Works matching IS 00071188 AND DT 2010 AND VI 160 AND IP 2

Results: 22

New drugs for neglected infectious diseases: Chagas' disease.

Published in:

2010

By:

Machado, Fabiana S;
Tanowitz, Herbert B;
Teixeira, Mauro M

Publication type:

journal article

Methylenedioxymethamphetamine inhibits mitochondrial complex I activity in mice: a possible mechanism underlying neurotoxicity.

Published in:

2010

By:

Puerta, Elena;
Hervias, Isabel;
Goñi-Allo, Beatriz;
Zhang, Steven F;
Jordán, Joaquín;
Starkov, Anatoly A;
Aguirre, Norberto;
Goñi-Allo, Beatriz;
Jordán, Joaquín

Publication type:

journal article

Challenges for and current status of research into positive modulators of AMPA receptors.

Published in:

2010

By:

Ward, Simon E;
Bax, Benjamin D;
Harries, Mark

Publication type:

journal article

Selective alpha7 nicotinic acetylcholine receptor agonists worsen disease in experimental colitis.

Published in:

2010

By:

Snoek, Susanne A;
Verstege, Marleen I;
Van Der Zanden, Esmerij P;
Deeks, Nigel;
Bulmer, David C;
Skynner, Michael;
Lee, Kevin;
Te Velde, Anje A;
Boeckxstaens, Guy E;
De Jonge, Wouter J

Publication type:

journal article

Mitochondria as pharmacological targets.

Published in:

2010

By:

Moncada, S

Publication type:

journal article

Enhancement of inflammatory mediator release by beta(2)-adrenoceptor agonists in airway epithelial cells is reversed by glucocorticoid action.

Published in:

2010

By:

Holden, NS;
Rider, CF;
Bell, MJ;
Velayudhan, J;
King, EM;
Kaur, M;
Salmon, M;
Giembycz, MA;
Newton, R;
Holden, N S;
Rider, C F;
Bell, M J;
King, E M;
Giembycz, M A

Publication type:

journal article

Estimation of binding rate constants using a simultaneous mixed-effects method: application to monoamine transporter reuptake inhibitor reboxetine.

Published in:

2010

By:

Benson, Neil;
Snelder, Nelleke;
Ploeger, Bart;
Napier, Carolyn;
Sale, Harriet;
JM Birdsall, Nigel;
Butt, Richard P;
Van Der Graaf, Piet H;
Birdsall, Nigel J M

Publication type:

journal article

The metabolic enhancer piracetam ameliorates the impairment of mitochondrial function and neurite outgrowth induced by ß-amyloid peptide.

Published in:

British Journal of Pharmacology, 2010, v. 160, n. 2, p. 246, doi. 10.1111/j.1476-5381.2010.00656.x

By:

Kurz, C;
Ungerer, I;
Lipka, U;
Kirr, S;
Schütt, T;
Eckert, A;
Leuner, K;
Müller, WE

Publication type:

Article

A novel antagonist of the prostaglandin E(2) EP(4) receptor inhibits Th1 differentiation and Th17 expansion and is orally active in arthritis models.

Published in:

2010

By:

Chen, Q;
Muramoto, K;
Masaaki, N;
Ding, Y;
Yang, H;
Mackey, M;
Li, W;
Inoue, Y;
Ackermann, K;
Shirota, H;
Matsumoto, I;
Spyvee, M;
Schiller, S;
Sumida, T;
Gusovsky, F;
Lamphier, M

Publication type:

journal article

Shikonin reduces oedema induced by phorbol ester by interfering with IkappaBalpha degradation thus inhibiting translocation of NF-kappaB to the nucleus.

Published in:

2010

By:

Andújar, I;
Recio, MC;
Bacelli, T;
Giner, RM;
Ríos, JL;
Andújar, I;
Recio, M C;
Giner, R M;
Ríos, J L

Publication type:

journal article

Novel ruthenium complexes as potential drugs for Chagas's disease: enzyme inhibition and in vitro/in vivo trypanocidal activity.

Published in:

2010

By:

Silva, Jean Jerley Nogueira;
Guedes, Paulo Marcos Matta;
Zottis, Aderson;
Balliano, Tatiane Luciano;
Nascimento Silva, Francisco Ordelei;
França Lopes, Luiz Gonzaga;
Ellena, Javier;
Oliva, Glaucius;
Andricopulo, Adriano Defini;
Franco, Douglas Wagner;
Silva, João Santana;
França Lopes, Luiz Gonzaga;
Silva, João Santana

Publication type:

journal article

Disruption of cellular cholesterol transport and homeostasis as a novel mechanism of action of membrane-targeted alkylphospholipid analogues.

Published in:

2010

By:

Carrasco, María P;
Jiménez-López, José M;
Ríos-Marco, Pablo;
Segovia, Josefa L;
Marco, Carmen;
Carrasco, María P;
Jiménez-López, José M;
Ríos-Marco, Pablo

Publication type:

journal article

Isoflurane protects cardiomyocytes and mitochondria by immediate and cytosol-independent action at reperfusion.

Published in:

2010

By:

Pravdic, D;
Mio, Y;
Sedlic, F;
Pratt, PF;
Warltier, DC;
Bosnjak, ZJ;
Bienengraeber, M;
Pratt, P F;
Warltier, D C;
Bosnjak, Z J

Publication type:

journal article

High-throughput screening and small animal models, where are we?

Published in:

British Journal of Pharmacology, 2010, v. 160, n. 2, p. 204, doi. 10.1111/j.1476-5381.2010.00725.x

By:

Giacomotto, Jean;
Ségalat, Laurent

Publication type:

Article

Pharmacological characterization of the first potent and selective antagonist at the cysteinyl leukotriene 2 (CysLT(2)) receptor.

Published in:

2010

By:

Wunder, F;
Tinel, H;
Kast, R;
Geerts, A;
Becker, EM;
Kolkhof, P;
Hütter, J;
Ergüden, J;
Härter, M;
Becker, E M;
Hütter, J;
Ergüden, J;
Härter, M

Publication type:

journal article

Atomoxetine acts as an NMDA receptor blocker in clinically relevant concentrations.

Published in:

2010

By:

Ludolph, Andrea G;
Udvardi, Patrick T;
Schaz, Ulrike;
Henes, Carolin;
Adolph, Oliver;
Weigt, Henry U;
Fegert, Joerg M;
Boeckers, Tobias M;
Föhr, Karl J;
Föhr, Karl J

Publication type:

journal article

Ouabain attenuates cardiotoxicity induced by other cardiac steroids.

Published in:

2010

By:

Nesher, M;
Shpolansky, U;
Viola, N;
Dvela, M;
Buzaglo, N;
Ben-Ami, H Cohen;
Rosen, H;
Lichtstein, D;
Cohen Ben-Ami, H

Publication type:

journal article

A novel role for the metabotropic glutamate receptor-7: modulation of faecal water content and colonic electrolyte transport in the mouse.

Published in:

2010

By:

Julio-Pieper, M;
Hyland, NP;
Bravo, JA;
Dinan, TG;
Cryan, JF;
Hyland, N P;
Bravo, J A;
Dinan, T G;
Cryan, J F

Publication type:

journal article

Signal transduction by protease-activated receptors.

Published in:

2010

By:

Soh, Unice JK;
Dores, Michael R;
Chen, Buxin;
Trejo, JoAnn;
Soh, Unice J K

Publication type:

journal article

Pre-clinical properties of the alpha4beta2 nicotinic acetylcholine receptor partial agonists varenicline, cytisine and dianicline translate to clinical efficacy for nicotine dependence.

Published in:

2010

By:

Rollema, H;
Shrikhande, A;
Ward, KM;
Tingley III, FD;
Coe, JW;
O'Neill, BT;
Tseng, E;
Wang, EQ;
Mather, RJ;
Hurst, RS;
Williams, KE;
De Vries, M;
Cremers, T;
Bertrand, S;
Bertrand, D;
Ward, K M;
Tingley, F D 3rd;
Coe, J W;
O'Neill, B T;
Wang, E Q

Publication type:

journal article

Increased brain damage after ischaemic stroke in mice lacking the chemokine receptor CCR5.

Published in:

2010

By:

Sorce, S;
Bonnefont, J;
Julien, S;
Marq-Lin, N;
Rodriguez, I;
Dubois-Dauphin, M;
Krause, KH;
Krause, K H

Publication type:

journal article

Nitric oxide donor trans-[RuCl([15]aneN)NO] as a possible therapeutic approach for Chagas' disease.

Published in:

2010

By:

Guedes, Paulo MM;
Oliveira, Fabiana S;
Gutierrez, Fredy RS;
Da Silva, Grace Kelly;
Rodrigues, Gerson Jhonatan;
Bendhack, Lusiane Maria;
Franco, Douglas W;
Do Valle Matta, Maria A;
Zamboni, Dario S;
Da Silva, Roberto Santana;
Silva, João Santana;
Guedes, Paulo M M;
Gutierrez, Fredy R S;
Silva, João Santana

Publication type:

journal article