Works matching DE "TDP-43 proteinopathies"
Results: 131
Distinct clinicopathologic clusters of persons with TDP-43 proteinopathy.
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- Acta Neuropathologica, 2020, v. 140, n. 5, p. 659, doi. 10.1007/s00401-020-02211-0
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- Article
Degeneration of the locus coeruleus is a common feature of tauopathies and distinct from TDP-43 proteinopathies in the frontotemporal lobar degeneration spectrum.
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- Acta Neuropathologica, 2020, v. 140, n. 5, p. 675, doi. 10.1007/s00401-020-02210-1
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- Publication type:
- Article
Antibody against TDP-43 phosphorylated at serine 375 suggests conformational differences of TDP-43 aggregates among FTLD–TDP subtypes.
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- Acta Neuropathologica, 2020, v. 140, n. 5, p. 645, doi. 10.1007/s00401-020-02207-w
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- Article
Caspase-4 mediates cytoplasmic accumulation of TDP-43 in the primate brains.
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- Acta Neuropathologica, 2019, v. 137, n. 6, p. 919, doi. 10.1007/s00401-019-01979-0
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- Article
Genome-wide analyses as part of the international FTLD-TDP whole-genome sequencing consortium reveals novel disease risk factors and increases support for immune dysfunction in FTLD.
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- Acta Neuropathologica, 2019, v. 137, n. 6, p. 879, doi. 10.1007/s00401-019-01962-9
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- Article
Expansion of the classification of FTLD-TDP: distinct pathology associated with rapidly progressive frontotemporal degeneration.
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- Acta Neuropathologica, 2017, v. 134, n. 1, p. 65, doi. 10.1007/s00401-017-1679-9
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- Article
Depletion of TDP-43 decreases fibril and plaque β-amyloid and exacerbates neurodegeneration in an Alzheimer's mouse model.
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- Acta Neuropathologica, 2016, v. 132, n. 6, p. 859, doi. 10.1007/s00401-016-1637-y
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- Article
The phosphatase calcineurin regulates pathological TDP-43 phosphorylation.
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- Acta Neuropathologica, 2016, v. 132, n. 4, p. 545, doi. 10.1007/s00401-016-1600-y
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- Article
Functional recovery in new mouse models of ALS/FTLD after clearance of pathological cytoplasmic TDP-43.
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- Acta Neuropathologica, 2015, v. 130, n. 5, p. 643, doi. 10.1007/s00401-015-1460-x
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- Article
Hippocampal sclerosis in Lewy body disease is a TDP-43 proteinopathy similar to FTLD-TDP Type A.
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- Acta Neuropathologica, 2015, v. 129, n. 1, p. 53, doi. 10.1007/s00401-014-1358-z
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- Article
Peripheral proteinopathy in neurodegenerative diseases.
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- Translational Neurodegeneration, 2025, v. 14, n. 1, p. 1, doi. 10.1186/s40035-024-00461-6
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- Article
In vivo diagnosis of TDP-43 proteinopathies: in search of biomarkers of clinical use.
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- Translational Neurodegeneration, 2024, v. 13, n. 1, p. 1, doi. 10.1186/s40035-024-00419-8
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- Article
Novel data-driven subtypes and stages of brain atrophy in the ALS–FTD spectrum.
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- Translational Neurodegeneration, 2023, v. 12, n. 1, p. 1, doi. 10.1186/s40035-023-00389-3
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- Publication type:
- Article
Mitigating a TDP-43 proteinopathy by targeting ataxin-2 using RNA-targeting CRISPR effector proteins.
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- Nature Communications, 2023, v. 14, n. 1, p. 1, doi. 10.1038/s41467-023-42147-z
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- Article
Alterations in stress granule dynamics driven by TDP-43 and FUS: a link to pathological inclusions in ALS?
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- Frontiers in Cellular Neuroscience, 2015, v. 9, p. 1, doi. 10.3389/fncel.2015.00423
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- Article
Targeting TDP-43 phosphorylation by Casein Kinase-1δ inhibitors: a novel strategy for the treatment of frontotemporal dementia.
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- Molecular Neurodegeneration, 2016, v. 11, p. 1, doi. 10.1186/s13024-016-0102-7
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- Article
Erratum to: Endogenous TDP-43, but not FUS, contributes to stress granule assembly via G3BP.
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- 2015
- Publication type:
- Correction Notice
Differential toxicity of TAR DNA‐binding protein 43 isoforms depends on their submitochondrial localization in neuronal cells.
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- Journal of Neurochemistry, 2018, v. 146, n. 5, p. 585, doi. 10.1111/jnc.14465
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- Article
Molecular neuropathology of frontotemporal dementia: insights into disease mechanisms from postmortem studies.
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- Journal of Neurochemistry, 2016, v. 138, p. 54, doi. 10.1111/jnc.13588
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- Publication type:
- Article
Regulation of TDP-43 phosphorylation in aging and disease.
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- GeroScience, 2021, v. 43, n. 4, p. 1605, doi. 10.1007/s11357-021-00383-5
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- Article
Progression of motor neuron disease is accelerated and the ability to recover is compromised with advanced age in rNLS8 mice.
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- Acta Neuropathologica Communications, 2016, v. 4, p. 1, doi. 10.1186/s40478-016-0377-5
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- Publication type:
- Article
Pathological tau deposition in Motor Neurone Disease and frontotemporal lobar degeneration associated with TDP-43 proteinopathy.
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- Acta Neuropathologica Communications, 2016, v. 4, p. 1, doi. 10.1186/s40478-016-0301-z
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- Publication type:
- Article
Suppression of Linear Ubiquitination Ameliorates Cytoplasmic Aggregation of Truncated TDP-43.
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- Cells (2073-4409), 2022, v. 11, n. 15, p. 2398, doi. 10.3390/cells11152398
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- Article
Parkin beyond Parkinson's Disease—A Functional Meaning of Parkin Downregulation in TDP-43 Proteinopathies.
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- Cells (2073-4409), 2021, v. 10, n. 12, p. 3389, doi. 10.3390/cells10123389
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- Publication type:
- Article
Laminar distribution of the pathological changes in sporadic frontotemporal lobar degeneration with transactive response (TAR) DNA-binding protein of 43 kDa (TDP-43) proteinopathy: a quantitative study using polynomial curve fitting.
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- Neuropathology & Applied Neurobiology, 2013, v. 39, n. 4, p. 335, doi. 10.1111/j.1365-2990.2012.01291.x
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- Article
Body Complexion and Circulating Lipids in the Risk of TDP-43 Related Disorders.
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- Frontiers in Aging Neuroscience, 2022, v. 14, p. 1, doi. 10.3389/fnagi.2022.838141
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- Article
Recent Developments in Positron Emission Tomography Tracers for Proteinopathies Imaging in Dementia.
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- Frontiers in Aging Neuroscience, 2022, v. 13, p. 1, doi. 10.3389/fnagi.2021.751897
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- Article
Quantitative analysis of cryptic splicing associated with TDP-43 depletion.
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- BMC Medical Genomics, 2017, v. 10, p. 1, doi. 10.1186/s12920-017-0274-1
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- Article
α-Synuclein emulsifies TDP-43 prion-like domain—RNA liquid droplets to promote heterotypic amyloid fibrils.
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- Communications Biology, 2023, v. 6, n. 1, p. 1, doi. 10.1038/s42003-023-05608-1
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- Article
Targeting shared pathways in tauopathies and age-related macular degeneration: implications for novel therapies.
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- Frontiers in Aging Neuroscience, 2024, p. 1, doi. 10.3389/fnagi.2024.1371745
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- Article
DNA strand breaks and TDP-43 mislocation are absent in the murine hSOD1<sup>G93A</sup> model of amyotrophic lateral sclerosis in vivo and in vitro.
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- PLoS ONE, 2017, v. 12, n. 8, p. 1, doi. 10.1371/journal.pone.0183684
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- Article
Drosophila lines with mutant and wild type human TDP-43 replacing the endogenous gene reveals phosphorylation and ubiquitination in mutant lines in the absence of viability or lifespan defects.
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- PLoS ONE, 2017, v. 12, n. 7, p. 1, doi. 10.1371/journal.pone.0180828
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- Article
Augmented quantal release of acetylcholine at the vertebrate neuromuscular junction following tdp-43 depletion.
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- PLoS ONE, 2017, v. 12, n. 5, p. 1, doi. 10.1371/journal.pone.0177005
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- Article
Dysregulation of Translation in TDP-43 Proteinopathies: Deficits in the RNA Supply Chain and Local Protein Production.
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- Frontiers in Neuroscience, 2022, v. 16, p. 1, doi. 10.3389/fnins.2022.840357
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- Article
Reply: Limbic-predominant age-related TDP-43 encephalopathy (LATE).
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- 2019
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- Letter
Limbic-predominant age-related TDP-43 encephalopathy (LATE).
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- 2019
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- Publication type:
- Letter
Neurodegenerative disease concomitant proteinopathies are prevalent, age-related and APOE4-associated.
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- 2018
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- Publication type:
- journal article
The snowball effect of RNA binding protein dysfunction in amyotrophic lateral sclerosis.
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- 2018
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- Publication type:
- journal article
TDP-43 regulates the alternative splicing of hnRNP A1 to yield an aggregation-prone variant in amyotrophic lateral sclerosis.
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- 2018
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- journal article
Progranulin: a new avenue towards the understanding and treatment of neurodegenerative disease.
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- 2017
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- Publication type:
- journal article
Exosome secretion is a key pathway for clearance of pathological TDP-43.
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- 2016
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- Publication type:
- journal article
TDP-43 stage, mixed pathologies, and clinical Alzheimer's-type dementia.
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- 2016
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- journal article
TDP-43 proteinopathies: pathological identification of brain regions differentiating clinical phenotypes.
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- 2015
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- Publication type:
- journal article
Divergent Histopathological Networks of Frontotemporal Degeneration Proteinopathy Subytpes.
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- Journal of Neuroscience, 2022, v. 42, n. 18, p. 3868, doi. 10.1523/JNEUROSCI.2061-21.2022
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- Article
Decreased Hsp90 activity protects against TDP-43 neurotoxicity in a C. elegans model of amyotrophic lateral sclerosis.
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- PLoS Genetics, 2024, v. 20, n. 12, p. 1, doi. 10.1371/journal.pgen.1011518
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- Article
Clinical Criteria for a Limbic-Predominant Amnestic Neurodegenerative Syndrome.
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- Neurology Alert, 2024, v. 44, n. 1, p. 1
- Publication type:
- Article
Pathobiological Subtypes of Alzheimer Disease.
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- Dementia & Geriatric Cognitive Disorders, 2020, v. 49, n. 4, p. 321, doi. 10.1159/000508625
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- Article
Dysregulation of stress granule dynamics by DCTN1 deficiency exacerbates TDP-43 pathology in Drosophila models of ALS/FTD.
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- Acta Neuropathologica Communications, 2024, v. 12, n. 1, p. 1, doi. 10.1186/s40478-024-01729-8
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- Publication type:
- Article
Modelling TDP-43 proteinopathy in Drosophila uncovers shared and neuron-specific targets across ALS and FTD relevant circuits.
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- Acta Neuropathologica Communications, 2023, v. 11, n. 1, p. 1, doi. 10.1186/s40478-023-01656-0
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- Publication type:
- Article
Targeting the glycine-rich domain of TDP-43 with antibodies prevents its aggregation in vitro and reduces neurofilament levels in vivo.
- Published in:
- Acta Neuropathologica Communications, 2023, v. 11, n. 1, p. 1, doi. 10.1186/s40478-023-01592-z
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- Publication type:
- Article