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Professor Hamao Umezawa opened up a new road for the development of molecularly targeted therapeutic drugs for cancers.
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- Journal of Antibiotics, 2018, v. 71, n. 1, p. 37, doi. 10.1038/ja.2017.139
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Novel approaches for identification of anti-tumor drugs and new bioactive compounds.
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- Journal of Antibiotics, 2018, v. 71, n. 1, p. 39, doi. 10.1038/ja.2017.97
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Current landscape and future prospects of antiviral drugs derived from microbial products.
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- Journal of Antibiotics, 2018, v. 71, n. 1, p. 45, doi. 10.1038/ja.2017.115
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Autophagy-regulating protease Atg4: structure, function, regulation and inhibition.
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- Journal of Antibiotics, 2018, v. 71, n. 1, p. 72, doi. 10.1038/ja.2017.104
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Self-control of the PHO regulon: the PhoP-dependent protein PhoU controls negatively expression of genes of PHO regulon in Streptomyces coelicolor.
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- Journal of Antibiotics, 2018, v. 71, n. 1, p. 113, doi. 10.1038/ja.2017.130
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Quadoctomycin, a 48-membered macrolide antibiotic from Streptomyces sp. MM168-141F8.
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- Journal of Antibiotics, 2018, v. 71, n. 1, p. 91, doi. 10.1038/ja.2017.140
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In vivo efficacy of β-lactam/tripropeptin C in a mouse septicemia model and the mechanism of reverse β-lactam resistance in methicillin-resistant Staphylococcus aureus mediated by tripropeptin C.
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- Journal of Antibiotics, 2018, v. 71, n. 1, p. 79, doi. 10.1038/ja.2017.88
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New antituberculous drugs derived from natural products: current perspectives and issues in antituberculous drug development.
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- Journal of Antibiotics, 2018, v. 71, n. 1, p. 15, doi. 10.1038/ja.2017.126
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Biological activity of intervenolin analogs with a phenyl substituent.
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- Journal of Antibiotics, 2018, v. 71, n. 1, p. 86, doi. 10.1038/ja.2017.123
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A guanine derivative as a new MEK inhibitor produced by Streptomyces sp. MK63-43F2.
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- Journal of Antibiotics, 2018, v. 71, n. 1, p. 135, doi. 10.1038/ja.2017.100
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Ascosteroside D, a new mitochondrial respiration inhibitor discovered by pesticidal screening using insect ADP/ATP carrier protein-expressing Saccharomyces cerevisiae.
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- Journal of Antibiotics, 2018, v. 71, n. 1, p. 146, doi. 10.1038/ja.2017.118
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Our microbes not only produce antibiotics, they also overproduce amino acids.
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- Journal of Antibiotics, 2018, v. 71, n. 1, p. 26, doi. 10.1038/ja.2017.142
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Memory of Professor Hamao Umezawa.
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- Journal of Antibiotics, 2018, v. 71, n. 1, p. 2, doi. 10.1038/ja.2017.137
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Synthetic studies of viridiofungins, broad-spectrum antifungal agents and serine palmitoyl transferase inhibitors.
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- Journal of Antibiotics, 2018, v. 71, n. 1, p. 53, doi. 10.1038/ja.2017.110
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Cellular uptake of modified aminoglycosides.
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- Journal of Antibiotics, 2018, v. 71, n. 1, p. 142, doi. 10.1038/ja.2017.131
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Rakicidin F, a new antibacterial cyclic depsipeptide from a marine sponge-derived Streptomyces sp.
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- Journal of Antibiotics, 2018, v. 71, n. 1, p. 139, doi. 10.1038/ja.2017.92
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Engineered production and evaluation of 6′-deoxy-tallysomycin H-1 revealing new insights into the structure-activity relationship of the anticancer drug bleomycin.
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- Journal of Antibiotics, 2018, v. 71, n. 1, p. 97, doi. 10.1038/ja.2017.93
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Synthesis and antibacterial activity of novel lincomycin derivatives. III. Optimization of a phenyl thiadiazole moiety.
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- Journal of Antibiotics, 2018, v. 71, n. 1, p. 104, doi. 10.1038/ja.2017.59
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Microbial metabolites and derivatives targeted at inflammation and bone diseases therapy: chemistry, biological activity and pharmacology.
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- Journal of Antibiotics, 2018, v. 71, n. 1, p. 60, doi. 10.1038/ja.2017.138
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Valgamicin C, a novel cyclic depsipeptide containing the unusual amino acid cleonine, and related valgamicins A, T and V produced by Amycolatopsis sp. ML1-hF4.
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- Journal of Antibiotics, 2018, v. 71, n. 1, p. 129, doi. 10.1038/ja.2017.135
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Wakodecalines A and B, new decaline metabolites isolated from a fungus Pyrenochaetopsis sp. RK10-F058.
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- Journal of Antibiotics, 2018, v. 71, n. 1, p. 123, doi. 10.1038/ja.2017.103
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Preface: special issue Hamao Umezawa (1914-1986).
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- Journal of Antibiotics, 2018, v. 71, n. 1, p. 1, doi. 10.1038/ja.2017.136
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Destination of aminoglycoside antibiotics in the 'post-antibiotic era'.
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- Journal of Antibiotics, 2018, v. 71, n. 1, p. 4, doi. 10.1038/ja.2017.117
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