Works in Xenobiotica, 2015, Vol 45, Issue 11

Results: 10

A comprehensive assay for nine major cytochrome P450 enzymes activities with 16 probe reactions on human liver microsomes by a single LC/MS/MS run to support reliable in vitro inhibitory drug–drug interaction evaluation.

Published in:

Xenobiotica, 2015, v. 45, n. 11, p. 961, doi. 10.3109/00498254.2015.1036954

By:

Peng, Ying;
Wu, Hui;
Zhang, Xueyuan;
Zhang, Fengyi;
Qi, Huanhuan;
Zhong, Yunxi;
Wang, Yu;
Sang, Hua;
Wang, Guangji;
Sun, Jianguo

Publication type:

Article

In vitro glucuronidation of aprepitant: a moderate inhibitor of UGT2B7.

Published in:

Xenobiotica, 2015, v. 45, n. 11, p. 990, doi. 10.3109/00498254.2015.1038743

By:

House, Larry;
Ramirez, Jacqueline;
Seminerio, Michael;
Mirkov, Snezana;
Ratain, Mark J.

Publication type:

Article

Mechanism-based inhibition of CYPs and RMs-induced hepatoxicity by rutaecarpine.

Published in:

Xenobiotica, 2015, v. 45, n. 11, p. 978, doi. 10.3109/00498254.2015.1038742

By:

Zhang, Fang-Liang;
He, Xin;
Zhai, Yi-Ran;
He, Li-Na;
Zhang, Si-Chao;
Wang, Li-Li;
Yang, Ai-Hong;
An, Li-Jun

Publication type:

Article

Interspecies variation in phase I metabolism of bufalin in hepatic microsomes from mouse, rat, dog, minipig, monkey, and human.

Published in:

Xenobiotica, 2015, v. 45, n. 11, p. 954, doi. 10.3109/00498254.2015.1035359

By:

Ning, Jing;
Hou, Jie;
Wang, Ping;
Wu, Jing-Jing;
Dai, Zi-Ru;
Zou, Li-Wei;
Li, Wei;
Ge, Guang-Bo;
Ma, Xiao-Chi;
Yang, Ling

Publication type:

Article

Pharmacokinetics, dose proportionality and permeability of S002-333 and its enantiomers, a potent antithrombotic agent, in rabbits.

Published in:

Xenobiotica, 2015, v. 45, n. 11, p. 1016, doi. 10.3109/00498254.2015.1034224

By:

Saxena, Amrita;
Valicherla, Guru R.;
Joshi, Pankaj;
Saxena, Rohit;
Cheruvu, Srikanth H.;
Bhunia, Shome S.;
Jain, Girish K.;
Siddiqui, Hefazat H.;
Saxena, Anil K.;
Gayen, Jiaur R.

Publication type:

Article

Protective effects of berberine against doxorubicin-induced cardiotoxicity in rats by inhibiting metabolism of doxorubicin.

Published in:

Xenobiotica, 2015, v. 45, n. 11, p. 1024, doi. 10.3109/00498254.2015.1034223

By:

Hao, Gang;
Yu, Yunli;
Gu, Bingren;
Xing, Yiwen;
Xue, Man

Publication type:

Article

Evaluating the enantioselective distribution, degradation and excretion of epoxiconazole in mice following a single oral gavage.

Published in:

Xenobiotica, 2015, v. 45, n. 11, p. 1009, doi. 10.3109/00498254.2015.1033778

By:

Wang, Dezhen;
Qiu, Jing;
Zhu, Wentao;
Zhang, Ping;
Deng, Nian;
Wang, Xinru;
Wang, Yao;
Zhou, Zhiqiang

Publication type:

Article

Accurate identification of UDP-glucuronosyltransferase 1A1 (UGT1A1) inhibitors using UGT1A1-overexpressing HeLa cells.

Published in:

Xenobiotica, 2015, v. 45, n. 11, p. 945, doi. 10.3109/00498254.2015.1033502

By:

Sun, Hua;
Zhou, Xiaotong;
Wu, Baojian

Publication type:

Article

Metabolism and plasma pharmacokinetics of isoorientin, a natural active ingredient, in Sprague-Dawley male rats after oral and intravenous administration.

Published in:

Xenobiotica, 2015, v. 45, n. 11, p. 999, doi. 10.3109/00498254.2015.1028513

By:

Shi, Peiying;
Lin, Xinhua;
Yao, Hong

Publication type:

Article

In vitro functional analysis of 24 novel CYP2C19 variants recently found in the Chinese Han population.

Published in:

Xenobiotica, 2015, v. 45, n. 11, p. 1030, doi. 10.3109/00498254.2015.1028512

By:

Dai, Da-Peng;
Hu, Li-Ming;
Geng, Pei-Wu;
Wang, Shuang-Hu;
Cai, Jie;
Hu, Guo-Xin;
Cai, Jian-Ping

Publication type:

Article