Works matching IS 00099236 AND DT 2025 AND VI 117

Results: 176

Highlighted Articles.

Published in:: Clinical Pharmacology & Therapeutics, 2025, v. 117, n. 5, p. 1162, doi. 10.1002/cpt.3648
Publication type:: Article

Correction to "Lenacapavir: Playing the Long Game in the New Era of Antiretrovirals".

Published in:: Clinical Pharmacology & Therapeutics, 2025, v. 117, n. 5, p. 1470, doi. 10.1002/cpt.3647
Publication type:: Article

MRI Provides New Insights Into the Pharmacologic Mechanism of Bisacodyl: A Blueprint for Understanding Intestinal Drug Mechanisms.

Published in:

Clinical Pharmacology & Therapeutics, 2025, v. 117, n. 5, p. 1159, doi. 10.1002/cpt.3646

By:

Giacomini, Kathleen M.

Publication type:

Article

ASCPT News.

Published in:: Clinical Pharmacology & Therapeutics, 2025, v. 117, n. 5, p. 1164, doi. 10.1002/cpt.3638
Publication type:: Article

Integrated Evidence Planning for Enhancing Patient Care: Harnessing the Power of Real‐World Evidence.

Published in:

Clinical Pharmacology & Therapeutics, 2025, v. 117, n. 5, p. 1179, doi. 10.1002/cpt.3632

By:

Capkun, Gorana;
Olson, Melvin

Publication type:

Article

In this Issue.

Published in:: Clinical Pharmacology & Therapeutics, 2025, v. 117, n. 5, p. 1157, doi. 10.1002/cpt.3637
Publication type:: Article

Characterizing Treatment Effect Heterogeneity Using Real‐World Data.

Published in:

Clinical Pharmacology & Therapeutics, 2025, v. 117, n. 5, p. 1209, doi. 10.1002/cpt.3627

By:

Thelen, Haedi;
Hennessy, Sean

Publication type:

Article

Optimal Drug, Optimal Dose, or Both in the Pharmacological Treatment of Neonatal Opioid Withdrawal Syndrome?

Published in:

Clinical Pharmacology & Therapeutics, 2025, v. 117, n. 5, p. 1182, doi. 10.1002/cpt.3600

By:

Kraft, Walter K.

Publication type:

Article

Establishment of a Biomarker‐Directed Clinical Endpoint Model for Early‐Stage Parkinson's Disease Patients.

Published in:

Clinical Pharmacology & Therapeutics, 2025, v. 117, n. 5, p. 1460, doi. 10.1002/cpt.3593

By:

Gupta, Churni;
Kim, Chaejin;
Guzy, Serge;
Yoneyama, Tomoki;
Gharahi, Hamidreza;
Siripuram, Vijay Kumar;
Iadevaia, Sergio;
Barua, Dipak;
Hang, Yaming;
Iakovleva, Tatiana;
Boucher, Christina;
Vakilynejad, Majid;
Schmidt, Stephan;
Vozmediano, Valvanera

Publication type:

Article

Model‐Informed Selection of the Recommended Phase 2 Dosage for Anti‐TIGIT Immunotherapy Leveraging co‐Expressed PD‐1 Inhibitor Target Engagement.

Published in:

Clinical Pharmacology & Therapeutics, 2025, v. 117, n. 5, p. 1451, doi. 10.1002/cpt.3590

By:

Kareva, Irina;
Hu, Ping;
Pierre, Vadryn;
Kitzing, Thomas;
Victor, Anja;
Richter, Emilia;
Gao, Wei;
Venkatakrishnan, Karthik;
Zutshi, Anup

Publication type:

Article

Optimal Dosing Regimen for Epcoritamab, a Subcutaneous Bispecific Antibody, in Relapsed or Refractory Large B‐Cell Lymphoma.

Published in:

Clinical Pharmacology & Therapeutics, 2025, v. 117, n. 5, p. 1437, doi. 10.1002/cpt.3588

By:

Li, Tommy;
Gibiansky, Leonid;
Parikh, Apurvasena;
Putnins, Matthew;
Chiu, Christopher W.;
Sacchi, Mariana;
Feng, Huaibao;
Ahmadi, Tahamtan;
Gupta, Manish;
Xu, Steven

Publication type:

Article

The Role and Mechanisms of Aurora Kinases in Kidney Diseases.

Published in:

Clinical Pharmacology & Therapeutics, 2025, v. 117, n. 5, p. 1217, doi. 10.1002/cpt.3584

By:

Chang, Meiying;
Li, Qiuyi;
Shi, Zhenwei;
Zhuang, Shougang

Publication type:

Article

Bench to Budget: Integrated Evidence Generation for Medications.

Published in:

Clinical Pharmacology & Therapeutics, 2025, v. 117, n. 4, p. 869, doi. 10.1002/cpt.3603

By:

Schneeweiss, Sebastian;
Miksad, Rebecca

Publication type:

Article

Dose‐Optimization of a Novel Co‐Formulated Triple Combination Antimalarial Therapy: Artemether‐Lumefantrine‐Amodiaquine.

Published in:

Clinical Pharmacology & Therapeutics, 2025, v. 117, n. 5, p. 1248, doi. 10.1002/cpt.3582

By:

Tarning, Joel;
White, Nicholas J.;
Dondorp, Arjen M.

Publication type:

Article

Evolving Research and Development Landscape for Rare Diseases: Growing Concerns Over Orphan Drug Lag in Japan.

Published in:

Clinical Pharmacology & Therapeutics, 2025, v. 117, n. 5, p. 1325, doi. 10.1002/cpt.3553

By:

Enya, Kazuaki;
Kageyama, Itsuki;
Kobayashi, Yoshiyuki;
Lim, Yeongjoo;
Sengoku, Shintaro;
Kodama, Kota

Publication type:

Article

CB<sub>1</sub> Receptor Antagonist Selonabant (ANEB‐001) Blocks Acute THC Effects in Healthy Volunteers: A Phase II Randomized Controlled Trial.

Published in:

Clinical Pharmacology & Therapeutics, 2025, v. 117, n. 5, p. 1427, doi. 10.1002/cpt.3581

By:

Gorbenko, Andriy A.;
Heuberger, Jules A. A. C.;
Juachon, Maria;
Klaassen, Erica;
Tagen, Michael;
Lawler, Joseph F.;
Schneeberger, Daniel;
Cundy, Kenneth C.;
Klumpers, Linda E.;
Groeneveld, Geert J.

Publication type:

Article

Clinical Evaluation of Drug–Drug Interactions with Obeldesivir, an Orally Administered Antiviral Agent.

Published in:

Clinical Pharmacology & Therapeutics, 2025, v. 117, n. 5, p. 1403, doi. 10.1002/cpt.3575

By:

Peng, Chi‐Chi;
Humeniuk, Rita;
Raut, Anuja;
Kwan, Anna;
Mak, Lily;
Stacom, Caitlin;
Xiao, Deqing;
Chen, Shuguang;
Davies, Santosh;
Madera, Sharline;
Koullias, Yiannis;
Lichtman, Amos;
Llewellyn, Joe;
Amini, Elham;
Winter, Helen;
Caro, Luzelena

Publication type:

Article

Intracellular Penetration of Atazanavir, Ritonavir and Dolutegravir With Concomitant Rifampicin: A Dose Escalation Study.

Published in:

Clinical Pharmacology & Therapeutics, 2025, v. 117, n. 5, p. 1393, doi. 10.1002/cpt.3572

By:

De Nicolò, Amedeo;
Palermiti, Alice;
Mugerwa, Henry;
Nakabuye, Shamim;
Namusanje, Josephine;
Kobusingye, Josephine;
Odoch, Denis;
Lamorde, Mohammed;
Kengo, Allan;
Denti, Paolo;
Gausi, Kamunkhwala;
Maartens, Gary;
McIlleron, Helen;
Wiesner, Lubbe;
Khoo, Saye;
Waitt, Catriona;
D'Avolio, Antonio

Publication type:

Article

Navigating the Challenges of Cyclosporine as an Alternative to Rifampicin as an OATP1B Index Inhibitor.

Published in:

Clinical Pharmacology & Therapeutics, 2025, v. 117, n. 5, p. 1175, doi. 10.1002/cpt.3564

By:

Varma, Manthena V. S.;
Vourvahis, Manoli

Publication type:

Article

Model‐Based Prediction of Clinically Relevant Thrombocytopenia after Allogeneic Hematopoietic Stem Cell Transplantation.

Published in:

Clinical Pharmacology & Therapeutics, 2025, v. 117, n. 5, p. 1413, doi. 10.1002/cpt.3580

By:

Götz, Katharina M.;
Turki, Amin T.;
Och, Katharina;
Selzer, Dominik;
Brossette, Christian;
Graf, Norbert;
Rauch, Jochen;
Theobald, Stefan;
Braun, Yvonne;
Rohm, Kerstin;
Weiler, Gabriele;
Rüdesheim, Simeon;
Schwab, Matthias;
Eisenberg, Lisa;
Pfeifer, Nico;
Kiefer, Stephan;
Schwarz, Ulf;
Riede, Claudia;
Smola, Sigrun;
Beelen, Dietrich W.

Publication type:

Article

Machine Learning for Prediction of Drug Concentrations: Application and Challenges.

Published in:

Clinical Pharmacology & Therapeutics, 2025, v. 117, n. 5, p. 1236, doi. 10.1002/cpt.3577

By:

Huang, Shuqi;
Xu, Qihan;
Yang, Guoping;
Ding, Junjie;
Pei, Qi

Publication type:

Article

Magnetic Resonance Imaging Reveals Novel Insights into the Dual Mode of Action of Bisacodyl: A Randomized, Placebo‐controlled Trial in Constipation.

Published in:

Clinical Pharmacology & Therapeutics, 2025, v. 117, n. 5, p. 1284, doi. 10.1002/cpt.3532

By:

Aliyu, Abdulsalam;
Dellschaft, Neele;
Hoad, Caroline;
Williams, Hannah;
Gaudoin, Emily;
Sulaiman, Sarah;
Crooks, Colin;
Gowland, Penny;
Aran, Alexia;
Lange, Robert;
Bois De Fer, Beatrice;
Corsetti, Maura;
Marciani, Luca;
Spiller, Robin

Publication type:

Article

A Guide for Implementing DPYD Genotyping for Systemic Fluoropyrimidines into Clinical Practice.

Published in:

Clinical Pharmacology & Therapeutics, 2025, v. 117, n. 5, p. 1194, doi. 10.1002/cpt.3567

By:

Ho, Teresa T.;
Smith, D. Max;
Aquilante, Christina L.;
Cicali, Emily J.;
El Rouby, Nihal;
Hertz, Daniel L.;
Imanirad, Iman;
Patel, Jai N.;
Scott, Stuart A.;
Swain, Sandra M.;
Tuteja, Sony;
Hicks, J. Kevin

Publication type:

Article

Association of Influenza Vaccination During Pregnancy with Health Outcomes in Mothers and Children: A Population‐Based Cohort Study.

Published in:

Clinical Pharmacology & Therapeutics, 2025, v. 117, n. 5, p. 1381, doi. 10.1002/cpt.3565

By:

Lee, Hyesung;
Yoon, Dongwon;
Kim, Ju Hwan;
Noh, Yunha;
Joo, Eun‐Jeong;
Han, Jung Yeol;
Choe, Young June;
Shin, Ju‐Young

Publication type:

Article

Urinary Kidney Injury Biomarker Profiles in Healthy Individuals and After Nephrotoxic and Ischemic Injury.

Published in:

Clinical Pharmacology & Therapeutics, 2025, v. 117, n. 5, p. 1272, doi. 10.1002/cpt.3531

By:

Waikar, Sushrut S.;
Mogg, Robin;
Baker, Amanda F.;
Frendl, Gyorgy;
Topper, Michael;
Adler, Scott;
Sultana, Stefan;
Zhao, Runqi;
King, Nicholas M. P.;
Piccoli, Steven P.;
Sauer, John‐Michael;
Hoffmann, Steve;
Nunes, Irene;
Sistare, Frank D.

Publication type:

Article

Mapping the Clinical Development Trajectory of Cell and Gene Therapy Products.

Published in:

Clinical Pharmacology & Therapeutics, 2025, v. 117, n. 5, p. 1264, doi. 10.1002/cpt.3512

By:

Elsallab, Magdi;
Ouvina, Michelle;
Arfe, Andrea;
Bourgeois, Florence T.

Publication type:

Article

Japan's Conditional/Time‐Limited Early Approval System in Regenerative Medicine: A Case Study of Rise and Falls of Autologous Skeletal Myoblast Sheets.

Published in:

Clinical Pharmacology & Therapeutics, 2025, v. 117, n. 5, p. 1171, doi. 10.1002/cpt.3562

By:

Hakariya, Hayase;
Ozaki, Akihiko;
Kaneda, Yudai;
Tanimoto, Tetsuya

Publication type:

Article

A 2024 Update on US FDA Implementation of Partial Area Under the Curve Into Bioavailability and Bioequivalence Assessments.

Published in:

Clinical Pharmacology & Therapeutics, 2025, v. 117, n. 5, p. 1185, doi. 10.1002/cpt.3561

By:

Hopefl, Robert;
Gong, Yuqing;
Bielski, Elizabeth;
Pillai, Venkateswaran C;
Newman, Bryan;
Qin, Bin;
Wang, Yan;
Yoon, Miyoung;
Zhang, Qiangnan;
Stier, Ethan;
Uppoor, Ramana;
Zhu, Hao;
Zhang, Lei;
Fang, Lanyan

Publication type:

Article

Cytokine Dynamics in Action: A Mechanistic Approach to Assess Interleukin 6 Related Therapeutic Protein‐Drug–Disease Interactions.

Published in:

Clinical Pharmacology & Therapeutics, 2025, v. 117, n. 5, p. 1369, doi. 10.1002/cpt.3560

By:

Pan, Xian;
Gill, Katherine L.;
Pansari, Amita;
Hatley, Oliver;
Curry, Liam;
Jamei, Masoud;
Gardner, Iain

Publication type:

Article

Effect of Target‐Mediated Disposition on Iptacopan Clinical Pharmacokinetics in Participants with Normal or Impaired Hepatic Function.

Published in:

Clinical Pharmacology & Therapeutics, 2025, v. 117, n. 5, p. 1358, doi. 10.1002/cpt.3559

By:

Burmeister Getz, Elise;
Stein, Richard R.;
Fink, Martin;
Kulmatycki, Kenneth;
Baltcheva, Irina;
Weis, Wendy;
Shah, Bharti;
Lawitz, Eric;
Schmouder, Robert

Publication type:

Article

Methodological Insights on Biomarker‐Based Patient Selection: A Review of Scientific Advice Procedures at the European Medicines Agency.

Published in:

Clinical Pharmacology & Therapeutics, 2025, v. 117, n. 5, p. 1226, doi. 10.1002/cpt.3558

By:

Huber, Cynthia;
Zinserling, Joerg;
Benda, Norbert;
Vetter, Thorsten;
Rueckbeil, Marcia

Publication type:

Article

Characterization of NAT, GST, and CYP2E1 Genetic Variation in Sub‐Saharan African Populations: Implications for Treatment of Tuberculosis and Other Diseases.

Published in:

Clinical Pharmacology & Therapeutics, 2025, v. 117, n. 5, p. 1338, doi. 10.1002/cpt.3557

By:

Malinga, Thandeka V.B.;
Othman, Houcemeddine;
Paximadis, Maria;
Tiemessen, Caroline T.;
Ramsay, Michèle;
Hazelhurst, Scott;
Twesigomwe, David

Publication type:

Article

In this Issue.

Published in:: Clinical Pharmacology & Therapeutics, 2025, v. 117, n. 4, p. 867, doi. 10.1002/cpt.3602
Publication type:: Article

Investigation of Genomic and Transcriptomic Risk Factors of Clopidogrel Response in African Americans.

Published in:

Clinical Pharmacology & Therapeutics, 2025, v. 117, n. 5, p. 1313, doi. 10.1002/cpt.3552

By:

Yang, Guang;
Alarcon, Cristina;
Chanfreau, Catherine;
Lee, Norman H.;
Friedman, Paula;
Nutescu, Edith;
Tuck, Matthew;
O'Brien, Travis;
Gong, Li;
Klein, Teri E.;
Chang, Kyong‐Mi;
Tsao, Philip S.;
Meltzer, David O.;
Lynch, Julie A.;
Tuteja, Sony;
Perera, Minoli A.

Publication type:

Article

Microdose Cocktail Study Reveals the Activity and Key Influencing Factors of OATP1B, P‐Gp, BCRP, and CYP3A in End‐Stage Renal Disease Patients.

Published in:

Clinical Pharmacology & Therapeutics, 2025, v. 117, n. 5, p. 1303, doi. 10.1002/cpt.3546

By:

Kong, Weijie;
Pan, Yuejuan;
Wu, Yujie;
Hu, Yiyi;
Jiang, Zhenbin;
Tian, Xinkui;
Bi, Shuhong;
Wang, Song;
Feng, Feifei;
Jin, Yuyan;
Li, Jiayu;
Li, Haiyan;
Wang, Yue;
Liang, Hao;
Tang, Wen;
Liu, Dongyang

Publication type:

Article

Model‐Informed Once‐Daily Dosing Strategy for Bedaquiline and Delamanid in Children, Adolescents and Adults with Tuberculosis.

Published in:

Clinical Pharmacology & Therapeutics, 2025, v. 117, n. 5, p. 1292, doi. 10.1002/cpt.3536

By:

Lin, Yu‐Jou;
van der Laan, Louvina E.;
Karlsson, Mats O.;
Garcia‐Prats, Anthony J.;
Hesseling, Anneke C.;
Svensson, Elin M.

Publication type:

Article

Modern Evidence Generation on Medication Effectiveness and Safety During Pregnancy: Study Design Considerations.

Published in:

Clinical Pharmacology & Therapeutics, 2025, v. 117, n. 4, p. 895, doi. 10.1002/cpt.3598

By:

Huybrechts, Krista F.;
Bateman, Brian T.;
Hernández‐Díaz, Sonia

Publication type:

Article

Franchise Data Strategy: "PIVOT"ing From Cognitive Dissonance Toward Making What Is Implicit, Explicit.

Published in:

Clinical Pharmacology & Therapeutics, 2025, v. 117, n. 4, p. 891, doi. 10.1002/cpt.3597

By:

Bhattacharya, Indranil;
Rathmann, Suchitrita;
Najdi, Safaa;
Ahmed, Mariam A.;
Heatherington, Anne

Publication type:

Article

Pharmacokinetic Modeling and Model‐Based Hypothesis Generation for Dose Optimization of Clonidine in Neonates With Neonatal Opioid Withdrawal Syndrome.

Published in:

Clinical Pharmacology & Therapeutics, 2025, v. 117, n. 5, p. 1254, doi. 10.1002/cpt.3507

By:

Tang, Fei;
Ng, Chee M.;
Horn, Jamie;
Bada, Henrietta S.;
Leggas, Markos

Publication type:

Article

Issue Information.

Published in:: Clinical Pharmacology & Therapeutics, 2025, v. 117, n. 5, p. 1149, doi. 10.1002/cpt.3321
Publication type:: Article

Keyword Index.

Published in:: Clinical Pharmacology & Therapeutics, 2025, v. 117, p. S135, doi. 10.1002/cpt.3609
Publication type:: Article

Issue Information.

Published in:: Clinical Pharmacology & Therapeutics, 2025, v. 117, p. S1, doi. 10.1002/cpt.3644
Publication type:: Article

American Society for Clinical Pharmacology and Therapeutics.

Published in:: Clinical Pharmacology & Therapeutics, 2025, v. 117, p. S5, doi. 10.1002/cpt.3607
Publication type:: Article

Author Index.

Published in:: Clinical Pharmacology & Therapeutics, 2025, v. 117, p. S124, doi. 10.1002/cpt.3608
Publication type:: Article

Clinical Evidence 2030.

Published in:

Clinical Pharmacology & Therapeutics, 2025, v. 117, n. 4, p. 884, doi. 10.1002/cpt.3596

By:

Arlett, Peter;
Umuhire, Denise;
Verpillat, Patrice;
Foggi, Paolo;
Wändel Liminga, Ulla;
Sepodes, Bruno;
Lunzer, Marianne;
Aylward, Brian;
Vamvakas, Spiros;
Roes, Kit;
Pétavy, Frank;
Thirstrup, Steffen;
Lamas, Maria;
Cooke, Emer;
Broich, Karl

Publication type:

Article

Highlighted Articles.

Published in:: Clinical Pharmacology & Therapeutics, 2025, v. 117, n. 4, p. 872, doi. 10.1002/cpt.3595
Publication type:: Article

Harmonizing HTA Evidence Needs and Expectations: Challenges and Opportunities to Improve Evidence Generation, Ensure Access and Affordability.

Published in:

Clinical Pharmacology & Therapeutics, 2025, v. 117, n. 4, p. 938, doi. 10.1002/cpt.3579

By:

Emond, Sarah K.;
Goettsch, Wim G.;
Ollendorf, Daniel A.

Publication type:

Article

Use of Real‐World Data and Real‐World Evidence in Rare Disease Drug Development: A Statistical Perspective.

Published in:

Clinical Pharmacology & Therapeutics, 2025, v. 117, n. 4, p. 946, doi. 10.1002/cpt.3576

By:

Chen, Jie;
Gruber, Susan;
Lee, Hana;
Chu, Haitao;
Lee, Shiowjen;
Tian, Haijun;
Wang, Yan;
He, Weili;
Jemielita, Thomas;
Song, Yang;
Tamura, Roy;
Tian, Lu;
Zhao, Yihua;
Chen, Yong;
van der Laan, Mark;
Nie, Lei

Publication type:

Article

ASCPT News.

Published in:: Clinical Pharmacology & Therapeutics, 2025, v. 117, n. 4, p. 874, doi. 10.1002/cpt.3594
Publication type:: Article

Palbociclib Is Safe for Breast Cancer Patients With Mild Hepatic Impairment: A Multicenter Retrospective Study Using Real‐World Data.

Published in:

Clinical Pharmacology & Therapeutics, 2025, v. 117, n. 4, p. 1115, doi. 10.1002/cpt.3574

By:

Bos, Alieke K.;
Willemsen, Annelieke E.C.A.B.;
Visser, Loes E.;
Stoker, Lennart J.;
Kingma, Jurjen S.;
Rommers, Mirjam K.;
Kuck, Emile M.;
van der Linden, Paul D.;
van Nuland, Merel

Publication type:

Article