Works matching Fenfluramine

Results: 655

Stereoselective Analysis of the Antiseizure Activity of Fenfluramine and Norfenfluramine in Mice: Is l -Norfenfluramine a Better Follow-Up Compound to Racemic-Fenfluramine?

Published in:

International Journal of Molecular Sciences, 2024, v. 25, n. 5, p. 2522, doi. 10.3390/ijms25052522

By:

Erenburg, Natalia;
Perucca, Emilio;
Bechard, Jeff;
Dube, Celine;
Weishaupt, Nina;
Sherrington, Robin;
Bialer, Meir

Publication type:

Article

Platelet monoamine oxidase B (MAO-B) activity and its relationship to DL-fenfluramine-induced prolactin response in healthy men.

Published in:

Journal of Neural Transmission, 2006, v. 113, n. 1, p. 33, doi. 10.1007/s00702-005-0306-4

By:

Eriksson, M.;
Berggren, U.;
Fahlke, C.;
Engel, J.;
Balldin, J.

Publication type:

Article

Improving Therapy of Pharmacoresistant Epilepsies: The Role of Fenfluramine.

Published in:

Frontiers in Pharmacology, 2024, p. 1, doi. 10.3389/fphar.2022.832929

By:

Dini, Gianluca;
Tulli, Eleonora;
Dell'Isola, Giovanni Battista;
Mencaroni, Elisabetta;
Di Cara, Giuseppe;
Striano, Pasquale;
Verrotti, Alberto

Publication type:

Article

Effects of repeated treatment with methcathinone, mephedrone, and fenfluramine on intracranial self-stimulation in rats.

Published in:

Psychopharmacology, 2019, v. 236, n. 3, p. 1057, doi. 10.1007/s00213-018-5029-y

By:

Suyama, J. A.;
Banks, M. L.;
Negus, S. S.

Publication type:

Article

The Effects of Fenfluramine on Blood and Tissue Serotonin (5-Hydroxytryptamine) Levels in Rats.

Published in:

Turkish Journal of Veterinary & Animal Sciences, 2005, v. 29, n. 3, p. 857

By:

Pirinçci, İbrahim;
AteŞŞahin, Ahmet;
Karahan, İzzet

Publication type:

Article

Fenfluramine Reduces [11C]Cimbi-36 Binding to the 5-HT2A Receptor in the Nonhuman Primate Brain.

Published in:

International Journal of Neuropsychopharmacology, 2017, v. 20, n. 9, p. 683, doi. 10.1093/ijnp/pyx051

By:

Kai-Chun Yang;
Stepanov, Vladimir;
Martinsson, Stefan;
Ettrup, Anders;
Akihiro Takano;
Knudsen, Gitte M.;
Halldin, Christer;
Farde, Lars;
Finnema, Sjoerd J.

Publication type:

Article

Efficacy and Safety of Fenfluramine in Epilepsy: A Systematic Review and Meta-analysis.

Published in:

Neurology & Therapy, 2023, v. 12, n. 2, p. 669, doi. 10.1007/s40120-023-00452-1

By:

Tabaee Damavandi, Payam;
Fabin, Natalia;
Giossi, Riccardo;
Matricardi, Sara;
Del Giovane, Cinzia;
Striano, Pasquale;
Meletti, Stefano;
Brigo, Francesco;
Trinka, Eugen;
Lattanzi, Simona

Publication type:

Article

Gold Nanoparticles-enhanced Chemiluminescence Determination of Fenfluramine.

Published in:

Journal of the Chinese Chemical Society, 2014, v. 61, n. 4, p. 425, doi. 10.1002/jccs.201300407

By:

Ma, Diao;
Quan, Jie;
Du, Jianxiu

Publication type:

Article

Retest Reliability of Prolactin Response to dl-Fenfluramine Challenge in Adults

Published in:

Neuropsychopharmacology, 2002, v. 26, n. 2, p. 269, doi. 10.1016/S0893-133X(01)00330-X

By:

Flory, Janine D.;
Manuck, Stephen B.;
Muldoon, Matthew F.

Publication type:

Article

INCREASE IN EXTRACELLULAR SEROTONIN BY THE SEROTONIN PRECURSOR 5-HTP AND THE SEROTONIN RELEASER FENFLURAMINE IMPAIR ACQUISITION AND EXPRESSION OF CONTEXT-CONDITIONED FEAR.

Published in:

2025

By:

Hagsäter, S. Melker;
Pettersson, Robert;
Anatasovski, Daniela;
Eriksson, Elias

Publication type:

Abstract

Improving Therapy of Pharmacoresistant Epilepsies: The Role of Fenfluramine.

Published in:

Frontiers in Pharmacology, 2022, v. 13, p. 1, doi. 10.3389/fphar.2022.832929

By:

Dini, Gianluca;
Tulli, Eleonora;
Dell'Isola, Giovanni Battista;
Mencaroni, Elisabetta;
Di Cara, Giuseppe;
Striano, Pasquale;
Verrotti, Alberto

Publication type:

Article

Fenfluramine-induced serotonergic neurotoxicity in mice: lack of neuroprotection by inhibition/ablation of nNOS.

Published in:

Journal of Neurochemistry, 2003, v. 87, n. 1, p. 268, doi. 10.1046/j.1471-4159.2003.02023.x

By:

Itzhak, Yossef;
Ali, Syed F.;
Anderson, Karen L.

Publication type:

Article

Impaired spatial and sequential learning in rats treated neonatally with d-fenfluramine.

Published in:

European Journal of Neuroscience, 2002, v. 16, n. 3, p. 491, doi. 10.1046/j.1460-9568.2002.02100.x

By:

Morford, L. L.;
Inman‐Wood, S. L.;
Gudelsky, G. A.;
Williams, M. T.;
Vorhees, C. V.

Publication type:

Article

Effect of fenfluramine on reinstatement of food seeking in female and male rats: implications for the predictive validity of the reinstatement model.

Published in:

Psychopharmacology, 2012, v. 221, n. 2, p. 341, doi. 10.1007/s00213-011-2585-9

By:

Pickens, Charles;
Cifani, Carlo;
Navarre, Brittany;
Eichenbaum, Hila;
Theberge, Florence;
Baumann, Michael;
Calu, Donna;
Shaham, Yavin

Publication type:

Article

Mice overexpressing the 5-hydroxytryptamine transporter show no alterations in feeding behaviour and increased non-feeding responses to fenfluramine.

Published in:

Psychopharmacology, 2008, v. 200, n. 2, p. 291, doi. 10.1007/s00213-008-1206-8

By:

Pringle, A.;
Jennings, K.;
Line, S.;
Bannerman, D.;
Higgs, S.;
Sharp, T.

Publication type:

Article

Effects of fenfluramine on free-operant timing behaviour: evidence for involvement of 5-HT2A receptors.

Published in:

Psychopharmacology, 2004, v. 176, n. 2, p. 154, doi. 10.1007/s00213-004-1871-1

By:

Body, S.;
Kheramin, S.;
Ho, M. -Y.;
Herrera, F. Miranda;
Bradshaw, C. M.;
Szabadi, E.

Publication type:

Article

Reduced hypophagic effects ofd-fenfluramine and the 5-HT2C receptor agonistmCPP in 5-HT1B receptor knockout mice.

Published in:

Psychopharmacology, 2004, v. 176, n. 1, p. 39, doi. 10.1007/s00213-004-1864-0

By:

Lee, Michelle D.;
Somerville, Elizabeth M.;
Kennett, Guy A.;
Dourish, Colin T.;
Clifton, Peter G.

Publication type:

Article

Valvular Heart Disease with the Use of Fenfluramine-Phentermine.

Published in:

2011

By:

Surapaneni, Phani;
Vinales, Karyne L.;
Najib, Mohammad Q.;
Chaliki, Hari P.

Publication type:

Case Study

The Number of Previous Depressive Episodes Is Positively Associated with Cortisol Response to Fenfluramine Administration.

Published in:

Annals of the New York Academy of Sciences, 2004, v. 1032, n. 1, p. 283, doi. 10.1196/annals.1314.039

By:

SHER, LEO;
OQUENDO, MARIA A.;
GALFALVY, HANGA C.;
COOPER, THOMAS B.;
MANN, J JOHN

Publication type:

Article

Effects of repeated systemic administration of d-Fenfluramine on serotonin and glutamate release in rat ventral hippocampus: comparison with methamphetamine using in vivo microdialysis.

Published in:

Naunyn-Schmiedeberg's Archives of Pharmacology, 2001, v. 363, n. 4, p. 422, doi. 10.1007/s002100000381

By:

Rocher, Cyril;
Gardier, Alain M.

Publication type:

Article

Flow Injection Chemiluminescence Sensor with Novel Rhodanine Ramification for Determination of Fenfluramine Based on Molecularly Imprinted Polymer.

Published in:

Analytical Letters, 2009, v. 42, n. 5, p. 746, doi. 10.1080/00032710902722004

By:

Jing-hua, Yu;
Fu-wei, Wan;
Ping, Dai;
Shen-guang, Ge;
Bo, Li;
Jia-dong, Huang

Publication type:

Article

Preclinical efficacy profiles of the sigma‐1 modulator E1R and of fenfluramine in two chronic mouse epilepsy models.

Published in:

Epilepsia (Series 4), 2024, v. 65, n. 8, p. 2470, doi. 10.1111/epi.18037

By:

Pérez‐Pérez, Daniel;
Monío‐Baca, Cristina;
von Rüden, Eva‐Lotta;
Buchecker, Verena;
Wagner, Amelie;
Schönhoff, Katharina;
Zvejniece, Liga;
Klimpel, Dennis;
Potschka, Heidrun

Publication type:

Article

Comparative activity of the enantiomers of fenfluramine and norfenfluramine in rodent seizure models, and relationship with their concentrations in plasma and brain.

Published in:

Epilepsia (Series 4), 2023, v. 64, n. 6, p. 1673, doi. 10.1111/epi.17598

By:

Erenburg, Natalia;
Hamed, Roa'a;
Shaul, Chanan;
Perucca, Emilio;
Bialer, Meir

Publication type:

Article

Fenfluramine provides clinically meaningful reduction in frequency of drop seizures in patients with Lennox–Gastaut syndrome: Interim analysis of an open‐label extension study.

Published in:

Epilepsia (Series 4), 2023, v. 64, n. 1, p. 139, doi. 10.1111/epi.17431

By:

Knupp, Kelly G.;
Scheffer, Ingrid E.;
Ceulemans, Berten;
Sullivan, Joseph;
Nickels, Katherine C.;
Lagae, Lieven;
Guerrini, Renzo;
Zuberi, Sameer M.;
Nabbout, Rima;
Riney, Kate;
Agarwal, Anupam;
Lock, Michael;
Dai, David;
Farfel, Gail M.;
Galer, Bradley S.;
Gammaitoni, Arnold R.;
Polega, Shikha;
Davis, Ronald;
Gil‐Nagel, Antonio

Publication type:

Article

Fenfluramine significantly reduces day‐to‐day seizure burden by increasing number of seizure‐free days and time between seizures in patients with Dravet syndrome: A time‐to‐event analysis.

Published in:

Epilepsia (Series 4), 2022, v. 63, n. 1, p. 130, doi. 10.1111/epi.17106

By:

Sullivan, Joseph;
Specchio, Nicola;
Devinsky, Orrin;
Auvin, Stéphane;
Perry, M. Scott;
Strzelczyk, Adam;
Gil‐Nagel, Antonio;
Dai, David;
Galer, Bradley S.;
Gammaitoni, Arnold R.

Publication type:

Article

Fenfluramine HCl (Fintepla®) provides long‐term clinically meaningful reduction in seizure frequency: Analysis of an ongoing open‐label extension study.

Published in:

Epilepsia (Series 4), 2020, v. 61, n. 11, p. 2396, doi. 10.1111/epi.16722

By:

Sullivan, Joseph;
Scheffer, Ingrid E.;
Lagae, Lieven;
Nabbout, Rima;
Pringsheim, Milka;
Talwar, Dinesh;
Polster, Tilman;
Galer, Bradley;
Lock, Michael;
Agarwal, Anupam;
Gammaitoni, Arnold;
Morrison, Glenn;
Farfel, Gail

Publication type:

Article

Five-year extended follow-up status of 10 patients with Dravet syndrome treated with fenfluramine.

Published in:

Epilepsia (Series 4), 2016, v. 57, n. 7, p. e129, doi. 10.1111/epi.13407

By:

Ceulemans, Berten;
Schoonjans, An‐Sofie;
Marchau, Fabienne;
Paelinck, Bernard P.;
Lagae, Lieven

Publication type:

Article

Successful use of fenfluramine as an add-on treatment for Dravet syndrome.

Published in:

Epilepsia (Series 4), 2012, v. 53, n. 7, p. 1131, doi. 10.1111/j.1528-1167.2012.03495.x

By:

Ceulemans, Berten;
Boel, Marc;
Leyssens, Katrien;
Van Rossem, Carolin;
Neels, Pieter;
Jorens, Philippe G.;
Lagae, Lieven

Publication type:

Article

Optimal dose of fenfluramine in adjuvant treatment of drug-resistant epilepsy: evidence from randomized controlled trials.

Published in:

Frontiers in Neurology, 2024, p. 01, doi. 10.3389/fneur.2024.1371704

By:

Yingchun Xu;
Deng Chen;
Ling Liu

Publication type:

Article

Expert-Agreed Practical Recommendations on the Use of Fenfluramine in Developmental and Epileptic Encephalopathies Based on Clinical Experience and Literature Review.

Published in:

Neurology & Therapy, 2025, v. 14, n. 2, p. 447, doi. 10.1007/s40120-025-00713-1

By:

Villanueva, Vicente;
Soto-Insuga, Victor;
Smeyers, Patricia;
Aledo-Serrano, Ángel;
Sánchez-Carpintero, Rocío;
García-Peñas, Juan;
Gil-Nagel, Antonio

Publication type:

Article

Anxious Behavior and Fenfluramine-Induced Prolactin Secretion in Young Rhesus Macaques with Different Alleles of the Serotonin Reuptake Transporter Polymorphism (5HTTLPR).

Published in:

Behavior Genetics, 2004, v. 34, n. 3, p. 295, doi. 10.1023/B:BEGE.0000017873.61607.be

By:

Bethea, Cynthia L.;
Streicher, John M.;
Coleman, Kristine;
Pau, Francis K.-Y.;
Moessner, Rainald;
Cameron, Judy L.

Publication type:

Article

An investigation of the serotonergic effects of fenfluramine, dexfenfluramine and dexnorfenfluramine using platelets as neuronal models.

Published in:

Platelets, 2000, v. 11, n. 3, p. 161, doi. 10.1080/095371000403099

By:

Jagroop, I.A.;
Mikhailidis, D.P.

Publication type:

Article

Reintroducing Fenfluramine as a Treatment for Seizures: Current Knowledge, Recommendations and Gaps in Understanding.

Published in:

Neuropsychiatric Disease & Treatment, 2023, v. 19, p. 2013, doi. 10.2147/NDT.S417676

By:

Dini, Gianluca;
Cara, Giuseppe Di;
Ferrara, Pietro;
Striano, Pasquale;
Verrotti, Alberto

Publication type:

Article

Fenfluramine induced mitral stenosis complicated by massive left atrial thrombosis.

Published in:

2021

By:

Ennezat, Pierre-Vladimir;
Arnaud-Crozat, Eric;
Guerbaai, Raphaëlle-Ashley;
Stephanov, Olivier

Publication type:

Case Study

Neuroendocrine responses to fenfluramine and its relationship to personality in alcoholism.

Published in:

Journal of Neural Transmission, 2001, v. 108, n. 8/9, p. 1093, doi. 10.1007/s007020170027

By:

Weijers, H.-G.;
Wiesbeck, G. A.;
Jakob, F.;
Böning, J.

Publication type:

Article

Therapeutic drug monitoring of fenfluramine in clinical practice: Pharmacokinetic variability and impact of concomitant antiseizure medications.

Published in:

Epilepsia (Series 4), 2022, v. 63, n. 3, p. 686, doi. 10.1111/epi.17162

By:

Schoonjans, An‐Sofie;
Roosens, Laurence;
Dewals, Wendy;
Paelinck, Bernard P.;
Ceulemans, Berten

Publication type:

Article

Efficacy, tolerability, and retention of fenfluramine for the treatment of seizures in patients with Dravet syndrome: Compassionate use program in Germany.

Published in:

Epilepsia (Series 4), 2021, v. 62, n. 10, p. 2518, doi. 10.1111/epi.17034

By:

Strzelczyk, Adam;
Pringsheim, Milka;
Mayer, Thomas;
Polster, Tilman;
Klotz, Kerstin A.;
Muhle, Hiltrud;
Alber, Michael;
Trollmann, Regina;
Spors, Hartwig;
Kluger, Gerhard;
Kurlemann, Gerhard;
Schubert‐Bast, Susanne

Publication type:

Article

Effect of fenfluramine on convulsive seizures in CDKL5 deficiency disorder.

Published in:

Epilepsia (Series 4), 2021, v. 62, n. 7, p. e98, doi. 10.1111/epi.16923

By:

Devinsky, Orrin;
King, LaToya;
Schwartz, Danielle;
Conway, Erin;
Price, Dana

Publication type:

Article

Efficacy and safety of Fenfluramine hydrochloride for the treatment of seizures in Dravet syndrome: A real‐world study.

Published in:

Epilepsia (Series 4), 2020, v. 61, n. 11, p. 2405, doi. 10.1111/epi.16690

By:

Specchio, Nicola;
Pietrafusa, Nicola;
Doccini, Viola;
Trivisano, Marina;
Darra, Francesca;
Ragona, Francesca;
Cossu, Alberto;
Spolverato, Silvia;
Battaglia, Domenica;
Quintiliani, Michela;
Luigia Gambardella, Maria;
Rosati, Anna;
Mei, Davide;
Granata, Tiziana;
Dalla Bernardina, Bernardo;
Vigevano, Federico;
Guerrini, Renzo

Publication type:

Article

Efficacy of Fenfluramine and Norfenfluramine Enantiomers and Various Antiepileptic Drugs in a Zebrafish Model of Dravet Syndrome.

Published in:

Neurochemical Research, 2021, v. 46, n. 9, p. 2249, doi. 10.1007/s11064-021-03358-2

By:

Li, Jing;
Nelis, Maxim;
Sourbron, Jo;
Copmans, Daniëlle;
Lagae, Lieven;
Cabooter, Deirdre;
de Witte, Peter A. M.

Publication type:

Article

Comparison of (+)-methamphetamine, ±-Methylenedioxymethamphetamine, (+)-amphetamine and ±-fenfluramine in rats on egocentric learning in the Cincinnati water maze.

Published in:

Synapse, 2011, v. 65, n. 5, p. 368, doi. 10.1002/syn.20854

By:

VORHEES, CHARLES V.;
HE, ELIZABETH;
SKELTON, MATTHEW R.;
GRAHAM, DEVON L.;
SCHAEFER, TORI L.;
GRACE, CURTIS E.;
BRAUN, AMANDA A.;
AMOS-KROOHS, ROBYN;
WILLIAMS, MICHAEL T.

Publication type:

Article

Corrigendum: Improving therapy of pharmacoresistant epilepsies: The role of fenfluramine.

Published in:: Frontiers in Pharmacology, 2023, v. 14, p. 1, doi. 10.3389/fphar.2022.1116575
Publication type:: Article

The identification of two new urinary metabolites of fenfluramine inman

Published in:

Xenobiotica, 1983, v. 13, n. 1, p. 31

By:

McGilveray, I. J.;
Hawes, E. M.;
Cooper, J. K.;
Midha, K. K.;
Hubbard, J. W.;
Bailey, K.

Publication type:

Article

Fenfluramine for the Treatment of Dravet Syndrome and Lennox–Gastaut Syndrome.

Published in:

CNS Drugs, 2020, v. 34, n. 10, p. 1001, doi. 10.1007/s40263-020-00755-z

By:

Balagura, Ganna;
Cacciatore, Marta;
Grasso, Eleonora A.;
Striano, Pasquale;
Verrotti, Alberto

Publication type:

Article

Pharmacological Characterization of an Antisense Knockdown Zebrafish Model of Dravet Syndrome: Inhibition of Epileptic Seizures by the Serotonin Agonist Fenfluramine.

Published in:

PLoS ONE, 2015, v. 10, n. 5, p. 1, doi. 10.1371/journal.pone.0125898

By:

Zhang, Yifan;
Kecskés, Angéla;
Copmans, Daniëlle;
Langlois, Mélanie;
Crawford, Alexander D.;
Ceulemans, Berten;
Lagae, Lieven;
de Witte, Peter A. M.;
Esguerra, Camila V.

Publication type:

Article

Serotonin 5-HT2B receptor loss of function mutation in a patient with fenfluramine-associated primary pulmonary hypertension

Published in:

Cardiovascular Research, 2003, v. 60, n. 3, p. 518, doi. 10.1016/j.cardiores.2003.09.015

By:

Blanpain, Cédric;
Le Poul, Emmanuel;
Parma, Jasmine;
Knoop, Christiane;
Detheux, Michel;
Parmentier, Marc;
Vassart, Gilbert;
Abramowicz, Marc J.

Publication type:

Article

Fenfluramine for seizures associated with Sunflower syndrome.

Published in:

Developmental Medicine & Child Neurology, 2021, v. 63, n. 12, p. 1427, doi. 10.1111/dmcn.14965

By:

Geenen, Kennedy R;
Doshi, Samarth P;
Patel, Sandip;
Sourbron, Jo;
Falk, Amy;
Morgan, Amy;
Vu, Uyen;
Bruno, Patricia L;
Thiele, Elizabeth A

Publication type:

Article

Fenfluramine as antiseizure medication for epilepsy.

Published in:

Developmental Medicine & Child Neurology, 2021, v. 63, n. 8, p. 899, doi. 10.1111/dmcn.14822

By:

Gogou, Maria;
Cross, J Helen

Publication type:

Article

Risk of valvular heart disease associated with use of fenfluramine.

Published in:

BMC Cardiovascular Disorders, 2003, v. 3, p. 5, doi. 10.1186/1471-2261-3-5

By:

Hopkins, Paul N.;
Polukoff, Gerald I.

Publication type:

Article

Fenfluramine Suppresses Snack Intake Among Carbohydrate Cravers but not Among Noncarbohydrate Cravers.

Published in:

International Journal of Eating Disorders, 1987, v. 6, n. 6, p. 687, doi. 10.1002/1098-108X(198711)6:6<687::AID-EAT2260060602>3.0.CO;2-O

By:

Wurtman, Judith;
Wurtman, Richard;
Reynolds, Sharon;
Tsay, Rita;
Chew, Beverly

Publication type:

Article