Works matching IS 00071188 AND DT 2024 AND VI 181 AND IP 21

Results: 19

Advances in binding kinetics and mechanistic PK/PD modelling.

Published in:

British Journal of Pharmacology, 2024, v. 181, n. 21, p. 4089, doi. 10.1111/bph.17340

By:

Srinivasan, Bharath

Publication type:

Article

Targeting RNA with small molecules, from RNA structures to precision medicines: IUPHAR review: 40.

Published in:

British Journal of Pharmacology, 2024, v. 181, n. 21, p. 4152, doi. 10.1111/bph.17308

By:

Tong, Yuquan;
Childs‐Disney, Jessica L.;
Disney, Matthew D.

Publication type:

Article

Ticagrelor increases its own potency at the P2Y12 receptor by directly changing the plasma membrane lipid order in platelets.

Published in:

British Journal of Pharmacology, 2024, v. 181, n. 21, p. 4369, doi. 10.1111/bph.16500

By:

Pyrshev, Kyrylo;
Allemand, Florentin;
Rabani, Vahideh;
Yesylevskyy, Semen;
Davani, Siamak;
Ramseyer, Christophe;
Lagoutte‐Renosi, Jennifer

Publication type:

Article

Arbidol, an antiviral drug, identified as a sodium channel blocker with anticonvulsant activity.

Published in:

British Journal of Pharmacology, 2024, v. 181, n. 21, p. 4311, doi. 10.1111/bph.16496

By:

Li, Min;
Jin, Yuchen;
Wu, Jun;
Zhao, Miao;
Yu, Kexin;
Yu, Haibo

Publication type:

Article

Repurposing cyclovirobuxine D as a novel inhibitor of colorectal cancer progression via modulating the CCT3/YAP axis.

Published in:

British Journal of Pharmacology, 2024, v. 181, n. 21, p. 4348, doi. 10.1111/bph.16494

By:

Liu, Yiman;
Chen, Lu;
Wang, Jinghui;
Bao, Xiaomei;
Huang, Jiayan;
Qiu, Yuling;
Wang, Tao;
Yu, Haiyang

Publication type:

Article

Adjunctive therapy with an oral H2S donor provides additional therapeutic benefit beyond SGLT2 inhibition in cardiometabolic heart failure with preserved ejection fraction.

Published in:

British Journal of Pharmacology, 2024, v. 181, n. 21, p. 4294, doi. 10.1111/bph.16493

By:

Doiron, Jake E.;
Xia, Huijing;
Yu, Xiaoman;
Nevins, Alexandra R.;
LaPenna, Kyle B.;
Sharp, Thomas E.;
Goodchild, Traci T.;
Allerton, Timothy D.;
Elgazzaz, Mona;
Lazartigues, Eric;
Shah, Sanjiv J.;
Li, Zhen;
Lefer, David J.

Publication type:

Article

A vitamin D‐based strategy overcomes chemoresistance in prostate cancer.

Published in:

British Journal of Pharmacology, 2024, v. 181, n. 21, p. 4279, doi. 10.1111/bph.16492

By:

Len‐Tayon, Kateryna;
Beraud, Claire;
Fauveau, Clara;
Belorusova, Anna Y.;
Chebaro, Yassmine;
Mouriño, Antonio;
Massfelder, Thierry;
Chauchereau, Anne;
Metzger, Daniel;
Rochel, Natacha;
Laverny, Gilles

Publication type:

Article

A highly selective inhibitor of discoidin domain receptor‐1 (DDR1‐IN‐1) protects corneal epithelial cells from YAP/ACSL4‐mediated ferroptosis in dry eye.

Published in:

British Journal of Pharmacology, 2024, v. 181, n. 21, p. 4245, doi. 10.1111/bph.16491

By:

Dai, Yiqin;
Li, Yue;
Xu, Jianjiang;
Zhang, Jing

Publication type:

Article

Direct measurements of neurosteroid binding to specific sites on GABAA receptors.

Published in:

British Journal of Pharmacology, 2024, v. 181, n. 21, p. 4229, doi. 10.1111/bph.16490

By:

Chintala, Satyanarayana M.;
Tateiwa, Hiroki;
Qian, Mingxing;
Xu, Yuanjian;
Amtashar, Fatima;
Chen, Zi‐Wei;
Kirkpatrick, Charles C.;
Bracamontes, John;
Germann, Allison L.;
Akk, Gustav;
Covey, Douglas F.;
Evers, Alex S.

Publication type:

Article

Coptisine exerts anti‐tumour effects in triple‐negative breast cancer by targeting mitochondrial complex I.

Published in:

British Journal of Pharmacology, 2024, v. 181, n. 21, p. 4262, doi. 10.1111/bph.16489

By:

Shen, Yunfu;
Yang, You;
Wang, Zi;
Lin, Wanjun;
Feng, Na;
Shi, Meina;
Liu, Jiachen;
Ma, Wenzhe

Publication type:

Article

Inhibition of dynamin‐related protein 1‐filamin interaction improves systemic glucose metabolism.

Published in:

British Journal of Pharmacology, 2024, v. 181, n. 21, p. 4328, doi. 10.1111/bph.16487

By:

Kato, Yuri;
Ariyoshi, Kohei;
Nohara, Yasunobu;
Matsunaga, Naoya;
Shimauchi, Tsukasa;
Shindo, Naoya;
Nishimura, Akiyuki;
Mi, Xinya;
Kim, Sang Geon;
Ide, Tomomi;
Kawanishi, Eiji;
Ojida, Akio;
Nakashima, Naoki;
Mori, Yasuo;
Nishida, Motohiro

Publication type:

Article

Combination therapy enhances efficacy and overcomes toxicity of metal‐based anti‐diabetic agent.

Published in:

British Journal of Pharmacology, 2024, v. 181, n. 21, p. 4214, doi. 10.1111/bph.16485

By:

Shang, Bing;
Dong, Yaqiong;
Feng, Bo;
Zhao, Jingyan;
Wang, Zhi;
Crans, Debbie C.;
Yang, Xiaoda

Publication type:

Article

Spexin inhibits excessive autophagy‐induced ferroptosis to alleviate doxorubicin‐induced cardiotoxicity by upregulating Beclin 1.

Published in:

British Journal of Pharmacology, 2024, v. 181, n. 21, p. 4195, doi. 10.1111/bph.16484

By:

Ou, Wen;
Liu, Haiqiong;
Chen, Changhai;
Yang, Chaobo;
Zhao, Xiaoqing;
Zhang, Yu;
Zhang, Zhiyin;
Huang, Shuwen;
Mo, Huaqiang;
Lu, Weizhe;
Wang, Xianbao;
Chen, Aihua;
Yan, Jing;
Song, Xudong

Publication type:

Article

Inhibition of proline‐rich tyrosine kinase 2 restores cardioprotection by remote ischaemic preconditioning in type 2 diabetes.

Published in:

British Journal of Pharmacology, 2024, v. 181, n. 21, p. 4174, doi. 10.1111/bph.16483

By:

Erkens, Ralf;
Duse, Dragos Andrei;
Brum, Amanda;
Chadt, Alexandra;
Becher, Stefanie;
Siragusa, Mauro;
Quast, Christine;
Müssig, Johanna;
Roden, Michael;
Cortese‐Krott, Miriam;
Ibáñez, Borja;
Lammert, Eckhard;
Fleming, Ingrid;
Jung, Christian;
Al‐Hasani, Hadi;
Heusch, Gerd;
Kelm, Malte

Publication type:

Article

The translational value of ligand‐receptor binding kinetics in drug discovery.

Published in:

British Journal of Pharmacology, 2024, v. 181, n. 21, p. 4117, doi. 10.1111/bph.16241

By:

Liu, Hongli;
Zhang, Haoran;
IJzerman, Adriaan P.;
Guo, Dong

Publication type:

Article

Kinetic analysis of fluorescent ligand binding to cell surface receptors: Insights into conformational changes and allosterism in living cells.

Published in:

British Journal of Pharmacology, 2024, v. 181, n. 21, p. 4091, doi. 10.1111/bph.16185

By:

Hill, Stephen J.;
Kilpatrick, Laura E.

Publication type:

Article

Issue Information.

Published in:: British Journal of Pharmacology, 2024, v. 181, n. 21, p. 4087, doi. 10.1111/bph.16136
Publication type:: Article

The importance of binding kinetics and drug–target residence time in pharmacology.

Published in:

British Journal of Pharmacology, 2024, v. 181, n. 21, p. 4103, doi. 10.1111/bph.16104

By:

Knockenhauer, Kevin E.;
Copeland, Robert A.

Publication type:

Article

Soluble GC stimulators and activators: Past, present and future.

Published in:

British Journal of Pharmacology, 2024, v. 181, n. 21, p. 4130, doi. 10.1111/bph.15698

By:

Sandner, Peter;
Follmann, Markus;
Becker‐Pelster, Eva;
Hahn, Michael G.;
Meier, Christian;
Freitas, Cecilia;
Roessig, Lothar;
Stasch, Johannes‐Peter

Publication type:

Article

Works matching IS 00071188 AND DT 2024 AND VI 181 AND IP 21

Advances in binding kinetics and mechanistic PK/PD modelling.

Targeting RNA with small molecules, from RNA structures to precision medicines: IUPHAR review: 40.

Ticagrelor increases its own potency at the P2Y<sub>12</sub> receptor by directly changing the plasma membrane lipid order in platelets.

Arbidol, an antiviral drug, identified as a sodium channel blocker with anticonvulsant activity.

Repurposing cyclovirobuxine D as a novel inhibitor of colorectal cancer progression via modulating the CCT3/YAP axis.

Adjunctive therapy with an oral H<sub>2</sub>S donor provides additional therapeutic benefit beyond SGLT2 inhibition in cardiometabolic heart failure with preserved ejection fraction.

A vitamin D‐based strategy overcomes chemoresistance in prostate cancer.

A highly selective inhibitor of discoidin domain receptor‐1 (DDR1‐IN‐1) protects corneal epithelial cells from YAP/ACSL4‐mediated ferroptosis in dry eye.

Direct measurements of neurosteroid binding to specific sites on GABA<sub>A</sub> receptors.

Coptisine exerts anti‐tumour effects in triple‐negative breast cancer by targeting mitochondrial complex I.

Inhibition of dynamin‐related protein 1‐filamin interaction improves systemic glucose metabolism.

Combination therapy enhances efficacy and overcomes toxicity of metal‐based anti‐diabetic agent.

Spexin inhibits excessive autophagy‐induced ferroptosis to alleviate doxorubicin‐induced cardiotoxicity by upregulating Beclin 1.

Inhibition of proline‐rich tyrosine kinase 2 restores cardioprotection by remote ischaemic preconditioning in type 2 diabetes.

The translational value of ligand‐receptor binding kinetics in drug discovery.

Kinetic analysis of fluorescent ligand binding to cell surface receptors: Insights into conformational changes and allosterism in living cells.

Issue Information.

The importance of binding kinetics and drug–target residence time in pharmacology.

Soluble GC stimulators and activators: Past, present and future.