Works matching DE "TUMOR microenvironment"

Results: 5000

Stroma areactive invasion front areas (SARIFA) in 1,298 pT3/pT4 colorectal cancers: A strong prognostic parameter complementing established morphological criteria.

Published in:

Histopathology, 2025, v. 87, n. 3, p. 464, doi. 10.1111/his.15501

By:

Foersch, Sebastian;
Harb, Nuwar;
Litmeyer, Anne‐Sophie;
Roth, Wilfried;
Breus, Irina;
Schraml, Johannes;
Weiß, Annika;
Steiger, Katja;
Teply‐Szymanski, Julia;
Bartsch, Detlef K;
Denkert, Carsten;
Schmitt, Maxime;
Jesinghaus, Moritz

Publication type:

Article

Music therapy in modulating immune responses and enhancing cancer treatment outcomes.

Published in:

Frontiers in Immunology, 2025, p. 1, doi. 10.3389/fimmu.2025.1639047

By:

Fu, Ye;
Wu, Ke;
Zhuang, Jiajia;
Chen, Yisheng;
Jia, Lina;
Luo, Zhiwen;
Sun, Rong

Publication type:

Article

Immunosuppressive cells in acute myeloid leukemia: mechanisms and therapeutic target.

Published in:

Frontiers in Immunology, 2025, p. 1, doi. 10.3389/fimmu.2025.1627161

By:

Liu, Mengnan;
Yang, Mengting;
Qi, Yue;
Ma, Yuting;
Guo, Qulian;
Guo, Ling;
Liu, Chunyan;
Liu, Wenjun;
Xiao, Lan;
Yang, You

Publication type:

Article

Targeting CSC-immune cell crosstalk to overcome chemoresistance and enhance immunotherapy efficacy.

Published in:

Frontiers in Immunology, 2025, p. 1, doi. 10.3389/fimmu.2025.1620807

By:

Yu, Guanxiao;
Gong, Jianbao

Publication type:

Article

Pygo2+ T cells possess immunosuppressive features and inferior immunotherapeutic response in gastric cancer.

Published in:

Frontiers in Immunology, 2025, p. 1, doi. 10.3389/fimmu.2025.1596434

By:

Chang, Weilong;
Yan, Huifang;
Zhang, Yawei;
Sang, Zibo;
Bu, Bei;
Deng, Rui;
Li, Kaibo;
Li, Jiajing;
Fu, Yang;
Cui, Jinyuan

Publication type:

Article

Recent progress in the study of exosomes in the gastric cancer immune microenvironment.

Published in:

Frontiers in Immunology, 2025, p. 1, doi. 10.3389/fimmu.2025.1595124

By:

Liu, Haibo;
Zhu, Lei;
Yin, Jianmei

Publication type:

Article

WISP1 drives esophageal squamous cell carcinoma progression via modulation of cancer-associated fibroblasts and immune microenvironment.

Published in:

Frontiers in Immunology, 2025, p. 1, doi. 10.3389/fimmu.2025.1586790

By:

Yi, Zhiqiang;
Zhang, Qiqi;
Tao, Ting;
Liu, Xiaojia;
Li, Hui;
Li, Xiujuan;
Zhang, Zhiqiang

Publication type:

Article

Signalling pathways and cellular functions of KDEL receptors: implications in cancer biology.

Published in:

Cellular & Molecular Life Sciences, 2025, v. 82, n. 1, p. 1, doi. 10.1007/s00018-025-05820-8

By:

Dufrusine, Beatrice;
Cela, Ilaria;
Gramegna Tota, Chiara;
Palumbo, Marta;
Sallese, Michele

Publication type:

Article

Letter to editor: SIGMAR1 screened by a GPCR-related classifier regulates endoplasmic reticulum stress in bladder cancer.

Published in:

2025

By:

Zhang, Xiaoman;
Cong, Yipeng;
Zheng, Xu;
Wu, Guangzhen

Publication type:

Letter

An oral heme oxygenase inhibitor targets immunosuppressive perivascular macrophages in preclinical models of cancer.

Published in:

Science Translational Medicine, 2025, v. 17, n. 810, p. 1, doi. 10.1126/scitranslmed.ads3085

By:

Bahri, Meriem;
Al-Adhami, Taha;
Demirel, Emre;
Sarkar, Jit;
Feehan, Karen T.;
Anstee, Joanne E.;
Cheung, Tik Shing;
Sosnowska, Dominika;
Woodman, Chloé A.;
Macmorland, William;
Yang, Dorothy D.;
Rosekilly, James;
Gitsaki-Taylor, Renee;
Gillett, Cheryl E.;
Scudamore, Cheryl L.;
Spicer, James;
Rahman, Khondaker Miraz;
Arnold, James N.

Publication type:

Article

Unlocking the secret of glioblastoma multiforme: the role of lactylation in tumor progression, drug resistance and immune microenvironment.

Published in:

Cancer Cell International, 2025, v. 25, n. 1, p. 1, doi. 10.1186/s12935-025-03933-5

By:

Xiao, Yifei;
Zheng, Ruipeng;
Lv, Fengjun;
Yang, Guang;
Ge, Haitao;
Yang, Mingchun;
Wang, Kan;
Cheng, Yu

Publication type:

Article

Multi-omics profiling of metastatic colorectal cancer reveals the transcriptional network of focal adhesion and immune suppression and the role of p-RPS6.

Published in:

Cancer Cell International, 2025, v. 25, n. 1, p. 1, doi. 10.1186/s12935-025-03924-6

By:

Jiang, Yimei;
Li, Zhe;
Zheng, Fang;
Jia, Wenqing;
Guo, Zichao;
Xu, Zhuoqing;
Huang, Chenhao;
Li, Zhiliang;
Wang, Changgang;
Liu, Kun;
Feng, Haoran;
Zhao, Ren;
Cheng, Xi

Publication type:

Article

Investigating the potential role of miR-451a as a tumor suppressor in immunogenic cell death induction and dendritic cell maturation in colorectal cancer cell lines.

Published in:

Cancer Cell International, 2025, v. 25, n. 1, p. 1, doi. 10.1186/s12935-025-03919-3

By:

Azizi, Mahdieh;
Andalib, Alireza;
Rezaei, Marzieh

Publication type:

Article

Enhanced homing and efficacy of HER2-CAR T cells via CXCR5/CCR6 co-expression for HER2-positive NSCLC.

Published in:

Journal of Translational Medicine, 2025, v. 23, n. 1, p. 1, doi. 10.1186/s12967-025-06866-9

By:

Hu, Xiaoyuan;
Ge, Chunlei;
Huang, Caixiu;
He, Dan;
Yao, Xiaoxuan;
Cheng, Jiaxing;
Guo, Jiyin;
Li, Ke;
Ye, Yunshan;
Li, Li;
Xia, Jianchuan;
Li, Tao;
Yao, Hong

Publication type:

Article

Distinct Lung Adenocarcinoma-Associated Microbiota Are Associated with Inflammatory Immune Landscapes and Tumor Cell Proliferation via LCIIAR–ISG15 Regulatory Networks.

Published in:

Cancer Management & Research, 2025, v. 17, p. 1315, doi. 10.2147/CMAR.S520098

By:

Liu, Shipu;
Zhang, Zijian

Publication type:

Article

Tumor-derived small extracellular vesicles reprogram sensory nerves to drive immunosuppression in the tumor microenvironment.

Published in:

Science Signaling, 2025, v. 18, n. 898, p. 1, doi. 10.1126/scisignal.ady6769

By:

Boyd, Leah;
Borniger, Jeremy C.

Publication type:

Article

Identification of novel molecular subtypes and construction of a prognostic signature via multi-omics analysis and machine learning in lung adenocarcinoma.

Published in:

Frontiers in Oncology, 2025, p. 1, doi. 10.3389/fonc.2025.1590216

By:

Ma, Ke;
Xu, Jie;
Wang, Congyue;
Cao, Xu;
Yu, Wenjie;
Xi, Jingjing;
Zhang, Xuan;
Zhan, Jiamin;
Liu, Yang;
Yu, Aoyang;
Liu, Shuhan;
Liu, Yanhua;
Chen, Chong;
Mai, Xiaoli

Publication type:

Article

The protease-activated receptors are expressed in glioblastoma and differentially modulate adherent versus stem-like growth of LN-18 GBM cells.

Published in:

Frontiers in Oncology, 2025, p. 1, doi. 10.3389/fonc.2025.1582996

By:

Bien-Möller, Sandra;
Grober, Antonia;
Albrecht, Judith;
Paland, Heiko;
Weitmann, Kerstin;
Bialke, Angela;
Marx, Sascha;
Vogelgesang, Silke;
Tzvetkov, Mladen V.;
Hoffmann, Wolfgang;
Schroeder, Henry W. S.;
Rauch, Bernhard H.

Publication type:

Article

Integrating proteomics and machine learning reveals characteristics and risks of lymph node-independent distant metastasis in colorectal cancer.

Published in:

Frontiers in Immunology, 2025, p. 1, doi. 10.3389/fimmu.2025.1622528

By:

Zheng, Chenxiao;
Zhu, Baiwang;
Chen, Yanyu;
Shahid, Numan;
Hu, Yiwang;
Ali Husain, Hajar Mansoor Ahmed;
Ou, Binbin;
Zhang, Qiongying;
Jin, Haobo;
Zheng, Yating;
Li, Peng;
Pan, Yifei;
Zhang, Xiaodong

Publication type:

Article

Granzyme B and melittin in cancer immunotherapy: molecular mechanisms and therapeutic perspectives in head and neck cancers.

Published in:

Frontiers in Immunology, 2025, p. 1, doi. 10.3389/fimmu.2025.1628014

By:

Majchrzak, Adam;
Lewandowski, Filip;
Hrynkiewicz, Rafał;
Poniewierska-Baran, Agata;
Bębnowska, Dominika;
Niedźwiedzka-Rystwej, Paulina

Publication type:

Article

Unveiling mitochondrial transfer in tumor immune evasion: mechanisms, challenges, and clinical implications.

Published in:

Frontiers in Immunology, 2025, p. 1, doi. 10.3389/fimmu.2025.1625814

By:

Liu, Ruoyan;
Shan, Wenhui;
Wang, Zhening;
Wang, Hong;
Li, Chunyan;
Yang, Lei;
Guo, Rui

Publication type:

Article

DUSP9 is Up-Regulated and Promotes Tumor Progression in Head and Neck Squamous Cell Carcinoma.

Published in:

Journal of Cancer, 2025, v. 16, n. 11, p. 3403, doi. 10.7150/jca.110597

By:

Yuzhe Hu;
Yue Li;
Chenfeng Jiang;
Wenling Han;
Xiaohong Chen;
Pingzhang Wang;
Hongbo Xu

Publication type:

Article

Strategies to Overcome PD-1/PD-L1 Blockade Resistance: Focusing on Combination with Immune Checkpoint Blockades.

Published in:

Journal of Cancer, 2025, v. 16, n. 11, p. 3425, doi. 10.7150/jca.108163

By:

Dinglin Liu;
Haoyue Xiao;
Ying Xiang;
Dian Zhong;
Yuchen Liu;
Yunfei Wang;
Weijia Zhang

Publication type:

Article

Latest Advancements of Natural Products in Combating Ovarian Cancer.

Published in:

Journal of Cancer, 2025, v. 16, n. 11, p. 3497, doi. 10.7150/jca.118209

By:

Yangyuxiao Lu;
Hong Huang;
Yuling Chen;
Keren He;
Mengqi Fang;
Ye Xu;
Yuan Zhou;
Fangfang Tao

Publication type:

Article

Integrating Bulk RNA and Single-cell transcriptome to explore the role of glycan-related genes in lung adenocarcinoma.

Published in:

Journal of Cancer, 2025, v. 16, n. 11, p. 3314, doi. 10.7150/jca.115989

By:

Keyun Zhu;
Changqing Yang;
Guixin Wang;
XingKai Wang;
Chengbin Lin;
Yingxi Li;
Ningning He;
Yao Tian;
Weiyu Shen

Publication type:

Article

Toxicity Assessment of Mesoporous Silica Nanoparticles: Emphasizing Biological Factors in Nano-Bio Interactions.

Published in:

Nano Life, 2026, v. 16, n. 5, p. 1, doi. 10.1142/S179398442540001X

By:

Emmanuel, Odongo Ernest;
Kwak, Eunbi;
Chen, Qian;
Peng, Guotao

Publication type:

Article

Wnt5a suppresses colorectal cancer progression via TGF-β/NOTUM/OLFM4 axis in patient-derived organoids.

Published in:

Cell Communication & Signaling, 2025, v. 23, n. 1, p. 1, doi. 10.1186/s12964-025-02364-z

By:

Huang, Yewei;
Huang, Jiahao;
Yu, Jiazi;
Zhuang, Songlin;
Liu, Ming

Publication type:

Article

COEXIST: Coordinated single-cell integration of serial multiplexed tissue images.

Published in:

PLoS Computational Biology, 2025, v. 21, n. 8, p. 1, doi. 10.1371/journal.pcbi.1013325

By:

Heussner, Robert T.;
Watson, Cameron F.;
Eddy, Christopher Z.;
Wang, Kunlun;
Cramer, Eric M.;
Creason, Allison L.;
Mills, Gordon B.;
Chang, Young Hwan

Publication type:

Article

Cathepsin L‐Activatable Fluorescent Probe for Real‐Time Monitoring of Drug‐Resistant Breast Cancer Cells.

Published in:

Chemistry - A European Journal, 2025, v. 31, n. 43, p. 1, doi. 10.1002/chem.202501624

By:

Yu, Qiqi;
Chen, Sina;
Yu, Liping;
Xu, Dongdong;
Yin, Shouchun

Publication type:

Article

The dual role of CD36 in cancer: from lipid metabolism to tumor microenvironment regulation.

Published in:

Molecular Biology Reports, 2025, v. 52, n. 1, p. 1, doi. 10.1007/s11033-025-10885-6

By:

Yao, Yixuan;
Fang, Yanyuan;
Yuan, Bin;
Yang, Jing

Publication type:

Article

Peripheral nerves-cancer cross-talk: the next frontier in cancer treatment.

Published in:

Molecular & Cellular Biochemistry, 2025, v. 480, n. 8, p. 4533, doi. 10.1007/s11010-025-05256-5

By:

Wang, Leihan;
Qi, Teng;
Tang, Lingyun;
Wang, Yuehan;
ChenLiu, Zhenni;
Wang, Daorong;
Tang, Dong

Publication type:

Article

Development and validation of a hypoxia-immune-based microenvironment gene signature for predicting survival in non-small cell lung cancer.

Published in:

Discover Oncology, 2025, v. 16, n. 1, p. 1, doi. 10.1007/s12672-025-03319-z

By:

Zhang, Xiangwu;
Zhou, Rongxian;
Zhao, Guangqiang;
Chen, Wanling;
Zhao, Ping;
Huang, Yunchao;
Huang, Qiubo;
Ye, Lianhua

Publication type:

Article

Lysosome-derived biomarkers for predicting survival outcome in acute myeloid leukemia.

Published in:

Discover Oncology, 2025, v. 16, n. 1, p. 1, doi. 10.1007/s12672-025-03302-8

By:

Li, Gongchang;
Miao, Yangyang;
Yuan, Fang;
Zhang, Weiran;
Wu, Yali;
Zhu, Liqiang

Publication type:

Article

Decoding tumor-infiltrating lymphocytes heterogeneity in ductal carcinoma in situ: immune microenvironment dynamics and prognostic insights.

Published in:

Discover Oncology, 2025, v. 16, n. 1, p. 1, doi. 10.1007/s12672-025-03288-3

By:

Wang, Lingzi;
Yang, Yalong;
Song, Yuhang;
Zeng, Jiahui;
Zheng, Hongmei;
Wu, Xinhong

Publication type:

Article

Multimodal tumor microenvironment signature of colorectal cancer for prediction prognosis and chemotherapy benefit.

Published in:

NPJ Precision Oncology, 2025, v. 9, n. 1, p. 1, doi. 10.1038/s41698-025-01069-3

By:

Jiang, Wei;
Yang, Kun;
Xiao, Chanchan;
Ji, Hongli;
Yan, Botao;
Zhao, Shuhan;
Zhang, Biao;
Cheng, Jiaxin;
Xu, Shuoyu;
Wang, Guangxing;
Lin, Zexi;
Lu, Jianping;
Chen, Gang;
Zhuo, Shuangmu;
Yan, Jun

Publication type:

Article

Impact of HMGA1 on tumorigenesis, prognosis and immune microenvironment in HNSCC: a multi-omics study.

Published in:

NPJ Precision Oncology, 2025, v. 9, n. 1, p. 1, doi. 10.1038/s41698-025-01068-4

By:

Xu, Ziang;
Wang, Moxu;
Cai, Jilin;
Wang, Tianxiao;
Ni, Nan;
Liu, Tao;
Xue, Maojie;
Wang, Xiang;
Liu, Zhixuan;
Yuan, Hua;
Zhang, Wei;
Zhang, Ruyang

Publication type:

Article

Immune profiling of human vestibular schwannoma secretions identifies TNF-α and TWEAK as cytokines with synergistic potential to impair hearing.

Published in:

Journal of Neuroinflammation, 2025, v. 22, n. 1, p. 1, doi. 10.1186/s12974-025-03364-z

By:

Vasilijic, Sasa;
Seist, Richard;
Yin, Zhenzhen;
Xu, Lei;
Stankovic, Konstantina M.

Publication type:

Article

Promotion of the invasion and metastasis of breast cancer by B7-H3 through CCR5High tumor-associated macrophages.

Published in:

Cancer Cell International, 2025, v. 25, n. 1, p. 1, doi. 10.1186/s12935-025-03932-6

By:

Dai, Tiantian;
Xu, Zhihua;
Li, Yadi;
Wu, Mengni;
Qiu, Yue;
Chao, ZhuJun;
Jiang, Renhai;
Chen, Yan;
Lu, Linlin

Publication type:

Article

Analysis of the immune microenvironment in colorectal cancer with different KRAS gene subtypes.

Published in:

BMC Cancer, 2025, v. 25, n. 1, p. 1, doi. 10.1186/s12885-025-14660-5

By:

Huang, Jing;
Gong, Qian;
Li, Qingshu;
Xiao, Ming;
Li, Ming;
Zhang, Shuxian;
Wang, Yalan;
Tang, Yi

Publication type:

Article

Metabolic checkpoints in immune cell reprogramming: rewiring immunometabolism for cancer therapy.

Published in:

Molecular Cancer, 2025, v. 24, n. 1, p. 1, doi. 10.1186/s12943-025-02407-6

By:

Lv, Yingying;
Li, Zongshang;
Liu, Shutong;
Zhou, Zhaokai;
Song, Jinling;
Ba, Yuhao;
Weng, Siyuan;
Zuo, Anning;
Xu, Hui;
Luo, Peng;
Cheng, Quan;
Zhang, Chuhan;
Ning, Jingyuan;
Chen, Yukang;
Zhang, Yuyuan;
Liu, Zaoqu;
Han, Xinwei

Publication type:

Article

Identification of prognostic genes related to T cell proliferation in papillary thyroid cancer based on single-cell RNA sequencing and bulk RNA sequencing data.

Published in:

Clinical & Experimental Medicine, 2025, v. 25, n. 1, p. 1, doi. 10.1007/s10238-025-01826-5

By:

Meng, Qingkai;
Liu, Hongzhu;
Wang, Mengtong;
Jiang, Xin;
Wang, Yi;
Cao, Xiaoli;
Qu, Nina

Publication type:

Article

Identification of novel molecular subtypes and construction of a prognostic signature via multi-omics analysis and machine learning in lung adenocarcinoma.

Published in:

Frontiers in Oncology, 2025, p. 1, doi. 10.3389/fonc.2025.1590216

By:

Ma, Ke;
Xu, Jie;
Wang, Congyue;
Cao, Xu;
Yu, Wenjie;
Xi, Jingjing;
Zhang, Xuan;
Zhan, Jiamin;
Liu, Yang;
Yu, Aoyang;
Liu, Shuhan;
Liu, Yanhua;
Chen, Chong;
Mai, Xiaoli

Publication type:

Article

JMJD8 overexpression in breast cancer: implications for diagnosis, prognosis, and immune microenvironment interactions.

Published in:

Frontiers in Oncology, 2025, p. 1, doi. 10.3389/fonc.2025.1536278

By:

Zhu, Chenlei;
Xi, Tianyi;
Yang, Guorong;
Lu, Wen;
Wang, Sentai;
Cao, Jiwei

Publication type:

Article

Oncogenic CMTM6 drives M2a macrophages formation and fuels cervical cancer progression.

Published in:

Frontiers in Immunology, 2025, p. 1, doi. 10.3389/fimmu.2025.1621816

By:

Yin, Bo;
Chen, Chun;
Huang, Baoyou;
Ding, Jianyi;
Hu, Haoran;
Zhou, Huijuan;
Zhu, Yashi;
Huang, Tiefeng;
He, Xiang;
Lu, Yuan;
Han, Lingfei

Publication type:

Article

The pyroptosis-related gene signature predicts prognosis and reveals immune microenvironment infiltration in reclassified glioblastoma based on 2021 WHO classification.

Published in:

Frontiers in Immunology, 2025, p. 1, doi. 10.3389/fimmu.2025.1617036

By:

Zheng, Xiaohong;
Pan, Zhangchi;
Chen, Lina;
Wang, Can;
Li, Wenbin

Publication type:

Article

Unraveling NK cell heterogeneity through single-cell sequencing: insights from physiological and tumor contexts for clinical applications.

Published in:

Frontiers in Immunology, 2025, p. 1, doi. 10.3389/fimmu.2025.1612352

By:

Shen, Mingxin;
Liu, Yutong;
Shao, Liang;
Qu, Meng;
Song, Shixin;
Sun, Wei;
Zhang, Hao

Publication type:

Article

Integrated multi-omics analysis and machine learning identify G protein-coupled receptor-related signatures for diagnosis and clinical benefits in soft tissue sarcoma.

Published in:

Frontiers in Immunology, 2025, p. 1, doi. 10.3389/fimmu.2025.1561227

By:

Wang, Duo;
Tu, Jihao;
Liu, Jianfeng;
Piao, Yuting;
Zhao, Yiming;
Xiong, Ying;
Wang, Jianing;
Zheng, Xiaotian;
Liu, Bin

Publication type:

Article

Radiation therapy as a biological modifier of the breast cancer immune microenvironment.

Published in:

NPJ Breast Cancer, 2025, v. 11, n. 1, p. 1, doi. 10.1038/s41523-025-00801-3

By:

Galluzzi, Lorenzo;
Bolini, Lukas;
Shulman, Rebecca M.

Publication type:

Article

TIPE2 combined with immune cell infiltration predicts prognosis in colorectal cancer.

Published in:

Scientific Reports, 2025, v. 15, n. 1, p. 1, doi. 10.1038/s41598-025-10449-5

By:

Xia, Hengbo;
Pang, Qingqing;
Xu, Aman;
Hu, Jie

Publication type:

Article

Necroptosis in cancer: insight from epigenetic, post-transcriptional and post-translational modifications.

Published in:

Journal of Hematology & Oncology, 2025, v. 18, n. 1, p. 1, doi. 10.1186/s13045-025-01726-x

By:

Tang, Jinxin;
Zhuang, Yan;
Zhang, Yibo;
Hu, Hongkun;
Wang, Hua;
Xu, Haodong;
Li, Yintao;
Tu, Chao

Publication type:

Article