Works matching DE "TETRAHYDROBIOPTERIN"

Results: 348

Deficiencias de tetrahidrobiopterina (BH4): diagnóstico y tratamiento.

Published in:

Acta Pediatrica de Mexico, 2012, v. 33, n. 6, p. 319

By:

Martínez-Pardo, Mercedes

Publication type:

Article

PTR1-dependent synthesis of tetrahydrobiopterin contributes to oxidant susceptibility in the trypanosomatid protozoan parasite Leishmania major.

Published in:

Current Genetics, 2009, v. 55, n. 3, p. 287, doi. 10.1007/s00294-009-0244-z

By:

Nare, Bakela;
Garraway, Levi A.;
Vickers, Tim J.;
Beverley, Stephen M.

Publication type:

Article

L-Dopa Might Be Insufficient to Suppress Development of Prolactinomas in Dihydropteridine Reductase-Deficiency Patients.

Published in:

JCEM Case Reports, 2024, v. 2, n. 10, p. 1, doi. 10.1210/jcemcr/luae172

By:

Diaz-Moreno, Unai;
Gan, Cheng Guang;
Pujari, Divya;
Gan, Hoong-Wei;
Batzios, Spyros

Publication type:

Article

Tetrahydrobiopterin: Beyond Its Traditional Role as a Cofactor.

Published in:

Antioxidants, 2023, v. 12, n. 5, p. 1037, doi. 10.3390/antiox12051037

By:

Eichwald, Tuany;
da Silva, Lucila de Bortoli;
Staats Pires, Ananda Christina;
Niero, Laís;
Schnorrenberger, Erick;
Filho, Clovis Colpani;
Espíndola, Gisele;
Huang, Wei-Lin;
Guillemin, Gilles J.;
Abdenur, José E.;
Latini, Alexandra

Publication type:

Article

Relative Oral Bioavailability and Food Effects of Two Sepiapterin Formulations in Healthy Participants.

Published in:

Clinical Pharmacology in Drug Development, 2024, v. 13, n. 5, p. 506, doi. 10.1002/cpdd.1363

By:

Gao, Lan;
Kaushik, Diksha;
Xia, Yi;
Ingalls, Kimberly;
Milner, Sarah;
Smith, Neil;
Kong, Ronald

Publication type:

Article

Decreased Arteriolar Tetrahydrobiopterin is Linked to Superoxide Generation from Nitric Oxide Synthase in Mice Fed High Salt.

Published in:

Microcirculation, 2010, v. 17, n. 2, p. 147, doi. 10.1111/j.1549-8719.2009.00014.x

By:

NURKIEWICZ, TIMOTHY R.;
GUOYAO WU;
PENG LI;
BOEGEHOLD, MATTHEW A.

Publication type:

Article

Chronic oral supplementation with sepiapterin prevents endothelial dysfunction and oxidative stress in small mesenteric arteries from diabetic (db/db) mice.

Published in:

2003

By:

Pannirselvam, Malarvannan;
Simon, Valerie;
Verma, Subodh;
Anderson, Todd;
Triggle, Chris R.

Publication type:

journal article

Cellular basis of endothelial dysfunction in small mesenteric arteries from spontaneously diabetic (db/db -/- ) mice: role of decreased tetrahydrobiopterin bioavailability.

Published in:

British Journal of Pharmacology, 2002, v. 136, n. 2, p. 255, doi. 10.1038/sj.bjp.0704683

By:

Pannirselvam, Malarvannan;
Verma, Subodh;
Anderson, Todd J.;
Triggle, Chris R.

Publication type:

Article

Vitiligo is not caused by mutations in GTP-cyclohydrolase I gene.

Published in:

Clinical & Experimental Dermatology, 2000, v. 25, n. 2, p. 152, doi. 10.1046/j.1365-2230.2000.00599.x

By:

Bandyopadhyay;
Lawrence;
Majumder;
Ferrell;
Majumder

Publication type:

Article

Exendin-4 reverses endothelial dysfunction in mice fed a high-cholesterol diet by a GTP cyclohydrolase-1/tetrahydrobiopterin pathway.

Published in:

Molecular Medicine Reports, 2018, v. 18, n. 3, p. 3350, doi. 10.3892/mmr.2018.9345

By:

Tang, Zhiqi;
Liu, Lijuan;
Guo, Yujie;
Deng, Guoxiong;
Chen, Meixiang;
Wei, Jinru

Publication type:

Article

High-dose folic acid improves endothelial function by increasing tetrahydrobiopterin and decreasing homocysteine levels.

Published in:

Molecular Medicine Reports, 2014, v. 10, n. 3, p. 1609, doi. 10.3892/mmr.2014.2332

By:

MIN ZHANG;
JINLIN WEN;
XIANGJIANG WANG;
CHUN XIAO

Publication type:

Article

Tetrahydrobiopterin (BH4): Targeting endothelial nitric oxide synthase as a potential therapy for pulmonary hypertension.

Published in:

Cardiovascular Therapeutics, 2018, v. 36, n. 1, p. 1, doi. 10.1111/1755-5922.12312

By:

Francis, Bahaa N.;
Salameh, Maram;
Khamisy‐Farah, Rola;
Farah, Raymond

Publication type:

Article

Functional Characterization of Novel Phenylalanine Hydroxylase p.Gln226Lys Mutation Revealed Its Non-responsiveness to Tetrahydrobiopterin Treatment in Hepatoma Cellular Model.

Published in:

Biochemical Genetics, 2018, v. 56, n. 5, p. 533, doi. 10.1007/s10528-018-9858-5

By:

Klaassen, Kristel;
Djordjevic, Maja;
Skakic, Anita;
Desviat, Lourdes R.;
Pavlovic, Sonja;
Perez, Belen;
Stojiljkovic, Maja

Publication type:

Article

Evidence of Cellular Immune Activation in Children With Opsoclonus-Myoclonus: Cerebrospinal Fluid Neopterin.

Published in:

Journal of Child Neurology, 2004, v. 19, n. 12, p. 919, doi. 10.1177/08830738040190120201

By:

Pranzatelli, Michael R.

Publication type:

Article

Nitric Oxide in the Spinal Cord Is Involved in the Hyperalgesia Induced by Tetrahydrobiopterin in Chronic Restraint Stress Rats.

Published in:

Frontiers in Neuroscience, 2021, v. 15, p. N.PAG, doi. 10.3389/fnins.2021.593654

By:

Huang, Ying;
Jiao, Bo;
Zhu, Bo;
Xiong, Bingrui;
Lu, Pei;
Ai, Ling;
Yang, Ning;
Zhao, Yilin;
Xu, Hui

Publication type:

Article

Kynurenine, Tetrahydrobiopterin, and Cytokine Inflammatory Biomarkers in Individuals Affected by Diabetic Neuropathic Pain.

Published in:

Frontiers in Neuroscience, 2020, v. 14, p. N.PAG, doi. 10.3389/fnins.2020.00890

By:

Staats Pires, Ananda;
Heng, Benjamin;
Tan, Vanessa X.;
Latini, Alexandra;
Russo, Marc A.;
Santarelli, Danielle M.;
Bailey, Dominic;
Wynne, Katie;
O'Brien, Jayden A.;
Guillemin, Gilles J.;
Austin, Paul J.

Publication type:

Article

Kynurenine and Tetrahydrobiopterin Pathways Crosstalk in Pain Hypersensitivity.

Published in:

Frontiers in Neuroscience, 2020, v. 14, p. 1, doi. 10.3389/fnins.2020.00620

By:

Staats Pires, Ananda;
Tan, Vanessa X.;
Heng, Benjamin;
Guillemin, Gilles J.;
Latini, Alexandra

Publication type:

Article

Effects of Diabetes on Salivary Gland Protein Expression of Tetrahydrobiopterin and Nitric Oxide Synthesis and Function.

Published in:

2016

By:

Stewart, Cassandra R.;
Obi, Nneka;
Epane, Elodie C.;
Akbari, Alexander A.;
Halpern, Leslie;
Southerland, Janet H.;
Gangula, Pandu R.

Publication type:

journal article

Consensus guideline for the diagnosis and treatment of tetrahydrobiopterin (BH4) deficiencies.

Published in:

2020

By:

Opladen, Thomas;
López-Laso, Eduardo;
Cortès-Saladelafont, Elisenda;
Pearson, Toni S.;
Sivri, H. Serap;
Yildiz, Yilmaz;
Assmann, Birgit;
Kurian, Manju A.;
Leuzzi, Vincenzo;
Heales, Simon;
Pope, Simon;
Porta, Francesco;
García-Cazorla, Angeles;
Honzík, Tomáš;
Pons, Roser;
Regal, Luc;
Goez, Helly;
Artuch, Rafael;
Hoffmann, Georg F.;
Horvath, Gabriella

Publication type:

journal article

Bioanalysis of tetrahydrobiopterin with liquid chromatographic-mass spectrometric and its application for pharmacokinetics in apolipoprotein E knockout mice.

Published in:

Journal of Liquid Chromatography & Related Technologies, 2019, v. 42, n. 15/16, p. 494, doi. 10.1080/10826076.2019.1625376

By:

Aziz, Mohd Yusmaidie;
Chik, Zamri

Publication type:

Article

Inducible nitric oxide synthase: role of the N-terminal ß-hairpin hook and pterin-binding segment in dimerization and tetrahydrobiopterin interaction.

Published in:

EMBO Journal, 1999, v. 18, n. 22, p. 6260, doi. 10.1093/emboj/18.22.6260

By:

Ghosh, Dipak K.;
Crane, Brian R.;
Ghosh, Sanjay;
Wolan, Dennis;
Gachhui, Ratan;
Crooks, Carol;
Presta, Anthony;
Tainer, John A.;
Getzoff, Elizabeth D.;
Stuehr, Dennis J.

Publication type:

Article

N-terminal domain swapping and metal ion binding in nitric oxide synthase dimerization.

Published in:

EMBO Journal, 1999, v. 18, n. 22, p. 6271, doi. 10.1093/emboj/18.22.6271

By:

Crane, Brian R.;
Rosenfeld, Robin J.;
Arvai, Andrew S.;
Ghosh, Dipak K.;
Ghosh, Sanjav;
Tainer, John A.;
Stuehr, Dennis J.;
Getzoff, Elizabeth D.

Publication type:

Article

Heme deficiency in erythroid lineage causes differentiation arrest and cytoplasmic iron overload.

Published in:

EMBO Journal, 1999, v. 18, n. 22, p. 6282, doi. 10.1093/emboj/18.22.6282

By:

Nakajima, Osamu;
Takahashi, Satoru;
Harigae, Hideo;
Furuyama, Kazumichi;
Hayashi, Norio;
Sassa, Shigeru;
Yamamoto, Masayuki

Publication type:

Article

Article The 1.25 Å crystal structure of sepiapterin reductase reveals its binding mode to pterins and brain neurotransmitters.

Published in:

EMBO Journal, 1997, v. 16, n. 24, p. 7219, doi. 10.1093/emboj/16.24.7219

By:

Auerbach, Günter;
Herrmann, Anja;
Gütlich, Markus;
Fischer, Markus;
Jacob, Uwe;
Bacher, Adelbert;
Huber, Robert

Publication type:

Article

A systematic review and meta-analysis of pteridines in mild cognitive impairment and Alzheimer's disease.

Published in:

2025

By:

Mangoni, Arduino A.;
Zinellu, Angelo

Publication type:

Literature Review

Folate: a possible role in erectile dysfunction?

Published in:

2018

By:

Sansone, Massimiliano;
Sansone, Andrea;
Romano, Mariagrazia;
Seraceno, Silvia;
Di Luigi, Luigi;
Romanelli, Francesco

Publication type:

journal article

Photo‐Induced Disproportionation‐Mediated Photodynamic Therapy: Simultaneous Oxidation of Tetrahydrobiopterin and Generation of Superoxide Radicals.

Published in:

Angewandte Chemie, 2024, v. 136, n. 12, p. 1, doi. 10.1002/ange.202318783

By:

Teng, Kun‐Xu;
Zhang, Dongsheng;
Liu, Bin‐Kai;
Liu, Zheng‐Fei;
Niu, Li‐Ya;
Yang, Qing‐Zheng

Publication type:

Article

Tetrahydrobiopterin, Folate and Depression: A Modified Amine Hypothesis.

Published in:

Human Psychopharmacology: Clinical & Experimental, 1995, v. 10, n. 1, p. 1, doi. 10.1002/hup.470100102

By:

Anderson, D. N.;
Abou-Saleh, M. T.

Publication type:

Article

Antioxidants and endothelial nitric oxide synthesis.

Published in:

European Journal of Clinical Pharmacology, 2006, v. 62, p. 21, doi. 10.1007/s00228-005-0009-7

By:

Heller, Regine;
Werner-Felmayer, Gabriele;
Werner, Ernst R.

Publication type:

Article

Effect of peripherally administered lipopolysaccharide (LPS) on GTP cyclohydrolase I, tetrahydrobiopterin and norepinephrine in the locus coeruleus in mice.

Published in:

Stress: The International Journal on the Biology of Stress, 2007, v. 10, n. 2, p. 131, doi. 10.1080/10253890701350511

By:

Ota, A.;
Kaneko, Y. S.;
Mori, K.;
Nakashima, A.;
Nagatsu, I.;
Nagatsu, T.

Publication type:

Article

Irreversible neurological effects of late diagnosis phenylketonuria: A case presentation.

Published in:

International Journal of Medical Biochemistry, 2023, v. 6, n. 2, p. 133, doi. 10.14744/ijmb.2023.54376

By:

Gupta, Khyati;
Jain, Aviral;
Sawant, Vishal Dnyaneshwar;
Save, Sushma

Publication type:

Article

Evaluation of Tetrahydrobiopterin Pathway in Operating Room Workers: Changes in Biopterin Status and Tryptophan Metabolism.

Published in:

Bulletin of Environmental Contamination & Toxicology, 2012, v. 89, n. 6, p. 1125, doi. 10.1007/s00128-012-0845-y

By:

Baydar, Mustafa;
Capan, Zeynep;
Girgin, Gozde;
Palabiyik, S.;
Sahin, Gonul;
Fuchs, Dietmar;
Baydar, Terken

Publication type:

Article

De novo tetrahydrobiopterin biosynthesis is impaired in the inflammed striatum of parkin(-/-) mice.

Published in:

Cell Biology International, 2018, v. 42, n. 6, p. 725, doi. 10.1002/cbin.10969

By:

de Paula Martins, Roberta;
Glaser, Viviane;
Aguiar Jr, Aderbal S.;
de Paula Ferreira, Priscila Maximiliano;
Ghisoni, Karina;
da Luz Scheffer, Débora;
Lanfumey, Laurence;
Raisman-Vozari, Rita;
Corti, Olga;
De Paul, Ana Lucia;
da Silva, Rodrigo Augusto;
Latini, Alexandra

Publication type:

Article

Tetrahydrobiopterin (BH 4) Supplementation Prevents the Cardiorenal Effects of Diabetes in Mice by Reducing Oxidative Stress, Inflammation and Fibrosis.

Published in:

Biomedicines, 2022, v. 10, n. 10, p. N.PAG, doi. 10.3390/biomedicines10102479

By:

Novoa, Ulises;
Soto, Karen;
Valdés, Cristian;
Villaseñor, Jorge;
Treuer, Adriana V.;
González, Daniel R.

Publication type:

Article

Heterocyclizations of functionalized heterocumulenes with C,N-, C,O-, and C,S-binucleophiles: XII. Synthesis of alkyl 3-aryl-1,5-dioxo-2,3,5,6-tetrahydro-1 H-pyrimido-[1,6- a]quinoxaline-4-carboxylates.

Published in:

Russian Journal of Organic Chemistry, 2010, v. 46, n. 6, p. 890, doi. 10.1134/S1070428010060187

By:

Kushnir, O. V.;
Vovk, M. V.

Publication type:

Article

Reaction of 2-perfluoroalkanoylcyclohexane-1,3-diones with diazomethane.

Published in:

Russian Journal of Organic Chemistry, 2009, v. 45, n. 4, p. 519, doi. 10.1134/S1070428009040083

By:

Khlebnikova, T. S.;
Isakova, V. G.;
Lakhvich, F. A.

Publication type:

Article

Synthesis of 5-aryl-1-methyl-1,2,3,4-tetrahydrobenzo[ a]phenanthridines.

Published in:

Russian Journal of Organic Chemistry, 2009, v. 45, n. 4, p. 587, doi. 10.1134/S1070428009040198

By:

Kozlov, N. G.;
Basalaeva, L. I.

Publication type:

Article

Stabilizing Action of Tetrahydrobiopterin on the Activity of Neuronal Nitric Oxide Synthase.

Published in:

Neurophysiology, 2012, v. 44, n. 5, p. 351, doi. 10.1007/s11062-012-9305-x

By:

Tsyvkin, V.

Publication type:

Article

Cardiomyocyte tetrahydrobiopterin synthesis regulates fatty acid metabolism and susceptibility to ischaemia–reperfusion injury.

Published in:

Experimental Physiology, 2023, v. 108, n. 6, p. 874, doi. 10.1113/EP090795

By:

Chu, Sandy M.;
Heather, Lisa C.;
Chuaiphichai, Surawee;
Nicol, Thomas;
Wright, Benjamin;
Miossec, Matthieu;
Bendall, Jennifer K.;
Douglas, Gillian;
Crabtree, Mark J.;
Channon, Keith M.

Publication type:

Article

Tetrahydrobiopterin improves microcirculation in experimental sepsis.

Published in:

Clinical Hemorheology & Microcirculation, 2017, v. 67, n. 1, p. 15, doi. 10.3233/CH-160207

By:

Dumbarton, Tristan C.;
Maxan, Alexander;
Farah, Nizam;
Sharawy, Nivin;
Zhou, Juan;
Nantais, Jordan;
Lehmann, Christian

Publication type:

Article

Changes of asymmetric dimethylarginine, nitric oxide, tetrahydrobiopterin, and oxidative stress in patients with acute myocardial infarction by medical treatments.

Published in:

Clinical Hemorheology & Microcirculation, 2007, v. 37, n. 3, p. 269

By:

Yada, Toyotaka;
Kaji, Shuichiro;
Akasaka, Takashi;
Mochizuki, Seiichi;
Ogasawara, Yasuo;
Tanemoto, Kazuo;
Yoshida, Kiyoshi;
Kajiya, Fumihiko

Publication type:

Article

Tetrahydrobiopterin and Autism Spectrum Disorder: A Systematic Review of a Promising Therapeutic Pathway.

Published in:

2025

By:

Filho, Clóvis Colpani;
Melfior, Lucas;
Ramos, Sthephanie Luiz;
Pizi, Mateus Santos Oliveira;
Taruhn, Lilian Freitas;
Muller, Margrit Ellis;
Nunes, Thiago Kucera;
Schmitt, Luísa de Oliveira;
Gaspar, Joana Margarida;
de Oliveira, Miguel de Abreu;
Tassinari, Giovanna;
Cruz, Luisa;
Latini, Alexandra

Publication type:

Literature Review

The Critical Role of Tetrahydrobiopterin (BH4) Metabolism in Modulating Radiosensitivity: BH4/NOS Axis as an Angel or a Devil.

Published in:

Frontiers in Oncology, 2021, v. 11, p. 1, doi. 10.3389/fonc.2021.720632

By:

Feng, Yang;
Feng, Yahui;
Gu, Liming;
Liu, Pengfei;
Cao, Jianping;
Zhang, Shuyu

Publication type:

Article

Tetrahydrobiopterin Plays a Functionally Significant Role in Lipogenesis in the Oleaginous Fungus Mortierella alpina.

Published in:

Frontiers in Microbiology, 2020, p. 1, doi. 10.3389/fmicb.2020.00250

By:

Wang, Hongchao;
Zhang, Chen;
Chen, Haiqin;
Gu, Zhennan;
Zhao, Jianxin;
Zhang, Hao;
Chen, Yong Q.;
Chen, Wei

Publication type:

Article

Molecular epidemiology and genotype-phenotype correlation in phenylketonuria patients from South Spain.

Published in:

Journal of Human Genetics, 2013, v. 58, n. 5, p. 279, doi. 10.1038/jhg.2013.16

By:

Bueno, María A;
González-Lamuño, Domingo;
Delgado-Pecellín, Carmen;
Aldámiz-Echevarría, Luís;
Pérez, Belén;
Desviat, Lourdes R;
Couce, María L

Publication type:

Article

Commentary on the mutation spectrum of and founder effects affecting the PTS gene in East-Asian populations.

Published in:

Journal of Human Genetics, 2012, v. 57, n. 3, p. 159, doi. 10.1038/jhg.2011.153

By:

Shintaku, Haruo

Publication type:

Article

Mutation spectrum of and founder effects affecting the PTS gene in East Asian populations.

Published in:

Journal of Human Genetics, 2012, v. 57, n. 2, p. 145, doi. 10.1038/jhg.2011.146

By:

Chiu, Yen-Hui;
Chang, Ying-Chen;
Chang, Yu-Hsin;
Niu, Dau-Ming;
Yang, Yan-Ling;
Ye, Jun;
Jiang, Jianhui;
Okano, Yoshiyuki;
Lee, Dong Hwan;
Pangkanon, Suthipong;
Kuptanon, Chulaluck;
Hock, Ngu Lock;
Chiong, Mary Anne;
Cavan, Barbra V;
Hsiao, Kwang-Jen;
Liu, Tze-Tze

Publication type:

Article

Molecular characterization of phenylketonuria and tetrahydrobiopterin-responsive phenylalanine hydroxylase deficiency in Japan.

Published in:

Journal of Human Genetics, 2011, v. 56, n. 4, p. 306, doi. 10.1038/jhg.2011.10

By:

Okano, Yoshiyuki;
Kudo, Satoshi;
Nishi, Yasuaki;
Sakaguchi, Tomoko;
Aso, Kazuyoshi

Publication type:

Article

A limited spectrum of phenylalanine hydroxylase mutations is observed in phenylketonuria patients in western Poland and implications for treatment with 6R tetrahydrobiopterin.

Published in:

Journal of Human Genetics, 2009, v. 54, n. 6, p. 335, doi. 10.1038/jhg.2009.37

By:

Dobrowolski, Steven F.;
Borski, K.;
Ellingson, C. C.;
Koch, R.;
Levy, H. L.;
Naylor, E. W.

Publication type:

Article

Sapropterin.

Published in:

Drugs, 2009, v. 69, n. 4, p. 461, doi. 10.2165/00003495-200969040-00006

By:

Sanford, Mark;
Keating, Gillian M.

Publication type:

Article