Works matching DE "TREATMENT of African trypanosomiasis"

Results: 74

African Trypanosomiasis-Associated Anemia: The Contribution of the Interplay between Parasites and the Mononuclear Phagocyte System.

Published in:

Frontiers in Immunology, 2018, p. 1, doi. 10.3389/fimmu.2018.00218

By:

Stijlemans, Benoit;
De Baetselier, Patrick;
Magez, Stefan;
Van Ginderachter, Jo A.;
De Trez, Carl

Publication type:

Article

Short-course eflornithine in Gambian trypanosomiasis: a multicentre randomized controlled trial.

Published in:

Bulletin of the World Health Organization, 2000, v. 78, n. 11, p. 1284

By:

Pepin, Jacques;
Khonde, Nzambi

Publication type:

Article

Availability and affordability of treatment for Human African Trypanosomiasis.

Published in:

2001

By:

Etchegorry, M. Gastellu;
Helenport, J. P.;
Pecoul, B.;
Jannin, J.;
Legros, D.;
Etchegorry, M G

Publication type:

journal article

The phenomenon of treatment failures in Human African Trypanosomiasis.

Published in:

2001

By:

Brun, Reto;
Schumacher, Reto;
Schmid, Cecile;
Kunz, Christina;
Burri, Christian;
Brun, R;
Schumacher, R;
Schmid, C;
Kunz, C;
Burri, C

Publication type:

journal article

Pharmacokinetic investigations in patients from northern Angola refractory to melarsoprol treatment.

Published in:

2001

By:

Burri, C.;
Keiser, J.

Publication type:

journal article

The story of CGP 40 215: studies on its efficacy and pharmacokinetics in African green monkey infected with Trypanosoma brucei rhodesiense.

Published in:

2001

By:

Brun, R.;
Burri, C.;
Gichuki, C. W.

Publication type:

journal article

Discrepancy in plasma melarsoprol concentrations between HPLC and bioassay methods in patients with T. gambiense sleeping sickness indicates that melarsoprol is metabolized.

Published in:

Tropical Medicine & International Health, 1998, v. 3, n. 11, doi. 10.1046/j.1365-3156.1998.00327.x

By:

Bronner;
Brun;
Doua;
Ericsson;
Burri;
Keiser;
Miézan;
Boa;
Rombo;
Gustafsson

Publication type:

Article

Megazol combined with suramin: a chemotherapy regimen which reversed the CNS pathology in a model of human African trypanosomiasis in mice.

Published in:

Tropical Medicine & International Health, 1998, v. 3, n. 9

By:

Enanga;
Keita;
Chauvière;
Dumas;
Bouteille

Publication type:

Article

Potent Antitrypanosomal Activities of 3-Aminosteroids against African Trypanosomes: Investigation of Cellular Effects and of Cross-Resistance with Existing Drugs.

Published in:

Molecules, 2019, v. 24, n. 2, p. 268, doi. 10.3390/molecules24020268

By:

Nnadi, Charles O.;
Ebiloma, Godwin U.;
Black, Jennifer A.;
Nwodo, Ngozi J.;
Lemgruber, Leandro;
Schmidt, Thomas J.;
de Koning, Harry P.

Publication type:

Article

Tetrasubstituted Imidazolium Salts as Potent Antiparasitic Agents against African and American Trypanosomiases.

Published in:

Molecules, 2018, v. 23, n. 1, p. 177, doi. 10.3390/molecules23010177

By:

Ghashghaei, Ouldouz;
Kielland, Nicola;
Revés, Marc;
Taylor, Martin C.;
Kelly, John M.;
Di Pietro, Ornella;
Muñoz-Torrero, Diego;
Pérez, Belén;
Lavilla, Rodolfo

Publication type:

Article

Towards Point-of-Care Diagnostic and Staging Tools for Human African Trypanosomiaisis.

Published in:

Journal of Tropical Medicine (16879686), 2012, p. 1, doi. 10.1155/2012/340538

By:

Matovu, Enock;
Kazibwe, Anne Juliet;
Mugasa, Claire Mack;
Ndungu, Joseph Mathu;
Njiru, Zablon Kithingi

Publication type:

Article

Chemotherapy of Human African Trypanosomiasis.

Published in:

Interdisciplinary Perspectives on Infectious Diseases, 2009, p. 1, doi. 10.1155/2009/195040

By:

Bacchi, Cyrus J.

Publication type:

Article

Evaluation of Methanol Root Extract of Securidaca longipedunculata for Antitrypanosomal Activity in vitro and in vivo.

Published in:

Thai Journal of Pharmaceutical Sciences, 2015, v. 39, n. 4, p. 156

By:

Gabriel, Eke Ifeanyi;
Ebere, Ihedioha Thelma;
K., Ejimofor Favour;
Onyema, Ezeh Ikenna;
Adaku, Ezeudu Terry;
Uchenna, Eze Ukamaka;
Nwabuisi, Okoye Chidozie;
Otah, Anaga Aruh

Publication type:

Article

Quantitative evaluation of the strategy to eliminate human African trypanosomiasis in the Democratic Republic of Congo.

Published in:

Parasites & Vectors, 2015, v. 8, n. 1, p. 1, doi. 10.1186/s13071-015-1131-8

By:

Rock, Kat S.;
Torr, Steve J.;
Lumbala, Crispin;
Keeling, Matt J.

Publication type:

Article

A luciferase based viability assay for ATP detection in 384-wellformat for high throughput whole cell screening of Trypanosomabrucei brucei bloodstream form strain 427.

Published in:: Parasites & Vectors, 2009, v. 2, n. 1, p. 54, doi. 10.1186/1756-3305-2-54
Publication type:: Article

N-myristoyltransferase inhibitors as new leads to treat sleeping sickness.

Published in:

Nature, 2010, v. 464, n. 7289, p. 728, doi. 10.1038/nature08893

By:

Frearson, Julie A.;
Brand, Stephen;
McElroy, Stuart P.;
Cleghorn, Laura A. T.;
Smid, Ondrej;
Stojanovski, Laste;
Price, Helen P.;
Guther, M. Lucia S.;
Torrie, Leah S.;
Robinson, David A.;
Hallyburton, Irene;
Mpamhanga, Chidochangu P.;
Brannigan, James A.;
Wilkinson, Anthony J.;
Hodgkinson, Michael;
Hui, Raymond;
Wei Qiu;
Raimi, Olawale G.;
van Aalten, Daan M. F.;
Brenk, Ruth

Publication type:

Article

Monitoring the use of nifurtimox-eflornithine combination therapy (NECT) in the treatment of second stage gambiense human African trypanosomiasis.

Published in:

Research & Reports in Tropical Medicine, 2012, v. 3, p. 93, doi. 10.2147/rrtm.s34399

By:

Franco, Jose R.;
Simarro, Pere P.;
Diarra, Abdoulaye;
Ruiz-Postigo, Jose A.;
Samo, Mireille;
Jannin, Jean G.

Publication type:

Article

Nifurtimox-Eflornithine Combination Therapy for Second-Stage Gambiense Human African Trypanosomiasis: Médecins Sans Frontières Experience in the Democratic Republic of the Congo.

Published in:

Clinical Infectious Diseases, 2013, v. 56, n. 2, p. 195, doi. 10.1093/cid/cis886

By:

Alirol, Emilie;
Schrumpf, David;
Amici Heradi, Josué;
Riedel, Andrea;
de Patoul, Catherine;
Quere, Michel;
Chappuis, François

Publication type:

Article

Immunobiology of African Trypanosomes: Need of Alternative Interventions.

Published in:

Journal of Biomedicine & Biotechnology, 2010, p. 1, doi. 10.1155/2010/389153

By:

Baral, Toya Nath

Publication type:

Article

Trypanocidal and cytotoxic evaluation of synthesized thiosemicarbazones as potential drug leads against sleeping sickness.

Published in:

Molecular Biology Reports, 2014, v. 41, n. 3, p. 1617, doi. 10.1007/s11033-013-3008-2

By:

Glinma, Bienvenu;
Kpoviessi, Sika;
Gbaguidi, Fernand;
Kapanda, Coco;
Bero, Joanne;
Quetin-Leclercq, Joëlle;
Moudachirou, Mansourou;
Poupaert, Jacques;
Accrombessi, Georges;
Gachomo, Emma;
Baba-Moussa, Lamine;
Kotchoni, Simeon

Publication type:

Article

Combining tubercidin and cordycepin scaffolds results in highly active candidates to treat late-stage sleeping sickness.

Published in:

Nature Communications, 2019, v. 10, n. 1, p. N.PAG, doi. 10.1038/s41467-019-13522-6

By:

Hulpia, Fabian;
Mabille, Dorien;
Campagnaro, Gustavo D.;
Schumann, Gabriela;
Maes, Louis;
Roditi, Isabel;
Hofer, Anders;
de Koning, Harry P.;
Caljon, Guy;
Van Calenbergh, Serge

Publication type:

Article

Novel Markers for Treatment Outcome in Late-Stage Trypanosoma brucei gambiense Trypanosomiasis.

Published in:

Clinical Infectious Diseases, 2008, v. 47, n. 1, p. 15, doi. 10.1086/588668

By:

Lejon, Veerle;
Roger, Isabelle;
Ngoyi, Dieudonné Mumba;
Menten, Joris;
Robays, Jo;
N'Siesi, Francois X.;
Bisser, Sylvie;
Boelaert, Marleen;
Büscher, Philippe

Publication type:

Article

Melarsoprol-Free Drug Combinations for Second-Stage Gambian Sleeping Sickness: The Way to Go.

Published in:

2007

By:

Chappuis, François

Publication type:

Editorial

Kynurenine pathway inhibition reduces central nervous system inflammation in a model of human African trypanosomiasis.

Published in:

Brain: A Journal of Neurology, 2009, v. 132, n. 5, p. 1259, doi. 10.1093/brain/awp074

By:

Rodgers, Jean;
Stone, Trevor W.;
Barrett, Michael P.;
Bradley, Barbara;
Kennedy, Peter G. E.

Publication type:

Article

Heat shock and awe.

Published in:

Nature Medicine, 2011, v. 17, n. 6, p. 646, doi. 10.1038/nm0611-646

By:

Dolgin, Elie;
Motluk, Alison

Publication type:

Article

Resurrecting the resurrection drug.

Published in:

Nature Medicine, 2002, v. 8, n. 9, p. 908, doi. 10.1038/nm0902-908b

By:

Wickware, Potter

Publication type:

Article

Parasite infection: Understanding drug mechanisms of action.

Published in:

Nature Reviews Drug Discovery, 2012, v. 11, n. 3, p. 190, doi. 10.1038/nrd3692

By:

Harrison, Charlotte

Publication type:

Article

In brief.

Published in:: 2010
Publication type:: Abstract

Benzoxaborole treatment perturbs S-adenosyl-L-methionine metabolism in Trypanosoma brucei.

Published in:

PLoS Neglected Tropical Diseases, 2018, v. 12, n. 5, p. 1, doi. 10.1371/journal.pntd.0006450

By:

Steketee, Pieter C.;
Vincent, Isabel M.;
Achcar, Fiona;
Giordani, Federica;
Kim, Dong-Hyun;
Creek, Darren J.;
Freund, Yvonne;
Jacobs, Robert;
Rattigan, Kevin;
Horn, David;
Field, Mark C.;
MacLeod, Annette;
Barrett, Michael P.

Publication type:

Article

Evaluation of the Trypanosoma brucei 6-oxopurine salvage pathway as a potential target for drug discovery.

Published in:

PLoS Neglected Tropical Diseases, 2018, v. 12, n. 2, p. 1, doi. 10.1371/journal.pntd.0006301

By:

Doleželová, Eva;
Terán, David;
Gahura, Ondřej;
Kotrbová, Zuzana;
Procházková, Michaela;
Keough, Dianne;
Špaček, Petr;
Hocková, Dana;
Guddat, Luke;
Zíková, Alena

Publication type:

Article

Expression of interferon-inducible chemokines and sleep/wake changes during early encephalitis in experimental African trypanosomiasis.

Published in:

PLoS Neglected Tropical Diseases, 2017, v. 11, n. 8, p. 1, doi. 10.1371/journal.pntd.0005854

By:

Laperchia, Claudia;
Tesoriero, Chiara;
Seke-Etet, Paul F.;
La Verde, Valentina;
Colavito, Valeria;
Grassi-Zucconi, Gigliola;
Rodgers, Jean;
Montague, Paul;
Kennedy, Peter G. E.;
Bentivoglio, Marina

Publication type:

Article

Introducing the TrypanoGEN biobank: A valuable resource for the elimination of human African trypanosomiasis.

Published in:

PLoS Neglected Tropical Diseases, 2017, v. 11, n. 6, p. 1, doi. 10.1371/journal.pntd.0005438

By:

Ilboudo, Hamidou;
Noyes, Harry;
Mulindwa, Julius;
Kimuda, Magambo Phillip;
Koffi, Mathurin;
Kaboré, Justin Windingoudi;
Ahouty, Bernadin;
Ngoyi, Dieudonné Mumba;
Fataki, Olivier;
Simo, Gustave;
Ofon, Elvis;
Enyaru, John;
Chisi, John;
Kamoto, Kelita;
Simuunza, Martin;
Alibu, Vincent P.;
Lejon, Veerle;
Jamonneau, Vincent;
Macleod, Annette;
Camara, Mamadou

Publication type:

Article

Organic cation transporter 1 (OCT1) is involved in pentamidine transport at the human and mouse blood-brain barrier (BBB).

Published in:

PLoS ONE, 2017, v. 12, n. 3, p. 1, doi. 10.1371/journal.pone.0173474

By:

Sekhar, Gayathri N.;
Georgian, Ana R.;
Sanderson, Lisa;
Vizcay-Barrena, Gema;
Brown, Rachel C.;
Muresan, Paula;
Fleck, Roland A.;
Thomas, Sarah A.

Publication type:

Article

Vaccines against Chagas disease, human African trypanosomiasis and leishmaniasis.

Published in:: WHO Technical Report Series, 2012, n. 975, p. 55
Publication type:: Article

Drugs and drug resistance.

Published in:: WHO Technical Report Series, 2012, n. 975, p. 43
Publication type:: Article

<italic>Trypanosoma brucei rhodesiense</italic> infection in a Chinese traveler returning from the Serengeti National Park in Tanzania.

Published in:

2018

By:

Liu, Qin;
Chen, Xiao-Ling;
Chen, Mu-Xin;
Xie, Han-Guo;
Liu, Qing;
Chen, Zhu-Yun;
Lin, Yao-Ying;
Zheng, Hua;
Chen, Jia-Xu;
Zhang, Yi;
Zhou, Xiao-Nong

Publication type:

Case Study

Determination of an Optimal Dosing Regimen for Fexinidazole, a Novel Oral Drug for the Treatment of Human African Trypanosomiasis: First-in-Human Studies.

Published in:

Clinical Pharmacokinetics, 2014, v. 53, n. 6, p. 565, doi. 10.1007/s40262-014-0136-3

By:

Tarral, Antoine;
Blesson, Séverine;
Mordt, Olaf;
Torreele, Els;
Sassella, Daniela;
Bray, Michael;
Hovsepian, Lionel;
Evène, Eric;
Gualano, Virginie;
Felices, Mathieu;
Strub-Wourgaft, Nathalie

Publication type:

Article

Safety and Efficacy of the 10-Day Melarsoprol Schedule for the Treatment of Second Stage Rhodesiense Sleeping Sickness.

Published in:

PLoS Neglected Tropical Diseases, 2012, v. 6, n. 8, p. 1, doi. 10.1371/journal.pntd.0001695

By:

Kuepfer, Irene;
Schmid, Caecilia;
Allan, Mpairwe;
Edielu, Andrew;
Haary, Emma P.;
Kakembo, Abbas;
Kibona, Stafford;
Blum, Johannes;
Burri, Christian

Publication type:

Article

Early Prediction of Treatment Efficacy in Second-Stage Gambiense Human African Trypanosomiasis.

Published in:

PLoS Neglected Tropical Diseases, 2012, v. 6, n. 6, p. 1, doi. 10.1371/journal.pntd.0001662

By:

Priotto, Gerardo;
Chappuis, François;
Bastard, Mathieu;
Flevaud, Laurence;
Etard, Jean-François

Publication type:

Article

Factory Tsetse Flies Must Behave Like Wild Flies: A Prerequisite for the Sterile Insect Technique.

Published in:

2011

By:

Vreysen, Marc J. B.;
Saleh, Khalfan M.;
Lancelot, Renaud;
Bouyer, Jérémy

Publication type:

Opinion

Fexinidazole - A New Oral Nitroimidazole Drug Candidate Entering Clinical Development for the Treatment of Sleeping Sickness.

Published in:

PLoS Neglected Tropical Diseases, 2010, v. 4, n. 12, p. 1, doi. 10.1371/journal.pntd.0000923

By:

Torreele, Els;
Trunz, Bernadette Bourdin;
Tweats, David;
Kaiser, Marcel;
Brun, Reto;
Guy Mazué;
Bray, Michael A.;
Bernard Pécoul

Publication type:

Article

Bayesian Geostatistical Analysis and Prediction of Rhodesian Human African Trypanosomiasis.

Published in:

PLoS Neglected Tropical Diseases, 2010, v. 4, n. 12, p. 1, doi. 10.1371/journal.pntd.0000914

By:

Wardrop, Nicola A.;
Atkinson, Peter M.;
Gething, Peter W.;
Fèvre, Eric M.;
Picozzi, Kim;
Kakembo, Abbas S. L.;
Welburn, Susan C.

Publication type:

Article

Novel Naphthalene-Based Inhibitors of Trypanosoma brucei RNA Editing Ligase 1.

Published in:

PLoS Neglected Tropical Diseases, 2010, v. 4, n. 8, p. 1, doi. 10.1371/journal.pntd.0000803

By:

Durrant, Jacob D.;
Hall, Laurence;
Swift, Robert V.;
Landon, Melissa;
Schnaufer, Achim;
Rommie E. Amaro

Publication type:

Article

NECT Is Next: Implementing the New Drug Combination Therapy for Trypanosoma brucei gambiense Sleeping Sickness.

Published in:

2010

By:

Yun, Oliver;
Priotto, Gerardo;
Tong, Jacqueline;
Flevaud, Laurence;
Chappuis, François

Publication type:

Opinion

Diverse Effects on Mitochondrial and Nuclear Functions Elicited by Drugs and Genetic Knockdowns in Bloodstream Stage Trypanosoma brucei.

Published in:

PLoS Neglected Tropical Diseases, 2010, v. 4, n. 5, p. 1, doi. 10.1371/journal.pntd.0000678

By:

Worthen, Christal;
Jensen, Bryan C.;
Parsons, Marilyn

Publication type:

Article

Controlling Sleeping Sickness--"When Will They Ever Learn?".

Published in:

2010

By:

Molyneux, David;
Ndung'u, Joseph;
Maudlin, Ian

Publication type:

Opinion

Discovery of Infection Associated Metabolic Markers in Human African Trypanosomiasis.

Published in:

PLoS Neglected Tropical Diseases, 2015, v. 9, n. 10, p. 1, doi. 10.1371/journal.pntd.0004200

By:

Lamour, Sabrina D.;
Gomez-Romero, Maria;
Vorkas, Panagiotis A.;
Alibu, Vincent P.;
Saric, Jasmina;
Holmes, Elaine;
Sternberg, Jeremy M.

Publication type:

Article

On the Road to Elimination of Rhodesiense Human African Trypanosomiasis: First WHO Meeting of Stakeholders.

Published in:

2015

By:

Holmes, Peter

Publication type:

Proceeding

From Health Advice to Taboo: Community Perspectives on the Treatment of Sleeping Sickness in the Democratic Republic of Congo, a Qualitative Study.

Published in:

PLoS Neglected Tropical Diseases, 2015, v. 9, n. 4, p. 1, doi. 10.1371/journal.pntd.0003686

By:

Mpanya, Alain;
Hendrickx, David;
Baloji, Sylvain;
Lumbala, Crispin;
da Luz, Raquel Inocêncio;
Boelaert, Marleen;
Lutumba, Pascal

Publication type:

Article

Structures of <i>Trypanosoma brucei</i> Methionyl-tRNA Synthetase with Urea-Based Inhibitors Provide Guidance for Drug Design against Sleeping Sickness.

Published in:

PLoS Neglected Tropical Diseases, 2014, v. 8, n. 4, p. 1, doi. 10.1371/journal.pntd.0002775

By:

Koh, Cho Yeow;
Kim, Jessica E.;
Wetzel, Allan B.;
de van der Schueren, Will J.;
Shibata, Sayaka;
Ranade, Ranae M.;
Liu, Jiyun;
Zhang, Zhongsheng;
Gillespie, J. Robert;
Buckner, Frederick S.;
Verlinde, Christophe L. M. J.;
Fan, Erkang;
Hol, Wim G. J.

Publication type:

Article