Works in Journal of Clinical Investigation, 2012, Vol 122, Issue 1

Results: 61

A research institute at a turning point. Interview by Kathryn Claiborn.

Published in:

2012

By:

Roncarolo MG;
Roncarolo, Maria Grazia

Publication type:

Interview

Glucagonocentric restructuring of diabetes: a pathophysiologic and therapeutic makeover.

Published in:

2012

By:

Unger RH;
Cherrington AD;
Unger, Roger H;
Cherrington, Alan D

Publication type:

journal article

Creatine kinase-mediated improvement of function in failing mouse hearts provides causal evidence the failing heart is energy starved.

Published in:

2012

By:

Gupta A;
Akki A;
Wang Y;
Leppo MK;
Chacko VP;
Foster DB;
Caceres V;
Shi S;
Kirk JA;
Su J;
Lai S;
Paolocci N;
Steenbergen C;
Gerstenblith G;
Weiss RG;
Gupta, Ashish;
Akki, Ashwin;
Wang, Yibin;
Leppo, Michelle K;
Chacko, V P

Publication type:

journal article

Angiotensin receptor blockade attenuates cigarette smoke-induced lung injury and rescues lung architecture in mice.

Published in:

2012

By:

Podowski M;
Calvi C;
Metzger S;
Misono K;
Poonyagariyagorn H;
Lopez-Mercado A;
Ku T;
Lauer T;
McGrath-Morrow S;
Berger A;
Cheadle C;
Tuder R;
Dietz HC;
Mitzner W;
Wise R;
Neptune E;
Podowski, Megan;
Calvi, Carla;
Metzger, Shana;
Misono, Kaori

Publication type:

journal article

Heparan sulfate and heparanase play key roles in mouse β cell survival and autoimmune diabetes.

Published in:

2012

By:

Ziolkowski AF;
Popp SK;
Freeman C;
Parish CR;
Simeonovic CJ;
Ziolkowski, Andrew F;
Popp, Sarah K;
Freeman, Craig;
Parish, Christopher R;
Simeonovic, Charmaine J

Publication type:

journal article

Defective nuclear IKKα function in patients with ectodermal dysplasia with immune deficiency.

Published in:

2012

By:

Temmerman ST;
Ma CA;
Zhao Y;
Keenan J;
Aksentijevich I;
Fessler M;
Brown MR;
Knutsen A;
Shapiro R;
Jain A;
Temmerman, Stephane T;
Ma, Chi A;
Zhao, Yongge;
Keenan, Jeffrey;
Aksentijevich, Ivona;
Fessler, Margaret;
Brown, Margaret R;
Knutsen, Alan;
Shapiro, Ralph;
Jain, Ashish

Publication type:

journal article

Altered CD4+ T cell homing to the gut impairs mucosal immune reconstitution in treated HIV-infected individuals.

Published in:

2012

By:

Mavigner M;
Cazabat M;
Dubois M;
L'Faqihi FE;
Requena M;
Pasquier C;
Klopp P;
Amar J;
Alric L;
Barange K;
Vinel JP;
Marchou B;
Massip P;
Izopet J;
Delobel P;
Mavigner, Maud;
Cazabat, Michelle;
Dubois, Martine;
L'Faqihi, Fatima-Ezzahra;
Requena, Mary

Publication type:

journal article

Sinking your teeth into the problem of spinal cord injury.

Published in:: Journal of Clinical Investigation, 2012, v. 122, n. 1, p. 1
Publication type:: Article

Resisting the effects of chemotherapy.

Published in:: Journal of Clinical Investigation, 2012, v. 122, n. 1, p. 1
Publication type:: Article

MicroRNA-30e* promotes human glioma cell invasiveness in an orthotopic xenotransplantation model by disrupting the NF-κB/IκBα negative feedback loop.

Published in:

2012

By:

Jiang L;
Lin C;
Song L;
Wu J;
Chen B;
Ying Z;
Fang L;
Yan X;
He M;
Li J;
Li M;
Jiang, Lili;
Lin, Chuyong;
Song, Libing;
Wu, Jueheng;
Chen, Baixue;
Ying, Zhe;
Fang, Lishan;
Yan, Xiao;
He, Mian

Publication type:

journal article

Administration of BMP2/7 in utero partially reverses Rubinstein-Taybi syndrome-like skeletal defects induced by Pdk1 or Cbp mutations in mice.

Published in:

2012

By:

Shim JH;
Greenblatt MB;
Singh A;
Brady N;
Hu D;
Drapp R;
Ogawa W;
Kasuga M;
Noda T;
Yang SH;
Lee SK;
Rebel VI;
Glimcher LH;
Shim, Jae-Hyuck;
Greenblatt, Matthew B;
Singh, Anju;
Brady, Nicholas;
Hu, Dorothy;
Drapp, Rebecca;
Ogawa, Wataru

Publication type:

journal article

Redox redux: protecting the ischemic myocardium.

Published in:

Journal of Clinical Investigation, 2012, v. 122, n. 1, p. 30, doi. 10.1172/JCI61467

By:

Spindel, Oded N.;
Berk, Bradford C.

Publication type:

Article

Alleviating allergy by targeting HRF.

Published in:: Journal of Clinical Investigation, 2012, v. 122, n. 1, p. 1
Publication type:: Article

Alkylpurine-DNA-N-glycosylase confers resistance to temozolomide in xenograft models of glioblastoma multiforme and is associated with poor survival in patients.

Published in:

2012

By:

Agnihotri S;
Gajadhar AS;
Ternamian C;
Gorlia T;
Diefes KL;
Mischel PS;
Kelly J;
McGown G;
Thorncroft M;
Carlson BL;
Sarkaria JN;
Margison GP;
Aldape K;
Hawkins C;
Hegi M;
Guha A;
Agnihotri, Sameer;
Gajadhar, Aaron S;
Ternamian, Christian;
Gorlia, Thierry

Publication type:

journal article

Decreased cardiac L-type Ca²⁺ channel activity induces hypertrophy and heart failure in mice.

Published in:

2012

By:

Goonasekera SA;
Hammer K;
Auger-Messier M;
Bodi I;
Chen X;
Zhang H;
Reiken S;
Elrod JW;
Correll RN;
York AJ;
Sargent MA;
Hofmann F;
Moosmang S;
Marks AR;
Houser SR;
Bers DM;
Molkentin JD;
Goonasekera, Sanjeewa A;
Hammer, Karin;
Auger-Messier, Mannix

Publication type:

journal article

First responder homeostasis coordinated by LXRs.

Published in:: Journal of Clinical Investigation, 2012, v. 122, n. 1, p. 1
Publication type:: Article

Corrigendum.

Published in:: 2012
Publication type:: Correction Notice

A research institute at a turning point.

Published in:

2012

By:

Claiborn, Kathryn

Publication type:

Interview

Editorial position on publishing articles on human organ transplantation.

Published in:

2012

By:

Caplan, Arthur L.;
Rockman, Howard A.;
Turka, Laurence A.

Publication type:

Editorial

Hold tight or you'll fall off: CD151 helps podocytes stick in high-pressure situations.

Published in:

Journal of Clinical Investigation, 2012, v. 122, n. 1, p. 13, doi. 10.1172/JCI61858

By:

Pozzi, Ambra;
Zent, Roy

Publication type:

Article

Corrigendum.

Published in:: 2012
Publication type:: Correction Notice

Expression of concern.

Published in:: Journal of Clinical Investigation, 2012, v. 122, n. 1, p. 419, doi. 10.1172/JCI62190
Publication type:: Article

The flip-flop HuR: part of the problem or the solution in fighting cancer?

Published in:

Journal of Clinical Investigation, 2012, v. 122, n. 1, p. 16, doi. 10.1172/JCI61677

By:

Shultz, Jacqueline C.;
Chalfant, Charles E.

Publication type:

Article

Alteration of hypothalamic cellular dynamics in obesity.

Published in:

Journal of Clinical Investigation, 2012, v. 122, n. 1, p. 22, doi. 10.1172/JCI61562

By:

Lee, Edward B.;
Ahima, Rexford S.

Publication type:

Article

Epoxyeicosatrienoic acids: a double-edged sword in cardiovascular diseases and cancer.

Published in:

Journal of Clinical Investigation, 2012, v. 122, n. 1, p. 19, doi. 10.1172/JCI61453

By:

Dingzhi Wang;
DuBois, Raymond N.

Publication type:

Article

IL-1 and atherosclerosis: a murine twist to an evolving human story.

Published in:

Journal of Clinical Investigation, 2012, v. 122, n. 1, p. 27, doi. 10.1172/JCI61163

By:

Rader, Daniel J.

Publication type:

Article

Rare serotype adenoviral vectors for HIV vaccine development.

Published in:

Journal of Clinical Investigation, 2012, v. 122, n. 1, p. 25, doi. 10.1172/JCI60988

By:

Michael, Nelson L.

Publication type:

Article

Human adenovirus-specific T cells modulate HIV-specific T cell responses to an Ad5-vectored HIV-1 vaccine.

Published in:

Journal of Clinical Investigation, 2012, v. 122, n. 1, p. 359, doi. 10.1172/JCI60202

By:

Frahm, Nicole;
DeCamp, Allan C.;
Friedrich, David P.;
Carter, Donald K.;
Defawe, Olivier D.;
Kublin, James G.;
Casimiro, Danilo R.;
Duerr, Ann;
Robertson, Michael N.;
Buchbinder, Susan P.;
Yunda Huang;
Spies, Gregory A.;
De Rosa, Stephen C.;
McElrath, M. Juliana

Publication type:

Article

Glucagonocentric restructuring of diabetes: a pathophysiologic and therapeutic makeover.

Published in:

Journal of Clinical Investigation, 2012, v. 122, n. 1, p. 4, doi. 10.1172/JCI60016

By:

Unger, Roger H.;
Cherrington, Alan D.

Publication type:

Article

Drosophila and mammalian models uncover a role for the myoblast fusion gene TANC1 in rhabdomyosarcoma.

Published in:

Journal of Clinical Investigation, 2012, v. 122, n. 1, p. 403, doi. 10.1172/JCI59877

By:

Avirneni-Vadlamudi, Usha;
Galindo, Kathleen A.;
Endicott, Tiana R.;
Paulson, Vera;
Cameron, Scott;
Galindo, Rene L.

Publication type:

Article

Obesity is associated with hypothalamic injury in rodents and humans.

Published in:

Journal of Clinical Investigation, 2012, v. 122, n. 1, p. 1, doi. 10.1172/JCI59660

By:

Thaler, Joshua P.;
Chun-Xia Yi;
Schur, Ellen A.;
Guyenet, Stephan J.;
Hwang, Bang H.;
Dietrich, Marcelo O.;
Xiaolin Zhao;
Sarruf, David A.;
Izgur, Vitaly;
Maravilla, Kenneth R.;
Nguyen, Hong T.;
Fischer, Jonathan D.;
Matsen, Miles E.;
Wisse, Brent E.;
Morton, Gregory J.;
Horvath, Tamas L.;
Baskin, Denis G.;
Tschöp, Matthias H.;
Schwartz, Michael W.

Publication type:

Article

Administration of BMP2/7 in utero partially reverses Rubinstein-Taybi syndrome--like skeletal defects induced by Pdk1 or Cbp mutations in mice.

Published in:

Journal of Clinical Investigation, 2012, v. 122, n. 1, p. 91, doi. 10.1172/JCI59466

By:

Jae-Hyuck Shim;
Greenblatt, Matthew B.;
Singh, Anju;
Brady, Nicholas;
Hu, Dorothy;
Drapp, Rebecca;
Ogawa, Wataru;
Kasuga, Masato;
Noda, Tetsuo;
Sang-Hwa Yang;
Sang-Kyou Lee;
Rebel, Vivienne I.;
Glimcher, Laurie H.

Publication type:

Article

Intra-graft expression of genes involved in iron homeostasis predicts the development of operational tolerance in human liver transplantation.

Published in:

Journal of Clinical Investigation, 2012, v. 122, n. 1, p. 368, doi. 10.1172/JCI59411

By:

Bohne, Felix;
Martínez-Llordella, Marc;
Lozano, Juan-José;
Miquel, Rosa;
Benítez, Carlos;
Londoño, María-Carlota;
Manzia, Tommaso-María;
Angelico, Roberta;
Swinkels, Dorine W.;
Tjalsma, Harold;
López, Marta;
Abraldes, Juan G.;
Bonaccorsi-Riani, Eliano;
Jaeckel, Elmar;
Taubert, Richard;
Pirenne, Jacques;
Rimola, Antoni;
Tisone, Giuseppe;
Sánchez-Fueyo, Alberto

Publication type:

Article

Alkylpurine--DNA--N-glycosylase confers resistance to temozolomide in xenograft models of glioblastoma multiforme and is associated with poor survival in patients.

Published in:

Journal of Clinical Investigation, 2012, v. 122, n. 1, p. 253, doi. 10.1172/JCI59334

By:

Agnihotri, Sameer;
Gajadhar, Aaron S.;
Ternamian, Christian;
Gorlia, Thierry;
Diefes, Kristin L.;
Mischel, Paul S.;
Kelly, Joanna;
McGown, Gail;
Thorncroft, Mary;
Carlson, Brett L.;
Sarkaria, Jann N.;
Margison, Geoffrey P.;
Aldape, Kenneth;
Hawkins, Cynthia;
Hegi, Monika;
Guha, Abhijit

Publication type:

Article

Intravital imaging of CTLs killing islet cells in diabetic mice.

Published in:

Journal of Clinical Investigation, 2012, v. 122, n. 1, p. 119, doi. 10.1172/JCI59285

By:

Coppieters, Ken;
Amirian, Natalie;
von Herrath, Matthias

Publication type:

Article

Human dental pulp-derived stem cells promote locomotor recovery after complete transection of the rat spinal cord by multiple neuro-regenerative mechanisms.

Published in:

Journal of Clinical Investigation, 2012, v. 122, n. 1, p. 80, doi. 10.1172/JCI59251

By:

Sakai, Kiyoshi;
Yamamoto, Akihito;
Matsubara, Kohki;
Nakamura, Shoko;
Naruse, Mami;
Yamagata, Mari;
Sakamoto, Kazuma;
Tauchi, Ryoji;
Wakao, Norimitsu;
Imagama, Shiro;
Hibi, Hideharu;
Kadomatsu, Kenji;
Ishiguro, Naoki;
Ueda, Minoru

Publication type:

Article

Mutant TDP-43 in motor neurons promotes the onset and progression of ALS in rats.

Published in:

Journal of Clinical Investigation, 2012, v. 122, n. 1, p. 107, doi. 10.1172/JCI59130

By:

Cao Huang;
Jianbin Tong;
Fangfang Bi;
Hongxia Zhou;
Xu-Gang Xia

Publication type:

Article

Histamine-releasing factor has a proinflammatory role in mouse models of asthma and allergy.

Published in:

Journal of Clinical Investigation, 2012, v. 122, n. 1, p. 218, doi. 10.1172/JCI59072

By:

Kashiwakura, Jun-ichi;
Ando, Tomoaki;
Matsumoto, Kenji;
Kimura, Miho;
Kitaura, Jiro;
Matho, Michael H.;
Zajonc, Dirk M.;
Ozeki, Tomomitsu;
Ra, Chisei;
MacDonald, Susan M.;
Siraganian, Reuben P.;
Broide, David H.;
Kawakami, Yuko;
Kawakami, Toshiaki

Publication type:

Article

Altered CD4<sup>+</sup> T cell homing to the gut impairs mucosal immune reconstitution in treated HIV-infected individuals.

Published in:

Journal of Clinical Investigation, 2012, v. 122, n. 1, p. 62, doi. 10.1172/JCI59011

By:

Mavigner, Maud;
Cazabat, Michelle;
Dubois, Martine;
L'Faqihi, Fatima-Ezzahra;
Requena, Mary;
Pasquier, Christophe;
Klopp, Pascale;
Amar, Jacques;
Alric, Laurent;
Barange, Karl;
Vinel, Jean-Pierre;
Marchou, Bruno;
Massip, Patrice;
Izopet, Jacques;
Delobel, Pierre

Publication type:

Article

Oncogenic stress sensitizes murine cancers to hypomorphic suppression of ATR.

Published in:

Journal of Clinical Investigation, 2012, v. 122, n. 1, p. 241, doi. 10.1172/JCI58928

By:

Schoppy, David W.;
Ragland, Ryan L.;
Gilad, Oren;
Shastri, Nishita;
Peters, Ashley A.;
Murga, Matilde;
Fernandez-Capetillo, Oscar;
Diehl, J. Alan;
Brown, Eric J.

Publication type:

Article

Blood pressure influences end-stage renal disease of Cd151 knockout mice.

Published in:

Journal of Clinical Investigation, 2012, v. 122, n. 1, p. 348, doi. 10.1172/JCI58878

By:

Sachs, Norman;
Claessen, Nike;
Aten, Jan;
Kreft, Maaike;
Teske, Gwendoline J. D.;
Koeman, Anneke;
Zuurbier, Coert J.;
Janssen, Hans;
Sonnenberg, Arnoud

Publication type:

Article

MicroRNA-30e* promotes human glioma cell invasiveness in an orthotopic xenotransplantation model by disrupting the NF-κB/IκBα negative feedback loop.

Published in:

Journal of Clinical Investigation, 2012, v. 122, n. 1, p. 33, doi. 10.1172/JCI58849

By:

Lili Jiang;
Chuyong Lin;
Libing Song;
Jueheng Wu;
Baixue Chen;
Zhe Ying;
Lishan Fang;
Xiao Yan;
Mian He;
Jun Li;
Mengfeng Li

Publication type:

Article

In vitro modeling of the microvascular occlusion and thrombosis that occur in hematologic diseases using microfluidic technology.

Published in:

Journal of Clinical Investigation, 2012, v. 122, n. 1, p. 408, doi. 10.1172/JCI58753

By:

Tsai, Michelle;
Kita, Ashley;
Leach, Joseph;
Rounsevell, Ross;
Huang, James N.;
Moake, Joel;
Ware, Russell E.;
Fletcher, Daniel A.;
Lam, Wilbur A.

Publication type:

Article

Coordinate regulation of neutrophil homeostasis by liver X receptors in mice.

Published in:

Journal of Clinical Investigation, 2012, v. 122, n. 1, p. 337, doi. 10.1172/JCI58393

By:

Hong, Cynthia;
Kidani, Yoko;
A-Gonzalez, Noelia;
Tram Phung;
Ito, Ayaka;
Xin Rong;
Ericson, Katrin;
Mikkola, Hanna;
Beaven, Simon W.;
Miller, Lloyd S.;
Wen-Hai Shao;
Cohen, Philip L.;
Castrillo, Antonio;
Tontonoz, Peter;
Bensinger, Steven J.

Publication type:

Article

Correlation of rare coding variants in the gene encoding human glucokinase regulatory protein with phenotypic, cellular, and kinetic outcomes.

Published in:

Journal of Clinical Investigation, 2012, v. 122, n. 1, p. 205, doi. 10.1172/JCI46425

By:

Rees, Matthew G.;
Ng, David;
Ruppert, Sarah;
Turner, Clesson;
Beer, Nicola L.;
Swift, Amy J.;
Morken, Mario A.;
Below, Jennifer E.;
Blech, Ilana;
Mullikin, James C.;
McCarthy, Mark I.;
Biesecker, Leslie G.;
Gloyn, Anna L.;
Collins, Francis S.

Publication type:

Article

Remodeling of the arcuate nucleus energy-balance circuit is inhibited in obese mice.

Published in:

Journal of Clinical Investigation, 2012, v. 122, n. 1, p. 142, doi. 10.1172/JCI43134

By:

McNay, David E. G.;
Briançon, Nadege;
Kokoeva, Maia V.;
Maratos-Flier, Eleftheria;
Flier, Jeffrey S.

Publication type:

Article

Defective nuclear IKKα function in patients with ectodermal dysplasia with immune deficiency.

Published in:

Journal of Clinical Investigation, 2012, v. 122, n. 1, p. 315, doi. 10.1172/JCI42534

By:

Temmerman, Stephane T.;
Ma, Chi A.;
Yongge Zhao;
Keenan, Jeffrey;
Aksentijevich, Ivona;
Fessler, Margaret;
Brown, Margaret R.;
Knutsen, Alan;
Shapiro, Ralph;
Jain, Ashish

Publication type:

Article

Haptoglobin activates innate immunity to enhance acute transplant rejection in mice.

Published in:

Journal of Clinical Investigation, 2012, v. 122, n. 1, p. 383, doi. 10.1172/JCI58344

By:

Hua Shen;
Yang Song;
Colangelo, Christopher M.;
Wu, Terence;
Bruce, Can;
Scabia, Gaia;
Galan, Anjela;
Maffei, Margherita;
Goldstein, Daniel R.

Publication type:

Article

Creatine kinase--mediated improvement of function in failing mouse hearts provides causal evidence the failing heart is energy starved.

Published in:

Journal of Clinical Investigation, 2012, v. 122, n. 1, p. 291, doi. 10.1172/JCI57426

By:

Gupta, Ashish;
Akki, Ashwin;
Yibin Wang;
Leppo, Michelle K.;
Chacko, V. P.;
Foster, D. Brian;
Caceres, Viviane;
Sa Shi;
Kirk, Jonathan A.;
Su, Jason;
Lai, Shenghan;
Paolocci, Nazareno;
Steenbergen, Charles;
Gerstenblith, Gary;
Weiss, Robert G.

Publication type:

Article

Loss of Dnmt3b function upregulates the tumor modifier Ment and accelerates mouse lymphomagenesis.

Published in:

Journal of Clinical Investigation, 2012, v. 122, n. 1, p. 163, doi. 10.1172/JCI57292

By:

Hlady, Ryan A.;
Novakova, Slavomira;
Opavska, Jana;
Klinkebiel, David;
Peters, Staci L.;
Bies, Juraj;
Hannah, Jay;
Iqbal, Javeed;
Anderson, Kristi M.;
Siebler, Hollie M.;
Smith, Lynette M.;
Greiner, Timothy C.;
Bastola, Dhundy;
Joshi, Shantaram;
Lockridge, Oksana;
Simpson, Melanie A.;
Felsher, Dean W.;
Wagner, Kay-Uwe;
Chan, Wing C.;
Christman, Judith K.

Publication type:

Article