Works matching Eddy Arnold

Results: 37

Structural requirements for RNA degradation by HIV-1 reverse transcriptase.

Published in:

Nature Structural & Molecular Biology, 2013, v. 20, n. 12, p. 1341, doi. 10.1038/nsmb.2725

By:

Das, Kalyan;
Sarafianos, Stefan G;
Arnold, Eddy

Publication type:

Article

HIV-1 reverse transcriptase complex with DNA and nevirapine reveals non-nucleoside inhibition mechanism.

Published in:

Nature Structural & Molecular Biology, 2012, v. 19, n. 2, p. 253, doi. 10.1038/nsmb.2223

By:

Das, Kalyan;
Martinez, Sergio E;
Bauman, Joseph D;
Arnold, Eddy

Publication type:

Article

Structural basis of HIV-1 resistance to AZT by excision.

Published in:

Nature Structural & Molecular Biology, 2010, v. 17, n. 10, p. 1202, doi. 10.1038/nsmb.1908

By:

Xiongying Tu;
Kalyan Das;
Qianwei Han;
Bauman, Joseph D.;
Clark, Arthur D.;
Xiaorong Hou;
Frenkel, Yulia V.;
Gaffney, Barbara L.;
Jones, Roger A.;
Boyer, Paul L.;
Hughes, Stephen H.;
Sarafianos, Stefan G.;
Arnold, Eddy

Publication type:

Article

Structures of influenza A proteins and insights into antiviral drug targets.

Published in:

Nature Structural & Molecular Biology, 2010, v. 17, n. 5, p. 530, doi. 10.1038/nsmb.1779

By:

Das, Kalyan;
Aramini, James M.;
Li-Chung Ma;
Krug, Robert M.;
Arnold, Eddy

Publication type:

Article

Reply to: Is one solution good enough?

Published in:

2006

By:

Berman, Helen M.;
Henrick, Kim;
Nakamura, Haruki;
Arnold, Eddy

Publication type:

Letter

Structures of HIV-1 RT-DNA complexes before and after incorporation of the anti-AIDS drug tenofovir.

Published in:

Nature Structural & Molecular Biology, 2004, v. 11, n. 5, p. 469, doi. 10.1038/nsmb760

By:

Tuske, Steve;
Sarafianos, Stefan G.;
Clark Jr., Arthur D.;
Jianping Ding;
Naeger, Lisa K.;
White, Kirsten L.;
Miller, Michael D.;
Gibbs, Craig S.;
Boyer, Paul L.;
Clark, Patrick;
Gang Wang;
Gaffney, Barbara L.;
Jones, Roger A.;
Jerina, Donald M.;
Hughes, Stephen H.;
Arnold, Eddy

Publication type:

Article

On the detection of multiple-binding modes of ligands to proteins, from biological, structural, and modeling data.

Published in:

Journal of Computer-Aided Molecular Design, 2003, v. 17, n. 2-4, p. 129, doi. 10.1023/A:1025313705564

By:

Lewis, Paul J.;
De Jonge, Marc;
Daeyaert, Frits;
Kuymans, Luc;
Vinkers, Maarten;
Heeres, Jan;
Janssen, Paul A.J.;
Arnold, Eddy;
Das, Kalyan;
Clark Jr., Art D.;
Hughes, Stephen H.;
Boyer, Paul L.;
De Béthune, Marie-Pierre;
Pauwels, Rudi;
Andries, Koen;
Kukla, Mike;
Ludovici, Donald;
Decorte, Bart;
Kavash, Robert;
Chih Ho

Publication type:

Article

Structural Implications of Mutations Conferring Rifampin Resistance in Mycobacterium leprae.

Published in:

Scientific Reports, 2018, p. 1, doi. 10.1038/s41598-018-23423-1

By:

Vedithi, Sundeep Chaitanya;
Malhotra, Sony;
Das, Madhusmita;
Daniel, Sheela;
Kishore, Nanda;
George, Anuja;
Arumugam, Shantha;
Rajan, Lakshmi;
Ebenezer, Mannam;
Ascher, David B.;
Arnold, Eddy;
Blundell, Tom L.

Publication type:

Article

Molecular dynamics study of HIV-1 RT-DNA-nevirapine complexes explains NNRTI inhibition and resistance by connection mutations.

Published in:

Proteins, 2014, v. 82, n. 5, p. 815, doi. 10.1002/prot.24460

By:

Vijayan, R. S. K.;
Arnold, Eddy;
Das, Kalyan

Publication type:

Article

Artificial Intelligence and Administrative Discretion.

Published in:

American Review of Public Administration, 1999, v. 29, n. 4, p. 332, doi. 10.1177/02750749922064463

By:

Barth, Thomas J.;
Arnold, Eddy

Publication type:

Article

Structural basis of BLyS receptor recognition.

Published in:

Nature Structural Biology, 2002, v. 9, n. 4, p. 288, doi. 10.1038/nsb769

By:

Oren, Deena A.;
Li, Yuling;
Volovik, Yulia;
Morris, Tina S.;
Dharia, Chhaya;
Das, Kalyan;
Galperina, Olga;
Gentz, Reiner;
Arnold, Eddy

Publication type:

Article

Factors influencing the efficacy of rilpivirine in HIV-1 subtype C in low- and middle-income countries.

Published in:

Journal of Antimicrobial Chemotherapy (JAC), 2016, v. 71, n. 2, p. 367, doi. 10.1093/jac/dkv359

By:

Neogi, Ujjwal;
Häggblom, Amanda;
Singh, Kamalendra;
Rogers, Leonard C.;
Rao, Shwetha D.;
Amogne, Wondwossen;
Schülter, Eugen;
Zazzi, Maurizio;
Arnold, Eddy;
Sarafianos, Stefan G.;
Sönnerborg, Anders

Publication type:

Article

Crystal engineering of HIV-1 reverse transcriptase for structure-based drug design.

Published in:

Nucleic Acids Research, 2008, v. 36, n. 15, p. 5083, doi. 10.1093/nar/gkn464

By:

Bauman, Joseph D.;
Das, Kalyan;
Ho, William C.;
Baweja, Mukta;
Himmel, Daniel M.;
Clark, Arthur D.;
Oren, Deena A.;
Boyer, Paul L.;
Hughes, Stephen H.;
Shatkin, Aaron J.;
Arnold, Eddy

Publication type:

Article

Molecular model of SARS coronavirus polymerase: implications for biochemical functions and drug design.

Published in:

Nucleic Acids Research, 2003, v. 31, n. 24, p. 7117

By:

Xu, Xiang;
Liu, Yunqing;
Weiss, Susan;
Arnold, Eddy;
Sarafianos, Stefan G.;
Ding, Jianping

Publication type:

Article

Structure of HIV‐1 reverse transcriptase/d4TTP complex: Novel DNA cross‐linking site and pH‐dependent conformational changes.

Published in:

Protein Science: A Publication of the Protein Society, 2019, v. 28, n. 3, p. 587, doi. 10.1002/pro.3559

By:

Martinez, Sergio E.;
Bauman, Joseph D.;
Das, Kalyan;
Arnold, Eddy

Publication type:

Article

Structure of HIV-1 reverse transcriptase bound to a novel 38-mer hairpin template-primer DNA aptamer.

Published in:

Protein Science: A Publication of the Protein Society, 2016, v. 25, n. 1, p. 46, doi. 10.1002/pro.2776

By:

Miller, Matthew T.;
Tuske, Steve;
Das, Kalyan;
DeStefano, Jeffrey J.;
Arnold, Eddy

Publication type:

Article

Drug design for the third world: A conference report.

Published in:

Proteins, 2007, v. 66, n. 3, p. 509, doi. 10.1002/prot.21245

By:

Lattman, Eaton E.;
Hol, Wim G. J.;
Arnold, Eddy

Publication type:

Article

Molecular biology: An HIV secret uncovered.

Published in:

Nature, 2008, v. 453, n. 7192, p. 169, doi. 10.1038/453169b

By:

Arnold, Eddy;
Sarafianos, Stefan G.

Publication type:

Article

Michael G. Rossmann (1930–2019), pioneer in macromolecular and virus crystallography: scientist, mentor and friend.

Published in:

Acta Crystallographica: Section D, Structural Biology, 2019, v. 75, n. 6, p. 523, doi. 10.1107/S2059798319008398

By:

Arnold, Eddy;
Wu, Hao;
Johnson, John E.

Publication type:

Article

Correlations between Factors Determining the Pharmacokinetics and Antiviral Activity of HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitors of the Diaryltriazine and Diarylpyrimidine Classes of Compounds.

Published in:

Drugs in R&D, 2004, v. 5, n. 5, p. 245, doi. 10.2165/00126839-200405050-00001

By:

Lewi, Paul;
Arnold, Eddy;
Andries, Koen;
Bohets, Hilde;
Borghys, Herman;
Clark, Arthur;
Daeyaert, Frits;
Das, Kalyan;
de Béthune, Marie-Pierre;
Marc de Jonge;
Heeres, Jan;
Koymans, Luc;
Leempoels, Jos;
Peeters, Jef;
Timmerman, Philip;
Walter Van den Broeck;
Vanhoutte, Frédéric;
Klooster, Gerben van‘t;
Vinkers, Maarten;
Volovik, Yulia

Publication type:

Article

Snapshot of the equilibrium dynamics of a drug bound to HIV-1 reverse transcriptase.

Published in:

Nature Chemistry, 2013, v. 5, n. 3, p. 174, doi. 10.1038/nchem.1559

By:

Kuroda, Daniel G.;
Bauman, Joseph D.;
Challa, J. Reddy;
Patel, Disha;
Troxler, Thomas;
Das, Kalyan;
Arnold, Eddy;
Hochstrasser, Robin M.

Publication type:

Article

Structures of Wild-Type and AZT-Resistant HIV-1 Reverse Transcriptase Complexed with AZTppppA Yield Insights into the Nucleotide Excision Mechanism.

Published in:

FASEB Journal, 2007, v. 21, n. 5, p. A640

By:

Xiongying Tu;
Sarafianos, Stefan G.;
Qianwei Han;
Kalyan Das;
Xiaorong Hou;
Bauman, Joe;
Clark, Arthur D.;
Gaffney, Babara L.;
Jones, Roger A.;
Boyer, Paul L.;
Hughes, Stephen H.;
Arnold, Eddy

Publication type:

Article

Spectroscopic Studies of Rilpivirine (TMC278/R278474) in Complex with HIV-1 Reverse Transcriptase.

Published in:

FASEB Journal, 2007, v. 21, n. 5, p. A630, doi. 10.1096/fasebj.21.5.a630-c

By:

Rashin, Abraham H. L.;
Steege, Karen E.;
Lee, Benjamin J.;
Das, Kalyan;
Bauman, Joe;
Frenke, Yulia V.;
Arnold, Eddy;
Castner Jr., Edward W.

Publication type:

Article

Crystal Structure of a Retroviral Polyprotein: Prototype Foamy Virus Protease-Reverse Transcriptase (PR-RT).

Published in:

Viruses (1999-4915), 2021, v. 13, n. 8, p. 1495, doi. 10.3390/v13081495

By:

Harrison, Jerry Joe E. K.;
Tuske, Steve;
Das, Kalyan;
Ruiz, Francesc X.;
Bauman, Joseph D.;
Boyer, Paul L.;
DeStefano, Jeffrey J.;
Hughes, Stephen H.;
Arnold, Eddy

Publication type:

Article

Drug Resistance in Non-B Subtype HIV-1: Impact of HIV-1 Reverse Transcriptase Inhibitors.

Published in:

Viruses (1999-4915), 2014, v. 6, n. 9, p. 3535, doi. 10.3390/v6093535

By:

Singh, Kamalendra;
Flores, Jacqueline A.;
Kirby, Karen A.;
Neogi, Ujjwal;
Sonnerborg, Anders;
Atsuko Hachiya;
Das, Kalyan;
Arnold, Eddy;
McArthur, Carole;
Parniak, Michael;
Sarafianos, Stefan G.

Publication type:

Article

Chimeric Rhinoviruses Displaying MPER Epitopes Elicit Anti-HIV Neutralizing Responses.

Published in:

PLoS ONE, 2013, v. 8, n. 9, p. 1, doi. 10.1371/journal.pone.0072205

By:

Yi, Guohua;
Lapelosa, Mauro;
Bradley, Rachel;
Mariano, Thomas M.;
Dietz, Denise Elsasser;
Hughes, Scott;
Wrin, Terri;
Petropoulos, Chris;
Gallicchio, Emilio;
Levy, Ronald M.;
Arnold, Eddy;
Arnold, Gail Ferstandig

Publication type:

Article

A comparison of the ability of rilpivirine (TMC278) and selected analogues to inhibit clinically relevant HIV-1 reverse transcriptase mutants.

Published in:

Retrovirology, 2012, v. 9, n. 1, p. 99, doi. 10.1186/1742-4690-9-99

By:

Johnson, Barry C.;
Pauly, Gary T.;
Rai, Ganesha;
Patel, Disha;
Bauman, Joseph D.;
Baker, Heather L.;
Das, Kalyan;
Schneider, Joel P.;
Maloney, David J.;
Arnold, Eddy;
Thomas, Craig J.;
Hughes, Stephen H.

Publication type:

Article

Non-Nucleoside Reverse Transcriptase Inhibitors Join Forces with Integrase Inhibitors to Combat HIV.

Published in:

Pharmaceuticals (14248247), 2020, v. 13, n. 6, p. 122, doi. 10.3390/ph13060122

By:

Himmel, Daniel M.;
Arnold, Eddy

Publication type:

Article

Aryl and Arylalkyl Substituted 3‐Hydroxypyridin‐2(1H)‐ones: Synthesis and Evaluation as Inhibitors of Influenza A Endonuclease.

Published in:

ChemMedChem, 2019, v. 14, n. 12, p. 1204, doi. 10.1002/cmdc.201900084

By:

Sagong, Hye Yeon;
Bauman, Joseph D.;
Nogales, Aitor;
Martínez‐Sobrido, Luis;
Arnold, Eddy;
LaVoie, Edmond J.

Publication type:

Article

Structures of HIV-1 reverse transcriptase with pre- and post-translocation AZTMP-terminated DNA.

Published in:

EMBO Journal, 2002, v. 21, n. 23, p. 6614, doi. 10.1093/emboj/cdf637

By:

Sarafinos, Stefan G.;
Clark Jr., Arthur D.;
Das, Kalyan;
Tuske, Steve;
Birktoft, Jens J.;
Ilankumaran, Palanichamy;
Ramesha, Andagar R.;
Sayer, Jane M.;
Jerina, Donald M.;
Boyer, Paul L.;
Hughes, Stephen H.;
Arnold, Eddy

Publication type:

Article

Targeting HIV-1 Reverse Transcriptase Using a Fragment-Based Approach.

Published in:

Molecules, 2023, v. 28, n. 7, p. 3103, doi. 10.3390/molecules28073103

By:

Mansouri, Mahta;
Rumrill, Shawn;
Dawson, Shane;
Johnson, Adam;
Pinson, Jo-Anne;
Gunzburg, Menachem J.;
Latham, Catherine F.;
Barlow, Nicholas;
Mbogo, George W.;
Ellenberg, Paula;
Headey, Stephen J.;
Sluis-Cremer, Nicolas;
Tyssen, David;
Bauman, Joseph D.;
Ruiz, Francesc X.;
Arnold, Eddy;
Chalmers, David K.;
Tachedjian, Gilda

Publication type:

Article

Discovery of diarylpyrimidine derivatives bearing piperazine sulfonyl as potent HIV-1 nonnucleoside reverse transcriptase inhibitors.

Published in:

Communications Chemistry, 2023, v. 6, n. 1, p. 1, doi. 10.1038/s42004-023-00888-4

By:

Jiang, Xiangyi;
Huang, Boshi;
Rumrill, Shawn;
Pople, David;
Zalloum, Waleed A.;
Kang, Dongwei;
Zhao, Fabao;
Ji, Xiangkai;
Gao, Zhen;
Hu, Lide;
Wang, Zhao;
Xie, Minghui;
De Clercq, Erik;
Ruiz, Francesc X.;
Arnold, Eddy;
Pannecouque, Christophe;
Liu, Xinyong;
Zhan, Peng

Publication type:

Article

Structures of HIV-1 RT-RNA/DNA ternary complexes with dATP and nevirapine reveal conformational flexibility of RNA/DNA: insights into requirements for RNase H cleavage.

Published in:

Nucleic Acids Research, 2014, v. 42, n. 12, p. 8125, doi. 10.1093/nar/gku487

By:

Das, Kalyan;
Martinez, Sergio E.;
Bandwar, Rajiv P.;
Arnold, Eddy

Publication type:

Article

Design of quinoline SARS-CoV-2 papain-like protease inhibitors as oral antiviral drug candidates.

Published in:

Nature Communications, 2025, v. 16, n. 1, p. 1, doi. 10.1038/s41467-025-56902-x

By:

Jadhav, Prakash;
Liang, Xueying;
Ansari, Ahmadullah;
Tan, Bin;
Tan, Haozhou;
Li, Kan;
Chi, Xiang;
Ford, Alexandra;
Ruiz, Francesc Xavier;
Arnold, Eddy;
Deng, Xufang;
Wang, Jun

Publication type:

Article

Why Do HIV-1 and HIV-2 Use Different Pathways to Develop AZT Resistance?

Published in:

PLoS Pathogens, 2006, v. 2, n. 2, p. 0101, doi. 10.1371/journal.ppat.0020010

By:

Paul L., Boyer;
Stefan G., Sarafianos;
Patrick K., Clark;
Eddy, Arnold;
Stephen H., Hughes

Publication type:

Article

CATTLE CALL.

Published in:

2019

By:

Heineman, Kent

Publication type:

Joke/Riddle

VARIOUS ARTISTS • «MORE COUNTRY HITS».

Published in:

2016

By:

Olofsson, Claes-Håkan

Publication type:

Music Review