Works matching IS 00218820 AND DT 2018 AND VI 71 AND IP 2

Results: 24

Halistanol sulfates I and J, new SIRT1-3 inhibitory steroid sulfates from a marine sponge of the genus Halichondria.

Published in:

Journal of Antibiotics, 2018, v. 71, n. 2, p. 273, doi. 10.1038/ja.2017.145

By:

Nakamura, Fumiaki;
Kudo, Norio;
Tomachi, Yuki;
Nakata, Akiko;
Takemoto, Misao;
Ito, Akihiro;
Tabei, Hodaka;
Arai, Daisuke;
de Voogd, Nicole;
Yoshida, Minoru;
Nakao, Yoichi;
Fusetani, Nobuhiro

Publication type:

Article

Synthesis and SARs of novel lincomycin derivatives Part 5: optimization of lincomycin analogs exhibiting potent antibacterial activities by chemical modification at the 6- and 7-positions.

Published in:

Journal of Antibiotics, 2018, v. 71, n. 2, p. 298, doi. 10.1038/ja.2017.114

By:

Wakiyama, Yoshinari;
Kumura, Ko;
Umemura, Eijiro;
Masaki, Satomi;
Ueda, Kazutaka;
Sato, Yasuo;
Hirai, Yoko;
Hayashi, Yoshio;
Ajito, Keiichi

Publication type:

Article

Challenges and discoveries in the total synthesis of complex polyketide natural products.

Published in:

Journal of Antibiotics, 2018, v. 71, n. 2, p. 215, doi. 10.1038/ja.2017.111

By:

Paterson, Ian;
Lam, Nelson Yuen Sum

Publication type:

Article

Biography of Professor Nicolaou: a journey to the extremes of molecular complexity.

Published in:

Journal of Antibiotics, 2018, v. 71, n. 2, p. 149, doi. 10.1038/ja.2017.144

By:

Winssinger, Nicolas

Publication type:

Article

Using experimental evolution to identify druggable targets that could inhibit the evolution of antimicrobial resistance.

Published in:

Journal of Antibiotics, 2018, v. 71, n. 2, p. 279, doi. 10.1038/ja.2017.108

By:

Mehta, Heer H;
Prater, Amy G;
Shamoo, Yousif

Publication type:

Article

Large-scale preparation of key building blocks for the manufacture of fully synthetic macrolide antibiotics.

Published in:

Journal of Antibiotics, 2018, v. 71, n. 2, p. 318, doi. 10.1038/ja.2017.116

By:

Hogan, Philip C;
Chen, Chi-Li;
Mulvihill, Kristen M;
Lawrence, Jonathan F;
Moorhead, Eric;
Rickmeier, Jens;
Myers, Andrew G

Publication type:

Article

Enantiospecific total synthesis of the squalene synthase inhibitors (-)-CJ-13,982 and its enantiomer from a common intermediate.

Published in:

Journal of Antibiotics, 2018, v. 71, n. 2, p. 234, doi. 10.1038/ja.2017.127

By:

Sturgess, Dayna;
Chen, Zongjia;
White, Jonathan M;
Rizzacasa, Mark A

Publication type:

Article

Isolation and structure elucidation of lipopeptide antibiotic taromycin B from the activated taromycin biosynthetic gene cluster.

Published in:

Journal of Antibiotics, 2018, v. 71, n. 2, p. 333, doi. 10.1038/ja.2017.146

By:

Reynolds, Kirk A;
Luhavaya, Hanna;
Li, Jie;
Dahesh, Samira;
Nizet, Victor;
Yamanaka, Kazuya;
Moore, Bradley S

Publication type:

Article

Total synthesis of (+)-lysergic acid.

Published in:

Journal of Antibiotics, 2018, v. 71, n. 2, p. 240, doi. 10.1038/ja.2017.80

By:

Kanno, Rentaro;
Yokoshima, Satoshi;
Kanai, Motomu;
Fukuyama, Tohru

Publication type:

Article

Corrigendum: Total synthesis and absolute configuration of avenolide, extracellular factor in Streptomyces avermitilis.

Published in:

Journal of Antibiotics, 2018, v. 71, n. 2, p. 348, doi. 10.1038/ja.2017.148

By:

Uchida, Miho;
Takamatsu, Satoshi;
Arima, Shiho;
Miyamoto, Kiyoko T;
Kitani, Shigeru;
Nihira, Takuya;
Ikeda, Haruo;
Nagamitsu, Tohru

Publication type:

Article

A three-component coupling approach to the ACE-ring substructure of C19-diterpene alkaloids.

Published in:

Journal of Antibiotics, 2018, v. 71, n. 2, p. 326, doi. 10.1038/ja.2017.69

By:

Minagawa, Kosuke;
Urabe, Daisuke;
Inoue, Masayuki

Publication type:

Article

Heterocyclyl tetracyclines. 2. 7-Methoxy-8-pyrrolidinyltetracyclines: discovery of TP-2758, a potent, orally efficacious antimicrobial against Gram-negative pathogens.

Published in:

Journal of Antibiotics, 2018, v. 71, n. 2, p. 287, doi. 10.1038/ja.2017.86

By:

Sun, Cuixiang;
Deng, Yonghong;
Hunt, Diana K;
Fyfe, Corey;
Chen, Chi-Li;
Clark, Roger B;
Grossman, Trudy H;
Sutcliffe, Joyce A;
Xiao, Xiao-Yi

Publication type:

Article

Chemotherapeutics overcoming nonsense mutation-associated genetic diseases: medicinal chemistry of negamycin.

Published in:

Journal of Antibiotics, 2018, v. 71, n. 2, p. 205, doi. 10.1038/ja.2017.112

By:

Taguchi, Akihiro;
Hamada, Keisuke;
Hayashi, Yoshio

Publication type:

Article

A brief history of antibiotics and select advances in their synthesis.

Published in:

Journal of Antibiotics, 2018, v. 71, n. 2, p. 153, doi. 10.1038/ja.2017.62

By:

Nicolaou, Kyriacos C;
Rigol, Stephan

Publication type:

Article

Professor KC Nicolaou expanded the world of synthetic organic chemistry by total synthesis and his laboratories have fostered many talented researchers.

Published in:

Journal of Antibiotics, 2018, v. 71, n. 2, p. 151, doi. 10.1038/ja.2017.147

By:

Ajito, Keiichi

Publication type:

Article

Discovery of 2-hydroxyarbekacin, a new aminoglycoside antibiotic with reduced nephrotoxicity.

Published in:

Journal of Antibiotics, 2018, v. 71, n. 2, p. 345, doi. 10.1038/ja.2017.60

By:

Takahashi, Yoshiaki;
Umemura, Eijiro;
Kobayashi, Yoshihiko;
Murakami, Shoichi;
Nawa, Toru;
Morinaka, Akihiro;
Miyake, Toshiaki;
Shibasaki, Masakatsu

Publication type:

Article

Synthesis of unique spirocyclic orthoester-type derivatives of isothiazolo[4,3-d]pyrimidine nucleosides.

Published in:

Journal of Antibiotics, 2018, v. 71, n. 2, p. 342, doi. 10.1038/ja.2017.87

By:

Rovira, Alexander R;
Tor, Yitzhak

Publication type:

Article

Toward the total synthesis of luminamicin; an anaerobic antibiotic: construction of highly functionalized cis-decalin containing a bridged ether moiety.

Published in:

Journal of Antibiotics, 2018, v. 71, n. 2, p. 268, doi. 10.1038/ja.2017.77

By:

Ando, Hiroyasu;
Kimishima, Aoi;
Ohara, Motoyoshi;
Hirose, Tomoyasu;
Matsumaru, Takanori;
Takada, Hirokazu;
Morodome, Keisuke;
Miyamoto, Takehiro;
Sugawara, Akihiro;
Ōmura, Satoshi;
Sunazuka, Toshiaki

Publication type:

Article

Albiducins A and B, salicylaldehyde antibiotics from the ash tree-associated saprotrophic fungus Hymenoscyphus albidus.

Published in:

Journal of Antibiotics, 2018, v. 71, n. 2, p. 339, doi. 10.1038/ja.2017.66

By:

Halecker, Sandra;
Surup, Frank;
Solheim, Halvor;
Stadler, Marc

Publication type:

Article

Formal synthesis of englerin A utilizing regio- and diastereoselective [4+3] cycloaddition.

Published in:

Journal of Antibiotics, 2018, v. 71, n. 2, p. 257, doi. 10.1038/ja.2017.91

By:

Hagihara, Shuichi;
Hanaya, Kengo;
Sugai, Takeshi;
Shoji, Mitsuru

Publication type:

Article

Corrigendum: Microbial metabolites and derivatives targeted at inflammation and bone diseases therapy: chemistry, biological activity and pharmacology.

Published in:

Journal of Antibiotics, 2018, v. 71, n. 2, p. 349, doi. 10.1038/ja.2017.149

By:

Adachi, Hayamitsu;
Nakae, Koichi;
Sakamoto, Shuichi;
Nosaka, Chisato;
Atsumi, Sonoko;
Shibuya, Masabumi;
Higashi, Nobuaki;
Nakajima, Motowo;
Irimura, Tatsuro;
Nishimura, Yoshio

Publication type:

Article

Progress towards the total synthesis of hamigerans C and D: a direct approach to an elaborated 6-7-5 carbocyclic core.

Published in:

Journal of Antibiotics, 2018, v. 71, n. 2, p. 263, doi. 10.1038/ja.2017.96

By:

Duquette, Douglas Charles;
Jensen, Thomas;
Stoltz, Brian Mark

Publication type:

Article

Total synthesis of architecturally complex indole terpenoids: strategic and tactical evolution.

Published in:

Journal of Antibiotics, 2018, v. 71, n. 2, p. 185, doi. 10.1038/ja.2017.94

By:

Zou, Yike;
Smith, Amos B

Publication type:

Article

Synthesis of deoxyelephantopin analogues.

Published in:

Journal of Antibiotics, 2018, v. 71, n. 2, p. 248, doi. 10.1038/ja.2017.132

By:

Lagoutte, Roman;
Serba, Christelle;
Winssinger, Nicolas

Publication type:

Article