:

MIYAMOTO, SHIGEKI;
HUANG, TONY T.;
WUERZBERGER-DAVIS, SHELLY;
BORNMANN, WILLIAM G.;
PINK, JOHN J.;
TAGLIARINO, COLLEEN;
KINSELLA, TIMOTHY J.;
BOOTHMAN, DAVID A.

Publication type:

Article

Metabolism of CPT-11: Impact on Activity.

Published in:

Annals of the New York Academy of Sciences, 2000, v. 922, n. 1, p. 205, doi. 10.1111/j.1749-6632.2000.tb07039.x

By:

RIVORY, LAURENT P.

Publication type:

Article

Pharmacology of Camptothecin Esters.

Published in:

Annals of the New York Academy of Sciences, 2000, v. 922, n. 1, p. 216, doi. 10.1111/j.1749-6632.2000.tb07040.x

By:

LIEHR, JOACHIM G.;
HARRIS, NICK J.;
MENDOZA, JOHN;
AHMED, AHMED E.;
GIOVANELLA, BEPPINO C.

Publication type:

Article

Structure-Based Analysis of the Effects of Camptothecin on the Activities of Human Topoisomerase I.

Published in:

Annals of the New York Academy of Sciences, 2000, v. 922, n. 1, p. 56, doi. 10.1111/j.1749-6632.2000.tb07025.x

By:

CHAMPOUX, JAMES J.

Publication type:

Article

Modified Lactone/Carboxylate Salt Equilibria in Vivo by Liposomal Delivery of 9-Nitro-Camptothecin.

Published in:

Annals of the New York Academy of Sciences, 2000, v. 922, n. 1, p. 164, doi. 10.1111/j.1749-6632.2000.tb07034.x

By:

CHOW, DIANA S-L.;
GONG, LING;
WOLFE, MICHAEL D.;
GIOVANELLA, BEPPINO C.

Publication type:

Article

Dependence of Anticancer Activity of Camptothecins on Maintaining Their Lactone Function.

Published in:

Annals of the New York Academy of Sciences, 2000, v. 922, n. 1, p. 27, doi. 10.1111/j.1749-6632.2000.tb07022.x

By:

GIOVANELLA, B. C.;
HARRIS, N.;
MENDOZA, J.;
CAO, Z.;
LIEHR, J.;
STEHLIN, J. S.

Publication type:

Article

New Analogues of Camptothecins: Activity and Resistance.

Published in:

Annals of the New York Academy of Sciences, 2000, v. 922, n. 1, p. 175, doi. 10.1111/j.1749-6632.2000.tb07035.x

By:

BOVEN, EPIE;
HATTUM, ANNEMARIE H.;
HOOGSTEEN, ILSE;
SCHLÜPER, HENNIE M.M.;
PINEDO, H. M.

Publication type:

Article

Mechanism of Action of Camptothecin.

Published in:

Annals of the New York Academy of Sciences, 2000, v. 922, n. 1, p. 1, doi. 10.1111/j.1749-6632.2000.tb07020.x

By:

LIU, LEROY F.;
DESAI, SHYAMAL D.;
LI, TSAI-KUN;
MAO, YONG;
SUN, MEI;
SIM, SAI-PENG

Publication type:

Article

The Dual Topoisomerase Inhibitor, BN 80927, Is Highly Potent against Cell Proliferation and Tumor Growth.

Published in:

Annals of the New York Academy of Sciences, 2000, v. 922, n. 1, p. 303, doi. 10.1111/j.1749-6632.2000.tb07049.x

By:

HUCHET, MARION;
DEMARQUAY, DANIÈLE;
COULOMB, HÉLÈNE;
KASPRZYK, PHILIP;
CARLSON, MARK;
LAUER, JEFFREY;
VERGNE, OLIVIER;
BIGG, DENNIS

Publication type:

Article

NF-κB Activation in Topoisomerase I Inhibitor-Induced Apoptotic Cell Death in Human Non-Small Cell Lung Cancer.

Published in:

Annals of the New York Academy of Sciences, 2000, v. 922, n. 1, p. 343, doi. 10.1111/j.1749-6632.2000.tb07060.x

By:

TABATA, MASAHIRO;
GANAPATHI, RAM

Publication type:

Article

Kinetics of in Vitro Hydrolysis of Homocamptothecins As Measured by Fluorescence.

Published in:

Annals of the New York Academy of Sciences, 2000, v. 922, n. 1, p. 314, doi. 10.1111/j.1749-6632.2000.tb07052.x

By:

CHAUVIER, D.;
CHOURPA, I.;
BIGG, D. C.H.;
MANFAIT, M.

Publication type:

Article

Molecular and Biological Determinants of the Cytotoxic Actions of Camptothecins: Perspective for the Development of New Topoisomerase I Inhibitors.

Published in:

Annals of the New York Academy of Sciences, 2000, v. 922, n. 1, p. 11, doi. 10.1111/j.1749-6632.2000.tb07021.x

By:

KOHN, KURT W.;
POMMIER, YVES

Publication type:

Article

The Cascade Radical Annulation Approach to New Analogues of Camptothecins: Combinatorial Synthesis of Silatecans and Homosilatecans.

Published in:

Annals of the New York Academy of Sciences, 2000, v. 922, n. 1, p. 112, doi. 10.1111/j.1749-6632.2000.tb07030.x

By:

CURRAN, DENNIS P.;
JOSIEN, HUBERT;
BOM, DAVID;
GABARDA, ANA E.;
DU, WU

Publication type:

Article

Alternative Administration of Camptothecin Analogues.

Published in:

Annals of the New York Academy of Sciences, 2000, v. 922, n. 1, p. 237, doi. 10.1111/j.1749-6632.2000.tb07042.x

By:

VERSCHRAEGEN, C. F.;
JAECKLE, K.;
GIOVANELLA, B.;
KNIGHT, V.;
GILBERT, B. E.

Publication type:

Article

Intraperitoneal Topoisomerase-I Inhibitors: Preliminary Findings with 9-Aminocamptothecin.

Published in:

Annals of the New York Academy of Sciences, 2000, v. 922, n. 1, p. 178, doi. 10.1111/j.1749-6632.2000.tb07036.x

By:

MUGGIA, FRANCO;
LIEBES, LEONARD;
POTMESIL, MILAN;
HAMILTON, ANNE;
HOCHSTER, HOWARD;
HORNREICH, GILA;
SORICH, JOAN;
DOWNEY, ANDREA;
WASSERSTROM, HEATHER

Publication type:

Article

Introduction.

Published in:

Annals of the New York Academy of Sciences, 2000, v. 922, n. 1, p. xi, doi. 10.1111/j.1749-6632.2000.tb07019.x

By:

LIEHR, JOACHIM G.;
GIOVANELLA, BEPPINO

Publication type:

Article

Combined Radiation and 9-Nitrocamptothecin (Rubitecan) in the Treatment of Locally Advanced Pancreatic Cancer.

Published in:

Annals of the New York Academy of Sciences, 2000, v. 922, n. 1, p. 320, doi. 10.1111/j.1749-6632.2000.tb07054.x

By:

KEMP, K. R.;
LIEHR, J. G.;
GIOVANELLA, B.

Publication type:

Article

Concluding Remarks.

Published in:

Annals of the New York Academy of Sciences, 2000, v. 922, n. 1, p. 360, doi. 10.1111/j.1749-6632.2000.tb07065.x

By:

VERSCHRAEGEN, CLAIRE

Publication type:

Article

Preclinical and Phase I Clinical Studies with Ckd-602, a Novel Camptothecin Derivative.

Published in:

Annals of the New York Academy of Sciences, 2000, v. 922, n. 1, p. 324, doi. 10.1111/j.1749-6632.2000.tb07055.x

By:

LEE, J. H.;
LEE, J. M.;
LIM, K. H.;
KIM, J. K.;
AHN, S. K.;
BANG, Y. J.;
HONG, C. I.

Publication type:

Article

Ubiquitin, SUMO-1, and UCRP in Camptothecin Sensitivity and Resistance.

Published in:

Annals of the New York Academy of Sciences, 2000, v. 922, n. 1, p. 306, doi. 10.1111/j.1749-6632.2000.tb07050.x

By:

DESAI, SHYAMAL D.;
MAO, YONG;
SUN, MEI;
LI, TSAI-KUN;
WU, JIAXI;
LIU, LEROY F.

Publication type:

Article

The Combinatorial Synthesis of Racemic Homosilatecan Libraries via a Cascade Radical Annulation.

Published in:

Annals of the New York Academy of Sciences, 2000, v. 922, n. 1, p. 317, doi. 10.1111/j.1749-6632.2000.tb07053.x

By:

DU, WU;
GABARDA, ANA E.;
BOM, DAVID;
CURRAN, DENNIS P.

Publication type:

Article

Homocamptothecins: E-Ring Modified CPT Analogues.

Published in:

Annals of the New York Academy of Sciences, 2000, v. 922, n. 1, p. 100, doi. 10.1111/j.1749-6632.2000.tb07029.x

By:

LAVERGNE, OLIVIER;
DEMARQUAY, DANIELE;
KASPRZYK, PHILIP G.;
BIGG, DENNIS C.H.

Publication type:

Article

9-Nitrocamptothecin Liposome Aerosol Treatment of Human Cancer Subcutaneous Xenografts and Pulmonary Cancer Metastases in Mice.

Published in:

Annals of the New York Academy of Sciences, 2000, v. 922, n. 1, p. 151, doi. 10.1111/j.1749-6632.2000.tb07033.x

By:

KNIGHT, VERNON;
KLEINERMAN, EUGENIE S.;
WALDREP, J. CLIFFORD;
GIOVANELLA, BEPPINO C.;
GILBERT, BRIAN E.;
KOSHKINA, NADEZHDA V.

Publication type:

Article

Structure-Activity Relationship of Alkyl Camptothecin Esters.

Published in:

Annals of the New York Academy of Sciences, 2000, v. 922, n. 1, p. 122, doi. 10.1111/j.1749-6632.2000.tb07031.x

By:

CAO, ZHISONG;
FANTAZIS, PANAYOTIS;
MENDOZA, JOHN;
EARLY, JANET;
KOZIELSKI, ANTHONY;
HARRIS, NICK;
VARDEMAN, DANA;
LIEHR, JOACHIM;
STEHLIN, JOHN S.;
GIOVANELLA, BEPPINO

Publication type:

Article

Mechanisms of DNA Topoisomerase I-Induced Cell Killing in the Yeast: Saccharomyces cerevisiae.

Published in:

Annals of the New York Academy of Sciences, 2000, v. 922, n. 1, p. 65, doi. 10.1111/j.1749-6632.2000.tb07026.x

By:

FIORANI, PAOLA;
BJORNSTI, MARY-ANN

Publication type:

Article

Topotecan (Hycamptin) and Topotecan-Containing Regimens in the Treatment of Hematologic Malignancies.

Published in:

Annals of the New York Academy of Sciences, 2000, v. 922, n. 1, p. 247, doi. 10.1111/j.1749-6632.2000.tb07043.x

By:

BERAN, MILOSLAV;
KANTARJIAN, HAGOP M.

Publication type:

Article

Campthotecin Design and Delivery Approaches for Elevating Anti-Topoisomerase I Activities in Vivo.

Published in:

Annals of the New York Academy of Sciences, 2000, v. 922, n. 1, p. 36, doi. 10.1111/j.1749-6632.2000.tb07023.x

By:

BURKE, THOMAS G.;
BOM, DAVID

Publication type:

Article

Camptothecins as Probes of the Microenvironments of Topoisomerase I - DNA Complexes.

Published in:

Annals of the New York Academy of Sciences, 2000, v. 922, n. 1, p. 76, doi. 10.1111/j.1749-6632.2000.tb07027.x

By:

HECHT, SIDNEY M.

Publication type:

Article

p53 and p21 Are Major Cellular Determinants for DNA Topoisomerase I-Mediated Radiation Sensitization in Mammalian Cells.

Published in:

Annals of the New York Academy of Sciences, 2000, v. 922, n. 1, p. 298, doi. 10.1111/j.1749-6632.2000.tb07047.x

By:

CHEN, ALLAN Y.;
SCRUGGS, PAUL B.;
GENG, LING;
ROTHENBERG, MACE L.;
HALLAHAN, DENNIS E.

Publication type:

Article

Pharmacokinetics of Orally Administered Camptothecins.

Published in:

Annals of the New York Academy of Sciences, 2000, v. 922, n. 1, p. 195, doi. 10.1111/j.1749-6632.2000.tb07038.x

By:

GUPTA, ELORA;
VYAS, VIRAL;
AHMED, FARHEENA;
SINKO, PATRICK;
COOK, THOMAS;
RUBIN, ERIC

Publication type:

Article

Transport of Topoisomerase I Inhibitors by the Breast Cancer Resistance Protein: Potential Clinical Implications.

Published in:

Annals of the New York Academy of Sciences, 2000, v. 922, n. 1, p. 188, doi. 10.1111/j.1749-6632.2000.tb07037.x

By:

SCHELLENS, JAN H.M.;
MALIEPAARD, MARC;
SCHEPER, RIK J.;
SCHEFFER, GEORGE L.;
JONKER, JOHAN W.;
SMIT, JOHAN W.;
BEIJNEN, JOS H.;
SCHINKEL, ALFRED H.

Publication type:

Article