Works matching IS 00071188 AND DT 2008 AND VI 154 AND IP 7

Results: 20

The impact of varying autonomic states on the dynamic beat-to-beat QT-RR and QT-TQ interval relationships.

Published in:

2008

By:

Fossa, A. A.

Publication type:

journal article

Adrenaline reveals the torsadogenic effect of combined blockade of potassium channels in anaesthetized guinea pigs.

Published in:

2008

By:

Michael, G.;
Kane, K. A.;
Coker, S. J.

Publication type:

journal article

Predicting drug-induced changes in QT interval and arrhythmias: QT-shortening drugs point to gaps in the ICHS7B Guidelines.

Published in:

2008

By:

Lu, H. R.;
Vlaminckx, E.;
Hermans, A. N.;
Rohrbacher, J.;
Van Ammel, K.;
Towart, R.;
Pugsley, M.;
Gallacher, D. J.

Publication type:

journal article

Involvement of organic anion transporting polypeptides in the toxicity of hydrophilic pravastatin and lipophilic fluvastatin in rat skeletal myofibres.

Published in:

2008

By:

Sakamoto, K.;
Mikami, H.;
Kimura, J.

Publication type:

journal article

In vitro models of proarrhythmia.

Published in:

2008

By:

Lawrence, C. L.;
Pollard, C. E.;
Hammond, T. G.;
Valentin, J. -P.

Publication type:

journal article

Strategies to reduce the risk of drug-induced QT interval prolongation: a pharmaceutical company perspective.

Published in:

2008

By:

Pollard, C. E.;
Valentin, J. -P.;
Hammond, T. G.

Publication type:

journal article

Dose-response effects of sotalol on cardiovascular function in conscious, freely moving cynomolgus monkeys.

Published in:

2008

By:

Lynch III, J. J.;
Wilson, A. W.;
Hernandez, L. E.;
Nelson, R. A.;
Marsh, K. C.;
Cox, B. F.;
Mittelstadt, S. W.;
Lynch, J J 3rd

Publication type:

journal article

Moving towards better predictors of drug-induced torsades de pointes.

Published in:

2008

By:

Bass, A. S.;
Darpo, B.;
Valentin, J. -P.;
Sager, P.;
Thomas, K.

Publication type:

journal article

Key clinical considerations for demonstrating the utility of preclinical models to predict clinical drug-induced torsades de pointes.

Published in:

2008

By:

Sager, P. T.

Publication type:

journal article

The effect of changes in core body temperature on the QT interval in beagle dogs: a previously ignored phenomenon, with a method for correction.

Published in:

2008

By:

Van der Linde, H. J.;
Van Deuren, B.;
Teisman, A.;
Towart, R.;
Gallacher, D. J.

Publication type:

journal article

Cellular basis of drug-induced torsades de pointes.

Published in:

2008

By:

Roden, D. M.

Publication type:

journal article

Sensitive and reliable proarrhythmia in vivo animal models for predicting drug-induced torsades de pointes in patients with remodelled hearts.

Published in:

2008

By:

Sugiyama, A.

Publication type:

journal article

The failure of torcetrapib: what have we learned?

Published in:

2008

By:

Joy, T. R.;
Hegele, R. A.

Publication type:

journal article

Zebrafish: an emerging technology for in vivo pharmacological assessment to identify potential safety liabilities in early drug discovery.

Published in:

2008

By:

Barros, T. P.;
Alderton, W. K.;
Reynolds, H. M.;
Roach, A. G.;
Berghmans, S.

Publication type:

journal article

Torcetrapib-induced blood pressure elevation is independent of CETP inhibition and is accompanied by increased circulating levels of aldosterone.

Published in:

2008

By:

Forrest, M. J.;
Bloomfield, D.;
Briscoe, R. J.;
Brown, P. N.;
Cumiskey, A. -M.;
Ehrhart, J.;
Hershey, J. C.;
Keller, W. J.;
Ma, X.;
McPherson, H. E.;
Messina, E.;
Peterson, L. B.;
Sharif-Rodriguez, W.;
Siegl, P. K. S.;
Sinclair, P. J.;
Sparrow, C. P.;
Stevenson, A. S.;
Sun, S. -Y.;
Tsai, C.;
Vargas, H.

Publication type:

journal article

Predicting QT prolongation in humans during early drug development using hERG inhibition and an anaesthetized guinea-pig model.

Published in:

2008

By:

Yao, X.;
Anderson, D. L.;
Ross, S. A.;
Lang, D. G.;
Desai, B. Z.;
Cooper, D. C.;
Wheelan, P.;
McIntyre, M. S.;
Bergquist, M. L.;
MacKenzie, K. I.;
Becherer, J. D.;
Hashim, M. A.

Publication type:

journal article

The cardiovascular and pharmacokinetic profile of dofetilide in conscious telemetered beagle dogs and cynomolgus monkeys.

Published in:

2008

By:

Haushalter, T. M.;
Friedrichs, G. S.;
Reynolds, D. L.;
Barecki-Roach, M.;
Pastino, G.;
Hayes, R.;
Bass, A. S.

Publication type:

journal article

Literature-based evaluation of four 'hard endpoint' models for assessing drug-induced torsades de pointes liability.

Published in:

2008

By:

Vos, M. A.

Publication type:

journal article

International Life Sciences Institute (Health and Environmental Sciences Institute, HESI) initiative on moving towards better predictors of drug-induced torsades de pointes.

Published in:

2008

By:

Bass, A. S.;
Darpo, B.;
Breidenbach, A.;
Bruse, K.;
Feldman, H. S.;
Garnes, D.;
Hammond, T.;
Haverkamp, W.;
January, C.;
Koerner, J.;
Lawrence, C.;
Leishman, D.;
Roden, D.;
Valentin, J. P.;
Vos, M. A.;
Zhou, Y. -Y.;
Karluss, T.;
Sager, P.

Publication type:

journal article

Principles of safety pharmacology.

Published in:

2008

By:

Pugsley, M. K.;
Authier, S.;
Curtis, M. J.

Publication type:

journal article