Works matching Glucokinase

Results: 2510

Glucokinase and glucokinase regulatory proteins as molecular targets for novel antidiabetic drugs.

Published in:

Molecular Biology, 2015, v. 49, n. 4, p. 494, doi. 10.1134/S0026893315040147

By:

Rubtsov, P.;
Igudin, E.;
Tiulpakov, A.

Publication type:

Article

Evidence that glucokinase regulatory protein is expressed and interacts with glucokinase in rat brain.

Published in:

Journal of Neurochemistry, 2002, v. 80, n. 1, p. 45, doi. 10.1046/j.0022-3042.2001.00677.x

By:

Alvarez, Elvira;
Roncero, Isabel;
Chowen, Julie A.;
Vázquez, Patricia;
Blázquez, Enrique

Publication type:

Article

Role of Glucokinase in the Subcellular Localization of Glucokinase Regulatory Protein.

Published in:

International Journal of Molecular Sciences, 2015, v. 16, n. 4, p. 7377, doi. 10.3390/ijms16047377

By:

Ling Jin;
Tingting Guo;
Zhixin Li;
Zhen Lei;
Hui Li;
Yiqing Mao;
Xi Wang;
Na Zhou;
Yizhuang Zhang;
Ruobi Hu;
Xuehui Zhang;
Gang Niu;
David M. Irwin;
Huanran Tan

Publication type:

Article

Glucokinase and Glucokinase Regulatory Proteins are Functionally Coexpressed before Birth in the Rat Brain.

Published in:

Journal of Neuroendocrinology, 2009, v. 21, n. 12, p. 973, doi. 10.1111/j.1365-2826.2009.01919.x

By:

Roncero, I.;
Sanz, C.;
Álvarez, E.;
Vázquez, P.;
Barrio, P.A.;
Blázquez, E.

Publication type:

Article

Mutations in the glucokinase regulatory protein gene in 2p23 in obese French caucasians M. Veiga-da-Cunha et al.: Mutation in glucokinase regulatory protein.

Published in:

Diabetologia, 2003, v. 46, n. 5, p. 704, doi. 10.1007/s00125-003-1083-y

By:

Veiga-da-Cunha, M.;
Delplanque, J.;
Gillain, A.;
Bonthron, D. T.;
Boutin, P.;
Van Schaftingen, E.;
Froguel, P.

Publication type:

Article

Liver glucokinase gene expression is controlled by the onecut transcription factor hepatocyte nuclear factor-6 V.J. Lannoy et al.: Hepatocyte nuclear factor-6 and glucokinase.

Published in:

Diabetologia, 2002, v. 45, n. 8, p. 1136, doi. 10.1007/s00125-002-0856-z

By:

Lannoy, V.;
Decaux, J.;
Pierreux, C.;
Lemaigre, F.;
Rousseau, G.

Publication type:

Article

NOVEL MULTI ACTION THERAPY APPROACHES OF GLUCOKINASE ACTIVATOR TO TREAT TYPE 2 DIABETES.

Published in:

Journal of Advanced Scientific Research, 2020, v. 11, n. 3, p. 62

By:

Patidar, Dhanraj;
Jain, Ashish;
Mohanty, Pradeep Kumar;
Asati, Vivek

Publication type:

Article

A comprehensive review on glucokinase activators: Promising agents for the treatment of Type 2 diabetes.

Published in:

2022

By:

Thilagavathi, Ramasamy;
Hosseini‐Zare, Maryam Sadat;
Malini, Manokaran;
Selvam, Chelliah

Publication type:

Literature Review

QSAR Models Guided by Molecular Dynamics Applied to Human Glucokinase Activators.

Published in:

Chemical Biology & Drug Design, 2016, v. 87, n. 3, p. 455, doi. 10.1111/cbdd.12683

By:

Assis, Tamiris Maria;
Gajo, Giovanna Cardoso;
Assis, Letícia Cristina;
Garcia, Letícia Santos;
Silva, Daniela Rodrigues;
Ramalho, Teodorico Castro;
Cunha, Elaine Fontes Ferreira

Publication type:

Article

β‐Cell glucokinase expression was increased in type 2 diabetes subjects with better glycemic control.

Published in:

Journal of Diabetes, 2023, v. 15, n. 5, p. 409, doi. 10.1111/1753-0407.13380

By:

Liu, Jingwen;
Fu, Hui;
Kang, Fuyun;
Ning, Guang;
Ni, Qicheng;
Wang, Weiqing;
Wang, Qidi

Publication type:

Article

Comparative Structural and Functional Analysis of Staphylococcus aureus Glucokinase with other Bacterial Glucokinases.

Published in:

Indian Journal of Pharmaceutical Sciences, 2014, v. 76, n. 5, p. 430

By:

KUMAR, P. S.;
UMAR, Y. N. K.;
PRASAD, U. V.;
YESWANTH, S.;
SWARUPA, V.;
RAO, V. K.;
SRIKANTH, L.;
VENKATESH, K.;
VASU, D.;
SARMA, P. V. G. K.

Publication type:

Article

Effect of GRP119 Receptor Agonist, Compound MBX-2982, on Activity of Human Glucokinase.

Published in:

Bulletin of Experimental Biology & Medicine, 2017, v. 163, n. 5, p. 695, doi. 10.1007/s10517-017-3881-0

By:

Spasov, A.;
Kosolapov, V.;
Babkov, D.;
Maika, O.

Publication type:

Article

Predictive blood glucose lowering efficacy by Glucokinase activators in high fat fed female Zucker rats.

Published in:

British Journal of Pharmacology, 2006, v. 149, n. 3, p. 328, doi. 10.1038/sj.bjp.0706848

By:

Coope, G. J.;
Atkinson, A. M.;
Allott, C.;
McKerrecher, D.;
Johnstone, C.;
Pike, K. G.;
Holme, P. C.;
Vertigan, H.;
Gill, D.;
Coghlan, M. P.;
Leighton, B.

Publication type:

Article

Glucokinase regulatory protein is associated with mitochondria in hepatocytes

Published in:

FEBS Letters, 2006, v. 580, n. 8, p. 2065, doi. 10.1016/j.febslet.2006.03.009

By:

Arden, Catherine;
Baltrusch, Simone;
Agius, Loranne

Publication type:

Article

Present status of clinical deployment of glucokinase activators.

Published in:

Journal of Diabetes Investigation, 2015, v. 6, n. 2, p. 124, doi. 10.1111/jdi.12294

By:

Nakamura, Akinobu;
Terauchi, Yasuo

Publication type:

Article

ATP- and Polyphosphate-Dependent Glucokinases from Aerobic Methanotrophs.

Published in:

Microorganisms, 2019, v. 7, n. 2, p. 52, doi. 10.3390/microorganisms7020052

By:

Reshetnikov, Alexander S.;
Solntseva, Natalia P.;
Rozova, Olga N.;
Mustakhimov, Ildar I.;
Trotsenko, Yuri A.;
Khmelenina, Valentina N.

Publication type:

Article

Ischemic preconditioning maintains the immunoreactivities of glucokinase and glucokinase regulatory protein in neurons of the gerbil hippocampal CA1 region following transient cerebral ischemia.

Published in:

Molecular Medicine Reports, 2015, v. 12, n. 4, p. 4939, doi. 10.3892/mmr.2015.4021

By:

YOUNG SHIN CHO;
JUN HWI CHO;
BICH-NA SHIN;
GEUM-SIL CHO;
IN HYE KIM;
JOON HA PARK;
JI HYEON AHN;
TAEK GEUN OHK;
BYUNG-RYUL CHO;
YOUNG-MYEONG KIM;
SEONGKWEON HONG;
MOO-HO WON;
JAE-CHUL LEE

Publication type:

Article

Regulation of liver glucokinase activity in rats with fructose-induced insulin resistance and impaired glucose and lipid metabolism.

Published in:

Canadian Journal of Physiology & Pharmacology, 2009, v. 87, n. 9, p. 702, doi. 10.1139/Y09-064

By:

Francini, Flavio;
Castro, María C.;
Gagliardino, Juan J.;
Massa, María L.

Publication type:

Article

In silico design of dehydrophenylalanine containing peptide activators of glucokinase using pharmacophore modelling, molecular dynamics and machine learning: implications in type 2 diabetes.

Published in:

Journal of Computer-Aided Molecular Design, 2024, v. 39, n. 1, p. 1, doi. 10.1007/s10822-024-00583-z

By:

Yadav, Siddharth;
Rana, Swati;
Manish, Manish;
Singh, Sohini;
Lynn, Andrew;
Mathur, Puniti

Publication type:

Article

Specificity evolution of the ADP-dependent sugar kinase family – in silico studies of the glucokinase/phosphofructokinase bifunctional enzyme from Methanocaldococcus jannaschii.

Published in:

FEBS Journal, 2008, v. 275, n. 16, p. 4033, doi. 10.1111/j.1742-4658.2008.06544.x

By:

Merino, Felipe;
Guixé, Victoria

Publication type:

Article

The role of glucose 6-phosphate in mediating the effects of glucokinase overexpression on hepatic glucose metabolism.

Published in:

FEBS Journal, 2006, v. 273, n. 2, p. 336, doi. 10.1111/j.1742-4658.2005.05067.x

By:

Härndahl, Linda;
Schmoll, Dieter;
Herling, Andreas W.;
Agius, Loranne

Publication type:

Article

Efficacy and safety of glucokinase activators for type 2 diabetes mellitus therapy: a meta-analysis of double-blind randomized controlled trials.

Published in:

European Review for Medical & Pharmacological Sciences, 2021, v. 25, n. 2, p. 914

By:

QU, Y.;
WANG, K.;
LIN, S.;
CAO, L.;
XU, Z.

Publication type:

Article

Evaluating the impact of glucokinase activation on risk of cardiovascular disease: a Mendelian randomisation analysis.

Published in:

Cardiovascular Diabetology, 2022, v. 21, n. 1, p. 1, doi. 10.1186/s12933-022-01613-6

By:

Wang, Ke;
Shi, Mai;
Huang, Chuiguo;
Fan, Baoqi;
Luk, Andrea O. Y.;
Kong, Alice P. S.;
Ma, Ronald C. W.;
Chan, Juliana C. N.;
Chow, Elaine

Publication type:

Article

Repair of diverse diabetic defects of β-cells in man and mouse by pharmacological glucokinase activation.

Published in:

Diabetes, Obesity & Metabolism, 2012, v. 14, p. 109, doi. 10.1111/j.1463-1326.2012.01652.x

By:

Doliba, Nicolai M.;
Fenner, Deborah;
Zelent, Bogumil;
Bass, Joseph;
Sarabu, Ramakanth;
Matschinsky, Franz M.

Publication type:

Article

Effect of high-fat diet on glucose homeostasis and gene expression in glucokinase knockout mice.

Published in:

Diabetes, Obesity & Metabolism, 2008, v. 10, n. 10, p. 885, doi. 10.1111/j.1463-1326.2007.00819.x

By:

Gorman, T.;
Hope, D. C. D.;
Brownlie, R.;
Yu, A.;
Gill, D.;
Löfvenmark, J.;
Wedin, M.;
Mayers, R. M.;
Snaith, M. R.;
Smith, D. M.

Publication type:

Article

Glucokinase regulatory protein: a balancing act between glucose and lipid metabolism in NAFLD.

Published in:

Frontiers in Endocrinology, 2023, p. 01, doi. 10.3389/fendo.2023.1247611

By:

Ziqi Zhang;
Guang Ji;
Meng Li

Publication type:

Article

Cg2091 encodes a polyphosphate/ATP-dependent glucokinase of Corynebacterium glutamicum.

Published in:

Applied Microbiology & Biotechnology, 2010, v. 87, n. 2, p. 703, doi. 10.1007/s00253-010-2568-5

By:

Lindner, Steffen N.;
Knebel, Sandra R.;
Pallerla, Srinivas R.;
Schoberth, Siegfried M.;
Wendisch, Volker F.

Publication type:

Article

FpOGT is required for fungal growth, stress response, and virulence of Fusarium proliferatum by affecting the expression of glucokinase and other glucose metabolism-related genes.

Published in:

Phytopathology Research, 2024, v. 6, n. 1, p. 1, doi. 10.1186/s42483-023-00221-w

By:

Gao, Yizhou;
Wang, Yitong;
He, Siming;
Li, Haibo;
Wang, Yuqing;
Wu, Zhihong

Publication type:

Article

Circadian rhythm, glucose metabolism and diabetic complications: the role of glucokinase and the enlightenment on future treatment.

Published in:

2025

By:

Zhang, Zhijun;
Wang, Shuo;
Gao, Ling

Publication type:

Literature Review

Functional Characterization of a Novel Heterozygous Mutation in the Glucokinase Gene That Causes MODY2 in Chinese Pedigrees.

Published in:

Frontiers in Endocrinology, 2021, v. 12, p. 1, doi. 10.3389/fendo.2021.803992

By:

Jiang, Feng;
Yan, Jing;
Zhang, Rong;
Ma, Xiaojing;
Bao, Yuqian;
Gu, Yujuan;
Hu, Cheng

Publication type:

Article

G/A Polymorphism at -258 of the Hepatic Glucokinase Promoter Is Not Associated with Decreased Birth Weight in Preterm Neonates.

Published in:

Neonatology (16617800), 2008, v. 94, n. 2, p. 71, doi. 10.1159/000113311

By:

Pawlowski, M.;
Kouklinos, A.;
Jopp-Petzina, G.;
Herkenrath, P.;
Fischer, M.;
Kribs, A.;
Roth, B.;
Roth, J.;
Tenbrock, K.

Publication type:

Article

Decreased Glucokinase Protein Expression in the Aged Gerbil Hippocampus.

Published in:

Cellular & Molecular Neurobiology, 2013, v. 33, n. 4, p. 477, doi. 10.1007/s10571-013-9928-5

By:

Lee, Choong;
Park, Joon;
Won, Moo-Ho

Publication type:

Article

Mutacja w genie glukokinazy jako przyczyna utrwalonej cukrzycy noworodkowej.

Published in:

Pediatric Endocrinology, Diabetes & Metabolism, 2012, v. 18, n. 1, p. 45

By:

Wajda-Cuszlag, Małgorzata;
Witkowski, Daniel;
Piontek, Elżbieta;
Wysocka-Mincewicz, Marta;
Borowiec, Maciej;
Młynarski, Wojciech;
Szalecki, Mieczysław

Publication type:

Article

Screening of Mutations and Polymorphisms in the Glucokinase Gene in Czech Diabetic and Healthy Control Populations.

Published in:

Physiological Research, 2008, v. 57, p. S99, doi. 10.33549/physiolres.931494

By:

Lukášová, P.;
Vcelák, J.;
Vanková, M.;
Vejražková, D.;
Andelová, K.;
Bendlová, B.

Publication type:

Article

Long term liver specific glucokinase gene defect induced diabetic cardiomyopathy by up regulating NADPH oxidase and down regulating insulin receptor and p-AMPK.

Published in:

Cardiovascular Diabetology, 2014, v. 13, n. 1, p. 3, doi. 10.1186/1475-2840-13-24

By:

Hui Li;
Xi Wang;
Yiqing Mao;
Ruobi Hu;
Wei Xu;
Zhen Lei;
Na Zhou;
Ling Jin;
Tingting Guo;
Zhixin Li;
Irwin, David M.;
Gang Niu;
Huanran Tan

Publication type:

Article

Enhancement of gene expression in <italic>Escherichia coli</italic> and characterization of highly stable ATP-dependent glucokinase from <italic>Pyrobaculum calidifontis</italic>.

Published in:

Extremophiles, 2018, v. 22, n. 2, p. 247, doi. 10.1007/s00792-017-0993-4

By:

Bibi, Tahira;
Ali, Musadiq;
Rashid, Naeem;
Muhammad, Majida Atta;
Akhtar, Muhammad

Publication type:

Article

Improved metabolic disorders of insulin receptor-deficient mice by transgenic overexpression of glucokinase in the liver M. Jackerott et al.: IR knockout mice overexpressing liver GK.

Published in:

Diabetologia, 2002, v. 45, n. 9, p. 1292, doi. 10.1007/s00125-002-0881-y

By:

Jackerott, M.;
Baudry, A.;
Bucchini, D.;
Jami, J.;
Joshi, R.

Publication type:

Article

Early-onset Type II diabetes mellitus in Italian families due to mutations in the genes encoding hepatic nuclear factor 1α and glucokinase.

Published in:

Diabetologia, 2001, v. 44, n. 10, p. 1326, doi. 10.1007/s001250100644

By:

Gragnoli, C.;
Cockburn, B. N.;
Chiaramonte, F.;
Gorini, A.;
Marietti, G.;
Marozzi, G.;
Signorini, A. M.

Publication type:

Article

High prevalence of glucokinase mutations in Italian children with MODY. Influence on glucose tolerance, first-phase insulin response, insulin sensitivity and BMI.

Published in:

Diabetologia, 2001, v. 44, n. 7, p. 898

By:

Massa, O.;
Meschi, F.;
Cuesta-Munoz, A.;
Caumo, A.;
Cerutti, F.;
Toni, S.;
Cherubini, V.;
Guazzarotti, L.;
Sulli, N.;
Matschinsky, F. M;
Lorini, R.;
Iafusco, D.;
Barbetti, F.

Publication type:

Article

A high prevalence of glucokinase mutations in gestational diabetic subjects selected by clinical criteria.

Published in:

Diabetologia, 2000, v. 43, n. 2, p. 250, doi. 10.1007/s001250050038

By:

Ellard, S.;
Beards, F.;
Allen, L. I. S.;
Shepherd, M.;
Ballantyne, E.;
Harvey, R.;
Hattersley, A. T.

Publication type:

Article

Glycemic Effect and Safety of a Systemic, Partial Glucokinase Activator, PF-04937319, in Patients With Type 2 Diabetes Mellitus Inadequately Controlled on Metformin-A Randomized, Crossover, Active-Controlled Study.

Published in:

Clinical Pharmacology in Drug Development, 2016, v. 5, n. 6, p. 517, doi. 10.1002/cpdd.261

By:

Denney, William S.;
Denham, Douglas S.;
Riggs, Michael R.;
Amin, Neeta B.

Publication type:

Article

Pharmacokinetic and Pharmacodynamic Drug Interaction Study of Piragliatin, a Glucokinase Activator, and Glyburide, a Sulfonylurea, in Type 2 Diabetic Patients.

Published in:

Clinical Pharmacology in Drug Development, 2016, v. 5, n. 6, p. 552, doi. 10.1002/cpdd.276

By:

Zhai, S.;
Georgy, A.;
Liang, Z.;
Zhi, J.

Publication type:

Article

Glucokinase activation leads to an unsustained hypoglycaemic effect with hepatic triglyceride accumulation in db/db mice.

Published in:

Diabetes, Obesity & Metabolism, 2022, v. 24, n. 3, p. 391, doi. 10.1111/dom.14586

By:

Kawata, Shinichiro;
Nakamura, Akinobu;
Miyoshi, Hideaki;
Yang, Kelaier;
Shigesawa, Ikumi;
Yamauchi, Yuki;
Tsuchida, Kazuhisa;
Omori, Kazuno;
Takahashi, Kiyohiko;
Nomoto, Hiroshi;
Kameda, Hiraku;
Cho, Kyu Yong;
Terauchi, Yasuo;
Atsumi, Tatsuya

Publication type:

Article

Liver glucokinase: An overview on the regulatorymechanisms of its activity.

Published in:

IUBMB Life, 2011, v. 63, n. 1, p. 1, doi. 10.1002/iub.411

By:

Massa, María L.;
Gagliardino, Juan J.;
Francini, Flavio

Publication type:

Article

Genetic and clinical characteristics of Chinese children with Glucokinase-maturity-onset diabetes of the young (GCK-MODY).

Published in:

2018

By:

Li, Xiuzhen;
Ting, Tzer Hwu;
Sheng, Huiying;
Liang, Cui Li;
Shao, Yongxian;
Jiang, Minyan;
Xu, Aijing;
Lin, Yunting;
Liu, Li

Publication type:

journal article

Characterization of Glucokinase Catalysis from a Pseudo-Dimeric View.

Published in:

Applied Biochemistry & Biotechnology, 2019, v. 189, n. 2, p. 345, doi. 10.1007/s12010-019-02998-z

By:

Chen, Hanchi;
Cai, Xiaoqing;
Xu, Anjie;
Zhu, Linjiang;
Lu, Yuele;
Chen, Xiaolong;
Liu, Shijie

Publication type:

Article

Biochemical characterization of novel glucokinase mutations isolated from Spanish maturity-onset diabetes of the young (MODY2) patients.

Published in:

Journal of Human Genetics, 2008, v. 53, n. 5, p. 460, doi. 10.1007/s10038-008-0271-5

By:

Estalella, Itziar;
Garcia-Gimeno, Maria;
Marina, Alberto;
Castaño, Luis;
Sanz, Pascual

Publication type:

Article

Recent drug development of dorzagliatin, a new glucokinase activator, with the potential to treat Type 2 diabetes: A review study.

Published in:

Journal of Diabetes, 2024, v. 16, n. 6, p. 1, doi. 10.1111/1753-0407.13563

By:

Jiang, Yu;
Wang, Luyao;
Dong, Zhenhua;
Xia, Baotian;
Pang, Shuguang

Publication type:

Article

Exendin-4 ameliorates diabetic symptoms through activation of glucokinase.

Published in:

Journal of Diabetes, 2012, v. 4, n. 4, p. 369, doi. 10.1111/j.1753-0407.2012.00193.x

By:

Dhanesha, Nirav;
Joharapurkar, Amit;
Shah, Gaurang;
Dhote, Vipin;
Kshirsagar, Samadhan;
Bahekar, Rajesh;
Jain, Mukul

Publication type:

Article

Characterization of Polyphosphate Glucokinase SC05059 from Streptomyces coelicolor A3(2).

Published in:

Bioscience, Biotechnology & Biochemistry, 2013, v. 77, n. 11, p. 2322, doi. 10.1271/bbb.130498

By:

Mai KOIDE;
Akimasa MIYANAGA;
Fumitaka KUDO;
Tadashi EGUCHI

Publication type:

Article