Works matching DE "TRYPANOTHIONE"

Results: 24

Understanding the Cross-Talk of Redox Metabolism and Fe-S Cluster Biogenesis in Leishmania Through Systems Biology Approach.

Published in:

Frontiers in Cellular & Infection Microbiology, 2019, v. 9, p. N.PAG, doi. 10.3389/fcimb.2019.00015

By:

Kumar, Anurag;
Chauhan, Nutan;
Singh, Shailza

Publication type:

Article

Trypanocidal Activity of Quinoxaline 1,4 Di-N-oxide Derivatives as Trypanothione Reductase Inhibitors.

Published in:

Molecules, 2017, v. 22, n. 2, p. 220, doi. 10.3390/molecules22020220

By:

Chacón-Vargas, Karla Fabiola;
Nogueda-Torres, Benjamin;
Sánchez-Torres, Luvia E.;
Suarez-Contreras, Erick;
Villalobos-Rocha, Juan Carlos;
Torres-Martinez, Yuridia;
Lara-Ramirez, Edgar E.;
Fiorani, Giulia;
Krauth-Siege, R. Luise;
Bolognesi, Maria Laura;
Monge, Antonio;
Rivera, Gildardo

Publication type:

Article

The receptor-dependent LQTA-QSAR: application to a set of trypanothione reductase inhibitors.

Published in:

Journal of Computer-Aided Molecular Design, 2012, v. 26, n. 9, p. 1055, doi. 10.1007/s10822-012-9598-2

By:

Barbosa, Euzébio;
Pasqualoto, Kerly;
Ferreira, Márcia

Publication type:

Article

In Silico Analyses of Epicoccamides on Selected Leishmania Trypanothione Reductase Enzyme-based Target.

Published in:

Indian Journal of Pharmaceutical Sciences, 2016, v. 78, n. 2, p. 259, doi. 10.4172/pharmaceutical-sciences.1000111

By:

FATIMA, NIGHAT;
MUMTAZ, AMARA;
SHAMIM, RAHAT;
QADIR, M. I.;
MUHAMMAD, S. A.

Publication type:

Article

Novel Inhibitors of Ornithine Decarboxylase of Leishmania Parasite ( Ld ODC): The Parasite Resists Ld ODC Inhibition by Overexpression of Spermidine Synthase.

Published in:

Chemical Biology & Drug Design, 2016, v. 87, n. 3, p. 352, doi. 10.1111/cbdd.12665

By:

Das, Mousumi;
Singh, Shalini;
Dubey, Vikash Kumar

Publication type:

Article

Molecular Dynamics Simulations of Peptide Inhibitors Complexed With Trypanosoma cruzi Trypanothione Reductase.

Published in:

Chemical Biology & Drug Design, 2012, v. 80, n. 4, p. 561, doi. 10.1111/j.1747-0285.2012.01429.x

By:

Da Rocha Pita, Samuel Silva;
Batista, Paulo Ricardo;
Albuquerque, Magaly Girão;
Pascutti, Pedro Geraldo

Publication type:

Article

Receptor-Dependent 4D-QSAR Analysis of Peptidemimetic Inhibitors of Trypanosoma cruzi Trypanothione Reductase with Receptor-Based Alignment.

Published in:

Chemical Biology & Drug Design, 2012, v. 79, n. 5, p. 740, doi. 10.1111/j.1747-0285.2012.01338.x

By:

da Rocha Pita, Samuel Silva;
Albuquerque, Magaly Girão;
Rodrigues, Carlos Rangel;
Castro, Helena Carla;
Hopfinger, Anton J.

Publication type:

Article

Development and use of a quantum dot probe to track multiple yeast strains in mixed culture.

Published in:

Scientific Reports, 2014, p. 1, doi. 10.1038/srep06971

By:

Gustafsson, Frida S.;
Whiteside, Matthew D.;
Jiranek, Vladimir;
Durall, Daniel M.

Publication type:

Article

Leishmania LABCG2 transporter is involved in ATP-dependent transport of thiols.

Published in:

Biochemical Journal, 2018, v. 475, n. 1, p. 87, doi. 10.1042/BCJ20170685

By:

Perea, Ana;
Manzano, José Ignacio;
Yasuhisa Kimura;
Kazumitsu Ueda;
Castanys, Santiago;
Gamarro, Francisco

Publication type:

Article

Comparative transcript expression analysis of miltefosine-sensitive and miltefosine-resistant Leishmania donovani.

Published in:

Parasitology Research, 2014, v. 113, n. 3, p. 1171, doi. 10.1007/s00436-014-3755-6

By:

Kulshrestha, Arpita;
Sharma, Vanila;
Singh, Ruchi;
Salotra, Poonam

Publication type:

Article

In-silico Investigation of Antitrypanosomal Phytochemicals from Nigerian Medicinal Plants.

Published in:

PLoS Neglected Tropical Diseases, 2012, v. 6, n. 7, p. 1, doi. 10.1371/journal.pntd.0001727

By:

Setzer, William N.;
Ogungbe, Ifedayo V.

Publication type:

Article

Activated Integrated Stress Response Induced by Salubrinal Promotes Cisplatin Resistance in Human Gastric Cancer Cells via Enhanced xCT Expression and Glutathione Biosynthesis.

Published in:

International Journal of Molecular Sciences, 2018, v. 19, n. 11, p. 3389, doi. 10.3390/ijms19113389

By:

Wang, Sheng-Fan;
Wung, Chih-Hsuan;
Chen, Meng-Shian;
Chen, Chian-Feng;
Yin, Pen-Hui;
Yeh, Tien-Shun;
Chang, Yuh-Lih;
Chou, Yueh-Ching;
Hung, Hung-Hsu;
Lee, Hsin-Chen

Publication type:

Article

Trypanothione Reductase: A Target Protein for a Combined In Vitro and In Silico Screening Approach.

Published in:

PLoS Neglected Tropical Diseases, 2015, v. 9, n. 6, p. 1, doi. 10.1371/journal.pntd.0003773

By:

Beig, Mathias;
Oellien, Frank;
Garoff, Linnéa;
Noack, Sandra;
Krauth-Siegel, R. Luise;
Selzer, Paul M.

Publication type:

Article

Structure-based discovery of the first non-covalent inhibitors of Leishmania major tryparedoxin peroxidase by high throughput docking.

Published in:

Scientific Reports, 2015, p. 9705, doi. 10.1038/srep09705

By:

Brindisi, Margherita;
Brogi, Simone;
Vallone, Alessandra;
Butini, Stefania;
Gemma, Sandra;
Campiani, Giuseppe;
Relitti, Nicola;
Novellino, Ettore;
Colotti, Gianni;
Ilari, Andrea;
Angiulli, Gabriella;
Di Chiaro, Francesco;
Fiorillo, Annarita

Publication type:

Article

Cyclobenzaprine Raises ROS Levels in Leishmania infantum and Reduces Parasite Burden in Infected Mice.

Published in:

PLoS Neglected Tropical Diseases, 2017, v. 11, n. 1, p. 1, doi. 10.1371/journal.pntd.0005281

By:

Cunha-Júnior, Edézio Ferreira;
Andrade-Neto, Valter Viana;
Lima, Marta Lopes;
da Costa-Silva, Thais Alves;
JuniorGalisteo, Andres J.;
Abengózar, Maria A.;
Barbas, Coral;
Rivas, Luis;
Almeida-Amaral, Elmo Eduardo;
Tempone, Andre Gustavo;
Torres-Santos, Eduardo Caio

Publication type:

Article

Identification of Novel Chemical Scaffolds Inhibiting Trypanothione Synthetase from Pathogenic Trypanosomatids.

Published in:

PLoS Neglected Tropical Diseases, 2016, v. 10, n. 4, p. 1, doi. 10.1371/journal.pntd.0004617

By:

Benítez, Diego;
Medeiros, Andrea;
Fiestas, Lucía;
Panozzo-Zenere, Esteban A.;
Maiwald, Franziska;
Prousis, Kyriakos C.;
Roussaki, Marina;
Calogeropoulou, Theodora;
Detsi, Anastasia;
Jaeger, Timo;
Šarlauskas, Jonas;
Peterlin Mašič, Lucíja;
Kunick, Conrad;
Labadie, Guillermo R.;
Flohé, Leopold;
Comini, Marcelo A.

Publication type:

Article

Stage-Dependent Expression and Up-Regulation of Trypanothione Synthetase in Amphotericin B Resistant <i>Leishmania donovani</i>.

Published in:

PLoS ONE, 2014, v. 9, n. 6, p. 1, doi. 10.1371/journal.pone.0097600

By:

Equbal, Asif;
Suman, Shashi Shekhar;
Anwar, Shadab;
Singh, Krishn Pratap;
Zaidi, Amir;
Sardar, Abul Hasan;
Das, Pradeep;
Ali, Vahab

Publication type:

Article

Molecular Dynamics Reveal Binding Mode of Glutathionylspermidine by Trypanothione Synthetase.

Published in:

PLoS ONE, 2013, v. 8, n. 2, p. 1, doi. 10.1371/journal.pone.0056788

By:

Koch, Oliver;
Cappel, Daniel;
Nocker, Monika;
Jäger, Timo;
Flohé, Leopold;
Sotriffer, Christoph A.;
Selzer, Paul M.

Publication type:

Article

Mathematical Modelling of Polyamine Metabolism in Bloodstream-Form Trypanosoma brucei: An Application to Drug Target Identification.

Published in:

PLoS ONE, 2013, v. 8, n. 1, p. 1, doi. 10.1371/journal.pone.0053734

By:

Xu Gu;
Reid, David;
Higham, Desmond J.;
Gilbert, David

Publication type:

Article

Inhibition of Leishmania infantum trypanothione reductase by diaryl sulfide derivatives.

Published in:

Journal of Enzyme Inhibition & Medicinal Chemistry, 2017, v. 32, n. 1, p. 304, doi. 10.1080/14756366.2016.1250755

By:

Saccoliti, Francesco;
Angiulli, Gabriella;
Pupo, Giovanni;
Pescatori, Luca;
Madia, Valentina Noemi;
Messore, Antonella;
Colotti, Gianni;
Fiorillo, Annarita;
Scipione, Luigi;
Gramiccia, Marina;
Di Muccio, Trentina;
Di Santo, Roberto;
Costi, Roberta;
Ilari, Andrea

Publication type:

Article

Sulfonamide-metal complexes endowed with potent anti- Trypanosoma cruzi activity.

Published in:

Journal of Enzyme Inhibition & Medicinal Chemistry, 2014, v. 29, n. 2, p. 230, doi. 10.3109/14756366.2013.766608

By:

Chohan, Zahid H.;
Hernandes, Marcelo Zaldini;
Sensato, Fabricio R.;
Moreira, Diogo Rodrigo Magalhaes;
Alves Pereira, Valéria Rego;
Neves, Juliana Kelle de Andrade Lemoine;
de Oliveira, Andresa Pereira;
de Oliveira, Beatriz Coutinho;
Lima Leite, Ana Cristina

Publication type:

Article

Synthesis and evaluation of substrate analogue inhibitors of trypanothione reductase.

Published in:

Journal of Enzyme Inhibition & Medicinal Chemistry, 2012, v. 27, n. 6, p. 784, doi. 10.3109/14756366.2011.604319

By:

Duyzend, Michael H.;
Clark, Christopher T.;
Simmons, Shayna L.;
Johnson, Wade B.;
Larson, Anna M.;
Leconte, Aaron M.;
Wills, Andrew W.;
Ginder-Vogel, Matthew;
Wilhelm, April K.;
Czechowicz, Josephine A.;
Alberg, David G.

Publication type:

Article

Mini review on tricyclic compounds as an inhibitor of trypanothione reductase.

Published in:

Journal of Pharmacy & Bioallied Sciences, 2014, v. 6, n. 4, p. 222, doi. 10.4103/0975-7406.142943

By:

Kumar, Suresh;
Ali, Md. Rahmat;
Bawa, Sandhya

Publication type:

Article

Identification and binding mode of a novel Leishmania Trypanothione reductase inhibitor from high throughput screening.

Published in:

PLoS Neglected Tropical Diseases, 2018, v. 12, n. 11, p. 1, doi. 10.1371/journal.pntd.0006969

By:

Turcano, Lorenzo;
Torrente, Esther;
Missineo, Antonino;
Andreini, Matteo;
Gramiccia, Marina;
Di Muccio, Trentina;
Genovese, Ilaria;
Fiorillo, Annarita;
Harper, Steven;
Bresciani, Alberto;
Colotti, Gianni;
Ilari, Andrea

Publication type:

Article