Works matching IS 00071188 AND DT 2012 AND VI 166 AND IP 3

Results: 37

A guide to picking the most selective kinase inhibitor tool compounds for pharmacological validation of drug targets.

Published in:

2012

By:

Uitdehaag JC;
Verkaar F;
Alwan H;
de Man J;
Buijsman RC;
Zaman GJ;
Uitdehaag, Joost C M;
Verkaar, Folkert;
Alwan, Husam;
de Man, Jos;
Buijsman, Rogier C;
Zaman, Guido J R

Publication type:

journal article

The use of animal models in diabetes research.

Published in:

2012

By:

King AJ;
King, Aileen J F

Publication type:

journal article

Corrigendum.

Published in:: 2012
Publication type:: Erratum

Caffeic acid phenethyl ester protects nigral dopaminergic neurons via dual mechanisms involving haem oxygenase-1 and brain-derived neurotrophic factor.

Published in:

British Journal of Pharmacology, 2012, v. 166, n. 3, p. 1151, doi. 10.1111/j.1476-5381.2012.01833.x

By:

Kurauchi, Y;
Hisatsune, A;
Isohama, Y;
Mishima, S;
Katsuki, H

Publication type:

Article

Small molecule chemokine mimetics suggest a molecular basis for the observation that CXCL10 and CXCL11 are allosteric ligands of CXCR3.

Published in:

British Journal of Pharmacology, 2012, v. 166, n. 3, p. 912, doi. 10.1111/j.1476-5381.2011.01660.x

By:

Nedjai, Belinda;
Li, Hubert;
Stroke, Ilana L;
Wise, Emma L;
Webb, Maria L;
Merritt, J Robert;
Henderson, Ian;
Klon, Anthony E;
Cole, Andrew G;
Horuk, Richard;
Vaidehi, Nagarajan;
Pease, James E

Publication type:

Article

Direct pharmacological monitoring of the developmental switch in NMDA receptor subunit composition using TCN 213, a GluN2A-selective, glycine-dependent antagonist.

Published in:

British Journal of Pharmacology, 2012, v. 166, n. 3, p. 924, doi. 10.1111/j.1476-5381.2011.01748.x

By:

McKay, S;
Griffiths, NH;
Butters, PA;
Thubron, EB;
Hardingham, GE;
Wyllie, DJA

Publication type:

Article

A prolyl oligopeptidase inhibitor, KYP-2047, reduces [alpha]-synuclein protein levels and aggregates in cellular and animal models of Parkinson's disease.

Published in:

2012

By:

Myöhänen TT;
Hannula MJ;
Van Elzen R;
Gerard M;
Van Der Veken P;
García-Horsman JA;
Baekelandt V;
Männistö PT;
Lambeir AM

Publication type:

Journal Article

Concordance of preclinical and clinical pharmacology and toxicology of therapeutic monoclonal antibodies and fusion proteins: cell surface targets.

Published in:

British Journal of Pharmacology, 2012, v. 166, n. 3, p. 823, doi. 10.1111/j.1476-5381.2011.01811.x

By:

Bugelski, Peter J;
Martin, Pauline L

Publication type:

Article

Adenosine-5'-triphosphate up-regulates proliferation of human cardiac fibroblasts.

Published in:

2012

By:

Chen JB;
Liu WJ;
Che H;
Liu J;
Sun HY;
Li GR;
Chen, Jing-Bo;
Liu, Wen-Juan;
Che, Hui;
Liu, Jie;
Sun, Hai-Ying;
Li, Gui-Rong

Publication type:

journal article

Inflammatory muscle pain is dependent on the activation of kinin B₁ and B₂ receptors and intracellular kinase pathways.

Published in:

2012

By:

Meotti FC;
Campos R;
da Silva K;
Paszcuk AF;
Costa R;
Calixto JB;
Meotti, F C;
Campos, R;
da Silva, Kabs;
Paszcuk, A F;
Costa, R;
Calixto, J B

Publication type:

journal article

Drug-like actions of autoantibodies against receptors of the autonomous nervous system and their impact on human heart function.

Published in:

2012

By:

Herda LR;
Felix SB;
Boege F;
Herda, L R;
Felix, S B;
Boege, F

Publication type:

journal article

Activation of NK₁ receptors in the locus coeruleus induces analgesia through noradrenergic-mediated descending inhibition in a rat model of neuropathic pain.

Published in:

2012

By:

Muto Y;
Sakai A;
Sakamoto A;
Suzuki H;
Muto, Y;
Sakai, A;
Sakamoto, A;
Suzuki, H

Publication type:

journal article

The yin and yang of chemokine receptor activation.

Published in:

British Journal of Pharmacology, 2012, v. 166, n. 3, p. 895, doi. 10.1111/j.1476-5381.2011.01759.x

By:

O'Boyle, Graeme

Publication type:

Article

Topical application of disodium isostearyl 2-O-L-ascorbyl phosphate, an amphiphilic ascorbic acid derivative, reduces neuropathic hyperalgesia in rats.

Published in:

British Journal of Pharmacology, 2012, v. 166, n. 3, p. 1058, doi. 10.1111/j.1476-5381.2012.01835.x

By:

Okubo, Kazumasa;
Nakanishi, Hiroki;
Matsunami, Maho;
Shibayama, Hiroharu;
Kawabata, Atsufumi

Publication type:

Article

A guide to picking the most selective kinase inhibitor tool compounds for pharmacological validation of drug targets.

Published in:

British Journal of Pharmacology, 2012, v. 166, n. 3, p. 858, doi. 10.1111/j.1476-5381.2012.01859.x

By:

Uitdehaag, Joost CM;
Verkaar, Folkert;
Alwan, Husam;
de Man, Jos;
Buijsman, Rogier C;
Zaman, Guido JR

Publication type:

Article

Triptolide increases transcript and protein levels of survival motor neurons in human SMA fibroblasts and improves survival in SMA-like mice.

Published in:

British Journal of Pharmacology, 2012, v. 166, n. 3, p. 1114, doi. 10.1111/j.1476-5381.2012.01829.x

By:

Hsu, Ya-Yun;
Jong, Yuh-Jyh;
Tsai, Hsin-Hung;
Tseng, Yu-Ting;
An, Li-Mei;
Lo, Yi-Ching

Publication type:

Article

Phospho-ibuprofen (MDC-917) incorporated in nanocarriers: anti-cancer activity in vitro and in vivo.

Published in:

British Journal of Pharmacology, 2012, v. 166, n. 3, p. 991, doi. 10.1111/j.1476-5381.2011.01799.x

By:

Nie, T;
Wong, CC;
Alston, N;
Aro, P;
Constantinides, PP;
Rigas, B

Publication type:

Article

Inhibition of high glucose-induced inflammatory response and macrophage infiltration by a novel curcumin derivative prevents renal injury in diabetic rats.

Published in:

British Journal of Pharmacology, 2012, v. 166, n. 3, p. 1169, doi. 10.1111/j.1476-5381.2012.01854.x

By:

Pan, Yong;
Wang, Yi;
Cai, Lu;
Cai, Yuepiao;
Hu, Jie;
Yu, Congcong;
Li, Jianling;
Feng, Zhiguo;
Yang, Shulin;
Li, Xiaokun;
Liang, Guang

Publication type:

Article

The GPCR OGR1 (GPR68) mediates diverse signalling and contraction of airway smooth muscle in response to small reductions in extracellular pH.

Published in:

British Journal of Pharmacology, 2012, v. 166, n. 3, p. 981, doi. 10.1111/j.1476-5381.2011.01807.x

By:

Saxena, H;
Deshpande, DA;
Tiegs, BC;
Yan, H;
Battafarano, RJ;
Burrows, WM;
Damera, G;
Panettieri, RA;
DuBose Jr, TD;
An, SS;
Penn, RB

Publication type:

Article

Dronedarone prevents microcirculatory abnormalities in the left ventricle during atrial tachypacing in pigs.

Published in:

British Journal of Pharmacology, 2012, v. 166, n. 3, p. 964, doi. 10.1111/j.1476-5381.2011.01784.x

By:

Bukowska, A;
Hammwöhner, M;
Sixdorf, A;
Schild, L;
Wiswedel, I;
Röhl, F-W;
Wolke, C;
Lendeckel, U;
Aderkast, C;
Bochmann, S;
Chilukoti, RK;
Mostertz, J;
Bramlage, P;
Goette, A

Publication type:

Article

A prolyl oligopeptidase inhibitor, KYP-2047, reduces α-synuclein protein levels and aggregates in cellular and animal models of Parkinson's disease.

Published in:

British Journal of Pharmacology, 2012, v. 166, n. 3, p. 1097, doi. 10.1111/j.1476-5381.2012.01846.x

By:

Myöhänen, TT;
Hannula, MJ;
Van Elzen, R;
Gerard, M;
Van Der Veken, P;
García-Horsman, JA;
Baekelandt, V;
Männistö, PT;
Lambeir, AM

Publication type:

Article

Drug-like actions of autoantibodies against receptors of the autonomous nervous system and their impact on human heart function.

Published in:

British Journal of Pharmacology, 2012, v. 166, n. 3, p. 847, doi. 10.1111/j.1476-5381.2012.01828.x

By:

Herda, LR;
Felix, SB;
Boege, F

Publication type:

Article

Differential inhibition of tumour cell-induced platelet aggregation by the nicotinate aspirin prodrug (ST0702) and aspirin.

Published in:

British Journal of Pharmacology, 2012, v. 166, n. 3, p. 938, doi. 10.1111/j.1476-5381.2011.01794.x

By:

Medina, Carlos;
Harmon, Shona;
Inkielewicz, Iwona;
Santos-Martinez, Maria Jose;
Jones, Michael;
Cantwell, Paula;
Bazou, Despina;
Ledwidge, Mark;
Radomski, Marek W.;
Gilmer, John F.

Publication type:

Article

Activation of NK1 receptors in the locus coeruleus induces analgesia through noradrenergic-mediated descending inhibition in a rat model of neuropathic pain.

Published in:

British Journal of Pharmacology, 2012, v. 166, n. 3, p. 1047, doi. 10.1111/j.1476-5381.2011.01820.x

By:

Muto, Y;
Sakai, A;
Sakamoto, A;
Suzuki, H

Publication type:

Article

Prostanoid EP1 receptors mediate up-regulation of the orphan nuclear receptor Nurr1 by cAMP-independent activation of protein kinase A, CREB and NF-κB.

Published in:

British Journal of Pharmacology, 2012, v. 166, n. 3, p. 1033, doi. 10.1111/j.1476-5381.2011.01817.x

By:

Ji, R;
Sanchez, CM;
Chou, CL;
Chen, XB;
Woodward, DF;
Regan, JW

Publication type:

Article

Adenosine-5′-triphosphate up-regulates proliferation of human cardiac fibroblasts.

Published in:

British Journal of Pharmacology, 2012, v. 166, n. 3, p. 1140, doi. 10.1111/j.1476-5381.2012.01831.x

By:

Chen, Jing-Bo;
Liu, Wen-Juan;
Che, Hui;
Liu, Jie;
Sun, Hai-Ying;
Li, Gui-Rong

Publication type:

Article

Loss of multidrug and toxin extrusion 1 (MATE1) is associated with metformin-induced lactic acidosis.

Published in:

British Journal of Pharmacology, 2012, v. 166, n. 3, p. 1183, doi. 10.1111/j.1476-5381.2012.01853.x

By:

Toyama, K;
Yonezawa, A;
Masuda, S;
Osawa, R;
Hosokawa, M;
Fujimoto, S;
Inagaki, N;
Inui, K;
Katsura, T

Publication type:

Article

Analysis of variance: variably complex.

Published in:

British Journal of Pharmacology, 2012, v. 166, n. 3, p. 801, doi. 10.1111/j.1476-5381.2012.01893.x

By:

Drummond, Gordon B;
Vowler, Sarah L

Publication type:

Article

Thiazolidinedione-dependent activation of sphingosine kinase 1 causes an anti-fibrotic effect in renal mesangial cells.

Published in:

British Journal of Pharmacology, 2012, v. 166, n. 3, p. 1018, doi. 10.1111/j.1476-5381.2012.01824.x

By:

Koch, A;
Völzke, A;
Wünsche, C;
Meyer zu Heringdorf, D;
Huwiler, A;
Pfeilschifter, J

Publication type:

Article

Pharmacological characterization of a small-molecule agonist for the chemokine receptor CXCR3.

Published in:

British Journal of Pharmacology, 2012, v. 166, n. 3, p. 898, doi. 10.1111/j.1476-5381.2011.01648.x

By:

Scholten, DJ;
Canals, M;
Wijtmans, M;
de Munnik, S;
Nguyen, P;
Verzijl, D;
de Esch, IJP;
Vischer, HF;
Smit, MJ;
Leurs, R

Publication type:

Article

The use of animal models in diabetes research.

Published in:

British Journal of Pharmacology, 2012, v. 166, n. 3, p. 877, doi. 10.1111/j.1476-5381.2012.01911.x

By:

King, Aileen JF

Publication type:

Article

Inflammatory muscle pain is dependent on the activation of kinin B1 and B2 receptors and intracellular kinase pathways.

Published in:

British Journal of Pharmacology, 2012, v. 166, n. 3, p. 1127, doi. 10.1111/j.1476-5381.2012.01830.x

By:

Meotti, FC;
Campos, R;
da Silva, KABS;
Paszcuk, AF;
Costa, R;
Calixto, JB

Publication type:

Article

Concordance of preclinical and clinical pharmacology and toxicology of monoclonal antibodies and fusion proteins: soluble targets.

Published in:

British Journal of Pharmacology, 2012, v. 166, n. 3, p. 806, doi. 10.1111/j.1476-5381.2011.01812.x

By:

Martin, Pauline L;
Bugelski, Peter J

Publication type:

Article

Subtype selective NMDA receptor antagonists induce recovery of synapses lost following exposure to HIV-1 Tat.

Published in:

British Journal of Pharmacology, 2012, v. 166, n. 3, p. 1002, doi. 10.1111/j.1476-5381.2011.01805.x

By:

Shin, AH;
Kim, HJ;
Thayer, SA

Publication type:

Article

Access of inhibitory neurosteroids to the NMDA receptor.

Published in:

British Journal of Pharmacology, 2012, v. 166, n. 3, p. 1069, doi. 10.1111/j.1476-5381.2011.01816.x

By:

Borovska, Jirina;
Vyklicky, Vojtech;
Stastna, Eva;
Kapras, Vojtech;
Slavikova, Barbora;
Horak, Martin;
Chodounska, Hana;
Vyklicky Jr, Ladislav

Publication type:

Article

The natural polyamines spermidine and spermine prevent bone loss through preferential disruption of osteoclastic activation in ovariectomized mice.

Published in:

British Journal of Pharmacology, 2012, v. 166, n. 3, p. 1084, doi. 10.1111/j.1476-5381.2012.01856.x

By:

Yamamoto, Tomomi;
Hinoi, Eiichi;
Fujita, Hiroyuki;
Iezaki, Takashi;
Takahata, Yoshifumi;
Takamori, Misa;
Yoneda, Yukio

Publication type:

Article

Pharmacological activity of a Bv8 analogue modified in position 24.

Published in:

British Journal of Pharmacology, 2012, v. 166, n. 3, p. 950, doi. 10.1111/j.1476-5381.2011.01797.x

By:

Lattanzi, R;
Sacerdote, P;
Franchi, S;
Canestrelli, M;
Miele, R;
Barra, D;
Visentin, S;
DeNuccio, C;
Porreca, F;
De Felice, M;
Guida, F;
Luongo, L;
de Novellis, V;
Maione, S;
Negri, L

Publication type:

Article

Works matching IS 00071188 AND DT 2012 AND VI 166 AND IP 3

A guide to picking the most selective kinase inhibitor tool compounds for pharmacological validation of drug targets.

The use of animal models in diabetes research.

Corrigendum.

Caffeic acid phenethyl ester protects nigral dopaminergic neurons via dual mechanisms involving haem oxygenase-1 and brain-derived neurotrophic factor.

Small molecule chemokine mimetics suggest a molecular basis for the observation that CXCL10 and CXCL11 are allosteric ligands of CXCR3.

Direct pharmacological monitoring of the developmental switch in NMDA receptor subunit composition using TCN 213, a GluN2A-selective, glycine-dependent antagonist.

A prolyl oligopeptidase inhibitor, KYP-2047, reduces [alpha]-synuclein protein levels and aggregates in cellular and animal models of Parkinson's disease.

Concordance of preclinical and clinical pharmacology and toxicology of therapeutic monoclonal antibodies and fusion proteins: cell surface targets.

Adenosine-5'-triphosphate up-regulates proliferation of human cardiac fibroblasts.

Inflammatory muscle pain is dependent on the activation of kinin B₁ and B₂ receptors and intracellular kinase pathways.

Drug-like actions of autoantibodies against receptors of the autonomous nervous system and their impact on human heart function.

Activation of NK₁ receptors in the locus coeruleus induces analgesia through noradrenergic-mediated descending inhibition in a rat model of neuropathic pain.

The yin and yang of chemokine receptor activation.

Topical application of disodium isostearyl 2-O-L-ascorbyl phosphate, an amphiphilic ascorbic acid derivative, reduces neuropathic hyperalgesia in rats.

A guide to picking the most selective kinase inhibitor tool compounds for pharmacological validation of drug targets.

Triptolide increases transcript and protein levels of survival motor neurons in human SMA fibroblasts and improves survival in SMA-like mice.

Phospho-ibuprofen (MDC-917) incorporated in nanocarriers: anti-cancer activity in vitro and in vivo.

Inhibition of high glucose-induced inflammatory response and macrophage infiltration by a novel curcumin derivative prevents renal injury in diabetic rats.

The GPCR OGR1 (GPR68) mediates diverse signalling and contraction of airway smooth muscle in response to small reductions in extracellular pH.

Dronedarone prevents microcirculatory abnormalities in the left ventricle during atrial tachypacing in pigs.

A prolyl oligopeptidase inhibitor, KYP-2047, reduces α-synuclein protein levels and aggregates in cellular and animal models of Parkinson's disease.

Drug-like actions of autoantibodies against receptors of the autonomous nervous system and their impact on human heart function.

Differential inhibition of tumour cell-induced platelet aggregation by the nicotinate aspirin prodrug (ST0702) and aspirin.

Activation of NK<sub>1</sub> receptors in the locus coeruleus induces analgesia through noradrenergic-mediated descending inhibition in a rat model of neuropathic pain.

Prostanoid EP<sub>1</sub> receptors mediate up-regulation of the orphan nuclear receptor Nurr1 by cAMP-independent activation of protein kinase A, CREB and NF-κB.

Adenosine-5′-triphosphate up-regulates proliferation of human cardiac fibroblasts.

Loss of multidrug and toxin extrusion 1 (MATE1) is associated with metformin-induced lactic acidosis.

Analysis of variance: variably complex.

Thiazolidinedione-dependent activation of sphingosine kinase 1 causes an anti-fibrotic effect in renal mesangial cells.

Pharmacological characterization of a small-molecule agonist for the chemokine receptor CXCR3.

The use of animal models in diabetes research.

Inflammatory muscle pain is dependent on the activation of kinin B<sub>1</sub> and B<sub>2</sub> receptors and intracellular kinase pathways.

Concordance of preclinical and clinical pharmacology and toxicology of monoclonal antibodies and fusion proteins: soluble targets.

Subtype selective NMDA receptor antagonists induce recovery of synapses lost following exposure to HIV-1 Tat.

Access of inhibitory neurosteroids to the NMDA receptor.

The natural polyamines spermidine and spermine prevent bone loss through preferential disruption of osteoclastic activation in ovariectomized mice.

Pharmacological activity of a Bv8 analogue modified in position 24.