Works matching IS 00071188 AND DT 2020 AND VI 177 AND IP 8

Results: 20

The role of mitochondrial dynamics in cardiovascular diseases.

Published in:

2020

By:

Forte, Maurizio;
Schirone, Leonardo;
Ameri, Pietro;
Basso, Cristina;
Catalucci, Daniele;
Modica, Jessica;
Chimenti, Cristina;
Crotti, Lia;
Frati, Giacomo;
Rubattu, Speranza;
Schiattarella, Gabriele Giacomo;
Torella, Daniele;
Perrino, Cinzia;
Indolfi, Ciro;
Sciarretta, Sebastiano;
Italian Society of Cardiology (SIC) Working group on Cellular and Molecular Biology of the Heart;
Italian Society of Cardiology Working group on Cellular and Molecular Biology of the Heart

Publication type:

journal article

Angiotensin-(1-7) mitigated angiotensin II-induced abdominal aortic aneurysms in apolipoprotein E-knockout mice.

Published in:

2020

By:

Xue, Fei;
Yang, Jianmin;
Cheng, Jing;
Sui, Wenhai;
Cheng, Cheng;
Li, Hongxuan;
Zhang, Meng;
Zhang, Jie;
Xu, Xingli;
Ma, Jing;
Lu, Lin;
Xu, Jinfeng;
Zhang, Yun;
Zhang, Cheng

Publication type:

journal article

Exploring occupancy of the histamine H3 receptor by pitolisant in humans using PET.

Published in:

2020

By:

Rusjan, P M;
Sabioni, P;
Di Ciano, P;
Mansouri, E;
Boileau, I;
Laveillé, A;
Capet, M;
Duvauchelle, T;
Schwartz, J C;
Robert, P;
Le Foll, B;
Rusjan, Pablo;
Sabioni, Pamela;
Di Ciano, Patricia;
Mansouri, Esmaeil;
Boileau, Isabelle;
Laveillé, Alexia;
Capet, Marc;
Duvauchelle, Thierry;
Schwartz, Jean-Charles

Publication type:

journal article

Evaluation of the profiles of CB1 cannabinoid receptor signalling bias using joint kinetic modelling.

Published in:

2020

By:

Zhu, Xiao;
Finlay, David B;
Glass, Michelle;
Duffull, Stephen B

Publication type:

journal article

An orally available hypoglycaemic peptide taken up by caveolae transcytosis displays improved hypoglycaemic effects and body weight control in db/db mice.

Published in:

2020

By:

Lu, Weisheng;
Tian, Hong;
Qian, Peng;
Li, Ying;
Wang, Yongkang;
Ge, Yang;
Sai, Wenbo;
Gao, Xiangdong;
Yao, Wenbing

Publication type:

journal article

Proteolysis-targeting chimeras in drug development: A safety perspective.

Published in:

2020

By:

Moreau, Kevin;
Coen, Muireann;
Zhang, Andrew X.;
Pachl, Fiona;
Castaldi, M. Paola;
Dahl, Goran;
Boyd, Helen;
Scott, Clay;
Newham, Pete

Publication type:

journal article

IL-11 in cardiac and renal fibrosis: Late to the party but a central player.

Published in:

2020

By:

Corden, Benjamin;
Adami, Eleonora;
Sweeney, Mark;
Schafer, Sebastian;
Cook, Stuart A.

Publication type:

journal article

Negative allosteric modulators of the human calcium-sensing receptor bind to overlapping and distinct sites within the 7-transmembrane domain.

Published in:

2020

By:

Josephs, Tracy M.;
Keller, Andrew N.;
Khajehali, Elham;
DeBono, Aaron;
Langmead, Christopher J.;
Conigrave, Arthur D.;
Capuano, Ben;
Kufareva, Irina;
Gregory, Karen J.;
Leach, Katie

Publication type:

journal article

Cell-permeable high-affinity tracers for Gq proteins provide structural insights, reveal distinct binding kinetics and identify small molecule inhibitors.

Published in:

2020

By:

Kuschak, Markus;
Namasivayam, Vigneshwaran;
Rafehi, Muhammad;
Voss, Jan H.;
Garg, Jaspal;
Schlegel, Jonathan G.;
Abdelrahman, Aliaa;
Kehraus, Stefan;
Reher, Raphael;
Küppers, Jim;
Sylvester, Katharina;
Hinz, Sonja;
Matthey, Michaela;
Wenzel, Daniela;
Fleischmann, Bernd K.;
Pfeifer, Alexander;
Inoue, Asuka;
Gütschow, Michael;
König, Gabriele M.;
Müller, Christa E.

Publication type:

journal article

CD74 knockout protects against LPS-induced myocardial contractile dysfunction through AMPK-Skp2-SUV39H1-mediated demethylation of BCLB.

Published in:

2020

By:

Luo, Yuanfei;
Fan, Congcong;
Yang, Mingjie;
Dong, Maolong;
Bucala, Richard;
Pei, Zhaohui;
Zhang, Yingmei;
Ren, Jun

Publication type:

journal article

Different receptor mechanisms underlying phytocannabinoid- versus synthetic cannabinoid-induced tetrad effects: Opposite roles of CB1 /CB2 versus GPR55 receptors.

Published in:

2020

By:

Wang, Xiao‐Fei;
Galaj, Ewa;
Bi, Guo‐Hua;
Zhang, Cindy;
He, Yi;
Zhan, Jia;
Bauman, Michael H.;
Gardner, Eliot L.;
Xi, Zheng‐Xiong;
Wang, Xiao-Fei;
Bi, Guo-Hua;
Xi, Zheng-Xiong

Publication type:

journal article

Identification, preclinical profile, and clinical proof of concept of an orally bioavailable pro-drug of miridesap.

Published in:

2020

By:

Richards, Duncan;
Bamford, Mark;
Liefaard, Lia;
Haque, Nazneen;
Lewis, Gareth;
Storey, Jim;
Fernando, Disala;
Kumar, Subramanya;
Thompson, Douglas;
Holmes, Duncan S.

Publication type:

journal article

Haemodynamic effects of the flavonoid quercetin in rats revisited.

Published in:

2020

By:

Vrolijk, Misha F.;
Essen, Helma;
Opperhuizen, Antoon;
Bast, Aalt;
Janssen, Ben J.;
van Essen, Helma

Publication type:

journal article

Fulditoxin, representing a new class of dimeric snake toxins, defines novel pharmacology at nicotinic ACh receptors.

Published in:

2020

By:

Foo, Chun Shin;
Jobichen, Chacko;
Hassan‐Puttaswamy, Varuna;
Dekan, Zoltan;
Tae, Han‐Shen;
Bertrand, Daniel;
Adams, David J.;
Alewood, Paul F.;
Sivaraman, J.;
Nirthanan, Selvanayagam;
Kini, R. Manjunatha;
Hassan-Puttaswamy, Varuna;
Tae, Han-Shen

Publication type:

journal article

Naringenin attenuates non-alcoholic fatty liver disease by down-regulating the NLRP3/NF-κB pathway in mice.

Published in:

2020

By:

Wang, Qinyu;
Ou, Yangjie;
Hu, Guomin;
Wen, Cong;
Yue, Shanshan;
Chen, Cong;
Xu, Lu;
Xie, Jiawei;
Dai, Hui;
Xiao, Han;
Zhang, Youyi;
Qi, Rong

Publication type:

journal article

Inactivation of Cys674 in SERCA2 increases BP by inducing endoplasmic reticulum stress and soluble epoxide hydrolase.

Published in:

2020

By:

Liu, Gang;
Wu, Fuhua;
Jiang, Xiaoli;
Que, Yumei;
Qin, Zhexue;
Hu, Pingping;
Lee, Kin Sing Stephen;
Yang, Jian;
Zeng, Chunyu;
Hammock, Bruce D.;
Tong, Xiaoyong

Publication type:

journal article

Paracetamol is a centrally acting analgesic using mechanisms located in the periaqueductal grey.

Published in:

2020

By:

Barrière, David André;
Boumezbeur, Fawzi;
Dalmann, Romain;
Cadeddu, Roberto;
Richard, Damien;
Pinguet, Jérémy;
Daulhac, Laurence;
Sarret, Philippe;
Whittingstall, Kevin;
Keller, Matthieu;
Mériaux, Sébastien;
Eschalier, Alain;
Mallet, Christophe

Publication type:

journal article

Butyrate protects against high-fat diet-induced atherosclerosis via up-regulating ABCA1 expression in apolipoprotein E-deficiency mice.

Published in:

2020

By:

Du, Yu;
Li, Xingxing;
Su, Chunyan;
Xi, Mei;
Zhang, Xiumin;
Jiang, Zhibo;
Wang, Li;
Hong, Bin

Publication type:

journal article

Novel neuroactive steroid with hypnotic and T‐type calcium channel blocking properties exerts effective analgesia in a rodent model of post‐surgical pain.

Published in:

British Journal of Pharmacology, 2020, v. 177, n. 8, p. 1735, doi. 10.1111/bph.14930

By:

Joksimovic, Sonja Lj.;
Joksimovic, Srdjan M.;
Manzella, Francesca M.;
Asnake, Betelehem;
Orestes, Peihan;
Raol, Yogendra H.;
Krishnan, Kathiresan;
Covey, Douglas F.;
Jevtovic‐Todorovic, Vesna;
Todorovic, Slobodan M.

Publication type:

Article

Issue Information.

Published in:: British Journal of Pharmacology, 2020, v. 177, n. 8, p. 1693, doi. 10.1111/bph.14727
Publication type:: Article

Works matching IS 00071188 AND DT 2020 AND VI 177 AND IP 8

The role of mitochondrial dynamics in cardiovascular diseases.

Angiotensin-(1-7) mitigated angiotensin II-induced abdominal aortic aneurysms in apolipoprotein E-knockout mice.

Exploring occupancy of the histamine H<sub>3</sub> receptor by pitolisant in humans using PET.

Evaluation of the profiles of CB<sub>1</sub> cannabinoid receptor signalling bias using joint kinetic modelling.

An orally available hypoglycaemic peptide taken up by caveolae transcytosis displays improved hypoglycaemic effects and body weight control in db/db mice.

Proteolysis-targeting chimeras in drug development: A safety perspective.

IL-11 in cardiac and renal fibrosis: Late to the party but a central player.

Negative allosteric modulators of the human calcium-sensing receptor bind to overlapping and distinct sites within the 7-transmembrane domain.

Cell-permeable high-affinity tracers for G<sub>q</sub> proteins provide structural insights, reveal distinct binding kinetics and identify small molecule inhibitors.

CD74 knockout protects against LPS-induced myocardial contractile dysfunction through AMPK-Skp2-SUV39H1-mediated demethylation of BCLB.

Different receptor mechanisms underlying phytocannabinoid- versus synthetic cannabinoid-induced tetrad effects: Opposite roles of CB<sub>1</sub> /CB<sub>2</sub> versus GPR55 receptors.

Identification, preclinical profile, and clinical proof of concept of an orally bioavailable pro-drug of miridesap.

Haemodynamic effects of the flavonoid quercetin in rats revisited.

Fulditoxin, representing a new class of dimeric snake toxins, defines novel pharmacology at nicotinic ACh receptors.

Naringenin attenuates non-alcoholic fatty liver disease by down-regulating the NLRP3/NF-κB pathway in mice.

Inactivation of Cys<sup>674</sup> in SERCA2 increases BP by inducing endoplasmic reticulum stress and soluble epoxide hydrolase.

Paracetamol is a centrally acting analgesic using mechanisms located in the periaqueductal grey.

Butyrate protects against high-fat diet-induced atherosclerosis via up-regulating ABCA1 expression in apolipoprotein E-deficiency mice.

Novel neuroactive steroid with hypnotic and T‐type calcium channel blocking properties exerts effective analgesia in a rodent model of post‐surgical pain.

Issue Information.