Works matching DE "THYMIDYLATE synthase"

Results: 419

Pleckstrin-2 promotes the progression of colorectal cancer via YTHDF2-mediated TYMS mRNA stability.

Published in:

Cellular & Molecular Life Sciences, 2025, v. 82, n. 1, p. 1, doi. 10.1007/s00018-025-05782-x

By:

Zhou, Qian;
Li, Yanxia;
Li, Xiaomei;
Zhang, Shujing;
Wang, Ying;
Li, Zhuoran;
Wang, Xia;
Li, Yuan;
Li, Jingxin;
Lu, Chunhua;
Shen, Yuemao;
Zhao, Baobing

Publication type:

Article

Molecular Mechanisms of Resistance to 5-Fluorocytosine in Laboratory Mutants of Candida glabrata.

Published in:

Mycopathologia, 2011, v. 171, n. 1, p. 11, doi. 10.1007/s11046-010-9342-1

By:

Vandeputte, Patrick;
Pineau, Laurent;
Larcher, Gérald;
Noel, Thierry;
Brèthes, Daniel;
Chabasse, Dominique;
Bouchara, Jean-Philippe

Publication type:

Article

Selective anti-tumor activity of the novel fluoropyrimidine polymer F10 towards G48a orthotopic GBM tumors.

Published in:

Journal of Neuro-Oncology, 2014, v. 116, n. 3, p. 447, doi. 10.1007/s11060-013-1321-1

By:

Gmeiner, William;
Lema-Tome, Carla;
Gibo, Denise;
Jennings-Gee, Jamie;
Milligan, Carol;
Debinski, Waldemar

Publication type:

Article

MALAT1-miRNAs network regulate thymidylate synthase and affect 5FU-based chemotherapy.

Published in:

Molecular Medicine, 2022, v. 28, n. 1, p. 1, doi. 10.1186/s10020-022-00516-2

By:

Matuszyk, Janusz

Publication type:

Article

Sitagliptin synergizes 5‐fluorouracil efficacy in colon cancer cells through MDR1‐mediated flux impairment and down regulation of NFκB2 and p‐AKT survival proteins.

Published in:

Journal of Biochemical & Molecular Toxicology, 2024, v. 38, n. 8, p. 1, doi. 10.1002/jbt.23796

By:

Eisa, Asmaa;
Hanafy, Shaden M.;
Khalil, Hany;
Elshal, Mohamed F.

Publication type:

Article

Effect of thymidylate synthase ( TYMS) gene polymorphisms with methotrexate treatment outcome in south Indian Tamil patients with rheumatoid arthritis.

Published in:

Clinical Rheumatology, 2017, v. 36, n. 6, p. 1253, doi. 10.1007/s10067-017-3608-7

By:

Muralidharan, Niveditha;
Misra, Durga;
Jain, Vikramraj;
Negi, Vir

Publication type:

Article

Role of thymidylate synthase and dihydropyrimidine dehydrogenase mRNA expressions in gallbladder carcinoma.

Published in:

Surgery Today, 2012, v. 42, n. 6, p. 565, doi. 10.1007/s00595-012-0118-8

By:

Iwahashi, Shuichi;
Shimada, Mitsuo;
Utsunomiya, Tohru;
Morine, Yuji;
Imura, Satoru;
Ikemoto, Tetsuya;
Mori, Hiroki;
Hanaoka, Jun

Publication type:

Article

Role of thymidylate synthase and dihydropyrimidine dehydrogenase mRNA in intrahepatic cholangiocarcinoma.

Published in:

Surgery Today, 2012, v. 42, n. 2, p. 135, doi. 10.1007/s00595-011-0054-z

By:

Morine, Yuji;
Shimada, Mitsuo;
Utsunomiya, Tohru;
Imura, Satoru;
Ikemoto, Tetsuya;
Hanaka, Jun;
Kanamoto, Mami;
Kurita, Nobuhiro;
Miyake, Hidenori

Publication type:

Article

QSAR and Molecular Docking of Pyrimidine Derivatives Against Plasmodium falciparum dihydrofolate reductasethymidylate synthase (PfDHFR-TS).

Published in:

Journal of Research in Pharmacy, 2022, v. 26, n. 6, p. 1723, doi. 10.29228/jrp.284

By:

TJITDA, Putra Jiwamurwa Pama;
NITBANI, Febri Odel;
MBUNGA, Dominus

Publication type:

Article

Distribution of soil viruses across China and their potential role in phosphorous metabolism.

Published in:

Environmental Microbiome, 2022, v. 17, n. 1, p. 1, doi. 10.1186/s40793-022-00401-9

By:

Han, Li-Li;
Yu, Dan-Ting;
Bi, Li;
Du, Shuai;
Silveira, Cynthia;
Cobián Güemes, Ana Georgina;
Zhang, Li-Mei;
He, Ji-Zheng;
Rohwer, Forest

Publication type:

Article

Cardiotoxicity of Fluoropyrimidines: Epidemiology, Mechanisms, Diagnosis, and Management.

Published in:

Journal of Clinical Medicine, 2021, v. 10, n. 19, p. 4426, doi. 10.3390/jcm10194426

By:

Jurczyk, Michał;
Król, Magdalena;
Midro, Aleksandra;
Kurnik-Łucka, Magdalena;
Poniatowski, Adrian;
Gil, Krzysztof

Publication type:

Article

Targeting Thymidylate Synthase and tRNA-Derived Non-Coding RNAs Improves Therapeutic Sensitivity in Colorectal Cancer.

Published in:

Antioxidants, 2022, v. 11, n. 11, p. 2158, doi. 10.3390/antiox11112158

By:

Yang, Changwon;
Song, Jisoo;
Park, Sunwoo;
Ham, Jiyeon;
Park, Wonhyoung;
Park, Hahyun;
An, Garam;
Hong, Taeyeon;
Kim, Hee Seung;
Song, Gwonhwa;
Lim, Whasun

Publication type:

Article

Synthesis and Characterization of Tin (Iv) Dithiocarbazate Complexes and Their Anticancer Properties.

Published in:

Malaysian Journal of Medicine & Health Sciences, 2017, v. 13, p. 16

By:

Ravoof, T. B. S. A.;
Yusof, EnisNadia Md;
Tahir, M. Ibrahim M.;
Veerakumarasivam, Abhi;
Latif, M. Alif M.

Publication type:

Article

Raltitrexed regulates proliferation and apoptosis of HGC-27 cells by upregulating RSK4.

Published in:

BMC Pharmacology & Toxicology, 2022, v. 23, n. 1, p. 1, doi. 10.1186/s40360-022-00605-2

By:

Hu, Cong;
Chen, Xinhua;
Lin, Xu;
Dai, Jun;
Yu, Jiang

Publication type:

Article

Enhanced anticancer effect of thymidylate synthase dimer disrupters by promoting intracellular accumulation.

Published in:

Frontiers in Pharmacology, 2024, p. 1, doi. 10.3389/fphar.2024.1477318

By:

Marverti, Gaetano;
Moschella, Maria Gaetana;
Belardo, Alice;
Lamesta, Michele;
Mercanile, Giada;
Tagliazucchi, Lorenzo;
Aiello, Daniele;
Venturelli, Alberto;
Illuminati, Davide;
Guerrini, Remo;
Losi, Lorena;
Ponterini, Glauco;
Costi, Maria Paola;
D'Arca, Domenico

Publication type:

Article

Identification of novel quinazolinone hybrids as cytotoxic agents against C6 glioma cell lines.

Published in:

Journal of the Chinese Chemical Society, 2022, v. 69, n. 6, p. 968, doi. 10.1002/jccs.202200058

By:

Pagilla, Shankaraiah;
Anagani Kanaka Durga, Bhavani;
Vodnala, Sumathi;
Kamutam, Ramakrishna;
Mudiraj, Anwita;
Phanithi, Prakash Babu;
Chetti, Prabhakar

Publication type:

Article

A patient with a severe allergic reaction secondary to Efudix 5% cream.

Published in:

Clinical & Experimental Dermatology, 2023, v. 48, n. 6, p. 699, doi. 10.1093/ced/llad072

By:

Lam, Mun Wai;
Cuell, Alexis

Publication type:

Article

Fingerprint loss associated with topical 5‐fluorouracil cream.

Published in:

Clinical & Experimental Dermatology, 2022, v. 47, n. 7, p. 1371, doi. 10.1111/ced.15181

By:

Chow, Whitney T. H.;
Potter, Matthew

Publication type:

Article

Polymorphisms in TYMS for Prediction of Capecitabine-Induced Hand-Foot Syndrome in Chinese Patients with Colorectal Cancer.

Published in:

Cancer Research & Treatment, 2021, v. 53, n. 3, p. 724, doi. 10.4143/crt.2020.457

By:

Si-Qi Dong;
Tong-Min Wang;
Jiang-Bo Zhang;
Yong-Qiao He;
Wen-Qiong Xue;
Zi-Yi Wu;
Da-Wei Yang;
Lian-Jing Cao;
Jing-Wen Huang;
Xi-Zhao Li;
Pei-Fen Zhang;
Xiao-Hui Zheng;
Wei-Hua Jia

Publication type:

Article

Phase II Study of Pemetrexed as a Salvage Chemotherapy for Thymidylate Synthase-Low Squamous Cell Lung Cancer.

Published in:

Cancer Research & Treatment, 2021, v. 53, n. 1, p. 87, doi. 10.4143/crt.2020.741

By:

Mihong Choi;
Heung Tae Kim;
Ji-Youn Han;
Geon Kook Lee;
Soo-Hyun Lee;
Kun Young Lim;
Jungnam Joo;
Hye Jin Won;
Jin Soo Lee;
Youngjoo Lee

Publication type:

Article

Synergistic effect of kaempferol and 5-fluorouracil on the growth of colorectal cancer cells by regulating the PI3K/Akt signaling pathway.

Published in:

Molecular Medicine Reports, 2019, v. 20, n. 1, p. 728, doi. 10.3892/mmr.2019.10296

By:

Li, Qiongyu;
Wei, Lihui;
Lin, Shan;
Chen, Youqin;
Lin, Jiumao;
Peng, Jun

Publication type:

Article

MEK inhibitor enhanced the antitumor effect of oxaliplatin and 5-fluorouracil in MEK1 Q56P-mutant colorectal cancer cells.

Published in:

Molecular Medicine Reports, 2019, v. 19, n. 2, p. 1092

By:

Jing, Changwen;
Li, Huizi;
Du, Yuanyuan;
Cao, Haixia;
Liu, Siwen;
Wang, Zhuo;
Ma, Rong;
Feng, Jifeng;
Wu, Jianzhong

Publication type:

Article

MicroRNA-215 is upregulated by treatment with Adriamycin and leads to the chemoresistance of hepatocellular carcinoma cells and tissues.

Published in:

Molecular Medicine Reports, 2015, v. 12, n. 4, p. 5274, doi. 10.3892/mmr.2015.4012

By:

LI WANG;
YAN MING WANG;
SONG XU;
WEI GUO WANG;
YANG CHEN;
JING YU MAO;
BO LE TIAN

Publication type:

Article

Expression of ERCC1, TYMS, RRM1, TUBB3, non-muscle myosin II, myoglobin and MyoD1 in lung adenocarcinoma pleural effusions predicts survival in patients receiving platinum-based chemotherapy.

Published in:

Molecular Medicine Reports, 2015, v. 11, n. 5, p. 3523, doi. 10.3892/mmr.2014.3141

By:

HAIJIAO JIANG;
HE WANG;
SHIYU WANG;
ZHENGTONG PEI;
ZHIMIN FU;
CHANGQING FANG;
JIAN WANG;
QINGJIE LU;
ENHUA WANG;
JIANHUA LI

Publication type:

Article

Raltitrexed induces mitochondrial-mediated apoptosis in SGC7901 human gastric cancer cells.

Published in:

Molecular Medicine Reports, 2014, v. 10, n. 4, p. 1927, doi. 10.3892/mmr.2014.2438

By:

SONG XUE;
YING-XIA CHEN;
SHU-KUI QIN;
AI-ZHEN YANG;
LIN WANG;
HAI-JUN XU;
HAI-YUN GENG

Publication type:

Article

Development of Robust Varicella Zoster Virus Luciferase Reporter Viruses for In Vivo Monitoring of Virus Growth and Its Antiviral Inhibition in Culture, Skin, and Humanized Mice.

Published in:

Viruses (1999-4915), 2022, v. 14, n. 4, p. N.PAG, doi. 10.3390/v14040826

By:

Lloyd, Megan G.;
Yee, Michael B.;
Flot, Joseph S.;
Liu, Dongmei;
Geiler, Brittany W.;
Kinchington, Paul R.;
Moffat, Jennifer F.

Publication type:

Article

A Novel Broad Host Range Phage Infecting Alteromonas.

Published in:

Viruses (1999-4915), 2021, v. 13, n. 6, p. 987, doi. 10.3390/v13060987

By:

Feng, Xuejin;
Yan, Wei;
Wang, Anan;
Ma, Ruijie;
Chen, Xiaowei;
Lin, Ta-Hui;
Chen, Yi-Lung;
Wei, Shuzhen;
Jin, Tao;
Jiao, Nianzhi;
Zhang, Rui

Publication type:

Article

Capsaicin Acts Through Reducing P38 MAPK-Dependent Thymidylate Synthase Expression to Enhance 5-Fluorouracil-Induced Cytotoxicity in Human Lung Cancer Cells.

Published in:

Natural Product Communications, 2021, v. 16, n. 2, p. 1, doi. 10.1177/1934578X21993335

By:

Chun-Liang Tung;
Jyh-Cheng Chen;
Jen-Chung Ko;
Li-Ling Liu;
Chin-Cheng Chien;
I-Hsiang Huang;
Yong-Cing Tsao;
Hsiang-Hung Cheng;
Tzu-Ying Chen;
Ting-Chuan Yen;
Yun-Wei Lin

Publication type:

Article

Genetic polymorphisms and gene expression of one-carbon metabolizing enzymes and their relation to breast cancer.

Published in:

Egyptian Journal of Medical Human Genetics, 2022, v. 23, n. 1, p. 1, doi. 10.1186/s43042-022-00296-8

By:

Eldeeb, Mona Kamal;
Shoaib, Mai Maher Abd-Elaziz;
Abd-Elmonem, Esraa Ahmed;
Saeed, Hesham Mahmoud Sayd;
Embaby, Amira Mohammad;
Farouk, Ayman Mohamed;
Rashad, Radwa Mohammed

Publication type:

Article

The Association Between Thymidylate Synthase Gene Polymorphisms and the Risk of Ischemic Stroke in Chinese Han Population.

Published in:

Biochemical Genetics, 2024, v. 62, n. 1, p. 468, doi. 10.1007/s10528-023-10431-8

By:

Yu, Fuhua;
Shi, Lei;
Wang, Qianru;
Xing, Xiaohui;
Li, Zhongchen;
Hou, Lei;
Zhou, Zhengshan;
Wang, Zengguang;
Xiao, Yilei

Publication type:

Article

In Silico, In Vitro and In Vivo Biological Evaluations of Angularly Fused Pyrido[3',2':4,5]furo[3,2-d]pyrimidines.

Published in:

Indian Journal of Pharmaceutical Sciences, 2024, v. 86, n. 5, p. 1852, doi. 10.36468/pharmaceutical-sciences.1452

By:

VACHALA, S. D.;
KOTHARI, S. K.;
LOGANATHAN, GEETHA PRIYA

Publication type:

Article

Preclinical emergence of vandetanib as a potent antitumour agent in mesothelioma: molecular mechanisms underlying its synergistic interaction with pemetrexed and carboplatin.

Published in:

2011

By:

Giovannetti, E;
Zucali, P A;
Assaraf, Y G;
Leon, L G;
Smid, K;
Alecci, C;
Giancola, F;
Destro, A;
Gianoncelli, L;
Lorenzi, E;
Roncalli, M;
Santoro, A;
Peters, G J

Publication type:

journal article

Thymidylate synthase as a determinant of pemetrexed sensitivity in non-small cell lung cancer.

Published in:

2011

By:

Takezawa, K.;
Okamoto, I.;
Okamoto, W.;
Takeda, M.;
Sakai, K.;
Tsukioka, S.;
Kuwata, K.;
Yamaguchi, H.;
Nishio, K.;
Nakagawa, K.

Publication type:

journal article

Vorinostat synergises with capecitabine through upregulation of thymidine phosphorylase.

Published in:

2010

By:

Di Gennaro, E.;
Piro, G.;
Chianese, M. I.;
Franco, R.;
Cintio, A. Di;
Moccia, T.;
Luciano, A.;
de Ruggiero, I.;
Bruzzese, F.;
Avallone, A.;
Arra, C.;
Budillon, A.;
Di Cintio, A

Publication type:

journal article

UGT1A and TYMS genetic variants predict toxicity and response of colorectal cancer patients treated with first-line irinotecan and fluorouracil combination therapy.

Published in:

2010

By:

Martinez-Balibrea, E;
Abad, A.;
Martínez-Cardús, A.;
Ginés, A.;
Valladares, M.;
Navarro, M.;
Aranda, E.;
Marcuello, E.;
Benavides, M.;
Massutí, B.;
Carrato, A.;
Layos, L.;
Manzano, J. L.;
Moreno, V.;
Martínez-Cardús, A;
Ginés, A;
Massutí, B

Publication type:

journal article

Identification of thymidylate synthase as a potential therapeutic target for lung cancer.

Published in:

2010

By:

Takezawa, K.;
Okamoto, I.;
Tsukioka, S.;
Uchida, J.;
Kiniwa, M.;
Fukuoka, M.;
Nakagawa, K.

Publication type:

journal article

Why is There Still Debate About Recommending DPYD‐Testing Before Fluoropyrimidine Treatment?

Published in:

Clinical Pharmacology & Therapeutics, 2023, v. 114, n. 4, p. 733, doi. 10.1002/cpt.3016

By:

Cascorbi, Ingolf

Publication type:

Article

Thymidylate Synthase, a New Myoepithelial Biomarker for Breast Lesions.

Published in:

International Journal of Surgical Pathology, 2019, v. 27, n. 8, p. 852, doi. 10.1177/1066896919858403

By:

Guo, Rui;
Tian, Yi;
Jin, Xueyuan;
Huang, Xiaozhong;
Yang, Jun

Publication type:

Article

Uncovering cancer vulnerabilities by machine learning prediction of synthetic lethality.

Published in:

Molecular Cancer, 2021, v. 20, n. 1, p. 1, doi. 10.1186/s12943-021-01405-8

By:

Benfatto, Salvatore;
Serçin, Özdemirhan;
Dejure, Francesca R.;
Abdollahi, Amir;
Zenke, Frank T.;
Mardin, Balca R.

Publication type:

Article

Genome-wide regulation of KSHV RNA splicing by viral RNA-binding protein ORF57.

Published in:

PLoS Pathogens, 2022, v. 18, n. 7, p. 1, doi. 10.1371/journal.ppat.1010311

By:

Majerciak, Vladimir;
Alvarado-Hernandez, Beatriz;
Lobanov, Alexei;
Cam, Maggie;
Zheng, Zhi-Ming

Publication type:

Article

Evolution of Metamorphism in Thymidylate Synthases Within the Primate Lineages.

Published in:

Journal of Molecular Evolution, 2011, v. 72, n. 3, p. 306, doi. 10.1007/s00239-011-9433-8

By:

BeiBei Luo;
Johnson, Saphronia R.;
Lebioda, Lukasz;
Berger, Sondra H.

Publication type:

Article

The novel anti-cancer fluoropyrimidine NUC-3373 is a potent inhibitor of thymidylate synthase and an effective DNA-damaging agent.

Published in:

Cancer Chemotherapy & Pharmacology, 2023, v. 91, n. 5, p. 401, doi. 10.1007/s00280-023-04528-5

By:

Bré, Jennifer;
Dickson, Alison L.;
Read, Oliver J.;
Zhang, Ying;
McKissock, Fiona G.;
Mullen, Peter;
Tang, Peijun;
Zickuhr, Greice M.;
Czekster, Clarissa M.;
Harrison, David J.

Publication type:

Article

Plasma deoxyuridine as a surrogate marker for toxicity and early clinical response in patients with metastatic colorectal cancer after 5-FU-based therapy in combination with arfolitixorin.

Published in:

Cancer Chemotherapy & Pharmacology, 2021, v. 87, n. 1, p. 31, doi. 10.1007/s00280-020-04173-2

By:

Taflin, Helena;
Odin, Elisabeth;
Carlsson, Göran;
Tell, Roger;
Gustavsson, Bengt;
Wettergren, Yvonne

Publication type:

Article

Inhibitors of class I HDACs and of FLT3 combine synergistically against leukemia cells with mutant FLT3.

Published in:

Archives of Toxicology, 2022, v. 96, n. 1, p. 177, doi. 10.1007/s00204-021-03174-1

By:

Wachholz, Vanessa;
Mustafa, Al-Hassan M.;
Zeyn, Yanira;
Henninger, Sven J.;
Beyer, Mandy;
Dzulko, Melanie;
Piée-Staffa, Andrea;
Brachetti, Christina;
Haehnel, Patricia S.;
Sellmer, Andreas;
Mahboobi, Siavosh;
Kindler, Thomas;
Brenner, Walburgis;
Nikolova, Teodora;
Krämer, Oliver H.

Publication type:

Article

Correlations of Clinicopathological Factors with Protein Expression Levels of Thymidylate Synthase, Dihydropyrimidine Dehydrogenase and Orotate Phosphoribosyltransferase in Colorectal Cancer.

Published in:

Chemotherapy (0009-3157), 2010, v. 56, n. 2, p. 120, doi. 10.1159/000313524

By:

Sumi, Tetsuo;
Katsumata, Kenji;
Tsuchida, Akihiko;
Ishizaki, Tetsuo;
Shimazu, Motohide;
Aoki, Tatsuya

Publication type:

Article

Evaluating serum level of thymidylate synthase in post burn keloid patients before and after intralesional injection of 5-fluorouracil.

Published in:

Scars, Burns & Healing, 2022, p. 1, doi. 10.1177/20595131211049043

By:

Ezzat Mohamad, Noha;
Abd El Raheem, Talal Ahmed;
Mahmoud, Rania Hosny;
Osama Hamed, Nehal

Publication type:

Article

Evaluating serum level of thymidylate synthase in post burn keloid patients before and after intralesional injection of 5-fluorouracil.

Published in:

Scars, Burns & Healing, 2022, v. 8, p. 1, doi. 10.1177/20595131211049043

By:

Mohamad, Noha Ezzat;
El Raheem, Talal Ahmed Abd;
Mahmoud, Rania Hosny;
Hamed, Nehal Osama

Publication type:

Article

Thymidylate Synthase Overexpression Drives the Invasive Phenotype in Colon Cancer Cells.

Published in:

Biomedicines, 2022, v. 10, n. 6, p. 1267, doi. 10.3390/biomedicines10061267

By:

Ciszewski, Wojciech M.;
Chmielewska-Kassassir, Małgorzata;
Wozniak, Lucyna A.;
Sobierajska, Katarzyna

Publication type:

Article

Predicting Agents That Can Overcome 5-FU Resistance in Colorectal Cancers via Pharmacogenomic Analysis.

Published in:

Biomedicines, 2021, v. 9, n. 8, p. 882, doi. 10.3390/biomedicines9080882

By:

Huang, Tsui-Chin;
Peng, Kuan-Chieh;
Kuo, Tzu-Ting;
Lin, Li-Chun;
Liu, Bai-Chia;
Ye, Shu-Ping;
Chu, Chien-Chou;
Hsia, Shih-Min;
Chang, Hsin-Yi

Publication type:

Article

PM2.5 induces cell cycle arrest through regulating mTOR/P70S6K1 signaling pathway.

Published in:

Experimental & Therapeutic Medicine, 2019, v. 17, n. 6, p. 4371

By:

Zhang, Yu;
Yang, Dan;
Yang, Biao;
Li, Bingyu;
Guo, Jie;
Xiao, Chunling

Publication type:

Article