Works matching IS 00099236 AND DT 2020 AND VI 107 AND IP 4

Results: 51

Data Science in Clinical Pharmacology and Drug Development for Improving Health Outcomes in Patients.
Published in:
Clinical Pharmacology & Therapeutics, 2020, v. 107, n. 4, p. 683, doi. 10.1002/cpt.1803
By:
- Peck, Richard W.;
- Shah, Pratik;
- Vamvakas, Spiros;
- Graaf, Piet H.
Publication type:
Article
In This Issue.
Published in:
Clinical Pharmacology & Therapeutics, 2020, v. 107, n. 4, p. 681, doi. 10.1002/cpt.1801
Publication type:
Article
ASCPT News.
Published in:
Clinical Pharmacology & Therapeutics, 2020, v. 107, n. 4, p. 689, doi. 10.1002/cpt.1800
Publication type:
Article
Highlights.
Published in:
Clinical Pharmacology & Therapeutics, 2020, v. 107, n. 4, p. 687, doi. 10.1002/cpt.1799
Publication type:
Article
An Introduction to Machine Learning.
Published in:
Clinical Pharmacology & Therapeutics, 2020, v. 107, n. 4, p. 871, doi. 10.1002/cpt.1796
By:
- Badillo, Solveig;
- Banfai, Balazs;
- Birzele, Fabian;
- Davydov, Iakov I.;
- Hutchinson, Lucy;
- Kam‐Thong, Tony;
- Siebourg‐Polster, Juliane;
- Steiert, Bernhard;
- Zhang, Jitao David
Publication type:
Article
Will Artificial Intelligence for Drug Discovery Impact Clinical Pharmacology?
Published in:
Clinical Pharmacology & Therapeutics, 2020, v. 107, n. 4, p. 780, doi. 10.1002/cpt.1795
By:
- Zhavoronkov, Alex;
- Vanhaelen, Quentin;
- Oprea, Tudor I.
Publication type:
Article
Emulation Differences vs. Biases When Calibrating Real‐World Evidence Findings Against Randomized Controlled Trials.
Published in:
Clinical Pharmacology & Therapeutics, 2020, v. 107, n. 4, p. 735, doi. 10.1002/cpt.1793
By:
- Franklin, Jessica M.;
- Glynn, Robert J.;
- Suissa, Samy;
- Schneeweiss, Sebastian
Publication type:
Article
Artificial Intelligence and Machine Learning: Will Clinical Pharmacologists Be Needed in the Next Decade? The John Henry Question.
Published in:
Clinical Pharmacology & Therapeutics, 2020, v. 107, n. 4, p. 697, doi. 10.1002/cpt.1792
By:
- Corrigan, Brian W.
Publication type:
Article
"In‐House" Data on the Outside—A Mobile Health Approach.
Published in:
Clinical Pharmacology & Therapeutics, 2020, v. 107, n. 4, p. 948, doi. 10.1002/cpt.1790
By:
- Huang, Qinlei;
- Crumley, Tami;
- Walters, Christina;
- Cluckers, Liesbeth;
- Heirman, Ingeborg;
- Railkar, Radha;
- Bhatia, Gaurav;
- Cantor, Matthew;
- Benko, Christopher;
- Izmailova, Elena S.;
- Rottey, Sylvie;
- Stoch, S. Aubrey
Publication type:
Article
An Application of Machine Learning in Pharmacovigilance: Estimating Likely Patient Genotype From Phenotypical Manifestations of Fluoropyrimidine Toxicity.
Published in:
Clinical Pharmacology & Therapeutics, 2020, v. 107, n. 4, p. 944, doi. 10.1002/cpt.1789
By:
- Correia Pinheiro, Luis;
- Durand, Julie;
- Dogné, Jean‐Michel
Publication type:
Article
MID3: Mission Impossible or Model‐Informed Drug Discovery and Development? Point‐Counterpoint Discussions on Key Challenges.
Published in:
Clinical Pharmacology & Therapeutics, 2020, v. 107, n. 4, p. 762, doi. 10.1002/cpt.1788
By:
- Krishnaswami, Sriram;
- Austin, Daren;
- Della Pasqua, Oscar;
- Gastonguay, Marc R.;
- Gobburu, Jogarao;
- Graaf, Piet H.;
- Ouellet, Daniele;
- Tannenbaum, Stacey;
- Visser, Sandra A. G.
Publication type:
Article
Development of a System for Postmarketing Population Pharmacokinetic and Pharmacodynamic Studies Using Real‐World Data From Electronic Health Records.
Published in:
Clinical Pharmacology & Therapeutics, 2020, v. 107, n. 4, p. 934, doi. 10.1002/cpt.1787
By:
- Choi, Leena;
- Beck, Cole;
- McNeer, Elizabeth;
- Weeks, Hannah L.;
- Williams, Michael L.;
- James, Nathan T.;
- Niu, Xinnan;
- Abou‐Khalil, Bassel W.;
- Birdwell, Kelly A.;
- Roden, Dan M.;
- Stein, C. Michael;
- Bejan, Cosmin A.;
- Denny, Joshua C.;
- Van Driest, Sara L.
Publication type:
Article
Integration of Omics Data Sources to Inform Mechanistic Modeling of Immune‐Oncology Therapies: A Tutorial for Clinical Pharmacologists.
Published in:
Clinical Pharmacology & Therapeutics, 2020, v. 107, n. 4, p. 858, doi. 10.1002/cpt.1786
By:
- Lazarou, Georgia;
- Chelliah, Vijayalakshmi;
- Small, Ben G.;
- Walker, Michael;
- Graaf, Piet H.;
- Kierzek, Andrzej M.
Publication type:
Article
Can We Rely on Results From IQVIA Medical Research Data UK Converted to the Observational Medical Outcome Partnership Common Data Model?: A Validation Study Based on Prescribing Codeine in Children.
Published in:
Clinical Pharmacology & Therapeutics, 2020, v. 107, n. 4, p. 915, doi. 10.1002/cpt.1785
By:
- Candore, Gianmario;
- Hedenmalm, Karin;
- Slattery, Jim;
- Cave, Alison;
- Kurz, Xavier;
- Arlett, Peter
Publication type:
Article
Get Real: Integration of Real‐World Data to Improve Patient Care.
Published in:
Clinical Pharmacology & Therapeutics, 2020, v. 107, n. 4, p. 722, doi. 10.1002/cpt.1784
By:
- Keizer, Ron J.;
- Dvergsten, Erik;
- Kolacevski, Andrej;
- Black, Aaron;
- Karovic, Sanja;
- Goswami, Srijib;
- Maitland, Michael L.
Publication type:
Article
Pharmacokinetics and Pharmacodynamics of Intensive Antituberculosis Treatment of Tuberculous Meningitis.
Published in:
Clinical Pharmacology & Therapeutics, 2020, v. 107, n. 4, p. 1023, doi. 10.1002/cpt.1783
By:
- Ding, Junjie;
- Thuy Thuong Thuong, Nguyen;
- Pham, Toi Van;
- Heemskerk, Dorothee;
- Pouplin, Thomas;
- Tran, Chau Thi Hong;
- Nguyen, Mai Thi Hoang;
- Nguyen, Phu Hoan;
- Phan, Loc Phu;
- Nguyen, Chau Van Vinh;
- Thwaites, Guy;
- Tarning, Joel
Publication type:
Article
Challenges in Alzheimer's Disease Drug Discovery and Development: The Role of Modeling, Simulation, and Open Data.
Published in:
Clinical Pharmacology & Therapeutics, 2020, v. 107, n. 4, p. 796, doi. 10.1002/cpt.1782
By:
- Conrado, Daniela J.;
- Duvvuri, Sridhar;
- Geerts, Hugo;
- Burton, Jackson;
- Biesdorf, Carla;
- Ahamadi, Malidi;
- Macha, Sreeraj;
- Hather, Gregory;
- Francisco Morales, Juan;
- Podichetty, Jagdeep;
- Nicholas, Timothy;
- Stephenson, Diane;
- Trame, Mirjam;
- Romero, Klaus;
- Corrigan, Brian
Publication type:
Article
Data Science Approaches for Effective Use of Mobile Device–Based Collection of Real‐World Data.
Published in:
Clinical Pharmacology & Therapeutics, 2020, v. 107, n. 4, p. 719, doi. 10.1002/cpt.1781
By:
- Omberg, Larsson;
- Chaibub Neto, Elias;
- Mangravite, Lara M.
Publication type:
Article
Real‐World Data and Physiologically‐Based Mechanistic Models for Precision Medicine.
Published in:
Clinical Pharmacology & Therapeutics, 2020, v. 107, n. 4, p. 694, doi. 10.1002/cpt.1780
By:
- Wang, Ken;
- Parrott, Neil;
- Olivares‐Morales, Andres;
- Dudal, Sherri;
- Singer, Thomas;
- Lavé, Thierry;
- Ribba, Benjamin
Publication type:
Article
Open Data for Clinical Pharmacology.
Published in:
Clinical Pharmacology & Therapeutics, 2020, v. 107, n. 4, p. 703, doi. 10.1002/cpt.1779
By:
- Burton, Jackson;
- Bhattacharya, Sanchita;
- Romero, Klaus;
- Conrado, Daniela J.
Publication type:
Article
Virtual Twins: Understanding the Data Required for Model‐Informed Precision Dosing.
Published in:
Clinical Pharmacology & Therapeutics, 2020, v. 107, n. 4, p. 742, doi. 10.1002/cpt.1778
By:
- Polasek, Thomas M.;
- Rostami‐Hodjegan, Amin
Publication type:
Article
Model‐Informed Artificial Intelligence: Reinforcement Learning for Precision Dosing.
Published in:
Clinical Pharmacology & Therapeutics, 2020, v. 107, n. 4, p. 853, doi. 10.1002/cpt.1777
By:
- Ribba, Benjamin;
- Dudal, Sherri;
- Lavé, Thierry;
- Peck, Richard W.
Publication type:
Article
Ability of Primary Care Health Databases to Assess Medicinal Products Discussed by the European Union Pharmacovigilance Risk Assessment Committee.
Published in:
Clinical Pharmacology & Therapeutics, 2020, v. 107, n. 4, p. 957, doi. 10.1002/cpt.1775
By:
- Flynn, Robert;
- Hedenmalm, Karin;
- Murray‐Thomas, Tarita;
- Pacurariu, Alexandra;
- Arlett, Peter;
- Shepherd, Hilary;
- Myles, Puja;
- Kurz, Xavier
Publication type:
Article
Pharmacometrics and Machine Learning Partner to Advance Clinical Data Analysis.
Published in:
Clinical Pharmacology & Therapeutics, 2020, v. 107, n. 4, p. 926, doi. 10.1002/cpt.1774
By:
- Koch, Gilbert;
- Pfister, Marc;
- Daunhawer, Imant;
- Wilbaux, Melanie;
- Wellmann, Sven;
- Vogt, Julia E.
Publication type:
Article
Machine Learning for Cancer Drug Combination.
Published in:
Clinical Pharmacology & Therapeutics, 2020, v. 107, n. 4, p. 749, doi. 10.1002/cpt.1773
By:
- Wang, Ziyan;
- Li, Hongyang;
- Guan, Yuanfang
Publication type:
Article
Regulatory Considerations for Building an In Silico Clinical Pharmacology Backbone by 2030.
Published in:
Clinical Pharmacology & Therapeutics, 2020, v. 107, n. 4, p. 746, doi. 10.1002/cpt.1772
By:
- Manolis, Efthymios;
- Musuamba, Flora T.;
- Karlsson, Kristin E.
Publication type:
Article
Application of Machine Learning in Drug Development and Regulation: Current Status and Future Potential.
Published in:
Clinical Pharmacology & Therapeutics, 2020, v. 107, n. 4, p. 726, doi. 10.1002/cpt.1771
By:
- Liu, Qi;
- Zhu, Hao;
- Liu, Chao;
- Jean, Daphney;
- Huang, Shiew‐Mei;
- ElZarrad, M. Khair;
- Blumenthal, Gideon;
- Wang, Yaning
Publication type:
Article
Small Models for Big Data.
Published in:
Clinical Pharmacology & Therapeutics, 2020, v. 107, n. 4, p. 710, doi. 10.1002/cpt.1770
By:
- Mistry, Hitesh B.;
- Orrell, David
Publication type:
Article
Electronic Health Records for Drug Repurposing: Current Status, Challenges, and Future Directions.
Published in:
Clinical Pharmacology & Therapeutics, 2020, v. 107, n. 4, p. 712, doi. 10.1002/cpt.1769
By:
- Xu, Hua;
- Li, Jianfu;
- Jiang, Xiaoqian;
- Chen, Qingxia
Publication type:
Article
Hippocampal Neuroimaging‐Informed Clinical Trial Enrichment Tool for Amnestic Mild Cognitive Impairment Using Open Data.
Published in:
Clinical Pharmacology & Therapeutics, 2020, v. 107, n. 4, p. 903, doi. 10.1002/cpt.1766
By:
- Conrado, Daniela J.;
- Burton, Jackson;
- Hill, Derek;
- Willis, Brian;
- Sinha, Vikram;
- Stone, Julie;
- Coello, Neva;
- Wang, Wenping;
- Chen, Danny;
- Nicholas, Timothy;
- Gold, Michael;
- Hartley, Emily;
- Kern, Volker D.;
- Romero, Klaus
Publication type:
Article
Scientific and Regulatory Considerations for an Ontogeny Knowledge Base for Pediatric Clinical Pharmacology.
Published in:
Clinical Pharmacology & Therapeutics, 2020, v. 107, n. 4, p. 707, doi. 10.1002/cpt.1763
By:
- Burckart, Gilbert J.;
- Seo, Shirley;
- Pawlyk, Aaron C.;
- McCune, Susan K.;
- Yao, Lynne P.;
- Giacoia, George P.;
- Wang, Yaning;
- Zineh, Issam
Publication type:
Article
Analytic and Data Sharing Options in Real‐World Multidatabase Studies of Comparative Effectiveness and Safety of Medical Products.
Published in:
Clinical Pharmacology & Therapeutics, 2020, v. 107, n. 4, p. 834, doi. 10.1002/cpt.1754
By:
- Toh, Sengwee
Publication type:
Article
Minimum Technical Data Elements for Liquid Biopsy Data Submitted to Public Databases.
Published in:
Clinical Pharmacology & Therapeutics, 2020, v. 107, n. 4, p. 730, doi. 10.1002/cpt.1747
By:
- Febbo, Phillip G.;
- Martin, Anne‐Marie;
- Scher, Howard I.;
- Barrett, J. Carl;
- Beaver, Julia A.;
- Beresford, Paul J.;
- Blumenthal, Gideon M.;
- Bramlett, Kelli;
- Compton, Carolyn;
- Dittamore, Ryan;
- Eberhard, David A.;
- Edelstein, Daniel;
- Godsey, James;
- Gruen, Andrew;
- Hanlon, Sean E.;
- Hicks, James;
- Hovelson, Daniel;
- Hullings, Melanie;
- Johann, Donald;
- Johnson, Justin
Publication type:
Article
Translational Knowledge Discovery Between Drug Interactions and Pharmacogenetics.
Published in:
Clinical Pharmacology & Therapeutics, 2020, v. 107, n. 4, p. 886, doi. 10.1002/cpt.1745
By:
- Wu, Heng‐Yi;
- Shendre, Aditi;
- Zhang, Shijun;
- Zhang, Pengyue;
- Wang, Lei;
- Zeruesenay, Desta;
- Rocha, Luis M.;
- Shatkay, Hagit;
- Quinney, Sara K.;
- Ning, Xia;
- Li, Lang
Publication type:
Article
Beyond the Randomized Clinical Trial: Innovative Data Science to Close the Pediatric Evidence Gap.
Published in:
Clinical Pharmacology & Therapeutics, 2020, v. 107, n. 4, p. 786, doi. 10.1002/cpt.1744
By:
- Goulooze, Sebastiaan C.;
- Zwep, Laura B.;
- Vogt, Julia E.;
- Krekels, Elke H.J.;
- Hankemeier, Thomas;
- Anker, John N.;
- Knibbe, Catherijne A.J.
Publication type:
Article
End Points, Collection, Processing, and Time: Four Key Elements to Consider When Planning for Use of Handheld Devices in a Drug Development Setting.
Published in:
Clinical Pharmacology & Therapeutics, 2020, v. 107, n. 4, p. 715, doi. 10.1002/cpt.1740
By:
- Pradhan, Vivek;
- Heatherington, Anne C.;
- Bhattacharya, Indranil
Publication type:
Article
Open Models for Clinical Pharmacology.
Published in:
Clinical Pharmacology & Therapeutics, 2020, v. 107, n. 4, p. 700, doi. 10.1002/cpt.1738
By:
- Kirouac, Daniel C.
Publication type:
Article
Changes in Manufacturing Processes of Biologic Therapies Can Alter the Immunogenicity Profile of the Product.
Published in:
Clinical Pharmacology & Therapeutics, 2020, v. 107, n. 4, p. 988, doi. 10.1002/cpt.1694
By:
- Vanderlaan, Martin;
- Maniatis, Aristides;
- Olney, Robert;
- Rahmaoui, Abdelkader;
- Yau, Linda;
- Quarmby, Valerie;
- Azzolino, Craig;
- Woods, Cynthia;
- Moawad, Dalia
Publication type:
Article
Exposure–Response Analyses of Upadacitinib Efficacy and Safety in Phase II and III Studies to Support Benefit–Risk Assessment in Rheumatoid Arthritis.
Published in:
Clinical Pharmacology & Therapeutics, 2020, v. 107, n. 4, p. 994, doi. 10.1002/cpt.1671
By:
- Nader, Ahmed;
- Mohamed, Mohamed‐Eslam F.;
- Winzenborg, Insa;
- Doelger, Eva;
- Noertersheuser, Peter;
- Pangan, Aileen L.;
- Othman, Ahmed A.
Publication type:
Article
Examining the Use of Real‐World Evidence in the Regulatory Process.
Published in:
Clinical Pharmacology & Therapeutics, 2020, v. 107, n. 4, p. 843, doi. 10.1002/cpt.1658
By:
- Beaulieu‐Jones, Brett K.;
- Finlayson, Samuel G.;
- Yuan, William;
- Altman, Russ B.;
- Kohane, Isaac S.;
- Prasad, Vinay;
- Yu, Kun‐Hsing
Publication type:
Article
Are Novel, Nonrandomized Analytic Methods Fit for Decision Making? The Need for Prospective, Controlled, and Transparent Validation.
Published in:
Clinical Pharmacology & Therapeutics, 2020, v. 107, n. 4, p. 773, doi. 10.1002/cpt.1638
By:
- Eichler, Hans‐Georg;
- Koenig, Franz;
- Arlett, Peter;
- Enzmann, Harald;
- Humphreys, Anthony;
- Pétavy, Frank;
- Schwarzer‐Daum, Brigitte;
- Sepodes, Bruno;
- Vamvakas, Spiros;
- Rasi, Guido
Publication type:
Article
Nonrandomized Real‐World Evidence to Support Regulatory Decision Making: Process for a Randomized Trial Replication Project.
Published in:
Clinical Pharmacology & Therapeutics, 2020, v. 107, n. 4, p. 817, doi. 10.1002/cpt.1633
By:
- Franklin, Jessica M.;
- Pawar, Ajinkya;
- Martin, David;
- Glynn, Robert J.;
- Levenson, Mark;
- Temple, Robert;
- Schneeweiss, Sebastian
Publication type:
Article
Big Data – How to Realize the Promise.
Published in:
Clinical Pharmacology & Therapeutics, 2020, v. 107, n. 4, p. 753, doi. 10.1002/cpt.1736
By:
- Cave, Alison;
- Brun, Nikolai C.;
- Sweeney, Fergus;
- Rasi, Guido;
- Senderovitz, Thomas
Publication type:
Article
A Machine‐Learning Approach to Identify a Prognostic Cytokine Signature That Is Associated With Nivolumab Clearance in Patients With Advanced Melanoma.
Published in:
Clinical Pharmacology & Therapeutics, 2020, v. 107, n. 4, p. 978, doi. 10.1002/cpt.1724
By:
- Wang, Rui;
- Shao, Xiao;
- Zheng, Junying;
- Saci, Abdel;
- Qian, Xiaozhong;
- Pak, Irene;
- Roy, Amit;
- Bello, Akintunde;
- Rizzo, Jasmine I.;
- Hosein, Fareeda;
- Moss, Rebecca A.;
- Wind‐Rotolo, Megan;
- Feng, Yan
Publication type:
Article
Beyond Randomized Clinical Trials: Use of External Controls.
Published in:
Clinical Pharmacology & Therapeutics, 2020, v. 107, n. 4, p. 806, doi. 10.1002/cpt.1723
By:
- Schmidli, Heinz;
- Häring, Dieter A.;
- Thomas, Marius;
- Cassidy, Adrian;
- Weber, Sebastian;
- Bretz, Frank
Publication type:
Article
Translational Informatics Connects Real‐World Information to Knowledge in an Increasingly Data‐Driven World.
Published in:
Clinical Pharmacology & Therapeutics, 2020, v. 107, n. 4, p. 738, doi. 10.1002/cpt.1719
By:
- McDonough, Caitrin W.;
- Breitenstein, Matthew K.;
- Shahin, Mohamed;
- Empey, Philip E.;
- Freimuth, Robert R.;
- Li, Lang;
- Liebman, Michael;
- Tuteja, Sony
Publication type:
Article
Reproducing Protocol‐Based Studies Using Parameterizable Tools—Comparison of Analytic Approaches Used by Two Medical Product Surveillance Networks.
Published in:
Clinical Pharmacology & Therapeutics, 2020, v. 107, n. 4, p. 966, doi. 10.1002/cpt.1698
By:
- Huang, Ting‐Ying;
- Welch, Emily C.;
- Shinde, Mayura U.;
- Platt, Robert W.;
- Filion, Kristian B.;
- Azoulay, Laurent;
- Maro, Judith C.;
- Platt, Richard;
- Toh, Sengwee
Publication type:
Article
Single Therapeutic and Supratherapeutic Doses of Ubrogepant Do Not Affect Cardiac Repolarization in Healthy Adults: Results From a Randomized Trial.
Published in:
Clinical Pharmacology & Therapeutics, 2020, v. 107, n. 4, p. 1014, doi. 10.1002/cpt.1696
By:
- Jakate, Abhijeet;
- Boinpally, Ramesh;
- Butler, Matthew;
- Lu, Kaifeng;
- McGeeney, Danielle;
- Periclou, Antonia
Publication type:
Article
Dose‐Dependent Inhibition of OATP1B by Rifampicin in Healthy Volunteers: Comprehensive Evaluation of Candidate Biomarkers and OATP1B Probe Drugs.
Published in:
Clinical Pharmacology & Therapeutics, 2020, v. 107, n. 4, p. 1004, doi. 10.1002/cpt.1695
By:
- Mori, Daiki;
- Kimoto, Emi;
- Rago, Brian;
- Kondo, Yusuke;
- King‐Ahmad, Amanda;
- Ramanathan, Ragu;
- Wood, Linda S.;
- Johnson, Jillian G.;
- Le, Vu H.;
- Vourvahis, Manoli;
- David Rodrigues, A.;
- Muto, Chieko;
- Furihata, Kenichi;
- Sugiyama, Yuichi;
- Kusuhara, Hiroyuki
Publication type:
Article
Choosing Among Common Data Models for Real‐World Data Analyses Fit for Making Decisions About the Effectiveness of Medical Products.
Published in:
Clinical Pharmacology & Therapeutics, 2020, v. 107, n. 4, p. 827, doi. 10.1002/cpt.1577
By:
- Schneeweiss, Sebastian;
- Brown, Jeff S.;
- Bate, Andrew;
- Trifirò, Gianluca;
- Bartels, Dorothee B.
Publication type:
Article