Works matching DE "TETRAHYDROFOLATE dehydrogenase"

Results: 532

Comprehensive analysis of Crotalaria willdenowiana DC.: GC–MS profiling, antioxidant and anticancer activities, molecular docking studies, and in silico ADME profiling.

Published in:

3 Biotech, 2025, v. 15, n. 8, p. 1, doi. 10.1007/s13205-025-04409-z

By:

Muthukrishnan, Sathish;
Raman, Chamundeeswari;
Chandrasekaran, Grevasan;
Soundhirapandi, Pavithra;
Chinnappan, Ganapathy;
Prakasam, Raja;
Palani, Manogar;
Pandiyan, Jeevan

Publication type:

Article

Exploring the Potential of Plant Cytokinins Against Common Human Pathogens: In Vitro Assessment and In Silico Insights.

Published in:

Plants (2223-7747), 2025, v. 14, n. 12, p. 1749, doi. 10.3390/plants14121749

By:

Lazarević, Jelena;
Veselinović, Aleksandar;
Stojiljković, Marija;
Petrović, Miloš;
Ciuffreda, Pierangela;
Santaniello, Enzo

Publication type:

Article

Hyperkalaemia: the unintended consequence of prescribing Co-trimoxazole for complex infections.

Published in:

Postgraduate Medical Journal, 2025, v. 101, n. 1197, p. 655, doi. 10.1093/postmj/qgaf022

By:

Lazarowicz, Andrew;
O'Connor, Matthew;
Morris, Audrey;
McFadyen, Angus;
Irvine, Sharon;
Isles, Chris

Publication type:

Article

Bacillibactin, a Potential Bacillus -Based Antibacterial Non-Ribosomal Peptide: In Silico Studies for Targeting Common Fish Pathogens.

Published in:

International Journal of Molecular Sciences, 2025, v. 26, n. 12, p. 5811, doi. 10.3390/ijms26125811

By:

Prazdnova, Evgeniya;
Zaikina, Anna;
Neurov, Alexey;
Mazanko, Maria;
Ranjan, Anuj;
Rudoy, Dmitry

Publication type:

Article

Effect and Mechanism of Cotrimoxazole Against Talaromyces marneffei in vitro.

Published in:

Mycopathologia, 2022, v. 187, n. 5/6, p. 579, doi. 10.1007/s11046-022-00673-2

By:

Chen, Jie;
Chen, Rongfeng;
Wei, Wudi;
Qin, Fengxiang;
Chen, Xiu;
He, Jinhao;
Zhang, Hong;
Wang, Gang;
Shi, Minjuan;
Qin, Tongxue;
Liao, Yinlu;
Wu, Yuting;
Lu, Beibei;
Tao, Xing;
Ye, Li;
Liang, Hao;
Jiang, Junjun

Publication type:

Article

Design, synthesis, antimicrobial activity, DFT, and molecular docking studies of pyridine‐pyrazole‐based dihydro‐1,3,4‐oxadiazoles against various bacterial and fungal targets.

Published in:

Journal of Biochemical & Molecular Toxicology, 2023, v. 37, n. 8, p. 1, doi. 10.1002/jbt.23377

By:

Desai, Nisheeth;
Jadeja, Dharmpalsinh;
Monapara, Jahnvi;
Panda, Saroj Kumar;
Rana, Malay Kumar;
Dave, Bharti

Publication type:

Article

Palladium‐Catalyzed Aminocarbonylation of Aryl Halides with N,N‐Dialkylformamide Acetals.

Published in:

Helvetica Chimica Acta, 2021, v. 104, n. 11, p. 1, doi. 10.1002/hlca.202100162

By:

Hirata, Shuichi;
Osako, Takao;
Uozumi, Yasuhiro

Publication type:

Article

A single-plasmid vector for transgene amplification using short hairpin RNA targeting the 3′-UTR of amplifiable dhfr.

Published in:

Applied Microbiology & Biotechnology, 2015, v. 99, n. 23, p. 10117, doi. 10.1007/s00253-015-6856-y

By:

Kang, Shin-Young;
Kim, Yeon-Gu;
Lee, Hong;
Lee, Eun

Publication type:

Article

Combinatorial engineering of ldh-a and bcl-2 for reducing lactate production and improving cell growth in dihydrofolate reductase-deficient Chinese hamster ovary cells.

Published in:

Applied Microbiology & Biotechnology, 2011, v. 92, n. 4, p. 779, doi. 10.1007/s00253-011-3475-0

By:

Jeon, Min;
Yu, Da;
Lee, Gyun

Publication type:

Article

In Silico Identification of Antifungal Compounds as Mutant DHFRase Inhibitors: Structure-Based Approach, Molecular Dynamics Simulation and Structural Integrity Analysis.

Published in:

Journal of Computational Biophysics & Chemistry, 2021, v. 20, n. 6, p. 589, doi. 10.1142/S2737416521500344

By:

Basak, Trambak;
Nath, Virendra;
Kumar, Vipin;
Goyal, Amit Kumar

Publication type:

Article

In Silico Study Probes Potential Inhibitors of Human Dihydrofolate Reductase for Cancer Therapeutics.

Published in:

Journal of Clinical Medicine, 2019, v. 8, n. 2, p. 233, doi. 10.3390/jcm8020233

By:

Rana, Rabia Mukhtar;
Rampogu, Shailima;
Zeb, Amir;
Son, Minky;
Park, Chanin;
Lee, Gihwan;
Yoon, Sanghwa;
Baek, Ayoung;
Parameswaran, Sarvanan;
Park, Seok Ju;
Lee, Keun Woo

Publication type:

Article

A Variation in FGF14 Is Associated with Downbeat Nystagmus in a Genome-Wide Association Study.

Published in:

Cerebellum, 2020, v. 19, n. 3, p. 348, doi. 10.1007/s12311-020-01113-x

By:

Strupp, Michael;
Maul, Stephan;
Konte, Bettina;
Hartmann, Annette M.;
Giegling, Ina;
Wollenteit, Sophia;
Feil, Katharina;
Rujescu, Dan

Publication type:

Article

INTERACTION OF PTERIDOPHYTIC BIOACTIVE COMPOUNDS WITH FUNGAL DIHYDROFOLATE REDUCTASE ENZYME AS INHIBITOR.

Published in:

Journal of Faculty of Pharmacy of Ankara University / Ankara Üniversitesi Eczacilik Fakültesi Dergisi, 2023, v. 47, n. 3, p. 1170, doi. 10.33483/jfpau.1270767

By:

SINGH, Manohar;
RAGHAV, Mansi;
SINGH, Akanksha;
KUMARI, Akanksha;
BANSAL, Priya;
PRAKASH, Surya;
KUMAR, Abhishek

Publication type:

Article

The Prevalence of SNP rs12517451 in Gene Transcribing Dihydrofolate Reductase and Drug Adverse Effects among MTXtreated Rheumatoid Arthritis Patients in Kelantan, Malaysia.

Published in:

Malaysian Journal of Medicine & Health Sciences, 2021, n. 3, p. 98

By:

Zahari, Mohamad Syazwan;
Rajaratinam, Harishini;
Bakar, Nur Salwani

Publication type:

Article

Co-delivery of STAT3 siRNA and methotrexate in breast cancer cells.

Published in:

Artificial Cells, Nanomedicine & Biotechnology, 2022, v. 50, n. 1, p. 29, doi. 10.1080/21691401.2022.2030746

By:

Shakeran, Zahra;
Varshosaz, Jaleh;
Keyhanfar, Mehrnaz;
Mohammad-Beigi, Hossein;
Rahimi, Karim;
Sutherland, Duncan S.

Publication type:

Article

Crystal structure of the plasmid-encoded R67 dihydrofolate reductase complexed with Congo red an amyloid binding dye.

Published in:

Scientific Reports, 2025, v. 15, n. 1, p. 1, doi. 10.1038/s41598-025-89539-3

By:

Narendra, Akshay N.;
Howell, Elizabeth E.;
Narayana, Narendra

Publication type:

Article

First-time report on compound isolation from two Colocasia species: vegetable-derived bioactive metabolites and their medicinal potential.

Published in:

Frontiers in Pharmacology, 2025, p. 1, doi. 10.3389/fphar.2024.1474706

By:

Alam, Safaet;
Richi, Fahmida Tasnim;
Emon, Nazim Uddin;
Chowdhury, Abu Asad;
Hasan, Choudhury Mahmood;
Haque, Mohammad Rashedul

Publication type:

Article

First-time report on compound isolation from two Colocasia species: vegetable-derived bioactive metabolites and their medicinal potential.

Published in:

Frontiers in Pharmacology, 2024, p. 1, doi. 10.3389/fphar.2024.1474706

By:

Alam, Safaet;
Richi, Fahmida Tasnim;
Emon, Nazim Uddin;
Chowdhury, Abu Asad;
Hasan, Choudhury Mahmood;
Haque, Mohammad Rashedul

Publication type:

Article

Emergence of Plasmid-Borne dfrA14 Trimethoprim Resistance Gene in Shigella sonnei.

Published in:

Frontiers in Cellular & Infection Microbiology, 2016, v. 6, p. 1, doi. 10.3389/fcimb.2016.00077

By:

Miranda, Alfonso;
Ávila, Bárbara;
Díaz, Patricia;
Rivas, Lina;
Bravo, Karen;
Astudillo, Javier;
Bueno, Constanza;
Ulloa, María T.;
Hermosilla, Germán;
Del Canto, Felipe;
Salazar, Juan C.;
Toro, Cecilia S.

Publication type:

Article

Drug design of human dihydrofolate reductase (hDHFR) inhibitors with deep learning.

Published in:

Journal of the Chinese Chemical Society, 2023, v. 70, n. 5, p. 1258, doi. 10.1002/jccs.202350068

By:

Wu, Yi‐Huan;
Cheng, Chih‐Yang;
Chen, Yen‐Yang;
Li, Feng‐Yin

Publication type:

Article

Microwave synthesis and antimalarial screening of novel 4-amino benzoic acid (PABA)-substituted pyrimidine derivatives as Plasmodium falciparum dihydrofolate reductase inhibitors.

Published in:

3 Biotech, 2022, v. 12, n. 8, p. 1, doi. 10.1007/s13205-022-03236-w

By:

Choudhury, Ayesha Aktar Khanam;
Vinayagam, Sathishkumar;
Adhikari, Nayana;
Ghosh, Surajit Kumar;
Sattu, Kamaraj

Publication type:

Article

Monitoring mRNA vaccine antigen expression in vivo using PET/CT.

Published in:

Nature Communications, 2025, v. 16, n. 1, p. 1, doi. 10.1038/s41467-025-57446-w

By:

Blizard, Gabrielle S.;
Dwivedi, Garima;
Pan, Yi-Gen;
Hou, Catherine;
Etersque, Jean M.;
Said, Hooda;
Chevrier, Anik;
Lavertu, Marc;
Ni, Houping;
Davis, Benjamin;
Tam, Ying;
Cao, Quy;
Mach, Robert H.;
Weissman, Drew;
Alameh, Mohamad-Gabriel;
Sellmyer, Mark A.

Publication type:

Article

Population genomics of Plasmodium ovale species in sub-Saharan Africa.

Published in:

Nature Communications, 2024, v. 15, n. 1, p. 1, doi. 10.1038/s41467-024-54667-3

By:

Carey-Ewend, Kelly;
Popkin-Hall, Zachary R.;
Simkin, Alfred;
Muller, Meredith;
Hennelly, Chris;
He, Wenqiao;
Moser, Kara A.;
Gaither, Claudia;
Niaré, Karamoko;
Aghakanian, Farhang;
Feleke, Sindew;
Brhane, Bokretsion G.;
Phanzu, Fernandine;
Kashamuka, Melchior Mwandagalirwa;
Aydemir, Ozkan;
Sutherland, Colin J.;
Ishengoma, Deus S.;
Ali, Innocent M.;
Ngasala, Billy;
Kalonji, Albert

Publication type:

Article

A proteome-wide structural systems approach reveals insights into protein families of all human herpesviruses.

Published in:

Nature Communications, 2024, v. 15, n. 1, p. 1, doi. 10.1038/s41467-024-54668-2

By:

Soh, Timothy K.;
Ognibene, Sofia;
Sanders, Saskia;
Schäper, Robin;
Kaufer, Benedikt B.;
Bosse, Jens B.

Publication type:

Article

Two‐ and Three‐dimensional Quantitative Structure‐activity Relationship Models Based on Conformer Structures.

Published in:

Molecular Informatics, 2021, v. 40, n. 3, p. 1, doi. 10.1002/minf.202000123

By:

Nitta, Fumika;
Kaneko, Hiromasa

Publication type:

Article

Pharmacoinformatic Study on the Selective Inhibition of the Protozoan Dihydrofolate Reductase Enzymes.

Published in:

Molecular Informatics, 2017, v. 36, n. 11, p. n/a, doi. 10.1002/minf.201600156

By:

Sharma, Vishnu K.;
Abbat, Sheenu;
Bharatam, P. V.

Publication type:

Article

Proteomic analysis of oridonin-induced apoptosis in multiple myeloma cells.

Published in:

Molecular Medicine Reports, 2017, v. 15, n. 4, p. 1807, doi. 10.3892/mmr.2017.6213

By:

JING ZHAO;
MEI ZHANG;
PENGCHENG HE;
JUNJIE ZHAO;
YING CHEN;
JUN QI;
YUAN WANG

Publication type:

Article

Unveiling the Connection: Viral Infections and Genes in dNTP Metabolism.

Published in:

Viruses (1999-4915), 2024, v. 16, n. 9, p. 1412, doi. 10.3390/v16091412

By:

Lo, Shih-Yen;
Lai, Meng-Jiun;
Yang, Chee-Hing;
Li, Hui-Chun

Publication type:

Article

Proteochemometric modelling coupled to in silico target prediction: an integrated approach for the simultaneous prediction of polypharmacology and binding affinity/potency of small molecules.

Published in:

Journal of Cheminformatics, 2015, v. 7, n. 1, p. 1, doi. 10.1186/s13321-015-0063-9

By:

Paricharak, Shardul;
Cortés-Ciriano, Isidro;
IJzerman, Adriaan P.;
Malliavin, Thérèse E.;
Bender, Andreas

Publication type:

Article

Synthesis and In-vitro / silico Evaluation of Fluorinated Chalcones.

Published in:

Oriental Journal of Chemistry, 2024, v. 40, n. 4, p. 1077, doi. 10.13005/ojc/400419

By:

Vane, Vilas;
Mokal, Ramesh;
Yashwante, Usha;
Meshram, Rohan;
Jadhavar, Suresh

Publication type:

Article

Evidence that a 'dynamic knockout' in Escherichia coli dihydrofolate reductase does not affect the chemical step of catalysis.

Published in:

Nature Chemistry, 2012, v. 4, n. 4, p. 292, doi. 10.1038/nchem.1296

By:

Loveridge, E. Joel;
Behiry, Enas M.;
Guo, Jiannan;
Allemann, Rudolf K.

Publication type:

Article

Genotyping of Cryptosporidium Parvum by PCR-Sequencing Analysis for The 70 Heat Shock Protein (HSP70) Gene and Dihydrofolate Reductase (DHFR) Gene.

Published in:

Indian Journal of Forensic Medicine & Toxicology, 2021, v. 15, n. 3, p. 5110, doi. 10.37506/ijfmt.v15i3.16246

By:

Mohammed, Sarmad Jassem;
Al-Watifi, Noora Amir;
Jameel, Zahraa Isam;
Mohammed, Amera Kamal;
Alasadi, Yusor Fadhil

Publication type:

Article

The prevalence of molecular markers of resistance to sulfadoxine-pyrimethamine among pregnant women at first antenatal clinic attendance and delivery in the forest-savannah area of Ghana.

Published in:

PLoS ONE, 2022, v. 17, n. 8, p. 1, doi. 10.1371/journal.pone.0271489

By:

Dosoo, David Kwame;
Bailey, Jeffrey A.;
Asante, Kwaku Poku;
Oppong, Felix Boakye;
Niaré, Karamoko;
Opoku-Mensah, Jones;
Owusu-Agyei, Seth;
Greenwood, Brian;
Chandramohan, Daniel

Publication type:

Article

Probing the origin of dihydrofolate reductase inhibition via proteochemometric modeling.

Published in:

Journal of Chemometrics, 2019, v. 33, n. 2, p. N.PAG, doi. 10.1002/cem.3090

By:

Hariri, Safoura;
Ghasemi, Jahan B.;
Shirini, Farhad;
Rasti, Behnam

Publication type:

Article

Toward resistance-compromised DHFR inhibitors part 1: Combined structure/ligand-based virtual screenings and ADME-Tox profiling.

Published in:

Journal of Chemometrics, 2016, v. 30, n. 8, p. 462, doi. 10.1002/cem.2814

By:

Gahtori, Prashant;
Pandey, Rahul;
Kumar, Vinod;
Ghosh, Surajit Kumar;
Das, Aparoop;
Kalita, Jun Moni;
Sahu, Supriya;
Prakash, Anil;
Bhattacharyya, Divya Ranjan

Publication type:

Article

Docking and pharmacophore-based alignment comparative molecular field analysis three-dimensional quantitative structure-activity relationship analysis of dihydrofolate reductase inhibitors by linear and nonlinear calibration methods.

Published in:

Journal of Chemometrics, 2013, v. 27, n. 10, p. 287, doi. 10.1002/cem.2515

By:

Ghasemi, Jahan B.;
Meftahi, Nastaran;
Pirhadi, Somayeh;
Tavakoli, Hossein

Publication type:

Article

A Genome‐wide association study identified HLA‐C associated with the effectiveness of methotrexate for psoriasis treatment.

Published in:

Journal of the European Academy of Dermatology & Venereology, 2021, v. 35, n. 12, p. e898, doi. 10.1111/jdv.17544

By:

Zhang, Y.;
Ding, X.;
Meng, Z.;
Chen, M.;
Zheng, X.;
Cai, M.;
Wu, J.;
Chang, Y.;
Zhang, Q.;
Jin, L.;
Qian, D.;
Li, X.;
Wu, M.;
Yan, K.;
Lu, Y.;
Zhang, X.

Publication type:

Article

In Silico, In Vitro and In Vivo Biological Evaluations of Angularly Fused Pyrido[3',2':4,5]furo[3,2-d]pyrimidines.

Published in:

Indian Journal of Pharmaceutical Sciences, 2024, v. 86, n. 5, p. 1852, doi. 10.36468/pharmaceutical-sciences.1452

By:

VACHALA, S. D.;
KOTHARI, S. K.;
LOGANATHAN, GEETHA PRIYA

Publication type:

Article

Antifolate Agents Against Wild and Mutant Strains of Plasmodium falciparum.

Published in:

Indian Journal of Pharmaceutical Sciences, 2014, v. 76, n. 2, p. 116

By:

SHAIKH, M. S.;
RANA, J.;
GAIKWAD, D.;
LEARTSAKULPANICH, U.;
AMBRE, PREMLATA K.;
PISSURLENKAR, R. R. S.;
COUTINHO, E. C.

Publication type:

Article

Single agent and combination studies of pralatrexate and molecular correlates of sensitivity.

Published in:

2011

By:

Serova, M.;
Bieche, I.;
Sablin, M.-P.;
Pronk, G. J.;
Vidaud, M.;
Cvitkovic, E.;
Faivre, S.;
Raymond, E.

Publication type:

journal article

Antiepileptic drugs, folate one‐carbon metabolism, genetics, and epigenetics: Congenital, developmental, and neuropsychological risks and antiepileptic action.

Published in:

Epilepsia (Series 4), 2024, v. 65, n. 12, p. 3469, doi. 10.1111/epi.18120

By:

Reynolds, Edward H.

Publication type:

Article

Growth‐mediated negative feedback shapes quantitative antibiotic response.

Published in:

Molecular Systems Biology, 2022, v. 18, n. 9, p. 1, doi. 10.15252/msb.202110490

By:

Angermayr, S Andreas;
Pang, Tin Yau;
Chevereau, Guillaume;
Mitosch, Karin;
Lercher, Martin J;
Bollenbach, Tobias

Publication type:

Article

Ultralight Ultrafast Enzymes.

Published in:

Angewandte Chemie, 2024, v. 136, n. 3, p. 1, doi. 10.1002/ange.202316488

By:

Zhang, Xuepei;
Meng, Zhaowei;
Beusch, Christian M.;
Gharibi, Hassan;
Cheng, Qing;
Lyu, Hezheng;
Di Stefano, Luciano;
Wang, Jijing;
Saei, Amir A.;
Végvári, Ákos;
Gaetani, Massimiliano;
Zubarev, Roman A.

Publication type:

Article

Third‐Generation Covalent TMP‐Tag for Fast Labeling and Multiplexed Imaging of Cellular Proteins.

Published in:

Angewandte Chemie, 2022, v. 134, n. 36, p. 1, doi. 10.1002/ange.202207905

By:

Mo, Jiaming;
Chen, Jingting;
Shi, Yabo;
Sun, Jingfu;
Wu, Yunxiang;
Liu, Tianyan;
Zhang, Junwei;
Zheng, Yu;
Li, Yulong;
Chen, Zhixing

Publication type:

Article

Drug Repurposing by Siderophore Conjugation: Synthesis and Biological Evaluation of Siderophore‐Methotrexate Conjugates as Antibiotics.

Published in:

Angewandte Chemie, 2022, v. 134, n. 36, p. 1, doi. 10.1002/ange.202204139

By:

Zhao, Sheng;
Wang, Zhi‐Peng;
Lin, Zihua;
Wei, Guoxing;
Wen, Xumei;
Li, Siyu;
Yang, Xiaohong;
Zhang, Qun;
Jing, Chunmei;
Dai, Yuanwei;
Guo, Jian;
He, Yun

Publication type:

Article

Folate metabolite profiling of different cell types and embryos suggests variation in folate one-carbon metabolism, including developmental changes in human embryonic brain.

Published in:

Molecular & Cellular Biochemistry, 2013, v. 378, n. 1/2, p. 229, doi. 10.1007/s11010-013-1613-y

By:

Leung, Kit-Yi;
Castro, Sandra;
Cabreiro, Filipe;
Gustavsson, Peter;
Copp, Andrew;
Greene, Nicholas

Publication type:

Article

Effects of salt on the structure, stability, and function of a halophilic dihydrofolate reductase from a hyperhalophilic archaeon, Haloarcula japonica strain TR-1.

Published in:

Extremophiles, 2015, v. 19, n. 2, p. 479, doi. 10.1007/s00792-015-0732-7

By:

Miyashita, Yurina;
Ohmae, Eiji;
Nakasone, Kaoru;
Katayanagi, Katsuo

Publication type:

Article

Comparative study on dihydrofolate reductases from Shewanella species living in deep-sea and ambient atmospheric-pressure environments.

Published in:

Extremophiles, 2011, v. 15, n. 2, p. 165, doi. 10.1007/s00792-010-0345-0

By:

Murakami, Chiho;
Ohmae, Eiji;
Tate, Shin-ichi;
Gekko, Kunihiko;
Nakasone, Kaoru;
Kato, Chiaki

Publication type:

Article

Prediction of allosteric communication pathways in proteins.

Published in:

Bioinformatics, 2022, v. 38, n. 14, p. 3590, doi. 10.1093/bioinformatics/btac380

By:

Haliloglu, Turkan;
Hacisuleyman, Aysima;
Erman, Burak

Publication type:

Article

MODELING OF NEW POTENTIAL INHIBITORS OF DIHYDROFOLATE REDUCTASE BASED ON 1,3,4-TH I AD I AZ OLE AMIDOALKYL DERIVATIVES.

Published in:

Issues of Chemistry & Chemical Technology / Voprosy Khimii & Khimicheskoi Tekhnologii, 2023, n. 5, p. 91, doi. 10.32434/0321-4095-2023-150-5-91-97

By:

Pavlova, V. V.;
Zadorotftnii, P. V.;
Kiselev, V. V.;
Kharchenko, A. V.;
Okhtina, O. V.

Publication type:

Article