Works in Journal of Clinical Investigation, 2017, Vol 127, Issue 4

Results: 44

Glucose-induced β cell production of IL-1β contributes to glucotoxicity in human pancreatic islets.

Published in:

2017

By:

Maedler, Kathrin;
Sergeev, Pavel;
Ris, Frédéric;
Oberholzer, José;
Joller-Jemelka, Helen I;
Spinas, Giatgen A;
Kaiser, Nurit;
Halban, Philippe A;
Donath, Marc Y

Publication type:

journal article

Fibroblastic niches prime T cell alloimmunity through Delta-like Notch ligands.

Published in:

2017

By:

Jooho Chung;
Ebens, Christen L.;
Perkey, Eric;
Radojcic, Vedran;
Koch, Ute;
Scarpellino, Leonardo;
Tong, Alexander;
Allen, Frederick;
Wood, Sherri;
Jiane Feng;
Friedman, Ann;
Granadier, David;
Tran, Ivy T.;
Qian Chai;
Onder, Lucas;
Minhong Yan;
Reddy, Pavan;
Blazar, Bruce R.;
Huang, Alex Y.;
Brennan, Todd V.

Publication type:

journal article

Alternatively spliced mu opioid receptor C termini impact the diverse actions of morphine.

Published in:

2017

By:

Jin Xu;
Zhigang Lu;
Narayan, Ankita;
Le Rouzic, Valerie P.;
Mingming Xu;
Hunkele, Amanda;
Brown, Taylor G.;
Hoefer, William F.;
Rossi, Grace C.;
Rice, Richard C.;
Martínez-Rivera, Arlene;
Rajadhyaksha, Anjali M.;
Cartegni, Luca;
Bassoni, Daniel L.;
Pasternak, Gavril W.;
Ying-Xian Pan;
Xu, Jin;
Lu, Zhigang;
Xu, Mingming;
Pan, Ying-Xian

Publication type:

journal article

Extracellular matrix proteomics identifies molecular signature of symptomatic carotid plaques.

Published in:

2017

By:

Langley, Sarah R.;
Willeit, Karin;
Didangelos, Athanasios;
Perisic Matic, Ljubica;
Skroblin, Philipp;
Barallobre-Barreiro, Javier;
Lengquist, Mariette;
Rungger, Gregor;
Kapustin, Alexander;
Kedenko, Ludmilla;
Molenaar, Chris;
Ruifang Lu;
Barwari, Temo;
Suna, Gonca;
Xiaoke Yin;
Iglseder, Bernhard;
Paulweber, Bernhard;
Willeit, Peter;
Shalhoub, Joseph;
Pasterkamp, Gerard

Publication type:

journal article

Estrogens enhance myoblast differentiation in facioscapulohumeral muscular dystrophy by antagonizing DUX4 activity.

Published in:

2017

By:

Teveroni, Emanuela;
Pellegrino, Marsha;
Sacconi, Sabrina;
Calandra, Patrizia;
Cascino, Isabella;
Farioli-Vecchioli, Stefano;
Puma, Angela;
Garibaldi, Matteo;
Morosetti, Roberta;
Tasca, Giorgio;
Ricci, Enzo;
Pietro Trevisan, Carlo;
Galluzzi, Giuliana;
Pontecorvi, Alfredo;
Crescenzi, Marco;
Deidda, Giancarlo;
Moretti, Fabiola;
Trevisan, Carlo Pietro

Publication type:

journal article

Autocrine lysophosphatidic acid signaling activates β-catenin and promotes lung allograft fibrosis.

Published in:

2017

By:

Pengxiu Cao;
Yoshiro Aoki;
Badri, Linda;
Walker, Natalie M.;
Manning, Casey M.;
Lagstein, Amir;
Fearon, Eric R.;
Lama, Vibha N.;
Cao, Pengxiu;
Aoki, Yoshiro

Publication type:

journal article

Sirtuin 2 regulates cellular iron homeostasis via deacetylation of transcription factor NRF2.

Published in:

2017

By:

Xiaoyan Yang;
Seong-Hoon Park;
Hsiang-Chun Chang;
Shapiro, Jason S.;
Vassilopoulos, Athanassios;
Sawicki, Konrad T.;
Chunlei Chen;
Meng Shang;
Burridge, Paul W.;
Epting, Conrad L.;
Wilsbacher, Lisa D.;
Jenkitkasemwong, Supak;
Knutson, Mitchell;
Gius, David;
Ardehali, Hossein;
Yang, Xiaoyan;
Park, Seong-Hoon;
Chang, Hsiang-Chun;
Chen, Chunlei;
Shang, Meng

Publication type:

journal article

T cells control the generation of nanomolar-affinity anti-glycan antibodies.

Published in:

2017

By:

Polonskaya, Zinaida;
Shenglou Deng;
Sarkar, Anita;
Kain, Lisa;
Comellas-Aragones, Marta;
McKay, Craig S.;
Kaczanowska, Katarzyna;
Holt, Marie;
McBride, Ryan;
Palomo, Valle;
Self, Kevin M.;
Taylor, Seth;
Irimia, Adriana;
Mehta, Sanjay R.;
Dan, Jennifer M.;
Brigger, Matthew;
Crotty, Shane;
Schoenberger, Stephen P.;
Paulson, James C.;
Wilson, Ian A.

Publication type:

journal article

Mutations in γ-secretase subunit-encoding PSENEN underlie Dowling-Degos disease associated with acne inversa.

Published in:

2017

By:

Ralser, Damian J.;
Basmanav, F. Buket Ü.;
Tafazzoli, Aylar;
Wititsuwannakul, Jade;
Delker, Sarah;
Danda, Sumita;
Thiele, Holger;
Wolf, Sabrina;
Busch, Michélle;
Pulimood, Susanne A.;
Altmüller, Janine;
Nürnberg, Peter;
Lacombe, Didier;
Hillen, Uwe;
Wenzel, Jörg;
Frank, Jorge;
Odermatt, Benjamin;
Betz, Regina C.

Publication type:

journal article

Loss of DDRGK1 modulates SOX9 ubiquitination in spondyloepimetaphyseal dysplasia.

Published in:

2017

By:

Egunsola, Adetutu T.;
Yangjin Bae;
Ming-Ming Jiang;
Liu, David S.;
Yuqing Chen-Evenson;
Bertin, Terry;
Shan Chen;
Lu, James T.;
Nevarez, Lisette;
Magal, Nurit;
Raas-Rothschild, Annick;
Swindell, Eric C.;
Cohn, Daniel H.;
Gibbs, Richard A.;
Campeau, Philippe M.;
Shohat, Mordechai;
Lee, Brendan H.;
Bae, Yangjin;
Jiang, Ming-Ming;
Chen-Evenson, Yuqing

Publication type:

journal article

The antiviral restriction factor IFN-induced transmembrane protein 3 prevents cytokine-driven CMV pathogenesis.

Published in:

2017

By:

Stacey, Maria A.;
Clare, Simon;
Clement, Mathew;
Marsden, Morgan;
Abdul-Karim, Juneid;
Kane, Leanne;
Harcourt, Katherine;
Brandt, Cordelia;
Fielding, Ceri A.;
Smith, Sarah E.;
Wash, Rachael S.;
Gimeno Brias, Silvia;
Stack, Gabrielle;
Notley, George;
Cambridge, Emma L.;
Isherwood, Christopher;
Speak, Anneliese O.;
Johnson, Zoë;
Ferlin, Walter;
Jones, Simon A.

Publication type:

journal article

Targeting PPARγ in the epigenome rescues genetic metabolic defects in mice.

Published in:

2017

By:

Soccio, Raymond E.;
Zhenghui Li;
Chen, Eric R.;
Yee Hoon Foong;
Benson, Kiara K.;
Dispirito, Joanna R.;
Mullican, Shannon E.;
Emmett, Matthew J.;
Briggs, Erika R.;
Peed, Lindsey C.;
Dzeng, Richard K.;
Medina, Carlos J.;
Jolivert, Jennifer F.;
Kissig, Megan;
Rajapurkar, Satyajit R.;
Damle, Manashree;
Hee-Woong Lim;
Kyoung-Jae Won;
Seale, Patrick;
Steger, David J.

Publication type:

journal article

Aggregation of scaffolding protein DISC1 dysregulates phosphodiesterase 4 in Huntington's disease.

Published in:

2017

By:

Motomasa Tanaka;
Koko Ishizuka;
Yoko Nekooki-Machida;
Ryo Endo;
Noriko Takashima;
Hideyuki Sasaki;
Yusuke Komi;
Gathercole, Amy;
Huston, Elaine;
Kazuhiro Ishii;
Kai-Wan Hui, Kelvin;
Masaru Kurosawa;
Sun-Hong Kim;
Nobuyuki Nukina;
Eiki Takimoto;
Houslay, Miles D.;
Akira Sawa;
Tanaka, Motomasa;
Ishizuka, Koko;
Nekooki-Machida, Yoko

Publication type:

journal article

Isocitrate dehydrogenase mutations suppress STAT1 and CD8+ T cell accumulation in gliomas.

Published in:

2017

By:

Kohanbash, Gary;
Carrera, Diego A.;
Shrivastav, Shruti;
Ahn, Brian J.;
Jahan, Naznin;
Mazor, Tali;
Chheda, Zinal S.;
Downey, Kira M.;
Watchmaker, Payal B.;
Beppler, Casey;
Warta, Rolf;
Amankulor, Nduka A.;
Herold-Mende, Christel;
Costello, Joseph F.;
Hideho Okada;
Okada, Hideho

Publication type:

journal article

Angiotensin AT1A receptors on leptin receptor-expressing cells control resting metabolism.

Published in:

2017

By:

Claflin, Kristin E.;
Sandgren, Jeremy A.;
Lambertz, Allyn M.;
Weidemann, Benjamin J.;
Littlejohn, Nicole K.;
Burnett, Colin M. L.;
Pearson, Nicole A.;
Morgan, Donald A.;
Gibson-Corley, Katherine N.;
Rahmouni, Kamal;
Grobe, Justin L.

Publication type:

journal article

Amino acid-insensitive mTORC1 regulation enables nutritional stress resilience in hematopoietic stem cells.

Published in:

2017

By:

Kalaitzidis, Demetrios;
Dongjun Lee;
Efeyan, Alejo;
Kfoury, Youmna;
Nayyar, Naema;
Sykes, David B.;
Mercier, Francois E.;
Papazian, Ani;
Baryawno, Ninib;
Victora, Gabriel D.;
Neuberg, Donna;
Sabatini, David M.;
Scadden, David T.;
Lee, Dongjun

Publication type:

journal article

B cells expressing the transcription factor T-bet drive lupus-like autoimmunity.

Published in:

2017

By:

Rubtsova, Kira;
Rubtsov, Anatoly V.;
Thurman, Joshua M.;
Mennona, Johanna M.;
Kappler, John W.;
Marrack, Philippa

Publication type:

journal article

Tissue-specific exosome biomarkers for noninvasively monitoring immunologic rejection of transplanted tissue.

Published in:

2017

By:

Vallabhajosyula, Prashanth;
Korutla, Laxminarayana;
Habertheuer, Andreas;
Ming Yu;
Rostami, Susan;
Chao-Xing Yuan;
Reddy, Sanjana;
Chengyang Liu;
Korutla, Varun;
Koeberlein, Brigitte;
Trofe-Clark, Jennifer;
Rickels, Michael R.;
Naji, Ali;
Yu, Ming;
Yuan, Chao-Xing;
Liu, Chengyang

Publication type:

journal article

Prostaglandin-mediated inhibition of serotonin signaling controls the affective component of inflammatory pain.

Published in:

2017

By:

Singh, Anand Kumar;
Zajdel, Joanna;
Mirrasekhian, Elahe;
Almoosawi, Nader;
Frisch, Isabell;
Klawonn, Anna M.;
Jaarola, Maarit;
Fritz, Michael;
Engblom, David

Publication type:

journal article

HDAC6-mediated acetylation of lipid droplet-binding protein CIDEC regulates fat-induced lipid storage.

Published in:

2017

By:

Hui Qian;
Yuanying Chen;
Zongqian Nian;
Lu Su;
Haoyong Yu;
Feng-Jung Chen;
Xiuqin Zhang;
Wenyi Xu;
Linkang Zhou;
Jiaming Liu;
Jinhai Yu;
Luxin Yu;
Yan Gao;
Hongchao Zhang;
Haihong Zhang;
Shimin Zhao;
Li Yu;
Rui-Ping Xiao;
Yuqian Bao;
Shaocong Hou

Publication type:

journal article

Anticancer kinase inhibitors impair intracellular viral trafficking and exert broad-spectrum antiviral effects.

Published in:

2017

By:

Bekerman, Elena;
Neveu, Gregory;
Shulla, Ana;
Brannan, Jennifer;
Szu-Yuan Pu;
Wang, Stanley;
Fei Xiao;
Barouch-Bentov, Rina;
Bakken, Russell R.;
Mateo, Roberto;
Govero, Jennifer;
Nagamine, Claude M.;
Diamond, Michael S.;
De Jonghe, Steven;
Herdewijn, Piet;
Dye, John M.;
Randall, Glenn;
Einav, Shirit;
Pu, Szu-Yuan;
Xiao, Fei

Publication type:

journal article

Membrane-organizing protein moesin controls Treg differentiation and antitumor immunity via TGF-β signaling.

Published in:

2017

By:

Ansa-Addo, Ephraim A.;
Yongliang Zhang;
Yi Yang;
Hussey, George S.;
Howley, Breege V.;
Salem, Mohammad;
Riesenberg, Brian;
Shaoli Sun;
Rockey, Don C.;
Karvar, Serhan;
Howe, Philip H.;
Bei Liu;
Zihai Li;
Zhang, Yongliang;
Yang, Yi;
Sun, Shaoli;
Liu, Bei;
Li, Zihai

Publication type:

journal article

Downregulation of GATA1 drives impaired hematopoiesis in primary myelofibrosis.

Published in:

2017

By:

Gilles, Laure;
Arslan, Ahmet Dirim;
Marinaccio, Christian;
Wen, Qiang Jeremy;
Arya, Priyanka;
McNulty, Maureen;
Qiong Yang;
Zhao, Jonathan C.;
Konstantinoff, Katerina;
Lasho, Terra;
Pardanani, Animesh;
Stein, Brady;
Plo, Isabelle;
Sundaravel, Sriram;
Wickrema, Amittha;
Migliaccio, Annarita;
Gurbuxani, Sandeep;
Vainchenker, William;
Platanias, Leonidas C.;
Tefferi, Ayalew

Publication type:

journal article

RANKL coordinates multiple osteoclastogenic pathways by regulating expression of ubiquitin ligase RNF146.

Published in:

2017

By:

Yoshinori Matsumoto;
Larose, Jose;
Kent, Oliver A.;
Lim, Melissa;
Changoor, Adele;
Zhang, Lucia;
Storozhuk, Yaryna;
Xiaohong Mao;
Grynpas, Marc D.;
Feng Cong;
Rottapel, Robert;
Matsumoto, Yoshinori;
Mao, Xiaohong;
Cong, Feng

Publication type:

journal article

AKT-mediated stabilization of histone methyltransferase WHSC1 promotes prostate cancer metastasis.

Published in:

2017

By:

Ni Li;
Wei Xue;
Huairui Yuan;
Baijun Dong;
Yufeng Ding;
Yongfeng Liu;
Min Jiang;
Shan Kan;
Tongyu Sun;
Jiale Ren;
Qiang Pan;
Xiang Li;
Peiyuan Zhang;
Guohong Hu;
Yan Wang;
Xiaoming Wang;
Qintong Li;
Jun Qin;
Li, Ni;
Xue, Wei

Publication type:

journal article

CD11b activation suppresses TLR-dependent inflammation and autoimmunity in systemic lupus erythematosus.

Published in:

2017

By:

Faridi, Mohd Hafeez;
Khan, Samia Q.;
Wenpu Zhao;
Ha Won Lee;
Altintas, Mehmet M.;
Kun Zhang;
Kumar, Vinay;
Armstrong, Andrew R.;
Carmona-Rivera, Carmelo;
Dorschner, Jessica M.;
Schnaith, Abigail M.;
Xiaobo Li;
Ghodke-Puranik, Yogita;
Moore, Erica;
Purmalek, Monica;
Irizarry-Caro, Jorge;
Tingting Zhang;
Day, Rachael;
Stoub, Darren;
Hoffmann, Victoria

Publication type:

journal article

Mesothelin/mucin 16 signaling in activated portal fibroblasts regulates cholestatic liver fibrosis.

Published in:

2017

By:

Yukinori Koyama;
Ping Wang;
Shuang Liang;
Keiko Iwaisako;
Xiao Liu;
Jun Xu;
Mingjun Zhang;
Mengxi Sun;
Min Cong;
Karin, Daniel;
Kojiro Taura;
Benner, Chris;
Heinz, Sven;
Bera, Tapan;
Brenner, David A.;
Kisseleva, Tatiana;
Koyama, Yukinori;
Wang, Ping;
Liang, Shuang;
Iwaisako, Keiko

Publication type:

journal article

FOXP1 controls mesenchymal stem cell commitment and senescence during skeletal aging.

Published in:

2017

By:

Hanjun Li;
Pei Liu;
Shuqin Xu;
Yinghua Li;
Dekker, Joseph D.;
Baojie Li;
Ying Fan;
Zhenlin Zhang;
Yang Hong;
Gong Yang;
Tingting Tang;
Yongxin Ren;
Tucker, Haley O.;
Zhengju Yao;
Xizhi Guo;
Li, Hanjun;
Liu, Pei;
Xu, Shuqin;
Li, Yinghua;
Li, Baojie

Publication type:

journal article

Laminar flow downregulates Notch activity to promote lymphatic sprouting.

Published in:

2017

By:

Dongwon Choi;
Eunkyung Park;
Eunson Jung;
Young Jin Seong;
Jaehyuk Yoo;
Esak Lee;
Mingu Hong;
Sunju Lee;
Hiroaki Ishida;
Burford, James;
Peti-Peterdi, Janos;
Adams, Ralf H.;
Srikanth, Sonal;
Yousang Gwack;
Chen, Christopher S.;
Vogel, Hans J.;
Koh, Chester J.;
Wong, Alex K.;
Young-Kwon Hong;
Choi, Dongwon

Publication type:

journal article

A "tail" of opioid receptor variants.

Published in:

2017

By:

Puig, Stephanie;
Gutstein, Howard B.

Publication type:

journal article

Resisting fatal attraction: a glioma oncometabolite prevents CD8+ T cell recruitment.

Published in:

2017

By:

Lucca, Liliana E.;
Hafler, David A.

Publication type:

journal article

T cells take directions from supporting cast in graft-versus-host disease.

Published in:

2017

By:

Amsen, Derk

Publication type:

journal article

Distinct but complementary contributions of PPAR isotypes to energy homeostasis.

Published in:

2017

By:

Dubois, Vanessa;
Eeckhoute, Jérôme;
Lefebvre, Philippe;
Staels, Bart

Publication type:

journal article

Nutrient-sensing nuclear receptors PPARα and FXR control liver energy balance.

Published in:

2017

By:

Preidis, Geoffrey A.;
Kang Ho Kim;
Moore, David D.;
Kim, Kang Ho

Publication type:

journal article

Genetic disorders of nuclear receptors.

Published in:

2017

By:

Achermann, John C.;
Schwabe, John;
Fairall, Louise;
Chatterjee, Krishna

Publication type:

journal article

Brain nuclear receptors and body weight regulation.

Published in:

2017

By:

Yong Xu;
O'Malley, Bert W.;
Elmquist, Joel K.;
Xu, Yong

Publication type:

journal article

Nuclear receptors: emerging drug targets for parasitic diseases.

Published in:

2017

By:

Zhu Wang;
Schaffer, Nathaniel E.;
Kliewer, Steven A.;
Mangelsdorf, David J.;
Wang, Zhu

Publication type:

journal article

Cardiac nuclear receptors: architects of mitochondrial structure and function.

Published in:

2017

By:

Vega, Rick B.;
Kelly, Daniel P.

Publication type:

journal article

The vitamin D receptor: contemporary genomic approaches reveal new basic and translational insights.

Published in:

2017

By:

Pike, J. Wesley;
Meyer, Mark B.;
Seong-Min Lee;
Onal, Melda;
Benkusky, Nancy A.;
Lee, Seong-Min

Publication type:

journal article

Glucocorticoid receptors: finding the middle ground.

Published in:

2017

By:

Desmet, Sofie J.;
De Bosscher, Karolien

Publication type:

journal article

Role of steroid receptor and coregulator mutations in hormone-dependent cancers.

Published in:

2017

By:

Groner, Anna C.;
Brown, Myles

Publication type:

journal article

Maturing of the nuclear receptor family.

Published in:

2017

By:

Lazar, Mitchell A.

Publication type:

journal article

Immunologist James E. Crowe is selected for 2017 ASCI/Korsmeyer Award.

Published in:

2017

By:

Jackson, Sarah

Publication type:

Biography

A conversation with Stuart Orkin.

Published in:

2017

By:

Neill, Ushma S.

Publication type:

Biography