Works about TOR proteins

Results: 323

The Role of S6K1 in Aging and Alzheimer's Disease: Mechanistic Insights and Therapeutic Potential.

Published in:

International Journal of Molecular Sciences, 2025, v. 26, n. 13, p. 5923, doi. 10.3390/ijms26135923

By:

Oddo, Salvatore;
Lanza, Marika;
Casili, Giovanna;
Caccamo, Antonella

Publication type:

Article

The molecular logic of Gtr1/2- and Pib2-dependent TORC1 regulation in budding yeast.

Published in:

eLife, 2025, p. 1, doi. 10.7554/eLife.94628

By:

Cecil, Jacob H.;
Padilla, Cristina M.;
Lipinski, Austin A.;
Langlais, Paul;
Xiangxia Luo;
Capaldi, Andrew P.

Publication type:

Article

Valproate independently activates Snf1, inhibits TORC1, and induces repression of INO1 transcription by increasing nuclear localization of Opi1.

Published in:

Scientific Reports, 2025, v. 15, n. 1, p. 1, doi. 10.1038/s41598-025-07540-2

By:

Case, Kendall C.;
Orkun, Lara;
Greenberg, Miriam L.

Publication type:

Article

Modulating ovarian cancer progression through FDX1-driven autophagy.

Published in:

NPJ Precision Oncology, 2025, v. 9, n. 1, p. 1, doi. 10.1038/s41698-025-00994-7

By:

Liu, Chang;
Wang, Siyu;
Zhao, Jiabao;
Qiu, Hui;
Du, Hongmei

Publication type:

Article

PTEN deficiency in postnatally developing Purkinje cells disrupts metabolic signaling, leading to dendritic abnormalities and sex-specific behavioral deficits.

Published in:

Scientific Reports, 2025, v. 15, n. 1, p. 1, doi. 10.1038/s41598-025-09059-y

By:

Walsh, Lindsay J.;
Espinal-San Miguel, Izabella M.;
Rodriguez, Ana V.;
Peña, Ursula M.;
Flynn, Kiley E.;
Remillard, Will C.;
Brazier, Siena R.;
Anderson, Natalia I.;
Clark, Aidan J.;
De Varona, Tiffany A.;
Soto, Ileana

Publication type:

Article

Evolution of growth factor signaling to the TSC complex to regulate mTORC1.

Published in:

Science Signaling, 2025, v. 18, n. 894, p. 1, doi. 10.1126/scisignal.adw4165

By:

Wang, Kun;
Lockwood, Sophie E.;
Manning, Brendan D.

Publication type:

Article

Repeated administration of L-alanine to mice reduces behavioural despair and increases hippocampal mammalian target of rapamycin signalling: Analysis of gender and metabolic effects.

Published in:

Journal of Psychopharmacology, 2025, v. 39, n. 6, p. 612, doi. 10.1177/02698811251332838

By:

Aziz, Abdullah;
Costa, Carolina Fernandes Ferreira Alves;
Zhao, Erying;
Radford-Smith, Daniel;
Probert, Fay;
Anthony, Daniel Clive;
Burnet, Philip William John

Publication type:

Article

饲料精氨酸对生长中期镜鲤生长及肌肉品质的影响.

Published in:

Journal of Hydrobiology / Shuisheng Shengwu Xuebao, 2025, v. 49, n. 7, p. 1, doi. 10.7541/2025.2024.0363

By:

高一琪;
范泽;
程镇燕;
吴迪;
王连生;
李晋南;
李晨辉

Publication type:

Article

Express yourself: how PP2A-B55 helps TORC1 talk to TORC2.

Published in:

Current Genetics, 2018, v. 64, n. 1, p. 43, doi. 10.1007/s00294-017-0721-8

By:

Martín, Ruth;
Lopez-Aviles, Sandra

Publication type:

Article

Specific signaling pathways mediated programmed cell death in tumor microenvironment and target therapies.

Published in:

Discover Oncology, 2025, v. 16, n. 1, p. 1, doi. 10.1007/s12672-025-02592-2

By:

Sun, Chengpeng;
Gui, Jiawei;
Sheng, Yilei;
Huang, Le;
Zhu, Xingen;
Huang, Kai

Publication type:

Article

Changes in cecal morphology, cell proliferation, antioxidant enzyme, volatile fatty acids, lipopolysaccharide, and cytokines in piglets during the postweaning period.

Published in:

Journal of Animal Science, 2020, v. 98, n. 3, p. N.PAG, doi. 10.1093/jas/skaa046

By:

Deng, Qingqing;
Tan, Xian;
Wang, Huiru;
Wang, Qiye;
Huang, Pengfei;
Li, Yali;
Li, Jianzhong;
Huang, Jing;
Yang, Huansheng;
Yin, Yulong

Publication type:

Article

The mammalian target of rapamycin-signaling pathway in regulating metabolism and growth<sup>2</sup>.

Published in:: Journal of Animal Science, 2008, v. 86, p. E36, doi. 10.2527/jas.2007-0567
Publication type:: Article

Long noncoding RNA HAGLROS regulates apoptosis and autophagy in Parkinson's disease via regulating miR-100/ATG10 axis and PI3K/Akt/mTOR pathway activation.

Published in:

Artificial Cells, Nanomedicine & Biotechnology, 2019, v. 47, n. 1, p. 2764, doi. 10.1080/21691401.2019.1636805

By:

Peng, Tao;
Liu, Xiaoyan;
Wang, Jingtao;
Liu, Yu;
Fu, Zhenqiang;
Ma, Xingrong;
Li, Junmin;
Sun, Guifang;
Ji, Yangfei;
Lu, Jingjing;
Wan, Wencui;
Lu, Hong

Publication type:

Article

Target of Rapamycin Is a Key Player for Auxin Signaling Transduction in Arabidopsis.

Published in:

Frontiers in Plant Science, 2016, p. 1, doi. 10.3389/fpls.2016.00291

By:

Kexuan Deng;
Lihua Yu;
Xianzhe Zheng;
Kang Zhang;
Pan Dong;
Maozhi Ren;
Wanjing Wang;
Jiankui Zhang;
Henriques, Rossana;
Magyar, Zoltan

Publication type:

Article

TOR-inhibitor insensitive-1 (TRIN1) regulates cotyledons greening in Arabidopsis.

Published in:

Frontiers in Plant Science, 2015, p. 1, doi. 10.3389/fpls.2015.00861

By:

Linxuan Li;
Yun Song;
Kai Wang;
Pan Dong;
Xueyan Zhang;
Fuguang Li;
Zhengguo Li;
Maozhi Ren

Publication type:

Article

TOR-inhibitor insensitive-1 (TRIN1) regulates cotyledons greening in Arabidopsis.

Published in:

Frontiers in Plant Science, 2015, p. 1, doi. 10.3389/fpls.2015.00861

By:

Linxuan Li;
Yun Song;
Kai Wang;
Pan Dong;
Xueyan Zhang;
Fuguang Li;
Zhengguo Li;
Maozhi Ren

Publication type:

Article

Sugar metabolism and the plant target of rapamycin kinase :a sweet opera TOR?

Published in:

Frontiers in Plant Science, 2013, v. 4, p. 1, doi. 10.3389/fpls.2013.00093

By:

Dobrenel, Thomas;
Marchive, Chloé;
Azzopardi, Marianne;
Clément, Gilles;
Moreau, Manon;
Sormani, Rodnay;
Robaglia, Christophe;
Meyer, Christian

Publication type:

Article

FTO – A Common Genetic Basis for Obesity and Cancer.

Published in:

Frontiers in Genetics, 2020, v. 11, p. N.PAG, doi. 10.3389/fgene.2020.559138

By:

Lan, Ning;
Lu, Ying;
Zhang, Yigan;
Pu, Shuangshuang;
Xi, Huaze;
Nie, Xin;
Liu, Jing;
Yuan, Wenzhen

Publication type:

Article

Interplay between cell growth and cell cycle in plants.

Published in:

Journal of Experimental Botany, 2014, v. 65, n. 10, p. 2703, doi. 10.1093/jxb/ert354

By:

Sablowski, Robert;
Carnier Dornelas, Marcelo

Publication type:

Article

Balancing act: matching growth with environment by the TOR signalling pathway.

Published in:

Journal of Experimental Botany, 2014, v. 65, n. 10, p. 2691, doi. 10.1093/jxb/eru049

By:

Henriques, Rossana;
Bögre, László;
Horváth, Beátrix;
Magyar, Zoltán

Publication type:

Article

ATP-competitive mTOR kinase inhibitors delay plant growth by triggering early differentiation of meristematic cells but no developmental patterning change.

Published in:

Journal of Experimental Botany, 2013, v. 64, n. 14, p. 4361, doi. 10.1093/jxb/ert242

By:

Montané, Marie-Hélène;
Menand, Benoît

Publication type:

Article

Tetrahydrocurcumin‑induced autophagy via suppression of PI3K/Akt/mTOR in non‑small cell lung carcinoma cells.

Published in:

Molecular Medicine Reports, 2018, v. 17, n. 4, p. 5964, doi. 10.3892/mmr.2018.8600

By:

Song, Guoqiang;
Lu, Honghui;
Chen, Fei;
Wang, Youmei;
Fan, Weibin;
Shao, Weifang;
Lu, Huoquan;
Lin, Bin

Publication type:

Article

Anticancer activity of caffeic acid n‑butyl ester against A431 skin carcinoma cell line occurs via induction of apoptosis and inhibition of the mTOR/PI3K/AKT signaling pathway.

Published in:

Molecular Medicine Reports, 2018, v. 17, n. 4, p. 5652, doi. 10.3892/mmr.2018.8599

By:

Zeng, Ning;
Hongbo, Tang;
Xu, Yi;
Wu, Min;
Wu, Yiping

Publication type:

Article

miR‑539 suppresses proliferation and induces apoptosis in renal cell carcinoma by targeting high mobility group A2.

Published in:

Molecular Medicine Reports, 2018, v. 17, n. 4, p. 5611, doi. 10.3892/mmr.2018.8578

By:

Ye, Zhi-Hua;
Gui, Ding-Wen

Publication type:

Article

Ouabain suppresses the growth and migration abilities of glioma U‑87MG cells through inhibiting the Akt/mTOR signaling pathway and downregulating the expression of HIF‑1α.

Published in:

Molecular Medicine Reports, 2018, v. 17, n. 4, p. 5595, doi. 10.3892/mmr.2018.8587

By:

Yang, Xiao-Sa;
Xu, Zhong-Wei;
Yi, Tai-Long;
Xu, Rui-Cheng;
Li, Jie;
Zhang, Wen-Bin;
Zhang, Sai;
Sun, Hong-Tao;
Yu, Ze-Qi;
Xu, Hao-Xiang;
Tu, Yue;
Cheng, Shi-Xiang

Publication type:

Article

Regulation of the cell cycle and PI3K/Akt/mTOR signaling pathway by tanshinone I in human breast cancer cell lines.

Published in:

Molecular Medicine Reports, 2015, v. 11, n. 2, p. 931, doi. 10.3892/mmr.2014.2819

By:

LI WANG;
JIANZHONG WU;
JIANWEI LU;
RONG MA;
DAWEI SUN;
JINHAI TANG

Publication type:

Article

Analysis of Blimp-1 and PD-1/PD-L1 Immune Checkpoint in an Autoimmune Thyroiditis Animal Model.

Published in:

International Journal of Endocrinology, 2020, p. 1, doi. 10.1155/2020/6543593

By:

Zhang, Xue;
Lv, Xiaoshu;
Chen, Mengya;
Liu, Haixia

Publication type:

Article

Analysis of Blimp-1 and PD-1/PD-L1 Immune Checkpoint in an Autoimmune Thyroiditis Animal Model.

Published in:

International Journal of Endocrinology, 2020, p. 1, doi. 10.1155/2020/6543593

By:

Zhang, Xue;
Lv, Xiaoshu;
Chen, Mengya;
Liu, Haixia

Publication type:

Article

Growth performance and TOR pathway gene expression of juvenile blunt snout bream, Megalobrama amblycephala, fed with diets replacing fish meal with cottonseed meal.

Published in:

Aquaculture Research, 2017, v. 48, n. 7, p. 3693, doi. 10.1111/are.13195

By:

Zhou, Qun ‐ Lan;
Habte ‐ Tsion, Habte ‐ Michael;
Ge, Xianping;
Liu, Bo;
Xie, Jun;
Ren, Mingchun;
Miao, Linghong;
Pan, Liangkun

Publication type:

Article

Ginsenoside protopanaxadiol protects adult retinal pigment epithelial-19 cells from chloroquine by modulating autophagy and apoptosis.

Published in:

PLoS ONE, 2022, v. 17, n. 12, p. 1, doi. 10.1371/journal.pone.0274763

By:

Lee, Haesung;
Nguyen Hoang, Anh Thu;
Lee, Sook-Jeong

Publication type:

Article

Exploratory phosphoproteomics profiling of Aedes aegypti Malpighian tubules during blood meal processing reveals dramatic transition in function.

Published in:

PLoS ONE, 2022, v. 17, n. 7, p. 1, doi. 10.1371/journal.pone.0271248

By:

Kandel, Yashoda;
Pinch, Matthew;
Lamsal, Mahesh;
Martinez, Nathan;
Hansen, Immo A.

Publication type:

Article

Transcriptomic Landscape of Polypide Development in the Freshwater Bryozoan Cristatella mucedo: From Budding to Degeneration.

Published in:

Journal of Experimental Zoology Part B: Molecular & Developmental Evolution, 2025, v. 344, n. 3, p. 119, doi. 10.1002/jez.b.23285

By:

Kvach, A. Yu.;
Kutyumov, V. A.;
Starunov, V. V.;
Ostrovsky, A. N.

Publication type:

Article

mTOR Mysteries: Nuances and Questions About the Mechanistic Target of Rapamycin in Neurodegeneration.

Published in:

Frontiers in Neuroscience, 2020, v. 14, p. N.PAG, doi. 10.3389/fnins.2020.00775

By:

Norwitz, Nicholas G.;
Querfurth, Henry

Publication type:

Article

Huangqi Decoction Serum Suppressed Proliferation and Migration of Rat Liver Sinusoidal Endothelial Cells via Angiogenesis Inhibition by Promoting AKT/mTOR-Dependent Autophagy.

Published in:

Indian Journal of Pharmaceutical Sciences, 2024, v. 86, n. 3, p. 1058, doi. 10.36468/pharmaceutical-sciences.1364

By:

CHENGYI WAN;
TIANLU HOU;
YANG CHENG

Publication type:

Article

Mechanism of Puerarin Regulating AMPK/mTOR Activated Autophagy Signal Pathway in the Treatment of Diabetic Nephropathy.

Published in:

Indian Journal of Pharmaceutical Sciences, 2023, v. 85, n. 5, p. 1512

By:

HONGXIA SU;
YUAN JANG;
JIHONG LV;
XUEYING GONG;
JIE WANG;
WENJUAN YANG

Publication type:

Article

In Silico and In Vitro Perspective to Elucidate the Anticancer Effect of Natural Compound Hesperetin in Inhibiting Mammalian Target of Rapamycin Pathway.

Published in:

Indian Journal of Pharmaceutical Sciences, 2021, v. 83, n. 5, p. 989, doi. 10.36468/pharmaceutical-sciences.852

By:

JAGANATHAN, S. S.;
ROBINSON, GLORIA JEMMI CHRISTOBEL;
PADMANABAN, ABIRAMI;
SAMUEL, SHILA;
RADHAKRISHNAN, V.

Publication type:

Article

Effects of Astragaloside on Biological Characteristics of Non-Small Cell Lung Cancer Cells via the Phosphatidylinositol 3-Kinase/Protein Kinase B/Mechanistic Target of Rapamycin Pathway.

Published in:

Indian Journal of Pharmaceutical Sciences, 2021, v. 83, n. 4, p. 865, doi. 10.36468/pharmaceutical-sciences.838

By:

YUXIA LIU;
YUE ZHAO;
PENG, Z.;
LI, S.;
AISHUAI WANG;
ZHENG, X.

Publication type:

Article

The Protein Tyrosine Phosphatase Shp2 Regulates Oligodendrocyte Differentiation and Early Myelination and Contributes to Timely Remyelination.

Published in:

Journal of Neuroscience, 2018, v. 38, n. 4, p. 787, doi. 10.1523/JNEUROSCI.2864-16.2017

By:

Harlow, Danielle E.;
Finseth, Lisbet T.;
Bourne, Jennifer N.;
Hickey, Sean P.;
Gould, Elizabeth A.;
Culp, Cecilia M.;
Ahrendsen, Jared T.;
Macklin, Wendy B.

Publication type:

Article

Imbalanced Mechanistic Target of Rapamycin C1 and C2 Activity in the Cerebellum of Angelman Syndrome Mice Impairs Motor Function.

Published in:

Journal of Neuroscience, 2015, v. 35, n. 11, p. 4706, doi. 10.1523/JNEUROSCI.4276-14.2015

By:

Jiandong Sun;
Yan Liu;
Moreno, Stephanie;
Baudry, Michel;
Xiaoning Bi

Publication type:

Article

A phase-1b study of everolimus plus paclitaxel in patients with small-cell lung cancer.

Published in:

British Journal of Cancer, 2013, v. 109, n. 6, p. 1482, doi. 10.1038/bjc.2013.467

By:

Sun, J M;
Kim, J R;
Do, I G;
Lee, S Y;
Lee, J;
Choi, Y L;
Ahn, J S;
Ahn, M J;
Park, K

Publication type:

Article

PTEN deficiency is associated with reduced sensitivity to mTOR inhibitor in human bladder cancer through the unhampered feedback loop driving PI3K/Akt activation.

Published in:

British Journal of Cancer, 2013, v. 109, n. 6, p. 1586, doi. 10.1038/bjc.2013.505

By:

Seront, E;
Pinto, A;
Bouzin, C;
Bertrand, L;
Machiels, J-P;
Feron, O

Publication type:

Article

Cytomegalic parvalbumin neurons in fetal cases of hemimegalencephaly.

Published in:

Epilepsia (Series 4), 2025, v. 66, n. 6, p. 2099, doi. 10.1111/epi.18325

By:

Gelot, Antoinette‐Bernabe;
Draia‐Nicolau, Tangra Ondina;
Mathieu, Rémi;
Silvagnoli, Lucas;
Watrin, Françoise;
Cardoso, Carlos;
Manent, Jean‐Bernard;
de Chevigny, Antoine;
Represa, Alfonso

Publication type:

Article

Distinct peripheral pro‐inflammatory profile associated with tuberous sclerosis complex and epilepsy.

Published in:

Epilepsia (Series 4), 2025, v. 66, n. 4, p. 1288, doi. 10.1111/epi.18261

By:

Balthazard, Renaud;
Drouin‐Engler, Rose‐Marie;
Bertrand, Samuel;
Zine‐Eddine, Faycal;
Li, Jimmy;
Tastet, Olivier;
Daigneault, Audrey;
Mamane, Victoria H.;
Ortega‐Delgado, Gloria Gabrielle;
Sreng Flores, Alina Maria;
Kaufmann, Daniel E.;
Major, Philippe;
House, Andrew A.;
Létourneau‐Guillon, Laurent;
Arbour, Nathalie;
Keezer, Mark R.;
Larochelle, Catherine

Publication type:

Article

The epilepsy–autism phenotype associated with developmental and epileptic encephalopathies: New mechanism‐based therapeutic options.

Published in:

Epilepsia (Series 4), 2025, v. 66, n. 4, p. 970, doi. 10.1111/epi.18209

By:

Specchio, Nicola;
Di Micco, Valentina;
Aronica, Eleonora;
Auvin, Stéphane;
Balestrini, Simona;
Brunklaus, Andreas;
Gardella, Elena;
Scheper, Mirte;
Taglialatela, Maurizio;
Trivisano, Marina;
Curatolo, Paolo

Publication type:

Article

Pathogenic MTOR somatic variant causing focal cortical dysplasia drives hyperexcitability via overactivation of neuronal GluN2C N‐methyl‐D‐aspartate receptors.

Published in:

Epilepsia (Series 4), 2024, v. 65, n. 7, p. 2111, doi. 10.1111/epi.18000

By:

Pineau, Louison;
Buhler, Emmanuelle;
Tarhini, Sarah;
Bauer, Sylvian;
Crepel, Valérie;
Watrin, Françoise;
Cardoso, Carlos;
Represa, Alfonso;
Szepetowski, Pierre;
Burnashev, Nail

Publication type:

Article

High-dose rapamycin blocks mossy fiber sprouting but not seizures in a mouse model of temporal lobe epilepsy.

Published in:

Epilepsia (Series 4), 2013, v. 54, n. 9, p. 1535, doi. 10.1111/epi.12246

By:

Heng, Kathleen;
Haney, Megan M.;
Buckmaster, Paul S.

Publication type:

Article

Natural product ligands of FKBP12: Immunosuppressive antifungal agents FK506, rapamycin, and beyond.

Published in:

PLoS Pathogens, 2023, v. 18, n. 1, p. 1, doi. 10.1371/journal.ppat.1011056

By:

Rivera, Angela;
Heitman, Joseph

Publication type:

Article

Correction: TOR-autophagy branch signaling via Imp1 dictates plant-microbe biotrophic interface longevity.

Published in:

2019

By:

Sun, Guangchao;
Elowsky, Christian;
Li, Gang;
Wilson, Richard A.

Publication type:

Correction Notice

TOR-autophagy branch signaling via Imp1 dictates plant-microbe biotrophic interface longevity.

Published in:

PLoS Genetics, 2018, v. 14, n. 11, p. 1, doi. 10.1371/journal.pgen.1007814

By:

Sun, Guangchao;
Elowsky, Christian;
Li, Gang;
Wilson, Richard A.

Publication type:

Article

Anti-proliferative effect of rosiglitazone on angiotensin II-induced vascular smooth muscle cell proliferation is mediated by the mTOR pathway.

Published in:

Cell Biology International, 2012, v. 36, n. 3, p. 305, doi. 10.1042/CBI20100524

By:

Kim, Jung-Sun;
Kim, Il-Kwon;
Lee, Se-Yeon;
Song, Byeong-Wook;
Cha, Min-Ji;
Song, Heesang;
Choi, Eunmi;
Lim, Soyeon;
Ham, Onju;
Jang, Yangsoo;
Hwang, Ki-Chul

Publication type:

Article