Works matching IS 00778923 AND DT 2000 AND VI 922 AND IP 1

Results: 47

Improvement of Therapeutic Index of Low-Dose Topotecan Delivered per os.
Published in:
Annals of the New York Academy of Sciences, 2000, v. 922, n. 1, p. 330, doi. 10.1111/j.1749-6632.2000.tb07057.x
By:
- PRATESI, GRAZIELLA;
- CESARE, MICHELANDREA;
- ZUNINO, FRANCO
Publication type:
Article
The Homocamptothecin, BN 80927, Is a Potent Topoisomerase I Poison and Topoisomerase II Catalytic Inhibitor.
Published in:
Annals of the New York Academy of Sciences, 2000, v. 922, n. 1, p. 301, doi. 10.1111/j.1749-6632.2000.tb07048.x
By:
- DEMARQUAY, DANIÈLE;
- COULOMB, HÉLÈNE;
- HUCHET, MARION;
- LESUEUR-GINOT, LAURENCE;
- CAMARA, JOSÉ;
- LAVERGNE, OLIVIER;
- BIGG, DENNIS
Publication type:
Article
Feasibility, Phase I, and Pharmacological Study of Aerosolized Liposomal 9-Nitro-20(S)-Camptothecin in Patients with Advanced Malignancies in the Lungs.
Published in:
Annals of the New York Academy of Sciences, 2000, v. 922, n. 1, p. 352, doi. 10.1111/j.1749-6632.2000.tb07063.x
By:
- VERSCHRAEGEN, C. F.;
- GILBERT, B. E.;
- HUARINGA, A. J.;
- NEWMAN, R.;
- HARRIS, N.;
- LEYVA, F. J.;
- KEUS, L.;
- CAMPBELL, K.;
- NELSON-TAYLOR, T.;
- KNIGHT, V.
Publication type:
Article
Camptothecin Dose, Schedule, and Timing of Administration for Clinical Radiation Sensitization.
Published in:
Annals of the New York Academy of Sciences, 2000, v. 922, n. 1, p. 334, doi. 10.1111/j.1749-6632.2000.tb07058.x
By:
- RICH, TYVIN A.;
- KIRICHENKO, ALEXANDER V.
Publication type:
Article
DX-8951f: Summary of Phase I Clinical Trials.
Published in:
Annals of the New York Academy of Sciences, 2000, v. 922, n. 1, p. 260, doi. 10.1111/j.1749-6632.2000.tb07044.x
By:
- JAGER, R.;
- CHEVERTON, P.;
- TAMANOI, K.;
- COYLE, J.;
- DUCHARME, M.;
- SAKAMOTO, N.;
- SATOMI, M.;
- SUZUKI, M.
Publication type:
Article
Phase I Study of 9-Nitro-20(S)-Camptothecin in Combination with Cisplatin for Patients with Advanced Malignancies.
Published in:
Annals of the New York Academy of Sciences, 2000, v. 922, n. 1, p. 345, doi. 10.1111/j.1749-6632.2000.tb07061.x
By:
- VERSCHRAEGEN, C. F.;
- VINCENT, M.;
- ABBRUZZESE, J. L.;
- SIEGLER, D.;
- KAVANAGH, J. J.;
- LOYER, E.;
- KUDELKA, A. P.;
- RUBIN, E.
Publication type:
Article
In Vitro Antitumor Activity of 9-Nitro-Camptothecin as a Single Agent and in Combination with other Antitumor Drugs.
Published in:
Annals of the New York Academy of Sciences, 2000, v. 922, n. 1, p. 293, doi. 10.1111/j.1749-6632.2000.tb07046.x
By:
- BERNACKI, RALPH J.;
- PERA, PAULA;
- GAMBACORTA, PETER;
- BRUN, YSEULT;
- GRECO, WILLIAM R.
Publication type:
Article
The Clinical Development of 9-Aminocamptothecin.
Published in:
Annals of the New York Academy of Sciences, 2000, v. 922, n. 1, p. 224, doi. 10.1111/j.1749-6632.2000.tb07041.x
By:
- TAKIMOTO, CHRIS H.;
- THOMAS, REBECCA
Publication type:
Article
A Spectrophotometric Study of the pH-Dependent and DNA Binding Properties of Topotecan.
Published in:
Annals of the New York Academy of Sciences, 2000, v. 922, n. 1, p. 309, doi. 10.1111/j.1749-6632.2000.tb07051.x
By:
- MILLER, STEVEN E.;
- PILCH, DANIEL S.
Publication type:
Article
Phase II Study of Intravenous DX-8951f in Patients with Advanced Ovarian, Tubal, or Peritoneal Cancer Refractory to Platinum, Taxane, and Topotecan.
Published in:
Annals of the New York Academy of Sciences, 2000, v. 922, n. 1, p. 349, doi. 10.1111/j.1749-6632.2000.tb07062.x
By:
- VERSCHRAEGEN, C. F.;
- LEVENBACK, C.;
- VINCENT, M.;
- WOLF, J.;
- BEVERS, M.;
- LOYER, E.;
- KUDELKA, A. P.;
- KAVANAGH, J. J.
Publication type:
Article
Mechanisms of Resistance to Camptothecins.
Published in:
Annals of the New York Academy of Sciences, 2000, v. 922, n. 1, p. 46, doi. 10.1111/j.1749-6632.2000.tb07024.x
By:
- SALEEM, AHAMED;
- EDWARDS, TROY K.;
- RASHEED, ZESHAAN;
- RUBIN, ERIC H.
Publication type:
Article
Conjugation of Camptothecins to Poly-(l-Glutamic Acid).
Published in:
Annals of the New York Academy of Sciences, 2000, v. 922, n. 1, p. 136, doi. 10.1111/j.1749-6632.2000.tb07032.x
By:
- SINGER, JACK W.;
- VRIES, PETER;
- BHATT, RAMA;
- TULINSKY, JOHN;
- KLEIN, PETER;
- LI, CHUN;
- MILAS, LUKA;
- LEWIS, ROBERT A.;
- WALLACE, SIDNEY
Publication type:
Article
Rapid Chromatin Reorganization Induced by Topoisomerase I-Mediated DNA Damage.
Published in:
Annals of the New York Academy of Sciences, 2000, v. 922, n. 1, p. 340, doi. 10.1111/j.1749-6632.2000.tb07059.x
By:
- SUN, MEI;
- DUANN, PU;
- LIN, CHIN-TAI;
- ZHANG, HUI;
- LIU, LEROY F.
Publication type:
Article
Inhibition of DNA Replication in Camptothecin-Treated Cells Is Regulated by Protein Kinases.
Published in:
Annals of the New York Academy of Sciences, 2000, v. 922, n. 1, p. 355, doi. 10.1111/j.1749-6632.2000.tb07064.x
By:
- ZHOU, XIANG-YANG;
- WANG, YA
Publication type:
Article
Action of Topoisomerase Targeting Drugs on Non-Hodgkin's Lymphoma and Leukemia: Correlation of Clinical and Cell Culture Studies.
Published in:
Annals of the New York Academy of Sciences, 2000, v. 922, n. 1, p. 326, doi. 10.1111/j.1749-6632.2000.tb07056.x
By:
- NAIR, J. S.;
- KANCHERLA, R.;
- SEITER, K.;
- TRAGANOS, F.;
- TSE-DINH, Y.-C.
Publication type:
Article
Preclinical and Clinical Trials of Topoisomerase Inhibitors.
Published in:
Annals of the New York Academy of Sciences, 2000, v. 922, n. 1, p. 92, doi. 10.1111/j.1749-6632.2000.tb07028.x
By:
- SAIJO, NAGAHIRO
Publication type:
Article
Cellular and Molecular Responses to Topoisomerase I Poisons: Exploiting Synergy for Improved Radiotherapy.
Published in:
Annals of the New York Academy of Sciences, 2000, v. 922, n. 1, p. 274, doi. 10.1111/j.1749-6632.2000.tb07045.x
By:
- MIYAMOTO, SHIGEKI;
- HUANG, TONY T.;
- WUERZBERGER-DAVIS, SHELLY;
- BORNMANN, WILLIAM G.;
- PINK, JOHN J.;
- TAGLIARINO, COLLEEN;
- KINSELLA, TIMOTHY J.;
- BOOTHMAN, DAVID A.
Publication type:
Article
Metabolism of CPT-11: Impact on Activity.
Published in:
Annals of the New York Academy of Sciences, 2000, v. 922, n. 1, p. 205, doi. 10.1111/j.1749-6632.2000.tb07039.x
By:
- RIVORY, LAURENT P.
Publication type:
Article
Pharmacology of Camptothecin Esters.
Published in:
Annals of the New York Academy of Sciences, 2000, v. 922, n. 1, p. 216, doi. 10.1111/j.1749-6632.2000.tb07040.x
By:
- LIEHR, JOACHIM G.;
- HARRIS, NICK J.;
- MENDOZA, JOHN;
- AHMED, AHMED E.;
- GIOVANELLA, BEPPINO C.
Publication type:
Article
Structure-Based Analysis of the Effects of Camptothecin on the Activities of Human Topoisomerase I.
Published in:
Annals of the New York Academy of Sciences, 2000, v. 922, n. 1, p. 56, doi. 10.1111/j.1749-6632.2000.tb07025.x
By:
- CHAMPOUX, JAMES J.
Publication type:
Article
Modified Lactone/Carboxylate Salt Equilibria in Vivo by Liposomal Delivery of 9-Nitro-Camptothecin.
Published in:
Annals of the New York Academy of Sciences, 2000, v. 922, n. 1, p. 164, doi. 10.1111/j.1749-6632.2000.tb07034.x
By:
- CHOW, DIANA S-L.;
- GONG, LING;
- WOLFE, MICHAEL D.;
- GIOVANELLA, BEPPINO C.
Publication type:
Article
Dependence of Anticancer Activity of Camptothecins on Maintaining Their Lactone Function.
Published in:
Annals of the New York Academy of Sciences, 2000, v. 922, n. 1, p. 27, doi. 10.1111/j.1749-6632.2000.tb07022.x
By:
- GIOVANELLA, B. C.;
- HARRIS, N.;
- MENDOZA, J.;
- CAO, Z.;
- LIEHR, J.;
- STEHLIN, J. S.
Publication type:
Article
New Analogues of Camptothecins: Activity and Resistance.
Published in:
Annals of the New York Academy of Sciences, 2000, v. 922, n. 1, p. 175, doi. 10.1111/j.1749-6632.2000.tb07035.x
By:
- BOVEN, EPIE;
- HATTUM, ANNEMARIE H.;
- HOOGSTEEN, ILSE;
- SCHLÜPER, HENNIE M.M.;
- PINEDO, H. M.
Publication type:
Article
Mechanism of Action of Camptothecin.
Published in:
Annals of the New York Academy of Sciences, 2000, v. 922, n. 1, p. 1, doi. 10.1111/j.1749-6632.2000.tb07020.x
By:
- LIU, LEROY F.;
- DESAI, SHYAMAL D.;
- LI, TSAI-KUN;
- MAO, YONG;
- SUN, MEI;
- SIM, SAI-PENG
Publication type:
Article
The Dual Topoisomerase Inhibitor, BN 80927, Is Highly Potent against Cell Proliferation and Tumor Growth.
Published in:
Annals of the New York Academy of Sciences, 2000, v. 922, n. 1, p. 303, doi. 10.1111/j.1749-6632.2000.tb07049.x
By:
- HUCHET, MARION;
- DEMARQUAY, DANIÈLE;
- COULOMB, HÉLÈNE;
- KASPRZYK, PHILIP;
- CARLSON, MARK;
- LAUER, JEFFREY;
- VERGNE, OLIVIER;
- BIGG, DENNIS
Publication type:
Article
NF-κB Activation in Topoisomerase I Inhibitor-Induced Apoptotic Cell Death in Human Non-Small Cell Lung Cancer.
Published in:
Annals of the New York Academy of Sciences, 2000, v. 922, n. 1, p. 343, doi. 10.1111/j.1749-6632.2000.tb07060.x
By:
- TABATA, MASAHIRO;
- GANAPATHI, RAM
Publication type:
Article
Kinetics of in Vitro Hydrolysis of Homocamptothecins As Measured by Fluorescence.
Published in:
Annals of the New York Academy of Sciences, 2000, v. 922, n. 1, p. 314, doi. 10.1111/j.1749-6632.2000.tb07052.x
By:
- CHAUVIER, D.;
- CHOURPA, I.;
- BIGG, D. C.H.;
- MANFAIT, M.
Publication type:
Article
Molecular and Biological Determinants of the Cytotoxic Actions of Camptothecins: Perspective for the Development of New Topoisomerase I Inhibitors.
Published in:
Annals of the New York Academy of Sciences, 2000, v. 922, n. 1, p. 11, doi. 10.1111/j.1749-6632.2000.tb07021.x
By:
- KOHN, KURT W.;
- POMMIER, YVES
Publication type:
Article
The Cascade Radical Annulation Approach to New Analogues of Camptothecins: Combinatorial Synthesis of Silatecans and Homosilatecans.
Published in:
Annals of the New York Academy of Sciences, 2000, v. 922, n. 1, p. 112, doi. 10.1111/j.1749-6632.2000.tb07030.x
By:
- CURRAN, DENNIS P.;
- JOSIEN, HUBERT;
- BOM, DAVID;
- GABARDA, ANA E.;
- DU, WU
Publication type:
Article
Alternative Administration of Camptothecin Analogues.
Published in:
Annals of the New York Academy of Sciences, 2000, v. 922, n. 1, p. 237, doi. 10.1111/j.1749-6632.2000.tb07042.x
By:
- VERSCHRAEGEN, C. F.;
- JAECKLE, K.;
- GIOVANELLA, B.;
- KNIGHT, V.;
- GILBERT, B. E.
Publication type:
Article
Intraperitoneal Topoisomerase-I Inhibitors: Preliminary Findings with 9-Aminocamptothecin.
Published in:
Annals of the New York Academy of Sciences, 2000, v. 922, n. 1, p. 178, doi. 10.1111/j.1749-6632.2000.tb07036.x
By:
- MUGGIA, FRANCO;
- LIEBES, LEONARD;
- POTMESIL, MILAN;
- HAMILTON, ANNE;
- HOCHSTER, HOWARD;
- HORNREICH, GILA;
- SORICH, JOAN;
- DOWNEY, ANDREA;
- WASSERSTROM, HEATHER
Publication type:
Article
Introduction.
Published in:
Annals of the New York Academy of Sciences, 2000, v. 922, n. 1, p. xi, doi. 10.1111/j.1749-6632.2000.tb07019.x
By:
- LIEHR, JOACHIM G.;
- GIOVANELLA, BEPPINO
Publication type:
Article
Combined Radiation and 9-Nitrocamptothecin (Rubitecan) in the Treatment of Locally Advanced Pancreatic Cancer.
Published in:
Annals of the New York Academy of Sciences, 2000, v. 922, n. 1, p. 320, doi. 10.1111/j.1749-6632.2000.tb07054.x
By:
- KEMP, K. R.;
- LIEHR, J. G.;
- GIOVANELLA, B.
Publication type:
Article
Concluding Remarks.
Published in:
Annals of the New York Academy of Sciences, 2000, v. 922, n. 1, p. 360, doi. 10.1111/j.1749-6632.2000.tb07065.x
By:
- VERSCHRAEGEN, CLAIRE
Publication type:
Article
Preclinical and Phase I Clinical Studies with Ckd-602, a Novel Camptothecin Derivative.
Published in:
Annals of the New York Academy of Sciences, 2000, v. 922, n. 1, p. 324, doi. 10.1111/j.1749-6632.2000.tb07055.x
By:
- LEE, J. H.;
- LEE, J. M.;
- LIM, K. H.;
- KIM, J. K.;
- AHN, S. K.;
- BANG, Y. J.;
- HONG, C. I.
Publication type:
Article
Ubiquitin, SUMO-1, and UCRP in Camptothecin Sensitivity and Resistance.
Published in:
Annals of the New York Academy of Sciences, 2000, v. 922, n. 1, p. 306, doi. 10.1111/j.1749-6632.2000.tb07050.x
By:
- DESAI, SHYAMAL D.;
- MAO, YONG;
- SUN, MEI;
- LI, TSAI-KUN;
- WU, JIAXI;
- LIU, LEROY F.
Publication type:
Article
The Combinatorial Synthesis of Racemic Homosilatecan Libraries via a Cascade Radical Annulation.
Published in:
Annals of the New York Academy of Sciences, 2000, v. 922, n. 1, p. 317, doi. 10.1111/j.1749-6632.2000.tb07053.x
By:
- DU, WU;
- GABARDA, ANA E.;
- BOM, DAVID;
- CURRAN, DENNIS P.
Publication type:
Article
Homocamptothecins: E-Ring Modified CPT Analogues.
Published in:
Annals of the New York Academy of Sciences, 2000, v. 922, n. 1, p. 100, doi. 10.1111/j.1749-6632.2000.tb07029.x
By:
- LAVERGNE, OLIVIER;
- DEMARQUAY, DANIELE;
- KASPRZYK, PHILIP G.;
- BIGG, DENNIS C.H.
Publication type:
Article
9-Nitrocamptothecin Liposome Aerosol Treatment of Human Cancer Subcutaneous Xenografts and Pulmonary Cancer Metastases in Mice.
Published in:
Annals of the New York Academy of Sciences, 2000, v. 922, n. 1, p. 151, doi. 10.1111/j.1749-6632.2000.tb07033.x
By:
- KNIGHT, VERNON;
- KLEINERMAN, EUGENIE S.;
- WALDREP, J. CLIFFORD;
- GIOVANELLA, BEPPINO C.;
- GILBERT, BRIAN E.;
- KOSHKINA, NADEZHDA V.
Publication type:
Article
Structure-Activity Relationship of Alkyl Camptothecin Esters.
Published in:
Annals of the New York Academy of Sciences, 2000, v. 922, n. 1, p. 122, doi. 10.1111/j.1749-6632.2000.tb07031.x
By:
- CAO, ZHISONG;
- FANTAZIS, PANAYOTIS;
- MENDOZA, JOHN;
- EARLY, JANET;
- KOZIELSKI, ANTHONY;
- HARRIS, NICK;
- VARDEMAN, DANA;
- LIEHR, JOACHIM;
- STEHLIN, JOHN S.;
- GIOVANELLA, BEPPINO
Publication type:
Article
Mechanisms of DNA Topoisomerase I-Induced Cell Killing in the Yeast: Saccharomyces cerevisiae.
Published in:
Annals of the New York Academy of Sciences, 2000, v. 922, n. 1, p. 65, doi. 10.1111/j.1749-6632.2000.tb07026.x
By:
- FIORANI, PAOLA;
- BJORNSTI, MARY-ANN
Publication type:
Article
Topotecan (Hycamptin) and Topotecan-Containing Regimens in the Treatment of Hematologic Malignancies.
Published in:
Annals of the New York Academy of Sciences, 2000, v. 922, n. 1, p. 247, doi. 10.1111/j.1749-6632.2000.tb07043.x
By:
- BERAN, MILOSLAV;
- KANTARJIAN, HAGOP M.
Publication type:
Article
Campthotecin Design and Delivery Approaches for Elevating Anti-Topoisomerase I Activities in Vivo.
Published in:
Annals of the New York Academy of Sciences, 2000, v. 922, n. 1, p. 36, doi. 10.1111/j.1749-6632.2000.tb07023.x
By:
- BURKE, THOMAS G.;
- BOM, DAVID
Publication type:
Article
Camptothecins as Probes of the Microenvironments of Topoisomerase I - DNA Complexes.
Published in:
Annals of the New York Academy of Sciences, 2000, v. 922, n. 1, p. 76, doi. 10.1111/j.1749-6632.2000.tb07027.x
By:
- HECHT, SIDNEY M.
Publication type:
Article
p53 and p21 Are Major Cellular Determinants for DNA Topoisomerase I-Mediated Radiation Sensitization in Mammalian Cells.
Published in:
Annals of the New York Academy of Sciences, 2000, v. 922, n. 1, p. 298, doi. 10.1111/j.1749-6632.2000.tb07047.x
By:
- CHEN, ALLAN Y.;
- SCRUGGS, PAUL B.;
- GENG, LING;
- ROTHENBERG, MACE L.;
- HALLAHAN, DENNIS E.
Publication type:
Article
Pharmacokinetics of Orally Administered Camptothecins.
Published in:
Annals of the New York Academy of Sciences, 2000, v. 922, n. 1, p. 195, doi. 10.1111/j.1749-6632.2000.tb07038.x
By:
- GUPTA, ELORA;
- VYAS, VIRAL;
- AHMED, FARHEENA;
- SINKO, PATRICK;
- COOK, THOMAS;
- RUBIN, ERIC
Publication type:
Article
Transport of Topoisomerase I Inhibitors by the Breast Cancer Resistance Protein: Potential Clinical Implications.
Published in:
Annals of the New York Academy of Sciences, 2000, v. 922, n. 1, p. 188, doi. 10.1111/j.1749-6632.2000.tb07037.x
By:
- SCHELLENS, JAN H.M.;
- MALIEPAARD, MARC;
- SCHEPER, RIK J.;
- SCHEFFER, GEORGE L.;
- JONKER, JOHAN W.;
- SMIT, JOHAN W.;
- BEIJNEN, JOS H.;
- SCHINKEL, ALFRED H.
Publication type:
Article