Works matching DNA alkylation

Results: 379

Archaeal DNA alkylation repair conducted by DNA glycosylase and methyltransferase.

Published in:

Applied Microbiology & Biotechnology, 2023, v. 107, n. 10, p. 3131, doi. 10.1007/s00253-023-12506-3

By:

Yin, Youcheng;
Zhang, Likui

Publication type:

Article

Interdependent Sequence Selectivity and Diastereoselectivity in the Alkylation of DNA by Decarbamoylmitomycin C.

Published in:

Chemistry - A European Journal, 2018, v. 24, n. 50, p. 13278, doi. 10.1002/chem.201802038

By:

Aguilar, William;
Paz, Manuel M.;
Vargas, Anayatzinc;
Zheng, Maggie;
Cheng, Shu‐yuan;
Champeil, Elise

Publication type:

Article

Versatile cell-based assay for measuring DNA alkylation damage and its repair.

Published in:

Scientific Reports, 2021, v. 11, n. 1, p. 1, doi. 10.1038/s41598-021-97523-w

By:

Li, Yong;
Mao, Peng;
Basenko, Evelina Y.;
Lewis, Zachary;
Smerdon, Michael J.;
Czaja, Wioletta

Publication type:

Article

Sequence-Specific DNA Alkylation by Tandem Py-Im Polyamide Conjugates.

Published in:

Chemistry - An Asian Journal, 2014, v. 9, n. 9, p. 2527, doi. 10.1002/asia.201402331

By:

Taylor, Rhys Dylan;
Kawamoto, Yusuke;
Hashiya, Kaori;
Bando, Toshikazu;
Sugiyama, Hiroshi

Publication type:

Article

DNA Polymerases ImuC and DinB Are Involved in DNA Alkylation Damage Tolerance in Pseudomonas aeruginosa and Pseudomonas putida.

Published in:

PLoS ONE, 2017, v. 12, n. 1, p. 1, doi. 10.1371/journal.pone.0170719

By:

Jatsenko, Tatjana;
Sidorenko, Julia;
Saumaa, Signe;
Kivisaar, Maia

Publication type:

Article

Alkyladenine DNA glycosylase deficiency uncouples alkylation-induced strand break generation from PARP-1 activation and glycolysis inhibition.

Published in:

Scientific Reports, 2020, v. 10, n. 1, p. 1, doi. 10.1038/s41598-020-59072-6

By:

Alhumaydhi, Fahad A.;
de O. Lopes, Debora;
Bordin, Diana L.;
Aljohani, Abdullah S. M.;
Lloyd, Cameron B.;
McNicholas, Michael D.;
Milano, Larissa;
Charlier, Clara F.;
Villela, Izabel;
Henriques, João Antonio P.;
Plant, Kathryn E.;
Elliott, Ruan M.;
Meira, Lisiane B.

Publication type:

Article

DNA Alkylation Damage by Nitrosamines and Relevant DNA Repair Pathways.

Published in:

International Journal of Molecular Sciences, 2023, v. 24, n. 5, p. 4684, doi. 10.3390/ijms24054684

By:

Fahrer, Jörg;
Christmann, Markus

Publication type:

Article

Synthesis and in vitro anticancer evaluation of 1,8-naphthalimide N(4) and S(4)-derivatives combining DNA intercalation and alkylation capabilities.

Published in:

Research on Chemical Intermediates, 2016, v. 42, n. 3, p. 1741, doi. 10.1007/s11164-015-2115-1

By:

Brider, Tamara;
Redko, Boris;
Oron-Herman, Mor;
Cohen-Matzlich, Adi;
Gerlitz, Gabriel;
Gellerman, Gary;
Grynszpan, Flavio

Publication type:

Article

Evaluation of the DNA Alkylation Properties of a Chlorambucil‐Conjugated Cyclic Pyrrole‐Imidazole Polyamide.

Published in:

Chemistry - A European Journal, 2021, v. 27, n. 8, p. 2782, doi. 10.1002/chem.202004421

By:

Hirose, Yuki;
Hashiya, Kaori;
Bando, Toshikazu;
Sugiyama, Hiroshi

Publication type:

Article

Sequence-Specific DNA Alkylation Targeting for Kras Codon 13 Mutation by Pyrrole–Imidazole Polyamide seco-CBI Conjugates.

Published in:

Chemistry - A European Journal, 2014, v. 20, n. 5, p. 1310, doi. 10.1002/chem.201303295

By:

Taylor, Rhys Dylan;
Asamitsu, Sefan;
Takenaka, Tomohiro;
Yamamoto, Makoto;
Hashiya, Kaori;
Kawamoto, Yusuke;
Bando, Toshikazu;
Nagase, Hiroki;
Sugiyama, Hiroshi

Publication type:

Article

Preliminary study of mechanism of action of SN38 derivatives. Physicochemical data, evidence of interaction and alkylation of DNA octamer d(GCGATCGC)2.

Published in:

Magnetic Resonance in Chemistry, 2017, v. 55, n. 2, p. 128, doi. 10.1002/mrc.4508

By:

Naumczuk, Beata;
Kawęcki, Robert;
Bocian, Wojciech;
Bednarek, Elżbieta;
Sitkowski, Jerzy;
Kozerski, Lech

Publication type:

Article

Analysis of DNA alkylation damage and repair in mammalian cells by the comet assay.

Published in:

Mutagenesis, 1996, v. 11, n. 2, p. 169, doi. 10.1093/mutage/11.2.169

By:

Fortini, P.;
Raspaglio, G.;
Falchi, M.;
Dogliotti, E.

Publication type:

Article

Sequence selectivity of azinomycin B in DNA alkylation and cross-linking: a QM/MM study.

Published in:

Journal of Molecular Modeling, 2013, v. 19, n. 1, p. 383, doi. 10.1007/s00894-012-1557-2

By:

Senthilnathan, Dhurairajan;
Kalaiselvan, Anbarasan;
Venuvanalingam, Ponnambalam

Publication type:

Article

Development of the adverse outcome pathway 'alkylation of DNA in male premeiotic germ cells leading to heritable mutations' using the OECD's users' handbook supplement.

Published in:

Environmental & Molecular Mutagenesis, 2015, v. 56, n. 9, p. 724, doi. 10.1002/em.21954

By:

Yauk, Carole L.;
Lambert, Iain B.;
Meek, M.E. (Bette);
Douglas, George R.;
Marchetti, Francesco

Publication type:

Article

Glutamine deficiency induces DNA alkylation damage and sensitizes cancer cells to alkylating agents through inhibition of ALKBH enzymes.

Published in:

PLoS Biology, 2017, v. 15, n. 11, p. 1, doi. 10.1371/journal.pbio.2002810

By:

Tran, Thai Q.;
Ishak Gabra, Mari B.;
Lowman, Xazmin H.;
Yang, Ying;
Reid, Michael A.;
Pan, Min;
O’Connor, Timothy R.;
Kong, Mei

Publication type:

Article

Protein Recognition in Drug-Induced DNA Alkylation: When the Moonlight Protein GAPDH Meets S23906-1/DNA Minor Groove Adducts.

Published in:

International Journal of Molecular Sciences, 2015, v. 16, n. 11, p. 26555, doi. 10.3390/ijms161125971

By:

Savreux-Lenglet, Gaëlle;
Depauw, Sabine;
David-Cordonnier, Marie-Hélène

Publication type:

Article

REV1 coordinates a multi-faceted tolerance response to DNA alkylation damage and prevents chromosome shattering in Drosophila melanogaster.

Published in:

PLoS Genetics, 2024, v. 20, n. 7, p. 1, doi. 10.1371/journal.pgen.1011181

By:

Khodaverdian, Varandt;
Sano, Tokio;
Maggs, Lara;
Tomarchio, Gina;
Dias, Ana;
Tran, Mai;
Clairmont, Connor;
McVey, Mitch

Publication type:

Article

Insight into the molecular initiating event of mutagenic N-nitrosamines: a computational study on DNA alkylation by their diazonium ions.

Published in:

Environmental Toxicology & Chemistry, 2025, v. 44, n. 3, p. 777, doi. 10.1093/etojnl/vgae088

By:

Cheng, Shiyang;
Qiu, Houjun;
Ding, Wen;
Kong, Chuiyuan;
Ma, Juchen;
Hou, Runze;
Liu, Chunsheng;
Ji, Li

Publication type:

Article

Synthesis of Various Water Soluble and Stable Copper Complexes Bearing N‐Heterocyclic Carbene Ligands and Their Activity in DNA Alkylation.

Published in:

Helvetica Chimica Acta, 2019, v. 102, n. 1, p. N.PAG, doi. 10.1002/hlca.201800183

By:

Geigle, Stefanie;
Rasale, Dnyaneshwar B.;
Gillingham, Dennis

Publication type:

Article

DNA Alkylation of the RUNX‐Binding Sequence by CBI–PI Polyamide Conjugates**.

Published in:

Chemistry - A European Journal, 2020, v. 26, n. 64, p. 14639, doi. 10.1002/chem.202002166

By:

Maeda, Rina;
Ito, Shinji;
Hashiya, Kaori;
Bando, Toshikazu;
Sugiyama, Hiroshi

Publication type:

Article

Pseudomonas putida AlkA and AlkB Proteins Comprise Different Defense Systems for the Repair of Alkylation Damage to DNA – In Vivo, In Vitro, and In Silico Studies.

Published in:

PLoS ONE, 2013, v. 8, n. 10, p. 1, doi. 10.1371/journal.pone.0076198

By:

Mielecki, Damian;
Saumaa, Signe;
Wrzesiński, Michał;
Maciejewska, Agnieszka M.;
Żuchniewicz, Karolina;
Sikora, Anna;
Piwowarski, Jan;
Nieminuszczy, Jadwiga;
Kivisaar, Maia;
Grzesiuk, Elżbieta

Publication type:

Article

Mutagenicity and toxicity of the DNA alkylation carcinogens 1, 2-dimethylhydrazine and azoxymethane in Escherichia coli and Salmonella typhimurium.

Published in:

Mutagenesis, 1996, v. 11, n. 3, p. 241, doi. 10.1093/mutage/11.3.241

By:

Wei, Xiao;
Nowak, Malgorzata;
Laferte, Suzanne;
Fontanie, Treena

Publication type:

Article

"Repaired and Activated" DNAzyme Enables the Monitoring of DNA Alkylation Repair in Live Cells.

Published in:

Angewandte Chemie, 2021, v. 133, n. 36, p. 20042, doi. 10.1002/ange.202106557

By:

Wang, Xiangnan;
Yi, Xin;
Huang, Zhimei;
He, Jianjun;
Wu, Zhenkun;
Chu, Xia;
Jiang, Jian‐Hui

Publication type:

Article

Inhibition of DNA alkylation damage with inorganic salts.

Published in:

Journal of Biological Inorganic Chemistry (JBIC), 2004, v. 9, n. 7, p. 894, doi. 10.1007/s00775-004-0597-1

By:

Hamilton, Elizabeth E.;
Wilker, Jonathan J.

Publication type:

Article

Dual-Action Therapeutics: DNA Alkylation and Antimicrobial Peptides for Cancer Therapy.

Published in:

Cancers, 2024, v. 16, n. 18, p. 3123, doi. 10.3390/cancers16183123

By:

Andrés, Celia María Curieses;
Pérez de la Lastra, José Manuel;
Munguira, Elena Bustamante;
Andrés Juan, Celia;
Pérez-Lebeña, Eduardo

Publication type:

Article

Sequence selectivity of DNA alkylation by adozelesin and carzelesin.

Published in:

Archives of Pharmacal Research, 1998, v. 21, n. 4, p. 385, doi. 10.1007/BF02974631

By:

Yoon, Jung-Hoon;
Lee, Chong-Soon

Publication type:

Article

DNA alkylation and neuro-oncogenesis by 3,3-dimethyl-1-phenyltriazene.

Published in:

Acta Neuropathologica, 1978, v. 43, n. 1/2, p. 105, doi. 10.1007/BF00685004

By:

Cooper, H.;
Hauenstein, E.;
Kolar, G.;
Kleihues, P.

Publication type:

Article

Activation barriers for DNA alkylation by carcinogenic methane diazonium ions.

Published in:

Journal of Computational Chemistry, 2006, v. 27, n. 3, p. 277, doi. 10.1002/jcc.20334

By:

Ekanayake, Kaushalya S.;
Lebreton, Pierre R.

Publication type:

Article

Alkylation and Cleavage of a DNA Fragment with Trioligonucleotide Reagent.

Published in:

Nucleosides, Nucleotides & Nucleic Acids, 2004, v. 23, n. 6/7, p. 825, doi. 10.1081/NCN-200026023

By:

Oshevski, S.I.

Publication type:

Article

2-[2-(Aziridin-1-yl)ethyl]-5,5-dimethyl-2,5-dihydro-4H-benzo [e]isoindol-4-one (Cytotoxic Oxonaphthalene-Pyrroles, Part IV).

Published in:

Molbank, 2012, v. 12, n. 4, p. 1, doi. 10.3390/M781

By:

Spreitzer, Helmut;
Puschmann, Christiane

Publication type:

Article

2-[3-(Aziridin-1-yl)-2-hydroxypropyl]-5,5-dimethyl-2,5-dihydro-4H-benzo[e]isoindol-4-one (Cytotoxic Oxonaphthalene-Pyrroles, Part III).

Published in:

Molbank, 2012, v. 12, n. 3, p. 1, doi. 10.3390/M772

By:

Spreitzer, Helmut;
Puschmann, Christiane

Publication type:

Article

Synthesis of 2‐Chloro‐3‐amino indenone derivatives and their evaluation as inhibitors of DNA dealkylation repair.

Published in:

Chemical Biology & Drug Design, 2021, v. 97, n. 6, p. 1170, doi. 10.1111/cbdd.13839

By:

Nigam, Richa;
Raveendra Babu, Kaki;
Ghosh, Topi;
Kumari, Bhavini;
Das, Prolay;
Anindya, Roy;
Ahmed Khan, Faiz

Publication type:

Article

Insight Into Factors Governing Formation, Synthesis and Stereochemical Configuration of DNA Adducts Formed by Mitomycins.

Published in:

Chemical Record, 2023, v. 23, n. 1, p. 1, doi. 10.1002/tcr.202200193

By:

Paz, Manuel M.;
Champeil, Elise

Publication type:

Article

Hoogsteen Base Pairings: A New Paradigm for DNA Replication, DNA Recognition, and DNA Repair.

Published in:

Journal of Experimental & Molecular Biology, 2022, v. 23, n. 1, p. 78, doi. 10.47743/jemb-2022-72

By:

Datta, Neelabh

Publication type:

Article

The interaction of DNA repair factors ASCC2 and ASCC3 is affected by somatic cancer mutations.

Published in:

Nature Communications, 2020, v. 11, n. 1, p. N.PAG, doi. 10.1038/s41467-020-19221-x

By:

Jia, Junqiao;
Absmeier, Eva;
Holton, Nicole;
Pietrzyk-Brzezinska, Agnieszka J.;
Hackert, Philipp;
Bohnsack, Katherine E.;
Bohnsack, Markus T.;
Wahl, Markus C.

Publication type:

Article

Alkylation of duplex DNA in nucleosome core particles by duocarmycin SA and yatakemycin.

Published in:

Nature Chemical Biology, 2006, v. 2, n. 2, p. 79, doi. 10.1038/nchembio761

By:

Trzupek, John D.;
Gottesfeld, Joel M.;
Boger, Dale L.

Publication type:

Article

Aag DNA Glycosylase Promotes Alkylation-Induced Tissue Damage Mediated by Parp1.

Published in:

PLoS Genetics, 2013, v. 9, n. 4, p. 1, doi. 10.1371/journal.pgen.1003413

By:

Calvo, Jennifer A.;
Moroski-Erkul, Catherine A.;
Lake, Annabelle;
Eichinger, Lindsey W.;
Shah, Dharini;
Jhun, Iny;
Limsirichai, Prajit;
Bronson, Roderick T.;
Christiani, David C.;
Meira, Lisiane B.;
Samson, Leona D.

Publication type:

Article

A systematic review on multipotent carcinogenic agent, N‐nitrosodiethylamine (NDEA), its major risk assessment, and precautions.

Published in:

Journal of Applied Toxicology, 2024, v. 44, n. 8, p. 1108, doi. 10.1002/jat.4574

By:

Janmeda, Pracheta;
Jain, Divya;
Chaudhary, Priya;
Meena, Mukesh;
Singh, Devendra

Publication type:

Article

PARG dysfunction enhances DNA double strand break formation in S-phase after alkylation DNA damage and augments different cell death pathways.

Published in:

Cell Death & Disease, 2013, v. 4, n. 6, p. 1, doi. 10.1038/cddis.2013.133

By:

H. Shirai;
A. R. Poetsch;
A. Gunji;
D. Maeda;
H. Fujimori;
H. Fujihara;
T. Yoshida;
H. Ogino;
M. Masutani

Publication type:

Article

The Mechanism of Action of Cyclophosphamide and Its Consequences for the Development of a New Generation of Oxazaphosphorine Cytostatics.

Published in:

Scientia Pharmaceutica, 2020, v. 88, n. 4, p. 1, doi. 10.3390/scipharm88040042

By:

Voelcker, Georg

Publication type:

Article

4,5-Dihydro-1,2,3-oxadiazole: A Very Elusive Key Intermediate in Various Important Chemical Transformations.

Published in:

Chemistry - A European Journal, 2015, v. 21, n. 43, p. 15092, doi. 10.1002/chem.201502326

By:

Banert, Klaus;
Singh, Neeraj;
Fiedler, Benjamin;
Friedrich, Joachim;
Korb, Marcus;
Lang, Heinrich

Publication type:

Article

Quantum chemical calculations of nitrosamine activation and deactivation pathways for carcinogenicity risk assessment.

Published in:

Frontiers in Pharmacology, 2024, p. 1, doi. 10.3389/fphar.2024.1415266

By:

Göller, Andreas H.;
Johanssen, Sandra;
Zalewski, Adam;
Ziegler, Verena

Publication type:

Article

Inflammation, necrosis, and the kinase RIP3 are key mediators of AAG-dependent alkylation-induced retinal degeneration.

Published in:

Science Signaling, 2019, v. 12, n. 568, p. N.PAG, doi. 10.1126/scisignal.aau9216

By:

Allocca, Mariacarmela;
Corrigan, Joshua J.;
Mazumder, Aprotim;
Fake, Kimberly R.;
Samson, Leona D.

Publication type:

Article

Analysis of the Tolerance to DNA Alkylating Damage in MEC1 and RAD53 Checkpoint Mutants of Saccharomyces cerevisiae.

Published in:

PLoS ONE, 2013, v. 8, n. 11, p. 1, doi. 10.1371/journal.pone.0081108

By:

Gallego-Sánchez, Alfonso;
Ufano, Sandra;
Andrés, Sonia;
Bueno, Avelino

Publication type:

Article

Cover Feature: Understanding the Alkylation Mechanism of 3‐Chloropiperidines – NMR Kinetic Studies and Isolation of Bicyclic Aziridinium Ions (Eur. J. Org. Chem. 44/2021).

Published in:

European Journal of Organic Chemistry, 2021, v. 2021, n. 44, p. 5896, doi. 10.1002/ejoc.202101371

By:

Helbing, Tim;
Georg, Mats;
Stöhr, Fabian;
Carraro, Caterina;
Becker, Jonathan;
Gatto, Barbara;
Göttlich, Richard

Publication type:

Article

Understanding the Alkylation Mechanism of 3‐Chloropiperidines – NMR Kinetic Studies and Isolation of Bicyclic Aziridinium Ions.

Published in:

European Journal of Organic Chemistry, 2021, v. 2021, n. 44, p. 5905, doi. 10.1002/ejoc.202101072

By:

Helbing, Tim;
Georg, Mats;
Stöhr, Fabian;
Carraro, Caterina;
Becker, Jonathan;
Gatto, Barbara;
Göttlich, Richard

Publication type:

Article

Immunological and mass spectrometry-based approaches to determine thresholds of the mutagenic DNA adduct O6-methylguanine in vivo.

Published in:

Archives of Toxicology, 2019, v. 93, n. 2, p. 559, doi. 10.1007/s00204-018-2355-0

By:

Kraus, Alexander;
McKeague, Maureen;
Seiwert, Nina;
Nagel, Georg;
Geisen, Susanne M.;
Ziegler, Nathalie;
Trantakis, Ioannis A.;
Kaina, Bernd;
Thomas, Adam D.;
Sturla, Shana J.;
Fahrer, Jörg

Publication type:

Article

An evidence-based review of the genotoxic and reproductive effects of sulfur mustard.

Published in:

Archives of Toxicology, 2017, v. 91, n. 3, p. 1143, doi. 10.1007/s00204-016-1911-8

By:

Khan, Fazlullah;
Niaz, Kamal;
Ismail Hassan, Fatima;
Abdollahi, Mohammad

Publication type:

Article

Antimutagenic components in Spatholobus suberectus Dunn against N-methyl-N-nitrosourea.

Published in:

Genes & Environment, 2019, v. 41, n. 1, p. 1, doi. 10.1186/s41021-019-0137-4

By:

Inami, Keiko;
Asada, Yoshihisa;
Harada, Takumi;
Okayama, Yuta;
Usui, Noriko;
Mochizuki, Masataka

Publication type:

Article

Chloroethylating anticancer drug-induced mutagenesis and its repair in Escherichia coli.

Published in:

Genes & Environment, 2019, v. 41, n. 1, p. N.PAG, doi. 10.1186/s41021-019-0123-x

By:

Yamada, Yoko;
Watanabe, Shinji;
Okamoto, Keinosuke;
Arimoto, Sakae;
Takahashi, Eizo;
Negishi, Kazuo;
Negishi, Tomoe

Publication type:

Article