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Inactivation of SAG/RBX2 E3 ubiquitin ligase suppresses KrasG12D-driven lung tumorigenesis.
Published in:
2014
By:
- Li, Hua;
- Tan, Mingjia;
- Jia, Lijun;
- Wei, Dongping;
- Zhao, Yongchao;
- Chen, Guoan;
- Xu, Jie;
- Zhao, Lili;
- Thomas, Dafydd;
- Beer, David G;
- Sun, Yi
Publication type:
journal article
SMN-targeted therapeutics for spinal muscular atrophy are we SMArt enough yet?
Published in:
Journal of Clinical Investigation, 2014, v. 124, n. 2, p. 487, doi. 10.1172/JCI74142
By:
- Swoboda, Kathryn J.
Publication type:
Article
Macrophages eliminate circulating tumor cells after monoclonal antibody therapy.
Published in:
Journal of Clinical Investigation, 2014, v. 124, n. 2, p. 812, doi. 10.1172/JCI66776
By:
- Gül, Nuray;
- Babes, Liane;
- Siegmund, Kerstin;
- Korthouwer, Rianne;
- Bögels, Marijn;
- Braster, Rens;
- Vidarsson, Gestur;
- ten Hagen, Timo L. M.;
- Kubes, Paul;
- van Egmond, Marjolein
Publication type:
Article
Prenatal retinoid deficiency leads to airway hyperresponsiveness in adult mice.
Published in:
Journal of Clinical Investigation, 2014, v. 124, n. 2, p. 801, doi. 10.1172/JCI70291
By:
- Chen, Felicia;
- Marquez, Hector;
- Youn-Kyung Kim;
- Jun Qian;
- Fengzhi Shao;
- Fine, Alan;
- Cruikshank, William W.;
- Quadro, Loredana;
- Cardoso, Wellington V.
Publication type:
Article
Normalizing glycosphingolipids restores function in CD4+ T cells from lupus patients.
Published in:
2014
By:
- McDonald, Georgia;
- Deepak, Shantal;
- Miguel, Laura;
- Hall, Cleo J;
- Isenberg, David A;
- Magee, Anthony I;
- Butters, Terry;
- Jury, Elizabeth C
Publication type:
journal article
SMN-targeted therapeutics for spinal muscular atrophy: are we SMArt enough yet?
Published in:
2014
By:
- Swoboda, Kathryn J
Publication type:
journal article
Changes in neural network homeostasis trigger neuropsychiatric symptoms.
Published in:
2014
By:
- Winkelmann, Aline;
- Maggio, Nicola;
- Eller, Joanna;
- Caliskan, Gürsel;
- Semtner, Marcus;
- Häussler, Ute;
- Jüttner, René;
- Dugladze, Tamar;
- Smolinsky, Birthe;
- Kowalczyk, Sarah;
- Chronowska, Ewa;
- Schwarz, Günter;
- Rathjen, Fritz G;
- Rechavi, Gideon;
- Haas, Carola A;
- Kulik, Akos;
- Gloveli, Tengis;
- Heinemann, Uwe;
- Meier, Jochen C
Publication type:
journal article
At last: classification of human mammary cells elucidates breast cancer origins.
Published in:
2014
By:
- Cardiff, Robert D;
- Borowsky, Alexander D
Publication type:
journal article
Opioid receptor-triggered spinal mTORC1 activation contributes to morphine tolerance and hyperalgesia.
Published in:
2014
By:
- Xu, Ji-Tian;
- Zhao, Jian-Yuan;
- Zhao, Xiuli;
- Ligons, Davinna;
- Tiwari, Vinod;
- Atianjoh, Fidelis E;
- Lee, Chun-Yi;
- Liang, Lingli;
- Zang, Weidong;
- Njoku, Dolores;
- Raja, Srinivasa N;
- Yaster, Myron;
- Tao, Yuan-Xiang
Publication type:
journal article
Irradiation and anti-PD-L1 treatment synergistically promote antitumor immunity in mice.
Published in:
2014
By:
- Deng, Liufu;
- Liang, Hua;
- Burnette, Byron;
- Beckett, Michael;
- Darga, Thomas;
- Weichselbaum, Ralph R;
- Fu, Yang-Xin
Publication type:
journal article
Targeting the cell cycle inhibitor p57Kip2 promotes adult human β cell replication.
Published in:
2014
By:
- Avrahami, Dana;
- Li, Changhong;
- Yu, Ming;
- Jiao, Yang;
- Zhang, Jia;
- Naji, Ali;
- Ziaie, Seyed;
- Glaser, Benjamin;
- Kaestner, Klaus H
Publication type:
journal article
Tie1 deletion inhibits tumor growth and improves angiopoietin antagonist therapy.
Published in:
2014
By:
- D'Amico, Gabriela;
- Korhonen, Emilia A;
- Anisimov, Andrey;
- Zarkada, Georgia;
- Holopainen, Tanja;
- Hägerling, René;
- Kiefer, Friedemann;
- Eklund, Lauri;
- Sormunen, Raija;
- Elamaa, Harri;
- Brekken, Rolf A;
- Adams, Ralf H;
- Koh, Gou Young;
- Saharinen, Pipsa;
- Alitalo, Kari
Publication type:
journal article
Macrophages eliminate circulating tumor cells after monoclonal antibody therapy.
Published in:
2014
By:
- Gül, Nuray;
- Babes, Liane;
- Siegmund, Kerstin;
- Korthouwer, Rianne;
- Bögels, Marijn;
- Braster, Rens;
- Vidarsson, Gestur;
- Ten Hagen, Timo L M;
- Kubes, Paul;
- van Egmond, Marjolein
Publication type:
journal article
MNK1 pathway activity maintains protein synthesis in rapalog-treated gliomas.
Published in:
2014
By:
- Grzmil, Michal;
- Huber, Roland M;
- Hess, Daniel;
- Frank, Stephan;
- Hynx, Debby;
- Moncayo, Gerald;
- Klein, Dominique;
- Merlo, Adrian;
- Hemmings, Brian A
Publication type:
journal article
Disruption of vascular Ca2+-activated chloride currents lowers blood pressure.
Published in:
2014
By:
- Heinze, Christoph;
- Seniuk, Anika;
- Sokolov, Maxim V;
- Huebner, Antje K;
- Klementowicz, Agnieszka E;
- Szijártó, István A;
- Schleifenbaum, Johanna;
- Vitzthum, Helga;
- Gollasch, Maik;
- Ehmke, Heimo;
- Schroeder, Björn C;
- Hübner, Christian A
Publication type:
journal article
Positive feedback between NF-κB and TNF-α promotes leukemia-initiating cell capacity.
Published in:
2014
By:
- Kagoya, Yuki;
- Yoshimi, Akihide;
- Kataoka, Keisuke;
- Nakagawa, Masahiro;
- Kumano, Keiki;
- Arai, Shunya;
- Kobayashi, Hiroshi;
- Saito, Taku;
- Iwakura, Yoichiro;
- Kurokawa, Mineo
Publication type:
journal article
Requirement of enhanced Survival Motoneuron protein imposed during neuromuscular junction maturation.
Published in:
Journal of Clinical Investigation, 2014, v. 124, n. 2, p. 785, doi. 10.1172/JCI72017
By:
- Kariya, Shingo;
- Obis, Teresa;
- Garone, Caterina;
- Akay, Turgay;
- Sera, Fusako;
- Shinichi Iwata;
- Shunichi Homma;
- Monani, Umrao R.
Publication type:
Article
Corrigendum.
Published in:
2014
Publication type:
Correction Notice
Taxonomy of breast cancer based on normal cell phenotype predicts outcome.
Published in:
Journal of Clinical Investigation, 2014, v. 124, n. 2, p. 859, doi. 10.1172/JCI70941
By:
- Santagata, Sandro;
- Thakkar, Ankita;
- Ergonul, Ayse;
- Bin Wang;
- Woo, Terri;
- Rong Hu;
- Harrell, J. Chuck;
- McNamara, George;
- Schwede, Matthew;
- Culhane, Aedin C.;
- Kindelberger, David;
- Rodig, Scott;
- Richardson, Andrea;
- Schnitt, Stuart J.;
- Tamimi, Rulla M.;
- Ince, Tan A.
Publication type:
Article
Prion disease tempo determined by host-dependent substrate reduction.
Published in:
Journal of Clinical Investigation, 2014, v. 124, n. 2, p. 847, doi. 10.1172/JCI72241
By:
- Mays, Charles E.;
- Chae Kim;
- Haldiman, Tracy;
- van der Merwe, Jacques;
- Lau, Agnes;
- Jing Yang;
- Grams, Jennifer;
- Di Bari, Michele A.;
- Nonno, Romolo;
- Telling, Glenn C.;
- Qingzhong Kong;
- Langeveld, Jan;
- McKenzie, Debbie;
- Westaway, David;
- Safar, Jiri G.
Publication type:
Article
Tie1 deletion inhibits tumor growth and improves angiopoietin antagonist therapy.
Published in:
Journal of Clinical Investigation, 2014, v. 124, n. 2, p. 824, doi. 10.1172/JCI68897
By:
- D'Amico, Gabriela;
- Korhonen, Emilia A.;
- Anisimov, Andrey;
- Zarkada, Georgia;
- Holopainen, Tanja;
- Hägerling, René;
- Kiefer, Friedemann;
- Eklund, Lauri;
- Sormunen, Raija;
- Elamaa, Harri;
- Brekken, Rolf A.;
- Adams, Ralf H.;
- Gou Young Koh;
- Saharinen, Pipsa;
- Alitalo, Kari
Publication type:
Article
Inactivation of SAG/RBX2 E3 ubiquitin ligase suppresses KrasG12D-driven lung tumorigenesis.
Published in:
Journal of Clinical Investigation, 2014, v. 124, n. 2, p. 835, doi. 10.1172/JCI70297
By:
- Hua Li;
- Mingjia Tan;
- Lijun Jia;
- Dongping Wei;
- Yongchao Zhao;
- Guoan Chen;
- Jie Xu;
- Lili Zhao;
- Thomas, Dafydd;
- Beer, David G.;
- Yi Sun
Publication type:
Article
Irradiation and anti--PD-L1 treatment synergistically promote antitumor immunity in mice.
Published in:
Journal of Clinical Investigation, 2014, v. 124, n. 2, p. 687, doi. 10.1172/JCI67313
By:
- Liufu Deng;
- Hua Liang;
- Burnette, Byron;
- Beckett, Michael;
- Darga, Thomas;
- Weichselbaum, Ralph R.;
- Yang-Xin Fu
Publication type:
Article
Disruption of vascular Ca2+-activated chloride currents lowers blood pressure.
Published in:
Journal of Clinical Investigation, 2014, v. 124, n. 2, p. 675, doi. 10.1172/JCI70025
By:
- Heinze, Christoph;
- Seniuk, Anika;
- Sokolov, Maxim V.;
- Huebner, Antje K.;
- Klementowicz, Agnieszka E.;
- Szijártó, István A.;
- Schleifenbaum, Johanna;
- Vitzthum, Helga;
- Gollasch, Maik;
- Ehmke, Heimo;
- Schroeder, Bjorn C.;
- Hubner, Christian A.
Publication type:
Article
Targeting the cell cycle inhibitor p57Kip2 promotes adult human β cell replication.
Published in:
Journal of Clinical Investigation, 2014, v. 124, n. 2, p. 670, doi. 10.1172/JCI69519
By:
- Avrahami, Dana;
- Changhong Li;
- Ming Yu;
- Yang Jiao;
- Jia Zhang;
- Ali Naji;
- Ziaie, Seyed;
- Glaser, Benjamin;
- Kaestner, Klaus H.
Publication type:
Article
Paradoxical insights into whole body metabolic adaptations following SGLT2 inhibition.
Published in:
Journal of Clinical Investigation, 2014, v. 124, n. 2, p. 485, doi. 10.1172/JCI74297
By:
- Cefalu, William T.
Publication type:
Article
Nutrient sensing by the mitochondrial transcription machinery dictates oxidative phosphorylation.
Published in:
Journal of Clinical Investigation, 2014, v. 124, n. 2, p. 768, doi. 10.1172/JCI69413
By:
- Lijun Liu;
- Minwoo Nam;
- Wei Fan;
- Akie, Thomas E.;
- Hoaglin, David C.;
- Guangping Gao;
- Keaney Jr., John F.;
- Cooper, Marcus P.
Publication type:
Article
Tgfbr2 disruption in postnatal smooth muscle impairs aortic wall homeostasis.
Published in:
Journal of Clinical Investigation, 2014, v. 124, n. 2, p. 755, doi. 10.1172/JCI69942
By:
- Wei Li;
- Qingle Li;
- Yang Jiao;
- Lingfeng Qin;
- Ali, Rahmat;
- Jing Zhou;
- Ferruzzi, Jacopo;
- Kim, Richard W.;
- Geirsson, Arnar;
- Dietz, Harry C.;
- Offermanns, Stefan;
- Humphrey, Jay D.;
- Tellides, George
Publication type:
Article
MNK1 pathway activity maintains protein synthesis in rapalog-treated gliomas.
Published in:
Journal of Clinical Investigation, 2014, v. 124, n. 2, p. 742, doi. 10.1172/JCI70198
By:
- Grzmil, Michal;
- Huber, Roland M.;
- Hess, Daniel;
- Frank, Stephan;
- Hynx, Debby;
- Moncayo, Gerald;
- Klein, Dominique;
- Merlo, Adrian;
- Hemmings, Brian A.
Publication type:
Article
NRF2-mediated Notch pathway activation enhances hematopoietic reconstitution following myelosuppressive radiation.
Published in:
Journal of Clinical Investigation, 2014, v. 124, n. 2, p. 730, doi. 10.1172/JCI70812
By:
- Jung-Hyun Kim;
- Thimmulappa, Rajesh K.;
- Kumar, Vineet;
- Wanchang Cui;
- Kumar, Sarvesh;
- Kombairaju, Ponvijay;
- Hao Zhang;
- Margolick, Joseph;
- Matsui, William;
- Macvittie, Thomas;
- Malhotra, Sanjay V.;
- Biswal, Shyam
Publication type:
Article
Human IgG Fc domain engineering enhances antitoxin neutralizing antibody activity.
Published in:
Journal of Clinical Investigation, 2014, v. 124, n. 2, p. 725, doi. 10.1172/JCI72676
By:
- Bournazos, Stylianos;
- Siu-Kei Chow;
- Abboud, Nareen;
- Casadevall, Arturo;
- Ravetch, Jeffrey V.
Publication type:
Article
Normalizing glycosphingolipids restores function in CD4+ T cells from lupus patients.
Published in:
Journal of Clinical Investigation, 2014, v. 124, n. 2, p. 712, doi. 10.1172/JCI69571
By:
- McDonald, Georgia;
- Deepak, Shantal;
- Miguel, Laura;
- Hall, Cleo J.;
- Isenberg, David A.;
- Magee, Anthony I.;
- Butters, Terry;
- Jury, Elizabeth C.
Publication type:
Article
Changes in neural network homeostasis trigger neuropsychiatric symptoms.
Published in:
Journal of Clinical Investigation, 2014, v. 124, n. 2, p. 696, doi. 10.1172/JCI71472
By:
- Winkelmann, Aline;
- Maggio, Nicola;
- Eller, Joanna;
- Caliskan, Gürsel;
- Semtner, Marcus;
- Häussler, Ute;
- Jüttner, Rene;
- Dugladze, Tamar;
- Smolinsky, Birthe;
- Kowalczyk, Sarah;
- Chronowska, Ewa;
- Schwarz, Günter;
- Rathjen, Fritz G.;
- Rechavi, Gideon;
- Haas, Carola A.;
- Kulik, Akos;
- Gloveli, Tengis;
- Heinemann, Uwe;
- Meier, Jochen C.
Publication type:
Article
OTX2 loss causes rod differentiation defect in CRX-associated congenital blindness.
Published in:
Journal of Clinical Investigation, 2014, v. 124, n. 2, p. 631, doi. 10.1172/JCI72722
By:
- Roger, Jerome E.;
- Hiriyanna, Avinash;
- Norimoto Gotoh;
- Hong Hao;
- Cheng, Debbie F.;
- Ratnapriya, Rinki;
- Kautzmann, Marie-Audrey I.;
- Bo Chang;
- Swaroop, Anand
Publication type:
Article
Orexin neurons suppress narcolepsy via 2 distinct efferent pathways.
Published in:
Journal of Clinical Investigation, 2014, v. 124, n. 2, p. 604, doi. 10.1172/JCI71017
By:
- Emi Hasegawa;
- Masashi Yanagisawa;
- Takeshi Sakurai;
- and Michihiro Mieda
Publication type:
Article
Cardiotoxicity of doxorubicin is mediated through mitochondrial iron accumulation.
Published in:
Journal of Clinical Investigation, 2014, v. 124, n. 2, p. 617, doi. 10.1172/JCI72931
By:
- Yoshihiko Ichikawa;
- Ghanefar, Mohsen;
- Bayeva, Marina;
- Rongxue Wu;
- Khechaduri, Arineh;
- Prasad, Sathyamangla V. Naga;
- Mutharasan, R. Kannan;
- Naik, Tejaswitha Jairaj;
- Ardehali, Hossein
Publication type:
Article
Neuronal ferritin heavy chain and drug abuse affect HIV-associated cognitive dysfunction.
Published in:
Journal of Clinical Investigation, 2014, v. 124, n. 2, p. 656, doi. 10.1172/JCI70090
By:
- Pitcher, Jonathan;
- Abt, Anna;
- Myers, Jaclyn;
- Han, Rachel;
- Snyder, Melissa;
- Graziano, Alessandro;
- Festa, Lindsay;
- Kutzler, Michele;
- Garcia, Fernando;
- Wen-Jun Gao;
- Fischer-Smith, Tracy;
- Rappaport, Jay;
- Meucci, Olimpia
Publication type:
Article
Phenothiazines induce PP2A-mediated apoptosis in T cell acute lymphoblastic leukemia.
Published in:
Journal of Clinical Investigation, 2014, v. 124, n. 2, p. 644, doi. 10.1172/JCI65093
By:
- Gutierrez, Alejandro;
- Li Pan;
- Groen, Richard W. J.;
- Baleydier, Frederic;
- Kentsis, Alex;
- Marineau, Jason;
- Grebliunaite, Ruta;
- Kozakewich, Elena;
- Reed, Casie;
- Pflumio, Francoise;
- Poglio, Sandrine;
- Uzan, Benjamin;
- Clemons, Paul;
- VerPlank, Lynn;
- An, Frank;
- Burbank, Jason;
- Norton, Stephanie;
- Tolliday, Nicola;
- Steen, Hanno;
- Weng, Andrew P.
Publication type:
Article
Lipids rule: resetting lipid metabolism restores T cell function in systemic lupus erythematosus.
Published in:
Journal of Clinical Investigation, 2014, v. 124, n. 2, p. 482, doi. 10.1172/JCI74141
By:
- Kidani, Yoko;
- Bensinger, Steven J.
Publication type:
Article
Opioid receptor--triggered spinal mTORC1 activation contributes to morphine tolerance and hyperalgesia.
Published in:
Journal of Clinical Investigation, 2014, v. 124, n. 2, p. 592, doi. 10.1172/JCI70236
By:
- Ji-Tian Xu;
- Jian-Yuan Zhao;
- Xiuli Zhao;
- Ligons, Davinna;
- Tiwari, Vinod;
- Atianjoh, Fidelis E.;
- Ohun-Yi Lee;
- Lingli Liang;
- Weidong Zang;
- Njoku, Dolores;
- Raja, Srinivasa N.;
- Yaster, Myron;
- Yuan-Xiang Tao
Publication type:
Article
An unexpected role for platelets in blocking Th17 differentiation.
Published in:
Journal of Clinical Investigation, 2014, v. 124, n. 2, p. 480, doi. 10.1172/JCI74231
By:
- Chakraverty, Ronjon
Publication type:
Article
At last classification of human mammary cells elucidates breast cancer origins.
Published in:
Journal of Clinical Investigation, 2014, v. 124, n. 2, p. 478, doi. 10.1172/JCI73910
By:
- Cardiff, Robert D.;
- Borowsky, Alexander D.
Publication type:
Article
Thrombocytopenia-associated mutations in the ANKRD26 regulatory region induce MAPK hyperactivation.
Published in:
Journal of Clinical Investigation, 2014, v. 124, n. 2, p. 580, doi. 10.1172/JCI71861
By:
- Bluteau, Dominique;
- Balduini, Alessandra;
- Balayn, Nathalie;
- Currao, Manuela;
- Nurden, Paquita;
- Deswarte, Caroline;
- Leverger, Guy;
- Noris, Patrizia;
- Perrotta, Silverio;
- Solary, Eric;
- Vainchenker, William;
- Debili, Najet;
- Favier, Remi;
- Raslova, Hana
Publication type:
Article
Sustained activation of SMAD3/SMAD4 by FOXM1 promotes TGF-β-dependent cancer metastasis.
Published in:
Journal of Clinical Investigation, 2014, v. 124, n. 2, p. 564, doi. 10.1172/JCI71104
By:
- Jianfei Xue;
- Xia Lin;
- Wen-Tai Chiu;
- Yao-Hui Chen;
- Guanzhen Yu;
- Mingguang Liu;
- Xin-Hua Feng;
- Sawaya, Raymond;
- Medema, René H.;
- Mien-Chie Hung;
- Suyun Huang
Publication type:
Article
Erythropoietin promotes breast tumorigenesis through tumor-initiating cell self-renewal.
Published in:
Journal of Clinical Investigation, 2014, v. 124, n. 2, p. 553, doi. 10.1172/JCI69804
By:
- Bing Zhou;
- Damrauer, Jeffrey S.;
- Bailey, Sean T.;
- Hadzic, Tanja;
- Youngtae Jeong;
- Clark, Kelly;
- Cheng Fan;
- Murphy, Laura;
- Lee, Cleo Y.;
- Troester, Melissa A.;
- Miller, C. Ryan;
- Jian Jin;
- Darr, David;
- Perou, Charles M.;
- Levine, Ross L.;
- Diehn, Maximilian;
- Kim, William Y.
Publication type:
Article
Platelet factor 4 limits Th17 differentiation and cardiac allograft rejection.
Published in:
Journal of Clinical Investigation, 2014, v. 124, n. 2, p. 543, doi. 10.1172/JCI71858
By:
- Guanfang Shi;
- Field, David J.;
- Kyung-ae Ko;
- Ture, Sara;
- Srivastava, Kalyan;
- Levy, Scott;
- Kowalska, M. Anna;
- Poncz, Mortimer;
- Fowell, Deborah J.;
- Morrel, Craig N.
Publication type:
Article
Positive feedback between NF-κB and TNF-α promotes leukemia-initiating cell capacity.
Published in:
Journal of Clinical Investigation, 2014, v. 124, n. 2, p. 528, doi. 10.1172/JCI68101
By:
- Yuki Kagoya;
- Akihide Yoshimi;
- Keisuke Kataoka;
- Masahiro Nakagawa;
- Keiki Kumano;
- Shunya Arai;
- Hiroshi Kobayashi;
- Taku Saito;
- Yoichiro Iwakura;
- Mineo Kurokawa
Publication type:
Article
Interplay between FGF21 and insulin action in the liver regulates metabolism.
Published in:
Journal of Clinical Investigation, 2014, v. 124, n. 2, p. 515, doi. 10.1172/JCI67353
By:
- Emanuelli, Brice;
- Vienberg, Sara G.;
- Smyth, Graham;
- Cheng, Christine;
- Stanford, Kristin I.;
- Arumugam, Manimozhiyan;
- Michael, Mervyn D.;
- Adams, Andrew C.;
- Kharitonenkov, Alexei;
- Kahn, C. Ronald
Publication type:
Article
Dapagliflozin improves muscle insulin sensitivity but enhances endogenous glucose production.
Published in:
Journal of Clinical Investigation, 2014, v. 124, n. 2, p. 509, doi. 10.1172/JCI70704
By:
- Merovci, Aurora;
- Solis-Herrera, Carolina;
- Daniele, Giuseppe;
- Eldor, Roy;
- Fiorentino, Teresa Vanessa;
- Tripathy, Devjit;
- Xiong, Juan;
- Perez, Zandra;
- Norton, Luke;
- Abdul-Ghani, Muhammad A.;
- DeFronzo, Ralph A.
Publication type:
Article
Metabolic response to sodium-glucose cotransporter 2 inhibition in type 2 diabetic patients.
Published in:
Journal of Clinical Investigation, 2014, v. 124, n. 2, p. 499, doi. 10.1172/JCI72227
By:
- Ferrannini, Ele;
- Muscelli, Elza;
- Frascerra, Silvia;
- Baldi, Simona;
- Mari, Andrea;
- Heise, Tim;
- Broedl, Uli C.;
- Woerle, Hans-Juergen
Publication type:
Article

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