Works matching IS 00071188 AND DT 2017 AND VI 174 AND IP 23

Results: 23

Beyond symptomatic effects: potential of donepezil as a neuroprotective agent and disease modifier in Alzheimer's disease.

Published in:

2017

By:

Kim, Seung Hyun;
Kandiah, Nagaendran;
Hsu, Jung‐Lung;
Suthisisang, Chuthamanee;
Udommongkol, Chesda;
Dash, Amitabh;
Hsu, Jung-Lung

Publication type:

journal article

Different protein kinase C isoenzymes mediate inhibition of cardiac rapidly activating delayed rectifier K+ current by different G-protein coupled receptors.

Published in:

2017

By:

Liu, Xueli;
Wang, Yuhong;
Zhang, Hua;
Shen, Li;
Xu, Yanfang

Publication type:

journal article

Activation of G protein-coupled oestrogen receptor 1 at the onset of reperfusion protects the myocardium against ischemia/reperfusion injury by reducing mitochondrial dysfunction and mitophagy.

Published in:

2017

By:

Feng, Yansheng;
Madungwe, Ngonidzashe B;
Cruz Junho, Carolina Victoria;
Bopassa, Jean C;
da Cruz Junho, Carolina Victoria

Publication type:

journal article

Induction of mast cell accumulation by chymase via an enzymatic activity- and intercellular adhesion molecule-1-dependent mechanism.

Published in:

2017

By:

Zhang, Huiyun;
Wang, Junling;
Wang, Ling;
Zhan, Mengmeng;
Li, Shigang;
Fang, Zeman;
Xu, Ciyan;
Zheng, Yanshan;
He, Shaoheng

Publication type:

journal article

Tetrandrine antagonizes acute megakaryoblastic leukaemia growth by forcing autophagy-mediated differentiation.

Published in:

2017

By:

Liu, Ting;
Zhang, Zhenxing;
Yu, Chunjie;
Zeng, Chang;
Xu, Xiaoqing;
Wu, Guixian;
Huang, Zan;
Li, Wenhua

Publication type:

journal article

p53-mediated regulation of bile acid disposition attenuates cholic acid-induced cholestasis in mice.

Published in:

2017

By:

Chen, Pan;
Li, Dongshun;
Chen, Yixin;
Sun, Jiahong;
Fu, Kaili;
Guan, Lihuan;
Zhang, Huizhen;
Jiang, Yiming;
Li, Xi;
Zeng, Xuezhen;
Chen, Xiao;
Huang, Min;
Bi, Huichang

Publication type:

journal article

Synthetic peptides designed to modulate adiponectin assembly improve obesity-related metabolic disorders.

Published in:

2017

By:

Hampe, Lutz;
Xu, Cheng;
Harris, Paul W R;
Chen, Jie;
Liu, Ming;
Middleditch, Martin;
Radjainia, Mazdak;
Wang, Yu;
Mitra, Alok K

Publication type:

journal article

Is systems pharmacology ready to impact upon therapy development? A study on the cholesterol biosynthesis pathway.

Published in:

2017

By:

Benson, Helen E;
Watterson, Steven;
Sharman, Joanna L;
Mpamhanga, Chido P;
Parton, Andrew;
Southan, Christopher;
Harmar, Anthony J;
Ghazal, Peter

Publication type:

journal article

Human podocytes express functional thermosensitive TRPV channels.

Published in:

2017

By:

Ambrus, Lídia;
Kelemen, Balázs;
Szabó, Tamás;
Bíró, Tamás;
Tóth, Balázs István;
Ambrus, Lídia;
Kelemen, Balázs;
Szabó, Tamás;
Bíró, Tamás;
Tóth, Balázs István

Publication type:

journal article

Agonism of free fatty acid receptors 1 and 4 generates peptide YY-mediated inhibitory responses in mouse colon.

Published in:

2017

By:

Moodaley, Runisha;
Smith, David M;
Tough, Iain R;
Schindler, Marcus;
Cox, Helen M

Publication type:

journal article

The monoacylglycerol lipase inhibitor KML29 with gabapentin synergistically produces analgesia in mice.

Published in:

2017

By:

Crowe, Molly S;
Wilson, Catheryn D;
Leishman, Emma;
Prather, Paul L;
Bradshaw, Heather B;
Banks, Matthew L;
Kinsey, Steven G

Publication type:

journal article

α-Spinasterol: a COX inhibitor and a transient receptor potential vanilloid 1 antagonist presents an antinociceptive effect in clinically relevant models of pain in mice.

Published in:

2017

By:

Brusco, Indiara;
Camponogara, Camila;
Carvalho, Fabiano Barbosa;
Schetinger, Maria Rosa Chitolina;
Oliveira, Mauro Schneider;
Trevisan, Gabriela;
Ferreira, Juliano;
Oliveira, Sara Marchesan

Publication type:

journal article

Principles of pharmacology in the eye.

Published in:

2017

By:

Awwad, Sahar;
Mohamed Ahmed, Abeer H A;
Sharma, Garima;
Heng, Jacob S;
Khaw, Peng T;
Brocchini, Steve;
Lockwood, Alastair

Publication type:

journal article

Magnesium therapy improves outcome in Streptococcus pneumoniae meningitis by altering pneumolysin pore formation.

Published in:

2017

By:

Hupp, Sabrina;
Ribes, Sandra;
Seele, Jana;
Bischoff, Carolin;
Förtsch, Christina;
Maier, Elke;
Benz, Roland;
Mitchell, Timothy J;
Nau, Roland;
Iliev, Asparouh I;
Förtsch, Christina

Publication type:

journal article

Selective targeting of M-type potassium Kv 7.4 channels demonstrates their key role in the regulation of dopaminergic neuronal excitability and depression-like behaviour.

Published in:

2017

By:

Li, Li;
Sun, Hui;
Ding, Jie;
Niu, Chenxu;
Su, Min;
Zhang, Ludi;
Li, Yingmin;
Wang, Chuan;
Gamper, Nikita;
Du, Xiaona;
Zhang, Hailin

Publication type:

journal article

Gα12 facilitates shortening in human airway smooth muscle by modulating phosphoinositide 3-kinase-mediated activation in a RhoA-dependent manner.

Published in:

2017

By:

Yoo, Edwin J;
Cao, Gaoyuan;
Koziol‐White, Cynthia J;
Ojiaku, Christie A;
Sunder, Krishna;
Jude, Joseph A;
Michael, James V;
Lam, Hong;
Pushkarsky, Ivan;
Damoiseaux, Robert;
Di Carlo, Dino;
Ahn, Kwangmi;
An, Steven S;
Penn, Raymond B;
Panettieri, Reynold A;
Koziol-White, Cynthia J;
Panettieri, Reynold A Jr

Publication type:

journal article

Issue Information.

Published in:: British Journal of Pharmacology, 2017, v. 174, n. 23, p. 4203, doi. 10.1111/bph.13606
Publication type:: Article

A new negative allosteric modulator, AP14145, for the study of small conductance calcium-activated potassium (KCa 2) channels.

Published in:

2017

By:

Simó‐Vicens, Rafel;
Kirchhoff, Jeppe E;
Dolce, Bernardo;
Abildgaard, Lea;
Speerschneider, Tobias;
Sørensen, Ulrik S;
Grunnet, Morten;
Diness, Jonas G;
Bentzen, Bo H;
Simó-Vicens, Rafel;
Sørensen, Ulrik S

Publication type:

journal article

Lon protease: a novel mitochondrial matrix protein in the interconnection between drug-induced mitochondrial dysfunction and endoplasmic reticulum stress.

Published in:

2017

By:

Polo, Miriam;
Alegre, Fernando;
Moragrega, Angela B;
Gibellini, Lara;
Marti‐Rodrigo, Alberto;
Blas‐Garcia, Ana;
Esplugues, Juan V;
Apostolova, Nadezda;
Marti-Rodrigo, Alberto;
Blas-Garcia, Ana

Publication type:

journal article

BK β1 subunit-dependent facilitation of ethanol inhibition of BK current and cerebral artery constriction is mediated by the β1 transmembrane domain 2.

Published in:

2017

By:

Kuntamallappanavar, Guruprasad;
Dopico, Alex M

Publication type:

journal article

Nonclinical cardiovascular safety of pitolisant: comparing International Conference on Harmonization S7B and Comprehensive in vitro Pro-arrhythmia Assay initiative studies.

Published in:

2017

By:

Ligneau, Xavier;
Shah, Rashmi R;
Berrebi‐Bertrand, Isabelle;
Mirams, Gary R;
Robert, Philippe;
Landais, Laurent;
Maison‐Blanche, Pierre;
Faivre, Jean‐François;
Lecomte, Jeanne‐Marie;
Schwartz, Jean‐Charles;
Berrebi-Bertrand, Isabelle;
Maison-Blanche, Pierre;
Faivre, Jean-François;
Lecomte, Jeanne-Marie;
Schwartz, Jean-Charles

Publication type:

journal article

Distinct in vivo target occupancy by bivalent- and induced-fit-like binding drugs.

Published in:

2017

By:

Vauquelin, Georges

Publication type:

journal article

Tetrahydrocannabinolic acid is a potent PPARγ agonist with neuroprotective activity.

Published in:

2017

By:

Nadal, Xavier;
Río, Carmen;
Casano, Salvatore;
Palomares, Belén;
Ferreiro‐Vera, Carlos;
Navarrete, Carmen;
Sánchez‐Carnerero, Carolina;
Cantarero, Irene;
Bellido, Maria Luz;
Meyer, Stefan;
Morello, Gaetano;
Appendino, Giovanni;
Muñoz, Eduardo;
Del Río, Carmen;
Palomares, Belén;
Ferreiro-Vera, Carlos;
Sánchez-Carnerero, Carolina;
Muñoz, Eduardo

Publication type:

journal article

Works matching IS 00071188 AND DT 2017 AND VI 174 AND IP 23

Beyond symptomatic effects: potential of donepezil as a neuroprotective agent and disease modifier in Alzheimer's disease.

Different protein kinase C isoenzymes mediate inhibition of cardiac rapidly activating delayed rectifier K<sup>+</sup> current by different G-protein coupled receptors.

Activation of G protein-coupled oestrogen receptor 1 at the onset of reperfusion protects the myocardium against ischemia/reperfusion injury by reducing mitochondrial dysfunction and mitophagy.

Induction of mast cell accumulation by chymase via an enzymatic activity- and intercellular adhesion molecule-1-dependent mechanism.

Tetrandrine antagonizes acute megakaryoblastic leukaemia growth by forcing autophagy-mediated differentiation.

p53-mediated regulation of bile acid disposition attenuates cholic acid-induced cholestasis in mice.

Synthetic peptides designed to modulate adiponectin assembly improve obesity-related metabolic disorders.

Is systems pharmacology ready to impact upon therapy development? A study on the cholesterol biosynthesis pathway.

Human podocytes express functional thermosensitive TRPV channels.

Agonism of free fatty acid receptors 1 and 4 generates peptide YY-mediated inhibitory responses in mouse colon.

The monoacylglycerol lipase inhibitor KML29 with gabapentin synergistically produces analgesia in mice.

α-Spinasterol: a COX inhibitor and a transient receptor potential vanilloid 1 antagonist presents an antinociceptive effect in clinically relevant models of pain in mice.

Principles of pharmacology in the eye.

Magnesium therapy improves outcome in Streptococcus pneumoniae meningitis by altering pneumolysin pore formation.

Selective targeting of M-type potassium K<sub>v</sub> 7.4 channels demonstrates their key role in the regulation of dopaminergic neuronal excitability and depression-like behaviour.

Gα<sub>12</sub> facilitates shortening in human airway smooth muscle by modulating phosphoinositide 3-kinase-mediated activation in a RhoA-dependent manner.

Issue Information.

A new negative allosteric modulator, AP14145, for the study of small conductance calcium-activated potassium (K<sub>Ca</sub> 2) channels.

Lon protease: a novel mitochondrial matrix protein in the interconnection between drug-induced mitochondrial dysfunction and endoplasmic reticulum stress.

BK β1 subunit-dependent facilitation of ethanol inhibition of BK current and cerebral artery constriction is mediated by the β1 transmembrane domain 2.

Nonclinical cardiovascular safety of pitolisant: comparing International Conference on Harmonization S7B and Comprehensive in vitro Pro-arrhythmia Assay initiative studies.

Distinct in vivo target occupancy by bivalent- and induced-fit-like binding drugs.

Tetrahydrocannabinolic acid is a potent PPARγ agonist with neuroprotective activity.