Works matching IS 00448249 AND DT 2003 AND VI 115 AND IP 22

Results: 36
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    Mechanistic Insights into the Conversion of Cyclohexene to Adipic Acid by H<sub>2</sub>O<sub>2</sub> in the Presence of a TAPO-5 Catalyst ( We thank the EPSRC (UK) for a rolling grant to Prof. Sir John Meurig Thomas and awards to Professors B.F.G. Johnson and K.D.M. Harris. We also thank Bayer AG, Leverkusen (Germany) for their support to Dr. Robert Raja, the Leverhulme Centre (UK), for supporting Dr. G. Sankar, Dr. M. Sanchez for helpful discussions, and Mr. G. Burns for technical assistance. )

    Published in:
    Angewandte Chemie, 2003, v. 115, n. 22, p. 2547, doi. 10.1002/ange.200390508
    By:
    • Sang-Ok Lee;
    • Robert Raja;
    • Kenneth D. M. Harris;
    • John Meurig Thomas;
    • Brian F. G. Johnson;
    • Gopinathan Sankar
    Publication type:
    Article
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    The High-Resolution Solution Structure of Epothilone A Bound to Tubulin: An Understanding of the Structure–Activity Relationships for a Powerful Class of Antitumor Agents ( This work was supported by the MPG, the DFG (Gr1112/11-1, Schi 230/14-1) and the Fonds der Chemischen Industrie. J.M. was supported by a stipend by the Fonds der Chemischen Industrie. Dr. G. Rihs and H. R. Walter of Novartis Pharma AG are thanked for the structure of epothilone A by X-ray crystallography. Dr. M. O. Steinmetz is acknowledged for his work to determine the polymerization state of tubulin in the NMR sample. )

    Published in:
    Angewandte Chemie, 2003, v. 115, n. 22, p. 2615, doi. 10.1002/ange.200351276
    By:
    • Teresa Carlomagno;
    • Marcel J. J. Blommers;
    • Jens Meiler;
    • Wolfgang Jahnke;
    • Thomas Schupp;
    • Frank Petersen;
    • Dieter Schinzer;
    • Karl-Heinz Altmann;
    • Christian Griesinger
    Publication type:
    Article
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    Highly Diastereoselective Tandem Reduction–Allylation Reactions of 1,4-Diketones with Zirconocene–Olefin Complexes ( This work was supported by Grants-in-Aid for Scientific Research from the Ministry of Education, Culture, Sports, Science, and Technology of Japan. We thank Prof. Tamejiro Hiyama and Dr. Masaki Shimizu (Kyoto University) for X-ray crystallographic analysis. K.F. acknowledges the JSPS for financial support. )

    Published in:
    Angewandte Chemie, 2003, v. 115, n. 22, p. 2654, doi. 10.1002/ange.200351480
    By:
    • Kazuya Fujita;
    • Hiroshi Shinokubo;
    • Koichiro Oshima
    Publication type:
    Article
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    A Total Synthesis of Epothilones Using Solid-Supported Reagents and Scavengers ( We gratefully acknowledge financial support for this work from AstraZeneca (to I.R.S.), the EPSRC (to P.S.J.), Merck Sharp & Dohme (to P.S.J.), Sankyo Co. Ltd., Japan (to T.T.), a B.P. endowment (to S.V.L.), and a Novartis Research Fellowship (to S.V.L.). The authors would like to thank Dr. Dearg Brown of AstraZeneca for support and useful discussions and Dr. Karl-Heinz Altmann of Novartis, Switzerland for a generous donation of authentic materials. )

    Published in:
    Angewandte Chemie, 2003, v. 115, n. 22, p. 2625, doi. 10.1002/ange.200351413
    By:
    • R. Ian Storer;
    • Toshiyasu Takemoto;
    • Philip S. Jackson;
    • Steven V. Ley
    Publication type:
    Article
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    Synthesis and Conformational Analysis of (E)-9,10-Dehydroepothilone B: A Suggestive Link between the Chemistry and Biology of Epothilones ( This work was supported by the National Institutes of Health (CA-28824). F.Y. is a Uehara Memorial Foundation Fellow. A.R. is a NIH Cancer Pharmacology Fellow (T32-CA62948). A.E.G. is a MSKCC Experimental Therapeutics Center Fellow. We thank Ms. Sylvi Rusli (NMR Core Facility, CA-02848) and Mrs. Anna Dudkina for mass spectral analyses. )

    Published in:
    Angewandte Chemie, 2003, v. 115, n. 22, p. 2622, doi. 10.1002/ange.200351407
    By:
    • Fumihiko Yoshimura;
    • Alexey Rivkin;
    • Ana E. Gabarda;
    • Ting-Chao Chou;
    • Huajin Dong;
    • George Sukenick;
    • Florence F. Morel;
    • Richard E. Taylor
    Publication type:
    Article
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    Reductive Dimerization of Tethered Pyrenes: Implications for the Reduction of Polcyclic Aromatic Hydrocarbons ( We are grateful to the United States–Israel Binational Science Foundation (BSF) (M.R.) and the Natural Sciences and Engineering Research Council (NSERC) of Canada (G.J.B.) for financial support. )

    Published in:
    Angewandte Chemie, 2003, v. 115, n. 22, p. 2651, doi. 10.1002/ange.200351376
    By:
    • Ivan Aprahamian;
    • Graham J. Bodwell;
    • James J. Fleming;
    • Gregory P. Manning;
    • Michael R. Mannion;
    • Tuvia Sheradsky;
    • Rudolf J. Vermeij;
    • Mordecai Rabinovitz
    Publication type:
    Article
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    A Fluorine Scan of Thrombin Inhibitors to Map the Fluorophilicity/Fluorophobicity of an Enzyme Active Site: Evidence for C—F···C=O Interactions ( We thank Dr. T. Tschopp for the measurement of enzyme inhibition constants. J.A.O. thanks the Carlsberg Foundation for a fellowship. The research was supported by the ETH Research Council and F. Hoffmann–La Roche Ltd. )

    Published in:
    Angewandte Chemie, 2003, v. 115, n. 22, p. 2611, doi. 10.1002/ange.200351268
    By:
    • Jacob A. Olsen;
    • David W. Banner;
    • Paul Seiler;
    • Ulrike Obst Sander;
    • Allan D'Arcy;
    • Martine Stihle;
    • Klaus Müller;
    • François Diederich
    Publication type:
    Article
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    Enantioselective Total Syntheses of the Cyclotryptamine Alkaloids Hodgkinsine and Hodgkinsine B ( This research was supported by the General Medical Sciences Institute of the NIH (grant GM-30859). NMR and mass spectra were determined at UC Irvine with instruments purchased with the assistance of the NSF and NIH shared instrumentation programs. We thank Professor Luisella Verotta, Università degli Studi, Milano, Italy, for a sample of hodgkinsine B and its characterization data. )

    Published in:
    Angewandte Chemie, 2003, v. 115, n. 22, p. 2632, doi. 10.1002/ange.200351261
    By:
    • Jeremy J. Kodanko;
    • Larry E. Overman
    Publication type:
    Article
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    Ein Phosphoran als polymergebundenes Acylanionenäquivalent: Linkerreagentien für schonende und vielseitige C-C-Kupplungen ( Ein Teil dieser Arbeit wurde auf der ORCHEM 2002 in Bad Nauheim präsentiert. Wir bedanken uns für die großzügige Unterstützung durch Prof. G. Jung und Prof. M. E. Maier, Tübingen, den Strukturfonds der Universität Tübingen, das DFG-Projekt “Reaktive Intermediate in polymeren Gelen” (Ra 895/2), den Fonds der Chemischen Industrie, die Novabiochem AG (Läufelfingen, Schweiz) und die Personal Chemistry GmbH (Konstanz). Wir danken Andreas Petri, Bojan Bister und Daniel Bischoff für Unterstützung bei den Analysen. )

    Published in:
    Angewandte Chemie, 2003, v. 115, n. 22, p. 2595, doi. 10.1002/ange.200351190
    By:
    • Steffen Weik;
    • Jörg Rademann
    Publication type:
    Article
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    Das erste Ozonid eines Phosphoroxids – Synthese, Charakterisierung und Kristallstruktur von P<sub>4</sub>O<sub>18</sub> ( Diese Arbeit wurde durch den Fonds der Chemischen Industrie gefördert. A.D. dankt der öffentlichen Hand für die seit 1992 gewährte finanzielle Unterstützung im Rahmen der Integrationsprogramme für die evaluierten Wissenschaftler der ehemaligen Akademie der Wissenschaften der DDR. Wir danken Dr. A.-R. Grimmer für die Festkörper-NMR-spektroskopischen Untersuchungen. )

    Published in:
    Angewandte Chemie, 2003, v. 115, n. 22, p. 2588, doi. 10.1002/ange.200351135
    By:
    • Anton Dimitrov;
    • Burkhard Ziemer;
    • Wolf-Dietrich Hunnius;
    • Manfred Meisel
    Publication type:
    Article
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    Stereospecific Construction of Contiguous Quaternary and Tertiary Stereocenters by Rearrangement from Indoline-2-methanol to 2,2,3-Trisubstituted Tetrahydroquinoline: Application to an Efficient Total Synthesis of Natural Virantmycin ( We thank Prof. Satoshi <FONT FACE="MetaPress 8">&#107mura (Kitasato Institute) for providing copies of NMR spectra of natural virantmycin and Mr. Youji Furukawa (Sankyo) for X-ray analysis. )

    Published in:
    Angewandte Chemie, 2003, v. 115, n. 22, p. 2644, doi. 10.1002/ange.200351069
    By:
    • Mayuko Ori;
    • Narihiro Toda;
    • Kazuko Takami;
    • Keiko Tago;
    • Hiroshi Kogen
    Publication type:
    Article
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    Derivation of Dihedral Angles from CH–CH Dipolar–Dipolar Cross-Correlated Relaxation Rates: A C–C Torsion Involving a Quaternary Carbon Atom in Epothilone A Bound to Tubulin ( This work was supported by the MPG, the DFG and the Fonds der Chemischen Industrie. V.M.S. is supported by the EU through a Marie Curie fellowship. All measurements were performed at the Large Scale Facility for Biomolecular NMR in Frankfurt (HPRI-1999-CT-00014). The authors thank T. Schupp and F. Petersen of Novartis Pharma AG for the preparation of <sup>13</sup>C-labeled epothilone. )

    Published in:
    Angewandte Chemie, 2003, v. 115, n. 22, p. 2619, doi. 10.1002/ange.200350950
    By:
    • Teresa Carlomagno;
    • Víctor M. Sánchez;
    • Marcel J. J. Blommers;
    • Christian Griesinger
    Publication type:
    Article
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