Works matching IS 00219738 AND DT 2014 AND VI 124 AND IP 2

Results: 56

Disruption of vascular Ca2+-activated chloride currents lowers blood pressure.

Published in:

2014

By:

Heinze, Christoph;
Seniuk, Anika;
Sokolov, Maxim V;
Huebner, Antje K;
Klementowicz, Agnieszka E;
Szijártó, István A;
Schleifenbaum, Johanna;
Vitzthum, Helga;
Gollasch, Maik;
Ehmke, Heimo;
Schroeder, Björn C;
Hübner, Christian A

Publication type:

journal article

SMN-targeted therapeutics for spinal muscular atrophy: are we SMArt enough yet?

Published in:

2014

By:

Swoboda, Kathryn J

Publication type:

journal article

At last: classification of human mammary cells elucidates breast cancer origins.

Published in:

2014

By:

Cardiff, Robert D;
Borowsky, Alexander D

Publication type:

journal article

Changes in neural network homeostasis trigger neuropsychiatric symptoms.

Published in:

2014

By:

Winkelmann, Aline;
Maggio, Nicola;
Eller, Joanna;
Caliskan, Gürsel;
Semtner, Marcus;
Häussler, Ute;
Jüttner, René;
Dugladze, Tamar;
Smolinsky, Birthe;
Kowalczyk, Sarah;
Chronowska, Ewa;
Schwarz, Günter;
Rathjen, Fritz G;
Rechavi, Gideon;
Haas, Carola A;
Kulik, Akos;
Gloveli, Tengis;
Heinemann, Uwe;
Meier, Jochen C

Publication type:

journal article

Targeting the cell cycle inhibitor p57Kip2 promotes adult human β cell replication.

Published in:

2014

By:

Avrahami, Dana;
Li, Changhong;
Yu, Ming;
Jiao, Yang;
Zhang, Jia;
Naji, Ali;
Ziaie, Seyed;
Glaser, Benjamin;
Kaestner, Klaus H

Publication type:

journal article

Normalizing glycosphingolipids restores function in CD4+ T cells from lupus patients.

Published in:

2014

By:

McDonald, Georgia;
Deepak, Shantal;
Miguel, Laura;
Hall, Cleo J;
Isenberg, David A;
Magee, Anthony I;
Butters, Terry;
Jury, Elizabeth C

Publication type:

journal article

Tie1 deletion inhibits tumor growth and improves angiopoietin antagonist therapy.

Published in:

2014

By:

D'Amico, Gabriela;
Korhonen, Emilia A;
Anisimov, Andrey;
Zarkada, Georgia;
Holopainen, Tanja;
Hägerling, René;
Kiefer, Friedemann;
Eklund, Lauri;
Sormunen, Raija;
Elamaa, Harri;
Brekken, Rolf A;
Adams, Ralf H;
Koh, Gou Young;
Saharinen, Pipsa;
Alitalo, Kari

Publication type:

journal article

Macrophages eliminate circulating tumor cells after monoclonal antibody therapy.

Published in:

2014

By:

Gül, Nuray;
Babes, Liane;
Siegmund, Kerstin;
Korthouwer, Rianne;
Bögels, Marijn;
Braster, Rens;
Vidarsson, Gestur;
Ten Hagen, Timo L M;
Kubes, Paul;
van Egmond, Marjolein

Publication type:

journal article

MNK1 pathway activity maintains protein synthesis in rapalog-treated gliomas.

Published in:

2014

By:

Grzmil, Michal;
Huber, Roland M;
Hess, Daniel;
Frank, Stephan;
Hynx, Debby;
Moncayo, Gerald;
Klein, Dominique;
Merlo, Adrian;
Hemmings, Brian A

Publication type:

journal article

Inactivation of SAG/RBX2 E3 ubiquitin ligase suppresses KrasG12D-driven lung tumorigenesis.

Published in:

2014

By:

Li, Hua;
Tan, Mingjia;
Jia, Lijun;
Wei, Dongping;
Zhao, Yongchao;
Chen, Guoan;
Xu, Jie;
Zhao, Lili;
Thomas, Dafydd;
Beer, David G;
Sun, Yi

Publication type:

journal article

Positive feedback between NF-κB and TNF-α promotes leukemia-initiating cell capacity.

Published in:

2014

By:

Kagoya, Yuki;
Yoshimi, Akihide;
Kataoka, Keisuke;
Nakagawa, Masahiro;
Kumano, Keiki;
Arai, Shunya;
Kobayashi, Hiroshi;
Saito, Taku;
Iwakura, Yoichiro;
Kurokawa, Mineo

Publication type:

journal article

Opioid receptor-triggered spinal mTORC1 activation contributes to morphine tolerance and hyperalgesia.

Published in:

2014

By:

Xu, Ji-Tian;
Zhao, Jian-Yuan;
Zhao, Xiuli;
Ligons, Davinna;
Tiwari, Vinod;
Atianjoh, Fidelis E;
Lee, Chun-Yi;
Liang, Lingli;
Zang, Weidong;
Njoku, Dolores;
Raja, Srinivasa N;
Yaster, Myron;
Tao, Yuan-Xiang

Publication type:

journal article

Irradiation and anti-PD-L1 treatment synergistically promote antitumor immunity in mice.

Published in:

2014

By:

Deng, Liufu;
Liang, Hua;
Burnette, Byron;
Beckett, Michael;
Darga, Thomas;
Weichselbaum, Ralph R;
Fu, Yang-Xin

Publication type:

journal article

Corrigendum.

Published in:: 2014
Publication type:: Correction Notice

Taxonomy of breast cancer based on normal cell phenotype predicts outcome.

Published in:

Journal of Clinical Investigation, 2014, v. 124, n. 2, p. 859, doi. 10.1172/JCI70941

By:

Santagata, Sandro;
Thakkar, Ankita;
Ergonul, Ayse;
Bin Wang;
Woo, Terri;
Rong Hu;
Harrell, J. Chuck;
McNamara, George;
Schwede, Matthew;
Culhane, Aedin C.;
Kindelberger, David;
Rodig, Scott;
Richardson, Andrea;
Schnitt, Stuart J.;
Tamimi, Rulla M.;
Ince, Tan A.

Publication type:

Article

Prion disease tempo determined by host-dependent substrate reduction.

Published in:

Journal of Clinical Investigation, 2014, v. 124, n. 2, p. 847, doi. 10.1172/JCI72241

By:

Mays, Charles E.;
Chae Kim;
Haldiman, Tracy;
van der Merwe, Jacques;
Lau, Agnes;
Jing Yang;
Grams, Jennifer;
Di Bari, Michele A.;
Nonno, Romolo;
Telling, Glenn C.;
Qingzhong Kong;
Langeveld, Jan;
McKenzie, Debbie;
Westaway, David;
Safar, Jiri G.

Publication type:

Article

Inactivation of SAG/RBX2 E3 ubiquitin ligase suppresses KrasG12D-driven lung tumorigenesis.

Published in:

Journal of Clinical Investigation, 2014, v. 124, n. 2, p. 835, doi. 10.1172/JCI70297

By:

Hua Li;
Mingjia Tan;
Lijun Jia;
Dongping Wei;
Yongchao Zhao;
Guoan Chen;
Jie Xu;
Lili Zhao;
Thomas, Dafydd;
Beer, David G.;
Yi Sun

Publication type:

Article

Erythropoietin promotes breast tumorigenesis through tumor-initiating cell self-renewal.

Published in:

Journal of Clinical Investigation, 2014, v. 124, n. 2, p. 553, doi. 10.1172/JCI69804

By:

Bing Zhou;
Damrauer, Jeffrey S.;
Bailey, Sean T.;
Hadzic, Tanja;
Youngtae Jeong;
Clark, Kelly;
Cheng Fan;
Murphy, Laura;
Lee, Cleo Y.;
Troester, Melissa A.;
Miller, C. Ryan;
Jian Jin;
Darr, David;
Perou, Charles M.;
Levine, Ross L.;
Diehn, Maximilian;
Kim, William Y.

Publication type:

Article

Platelet factor 4 limits Th17 differentiation and cardiac allograft rejection.

Published in:

Journal of Clinical Investigation, 2014, v. 124, n. 2, p. 543, doi. 10.1172/JCI71858

By:

Guanfang Shi;
Field, David J.;
Kyung-ae Ko;
Ture, Sara;
Srivastava, Kalyan;
Levy, Scott;
Kowalska, M. Anna;
Poncz, Mortimer;
Fowell, Deborah J.;
Morrel, Craig N.

Publication type:

Article

Positive feedback between NF-κB and TNF-α promotes leukemia-initiating cell capacity.

Published in:

Journal of Clinical Investigation, 2014, v. 124, n. 2, p. 528, doi. 10.1172/JCI68101

By:

Yuki Kagoya;
Akihide Yoshimi;
Keisuke Kataoka;
Masahiro Nakagawa;
Keiki Kumano;
Shunya Arai;
Hiroshi Kobayashi;
Taku Saito;
Yoichiro Iwakura;
Mineo Kurokawa

Publication type:

Article

Interplay between FGF21 and insulin action in the liver regulates metabolism.

Published in:

Journal of Clinical Investigation, 2014, v. 124, n. 2, p. 515, doi. 10.1172/JCI67353

By:

Emanuelli, Brice;
Vienberg, Sara G.;
Smyth, Graham;
Cheng, Christine;
Stanford, Kristin I.;
Arumugam, Manimozhiyan;
Michael, Mervyn D.;
Adams, Andrew C.;
Kharitonenkov, Alexei;
Kahn, C. Ronald

Publication type:

Article

Dapagliflozin improves muscle insulin sensitivity but enhances endogenous glucose production.

Published in:

Journal of Clinical Investigation, 2014, v. 124, n. 2, p. 509, doi. 10.1172/JCI70704

By:

Merovci, Aurora;
Solis-Herrera, Carolina;
Daniele, Giuseppe;
Eldor, Roy;
Fiorentino, Teresa Vanessa;
Tripathy, Devjit;
Xiong, Juan;
Perez, Zandra;
Norton, Luke;
Abdul-Ghani, Muhammad A.;
DeFronzo, Ralph A.

Publication type:

Article

Tie1 deletion inhibits tumor growth and improves angiopoietin antagonist therapy.

Published in:

Journal of Clinical Investigation, 2014, v. 124, n. 2, p. 824, doi. 10.1172/JCI68897

By:

D'Amico, Gabriela;
Korhonen, Emilia A.;
Anisimov, Andrey;
Zarkada, Georgia;
Holopainen, Tanja;
Hägerling, René;
Kiefer, Friedemann;
Eklund, Lauri;
Sormunen, Raija;
Elamaa, Harri;
Brekken, Rolf A.;
Adams, Ralf H.;
Gou Young Koh;
Saharinen, Pipsa;
Alitalo, Kari

Publication type:

Article

Macrophages eliminate circulating tumor cells after monoclonal antibody therapy.

Published in:

Journal of Clinical Investigation, 2014, v. 124, n. 2, p. 812, doi. 10.1172/JCI66776

By:

Gül, Nuray;
Babes, Liane;
Siegmund, Kerstin;
Korthouwer, Rianne;
Bögels, Marijn;
Braster, Rens;
Vidarsson, Gestur;
ten Hagen, Timo L. M.;
Kubes, Paul;
van Egmond, Marjolein

Publication type:

Article

Prenatal retinoid deficiency leads to airway hyperresponsiveness in adult mice.

Published in:

Journal of Clinical Investigation, 2014, v. 124, n. 2, p. 801, doi. 10.1172/JCI70291

By:

Chen, Felicia;
Marquez, Hector;
Youn-Kyung Kim;
Jun Qian;
Fengzhi Shao;
Fine, Alan;
Cruikshank, William W.;
Quadro, Loredana;
Cardoso, Wellington V.

Publication type:

Article

Requirement of enhanced Survival Motoneuron protein imposed during neuromuscular junction maturation.

Published in:

Journal of Clinical Investigation, 2014, v. 124, n. 2, p. 785, doi. 10.1172/JCI72017

By:

Kariya, Shingo;
Obis, Teresa;
Garone, Caterina;
Akay, Turgay;
Sera, Fusako;
Shinichi Iwata;
Shunichi Homma;
Monani, Umrao R.

Publication type:

Article

Nutrient sensing by the mitochondrial transcription machinery dictates oxidative phosphorylation.

Published in:

Journal of Clinical Investigation, 2014, v. 124, n. 2, p. 768, doi. 10.1172/JCI69413

By:

Lijun Liu;
Minwoo Nam;
Wei Fan;
Akie, Thomas E.;
Hoaglin, David C.;
Guangping Gao;
Keaney Jr., John F.;
Cooper, Marcus P.

Publication type:

Article

Tgfbr2 disruption in postnatal smooth muscle impairs aortic wall homeostasis.

Published in:

Journal of Clinical Investigation, 2014, v. 124, n. 2, p. 755, doi. 10.1172/JCI69942

By:

Wei Li;
Qingle Li;
Yang Jiao;
Lingfeng Qin;
Ali, Rahmat;
Jing Zhou;
Ferruzzi, Jacopo;
Kim, Richard W.;
Geirsson, Arnar;
Dietz, Harry C.;
Offermanns, Stefan;
Humphrey, Jay D.;
Tellides, George

Publication type:

Article

MNK1 pathway activity maintains protein synthesis in rapalog-treated gliomas.

Published in:

Journal of Clinical Investigation, 2014, v. 124, n. 2, p. 742, doi. 10.1172/JCI70198

By:

Grzmil, Michal;
Huber, Roland M.;
Hess, Daniel;
Frank, Stephan;
Hynx, Debby;
Moncayo, Gerald;
Klein, Dominique;
Merlo, Adrian;
Hemmings, Brian A.

Publication type:

Article

NRF2-mediated Notch pathway activation enhances hematopoietic reconstitution following myelosuppressive radiation.

Published in:

Journal of Clinical Investigation, 2014, v. 124, n. 2, p. 730, doi. 10.1172/JCI70812

By:

Jung-Hyun Kim;
Thimmulappa, Rajesh K.;
Kumar, Vineet;
Wanchang Cui;
Kumar, Sarvesh;
Kombairaju, Ponvijay;
Hao Zhang;
Margolick, Joseph;
Matsui, William;
Macvittie, Thomas;
Malhotra, Sanjay V.;
Biswal, Shyam

Publication type:

Article

Human IgG Fc domain engineering enhances antitoxin neutralizing antibody activity.

Published in:

Journal of Clinical Investigation, 2014, v. 124, n. 2, p. 725, doi. 10.1172/JCI72676

By:

Bournazos, Stylianos;
Siu-Kei Chow;
Abboud, Nareen;
Casadevall, Arturo;
Ravetch, Jeffrey V.

Publication type:

Article

Normalizing glycosphingolipids restores function in CD4+ T cells from lupus patients.

Published in:

Journal of Clinical Investigation, 2014, v. 124, n. 2, p. 712, doi. 10.1172/JCI69571

By:

McDonald, Georgia;
Deepak, Shantal;
Miguel, Laura;
Hall, Cleo J.;
Isenberg, David A.;
Magee, Anthony I.;
Butters, Terry;
Jury, Elizabeth C.

Publication type:

Article

Changes in neural network homeostasis trigger neuropsychiatric symptoms.

Published in:

Journal of Clinical Investigation, 2014, v. 124, n. 2, p. 696, doi. 10.1172/JCI71472

By:

Winkelmann, Aline;
Maggio, Nicola;
Eller, Joanna;
Caliskan, Gürsel;
Semtner, Marcus;
Häussler, Ute;
Jüttner, Rene;
Dugladze, Tamar;
Smolinsky, Birthe;
Kowalczyk, Sarah;
Chronowska, Ewa;
Schwarz, Günter;
Rathjen, Fritz G.;
Rechavi, Gideon;
Haas, Carola A.;
Kulik, Akos;
Gloveli, Tengis;
Heinemann, Uwe;
Meier, Jochen C.

Publication type:

Article

Irradiation and anti--PD-L1 treatment synergistically promote antitumor immunity in mice.

Published in:

Journal of Clinical Investigation, 2014, v. 124, n. 2, p. 687, doi. 10.1172/JCI67313

By:

Liufu Deng;
Hua Liang;
Burnette, Byron;
Beckett, Michael;
Darga, Thomas;
Weichselbaum, Ralph R.;
Yang-Xin Fu

Publication type:

Article

Disruption of vascular Ca2+-activated chloride currents lowers blood pressure.

Published in:

Journal of Clinical Investigation, 2014, v. 124, n. 2, p. 675, doi. 10.1172/JCI70025

By:

Heinze, Christoph;
Seniuk, Anika;
Sokolov, Maxim V.;
Huebner, Antje K.;
Klementowicz, Agnieszka E.;
Szijártó, István A.;
Schleifenbaum, Johanna;
Vitzthum, Helga;
Gollasch, Maik;
Ehmke, Heimo;
Schroeder, Bjorn C.;
Hubner, Christian A.

Publication type:

Article

Targeting the cell cycle inhibitor p57Kip2 promotes adult human β cell replication.

Published in:

Journal of Clinical Investigation, 2014, v. 124, n. 2, p. 670, doi. 10.1172/JCI69519

By:

Avrahami, Dana;
Changhong Li;
Ming Yu;
Yang Jiao;
Jia Zhang;
Ali Naji;
Ziaie, Seyed;
Glaser, Benjamin;
Kaestner, Klaus H.

Publication type:

Article

Neuronal ferritin heavy chain and drug abuse affect HIV-associated cognitive dysfunction.

Published in:

Journal of Clinical Investigation, 2014, v. 124, n. 2, p. 656, doi. 10.1172/JCI70090

By:

Pitcher, Jonathan;
Abt, Anna;
Myers, Jaclyn;
Han, Rachel;
Snyder, Melissa;
Graziano, Alessandro;
Festa, Lindsay;
Kutzler, Michele;
Garcia, Fernando;
Wen-Jun Gao;
Fischer-Smith, Tracy;
Rappaport, Jay;
Meucci, Olimpia

Publication type:

Article

Phenothiazines induce PP2A-mediated apoptosis in T cell acute lymphoblastic leukemia.

Published in:

Journal of Clinical Investigation, 2014, v. 124, n. 2, p. 644, doi. 10.1172/JCI65093

By:

Gutierrez, Alejandro;
Li Pan;
Groen, Richard W. J.;
Baleydier, Frederic;
Kentsis, Alex;
Marineau, Jason;
Grebliunaite, Ruta;
Kozakewich, Elena;
Reed, Casie;
Pflumio, Francoise;
Poglio, Sandrine;
Uzan, Benjamin;
Clemons, Paul;
VerPlank, Lynn;
An, Frank;
Burbank, Jason;
Norton, Stephanie;
Tolliday, Nicola;
Steen, Hanno;
Weng, Andrew P.

Publication type:

Article

OTX2 loss causes rod differentiation defect in CRX-associated congenital blindness.

Published in:

Journal of Clinical Investigation, 2014, v. 124, n. 2, p. 631, doi. 10.1172/JCI72722

By:

Roger, Jerome E.;
Hiriyanna, Avinash;
Norimoto Gotoh;
Hong Hao;
Cheng, Debbie F.;
Ratnapriya, Rinki;
Kautzmann, Marie-Audrey I.;
Bo Chang;
Swaroop, Anand

Publication type:

Article

Cardiotoxicity of doxorubicin is mediated through mitochondrial iron accumulation.

Published in:

Journal of Clinical Investigation, 2014, v. 124, n. 2, p. 617, doi. 10.1172/JCI72931

By:

Yoshihiko Ichikawa;
Ghanefar, Mohsen;
Bayeva, Marina;
Rongxue Wu;
Khechaduri, Arineh;
Prasad, Sathyamangla V. Naga;
Mutharasan, R. Kannan;
Naik, Tejaswitha Jairaj;
Ardehali, Hossein

Publication type:

Article

Orexin neurons suppress narcolepsy via 2 distinct efferent pathways.

Published in:

Journal of Clinical Investigation, 2014, v. 124, n. 2, p. 604, doi. 10.1172/JCI71017

By:

Emi Hasegawa;
Masashi Yanagisawa;
Takeshi Sakurai;
and Michihiro Mieda

Publication type:

Article

Opioid receptor--triggered spinal mTORC1 activation contributes to morphine tolerance and hyperalgesia.

Published in:

Journal of Clinical Investigation, 2014, v. 124, n. 2, p. 592, doi. 10.1172/JCI70236

By:

Ji-Tian Xu;
Jian-Yuan Zhao;
Xiuli Zhao;
Ligons, Davinna;
Tiwari, Vinod;
Atianjoh, Fidelis E.;
Ohun-Yi Lee;
Lingli Liang;
Weidong Zang;
Njoku, Dolores;
Raja, Srinivasa N.;
Yaster, Myron;
Yuan-Xiang Tao

Publication type:

Article

Thrombocytopenia-associated mutations in the ANKRD26 regulatory region induce MAPK hyperactivation.

Published in:

Journal of Clinical Investigation, 2014, v. 124, n. 2, p. 580, doi. 10.1172/JCI71861

By:

Bluteau, Dominique;
Balduini, Alessandra;
Balayn, Nathalie;
Currao, Manuela;
Nurden, Paquita;
Deswarte, Caroline;
Leverger, Guy;
Noris, Patrizia;
Perrotta, Silverio;
Solary, Eric;
Vainchenker, William;
Debili, Najet;
Favier, Remi;
Raslova, Hana

Publication type:

Article

Sustained activation of SMAD3/SMAD4 by FOXM1 promotes TGF-β-dependent cancer metastasis.

Published in:

Journal of Clinical Investigation, 2014, v. 124, n. 2, p. 564, doi. 10.1172/JCI71104

By:

Jianfei Xue;
Xia Lin;
Wen-Tai Chiu;
Yao-Hui Chen;
Guanzhen Yu;
Mingguang Liu;
Xin-Hua Feng;
Sawaya, Raymond;
Medema, René H.;
Mien-Chie Hung;
Suyun Huang

Publication type:

Article

Metabolic response to sodium-glucose cotransporter 2 inhibition in type 2 diabetic patients.

Published in:

Journal of Clinical Investigation, 2014, v. 124, n. 2, p. 499, doi. 10.1172/JCI72227

By:

Ferrannini, Ele;
Muscelli, Elza;
Frascerra, Silvia;
Baldi, Simona;
Mari, Andrea;
Heise, Tim;
Broedl, Uli C.;
Woerle, Hans-Juergen

Publication type:

Article

Evaluation of teriparatide treatment in adults with osteogenesis imperfecta.

Published in:

Journal of Clinical Investigation, 2014, v. 124, n. 2, p. 491, doi. 10.1172/JCI71101

By:

Orwoll, Eric S.;
Shapiro, Jay;
Veith, Sandra;
Ying Wang;
Lapidus, Jodi;
Vanek, Chaim;
Reeder, Jan L.;
Keaveny, Tony M.;
Lee, David C.;
Mullins, Mary A.;
Nagamani, Sandesh C. S.;
Lee, Brendan

Publication type:

Article

Paradoxical insights into whole body metabolic adaptations following SGLT2 inhibition.

Published in:

Journal of Clinical Investigation, 2014, v. 124, n. 2, p. 485, doi. 10.1172/JCI74297

By:

Cefalu, William T.

Publication type:

Article

SMN-targeted therapeutics for spinal muscular atrophy are we SMArt enough yet?

Published in:

Journal of Clinical Investigation, 2014, v. 124, n. 2, p. 487, doi. 10.1172/JCI74142

By:

Swoboda, Kathryn J.

Publication type:

Article

Osteogenesis imperfecta in adults.

Published in:

Journal of Clinical Investigation, 2014, v. 124, n. 2, p. 476, doi. 10.1172/JCI74230

By:

Bishop, Nick J.;
Walsh, Jennifer S.

Publication type:

Article

Lipids rule: resetting lipid metabolism restores T cell function in systemic lupus erythematosus.

Published in:

Journal of Clinical Investigation, 2014, v. 124, n. 2, p. 482, doi. 10.1172/JCI74141

By:

Kidani, Yoko;
Bensinger, Steven J.

Publication type:

Article