Works matching DE "T-cell exhaustion"

Results: 892

The POSH scaffold protein is essential for signal coordination leading to CD8 T cell differentiation and survival.

Published in:

Frontiers in Immunology, 2025, p. 1, doi. 10.3389/fimmu.2025.1630599

By:

Guldenpfennig, Caitlyn;
Guan, Yue;
Cseri, Bela;
Lopez, Elida;
Teixeiro, Emma;
Daniels, Mark

Publication type:

Article

Enrichment of decidual CD11c + CD8 + T cells with altered immune function in early pregnancy loss.

Published in:

Nature Communications, 2025, v. 16, n. 1, p. 1, doi. 10.1038/s41467-025-61992-8

By:

Guo, Ling;
Guo, Anliang;
Guo, Yaqiu;
Han, Shuwen;
Klein, Cameron;
Chen, Zi-Jiang;
Yan, Junhao;
Li, Yan

Publication type:

Article

ST2/IL-33 axis blockade inhibits regulatory T cell cytotoxicity towards CD8 T cells in the leukemic niche.

Published in:

Nature Communications, 2025, v. 16, n. 1, p. 1, doi. 10.1038/s41467-025-61647-8

By:

Jiang, Hua;
Fu, Denggang;
Pasupuleti, Santhosh Kumar;
Ramdas, Baskar;
Long, Alan;
Ramadan, Abdulraouf M.;
Yang, Jinfeng;
Kumar, Ramesh;
Hartman, Jessica H.;
Kendrick, B. Jacob;
Simpson, Ed;
Gao, Hongyu;
Liu, Yunlong;
Moore, Drew;
Subramanian, Suganya;
Berto, Stefano;
Gopalakrishnapillai, Anilkumar;
Barwe, Sonali P.;
Guo, Hongfen;
Cheung, Nai-Kong V.

Publication type:

Article

Population-level toggling of T cell immune escape at human leukocyte antigen anchor residues in SARS-CoV-2 Spike proteins, in an ethnically diverse population region.

Published in:

PLoS Computational Biology, 2025, v. 21, n. 7, p. 1, doi. 10.1371/journal.pcbi.1013261

By:

Ngandu, Nobubelo K.;
Fielding, Burtram C.;
van Heusden, Peter;
Mcinga, Kuhle;
Francis, Kriheska;
Harkins, Gordon

Publication type:

Article

Targeting SIRT2 induces MLH1 deficiency and boosts antitumor immunity in preclinical colorectal cancer models.

Published in:

Science Translational Medicine, 2025, v. 17, n. 807, p. 1, doi. 10.1126/scitranslmed.adv0766

By:

Gao, Qianling;
Yang, Lanlan;
Ye, Shubiao;
Mai, Mingru;
Liu, Yiting;
Jiang, Xuefei;
Feng, Xingzhi;
Yang, Zihuan

Publication type:

Article

Glutamine-driven metabolic reprogramming promotes CAR-T cell function through mTOR-SREBP2 mediated HMGCS1 upregulation in ovarian cancer.

Published in:

Journal of Translational Medicine, 2025, v. 23, n. 1, p. 1, doi. 10.1186/s12967-025-06853-0

By:

Chen, Jiannan;
Zhao, Lianfeng;
Li, Wenying;
Wang, Shuai;
Li, Jiayi;
Lv, Zhongyuan;
Zhao, Yaoyao;
Liang, Junqing;
Hu, Zhigang;
Pan, Feiyan;
He, Lingfeng;
Gu, Lili;
Guo, Zhigang

Publication type:

Article

Galectin-9 and Tim-3 in gastric cancer: a checkpoint axis driving T cell exhaustion and Treg-mediated immunosuppression independently of anti-PD-1 blockade.

Published in:

Frontiers in Immunology, 2025, p. 1, doi. 10.3389/fimmu.2025.1600792

By:

Hill, Charlotte N.;
Maita, Gabriela;
Cabrolier, Camille;
Aros, Constanza;
Vega-Letter, Ana Maria;
Gonzalez, Pamela;
Kalergis, Alexis M.;
Luz-Crawford, Patricia;
Owen, Gareth I.

Publication type:

Article

Tumor‐Infiltrating Lymphocytes in Breast and Female Genital Tract Cancers: Overlooked Potential and Unexplored Frontiers.

Published in:

Cancer Medicine, 2025, v. 14, n. 13, p. 1, doi. 10.1002/cam4.71023

By:

Skok, Kristijan;
Maccio, Umberto;
Martin, Spencer D.;
Bräutigam, Konstantin

Publication type:

Article

Targeting the nuclear orphan receptor NR4A1: a key target in lung cancer progression and therapeutic resistance.

Published in:

Frontiers in Oncology, 2025, p. 1, doi. 10.3389/fonc.2025.1566598

By:

Jin, Minhan;
Wang, Yuhui;
Song, Mingze;
Guo, Wenfei;
Li, Shirong;
Pu, Zeqing

Publication type:

Article

CD8+ T cells promote tubule-interstitial damage in malaria-induced acute kidney injury.

Published in:

Frontiers in Cellular & Infection Microbiology, 2025, p. 1, doi. 10.3389/fcimb.2025.1561806

By:

Teixeira, Douglas Esteves;
Alves, Sarah Aparecida dos Santos;
Pinheiro, Alessandro Sá;
Silva, Leandro Souza;
Silva-Aguiar, Rodrigo Pacheco;
Peruchetti, Diogo Barros;
Pádua, Tatiana Almeida;
Souza, Mariana Conceição;
Caruso-Neves, Celso;
Pinheiro, Ana Acacia Sá

Publication type:

Article

Abnormal metabolic activation of CD8+ T cells correlates with poor prognosis in acute myeloid leukemia.

Published in:

Journal of Translational Medicine, 2025, v. 23, n. 1, p. 1, doi. 10.1186/s12967-025-06833-4

By:

Wang, Bixia;
Tang, Jianing;
Zhou, Yang;
Huang, Qianqian;
Jiang, Xinya;
Zhang, Fangqing;
Fan, Shuang;
Zhang, Qi;
Zhou, Jingrui;
Wang, Yu;
Huang, Xiao-Jun;
Guo, Huidong

Publication type:

Article

Recent Advances in Immunotherapy for Melanoma: Perspectives on the Development of Novel Treatments: A Mini Review.

Published in:

Cancers, 2025, v. 17, n. 13, p. 2265, doi. 10.3390/cancers17132265

By:

Muto, Yusuke;
Fujimura, Taku;
Asano, Yoshihide

Publication type:

Article

Metabolic alterations driven by LDHA in CD8 + T cells promote immune evasion and therapy resistance in NSCLC.

Published in:

Scientific Reports, 2025, v. 15, n. 1, p. 1, doi. 10.1038/s41598-025-87361-5

By:

Wen, Hao;
Zhang, Panpan;
Zhao, Juan;
Liu, Yakui;
Wan, Lei;
Li, Haoran;
Yi, Jun;
Li, Xinqiang

Publication type:

Article

Dissecting the Immunological Microenvironment of Glioma Based on IDH Status: Implications for Immunotherapy.

Published in:

Cells (2073-4409), 2025, v. 14, n. 13, p. 1035, doi. 10.3390/cells14131035

By:

Kikuchi, Miyu;
Takami, Hirokazu;
Kobayashi, Yukari;
Nagaoka, Koji;
Kitagawa, Yosuke;
Nomura, Masashi;
Takayanagi, Shunsaku;
Tanaka, Shota;
Saito, Nobuhito;
Kakimi, Kazuhiro

Publication type:

Article

Bio-functional hydrogel coated membranes to decrease T-cell exhaustion in manufacturing of CAR T-cells.

Published in:

Frontiers in Immunology, 2025, p. 1, doi. 10.3389/fimmu.2025.1513148

By:

López Ruiz, Aida;
Slaughter, Eric;
Bomb, Kartik;
Swedzinski, Samantha L.;
LeValley, Paige J.;
Yun, Zaining;
McCoskey, Jacob;
Levine, Kara;
Steen, Jonathan;
Almasian, Joseph;
Chatterjee, Aparajita;
Carbrello, Christina;
Chang, Dustin S.;
Fuseini, Hubaida;
Abassi, Yama A.;
Lenhoff, Abraham M.;
Fromen, Catherine A.;
Kloxin, April M.

Publication type:

Article

Combination therapy with levofloxacin and the probiotic Clostridium butyricumMIYAIRI 588 enhances immune checkpoint inhibitor efficacy.

Published in:

International Journal of Cancer, 2025, v. 157, n. 5, p. 993, doi. 10.1002/ijc.35472

By:

Tajima, Kohei;
Hosonuma, Masahiro;
Funayama, Eiji;
Isobe, Junya;
Baba, Yuta;
Murayama, Masakazu;
Narikawa, Yoichiro;
Toyoda, Hitoshi;
Tsurui, Toshiaki;
Maruyama, Yuki;
Sasaki, Aya;
Amari, Yasunobu;
Yamazaki, Yoshitaka;
Nakashima, Rie;
Shida, Midori;
Sasaki, Akiko;
Sambe, Takehiko;
Wada, Satoshi;
Tsuji, Mayumi;
Kiuchi, Yuji

Publication type:

Article

YY1 enhances HIF-1α stability in tumor-associated macrophages to suppress anti-tumor immunity of prostate cancer in mice.

Published in:

Nature Communications, 2025, v. 16, n. 1, p. 1, doi. 10.1038/s41467-025-61560-0

By:

Li, Wenchao;
Chen, SaiSai;
Lu, Jian;
Mao, Weipu;
Zheng, Shiya;
Zhang, Minhao;
Wu, Tiange;
Chen, Yurui;
Lu, Kai;
Chu, Chunyan;
Shu, Chuanjun;
Hou, Yue;
Yang, Xue;
Shi, Naipeng;
Chen, Zhijun;
Zhang, Lihua;
Zhang, Lei;
Na, Rong;
Chen, Ming;
Ju, Shenghong

Publication type:

Article

Identification of disulfidptosis-related prognostic biomarkers associated with CD4 + and CD8 + T cells infiltration for sarcoma by integrating bioinformatic analysis and experimental validation.

Published in:

Discover Oncology, 2025, v. 16, n. 1, p. 1, doi. 10.1007/s12672-025-03127-5

By:

Tan, Wenliang;
Zhou, Xi;
Wang, Ting;
Wu, Shuanghua;
Mo, Ting;
Xie, Zhiqin;
Xie, Yang

Publication type:

Article

Tumor-secreted RGS17 impairs CD8 + T cell function in lung adenocarcinoma through affecting glucose metabolism mediated by PI3K/AKT pathway.

Published in:

Discover Oncology, 2025, v. 16, n. 1, p. 1, doi. 10.1007/s12672-025-02850-3

By:

Lou, Ming;
Tong, Ji-Chun;
Wu, Qi-Yong;
Zhu, Zheng;
Mao, Xiao-Liang;
Lu, Jia-Wei

Publication type:

Article

Metabolic alterations driven by LDHA in CD8 + T cells promote immune evasion and therapy resistance in NSCLC.

Published in:

Scientific Reports, 2025, v. 15, n. 1, p. 1, doi. 10.1038/s41598-025-87361-5

By:

Wen, Hao;
Zhang, Panpan;
Zhao, Juan;
Liu, Yakui;
Wan, Lei;
Li, Haoran;
Yi, Jun;
Li, Xinqiang

Publication type:

Article

Riplet promotes lipid metabolism changes associated with CD8 T cell exhaustion and anti–PD-1 resistance in hepatocellular carcinoma.

Published in:

Science Immunology, 2025, v. 10, n. 108, p. 1, doi. 10.1126/sciimmunol.ado3485

By:

Liang, Junnan;
Liao, Jingyu;
Chang, Ruizhi;
Jia, Wenlong;
Li, Ganxun;
Chen, Zeyu;
Wu, Hang;
Zhu, Chang;
Wen, Jingyuan;
Huang, Qibo;
Gao, Han;
Gui, Zichen;
Xu, Weiqi;
Liang, Huifang;
Liu, Qiumeng;
Xu, Dafeng;
Li, Zifu;
Xia, Limin;
Chen, Xiaoping;
Huang, Zhao

Publication type:

Article

A T-sejt-kostimulációgátlás reneszánsza arthritisekben.

Published in:

Immunology Quarterly / Immunológiai Szemle, 2025, v. 17, n. 1, p. 47

By:

ZOLTÁN, SZEKANECZ

Publication type:

Article

CAR-T cell therapy in brain malignancies: obstacles in the face of cellular trafficking and persistence.

Published in:

Frontiers in Immunology, 2025, p. 1, doi. 10.3389/fimmu.2025.1596499

By:

Yaacoub, Serge;
Vannoy, Elton;
Maslova, Stefanyda;
Haffey, Abigail;
Khorsandi, Khatereh;
Sheybani, Natasha;
Haydar, Dalia

Publication type:

Article

Caffeine enhances antitumor T-cell activity by suppressing kynurenine pathway in colorectal cancer.

Published in:

Nature Communications, 2025, v. 16, n. 1, p. 1, doi. 10.1038/s41467-025-60958-0

By:

Liu, Yuechen;
Liu, Zhengyu;
Hu, Yating;
Ling, Yunyan;
Qing, Shunjie;
Liu, Yang;
Zhan, Yizhi;
Shen, Zhiyong;
Fang, Yuan;
Deng, Haijun

Publication type:

Article

Single-cell signaling network profiling during redox stress reveals dynamic redox regulation in immune cells.

Published in:

Nature Communications, 2025, v. 16, n. 1, p. 1, doi. 10.1038/s41467-025-60727-z

By:

Wang, Yi-Chuan;
Wu, Ping-Hsun;
Ting, Wen-Chieh;
Wang, Yi-Fu;
Yang, Ming-Han;
Su, Tung-Hung;
Su, Jia-Ying;
Sun, Hsun-I;
Huang, Wei-Min;
Tsai, Pei-Ling;
Wernig, Gerlinde;
Ho, Ping-Chih;
Wang, Limei;
Wu, Chen-Tu;
Chang, Yih-Leong;
Chen, Tseng-Cheng;
Meng, Tzu-Ching;
Chang, Yao-Ming;
Lai, Shih-Lei;
Li, Chia-Wei

Publication type:

Article

Editorial: Combination immunotherapy and immune response assessment of brain tumours.

Published in:

2025

By:

Jiang, Haihui

Publication type:

Editorial

AAV-HBV mouse model replicates the intrahepatic immune landscape of chronic HBV patients at single-cell level.

Published in:

Frontiers in Immunology, 2025, p. 1, doi. 10.3389/fimmu.2025.1421712

By:

Conceição-Neto, Nádia;
Pierson, Wim;
Han, Qinglin;
Yao, Zhiyuan;
Wu, Qun;
Dockx, Koen;
Aerts, Liese;
De Maeyer, Dries;
Beyens, Matthias;
Berge, Koen Van den;
Li, Chris;
Kukolj, George;
Zhu, Ren;
Krishna, Vinod;
Podlaha, Ondřej;
Nájera, Isabel;
Van Gulck, Ellen

Publication type:

Article

CAR-T Cell Therapy: Limitations and Improvements.

Published in:

International Journal of High School Research, 2025, v. 7, n. 6, p. 45, doi. 10.36838/v7i6.45

By:

Rao, Pranit K.

Publication type:

Article

Adjuvanted RNA Origami—A Tunable Peptide Assembly Platform for Constructing Cancer Nanovaccines.

Published in:

Vaccines, 2025, v. 13, n. 6, p. 560, doi. 10.3390/vaccines13060560

By:

Yip, Theresa;
Tu, Xinyi;
Qi, Xiaodong;
Yan, Hao;
Chang, Yung

Publication type:

Article

Biological Sex Influences Human Bystander CD8+ T Cell Activation.

Published in:

European Journal of Immunology, 2025, v. 55, n. 6, p. 1, doi. 10.1002/eji.202451673

By:

Balint, Elizabeth;
Adaimy, Marie Joe;
Montemarano, Amelia;
Portillo, Ana L.;
Ashkar, Ali A.

Publication type:

Article

Comparative Analysis of the TCR Repertoire in Bone Marrow CD8+ T Cells From Patients With Acute Myeloid Leukemia, Myelodysplastic Neoplasms, and Chronic Myelomonocytic Leukemia.

Published in:

European Journal of Immunology, 2025, v. 55, n. 6, p. 1, doi. 10.1002/eji.202551796

By:

Katsiki, Kyriaki;
Tasis, Athanasios;
Filia, Anastasia;
Kotsianidis, Ioannis;
Mitroulis, Ioannis

Publication type:

Article

The Complex Role of CD8+ T Cells in Placental HIV Infection.

Published in:

European Journal of Immunology, 2025, v. 55, n. 6, p. 1, doi. 10.1002/eji.202451615

By:

Peta, Kimberly;
Matjila, Mushi;
Ikumi, Nadia

Publication type:

Article

Advancing precision medicine in immune checkpoint blockade for HIV/AIDS: Current strategies and future directions.

Published in:

BioScience Trends, 2025, v. 19, n. 3, p. 296, doi. 10.5582/bst.2025.01072

By:

Xiangyi Tang;
Cheng Wang;
Xiling Zhang;
Qibin Liao;
Hongzhou Lu

Publication type:

Article

Developmental immune network of airway lymphocytes and innate immune cells in patients with stable COPD.

Published in:

Frontiers in Immunology, 2025, p. 1, doi. 10.3389/fimmu.2025.1614655

By:

Liu, Lanlan;
Zhou, Mei;
Sun, Shengwen;
Chen, Long;
Li, Dehu;
Lv, Jiaxi;
Cheng, Rui;
Zhang, Jianchu;
Wu, Jianghua;
Xiong, Xianzhi

Publication type:

Article

Focusing on Selinexor for Holding and Bridging Prior to CAR-T in Relapsed/Refractory Multiple Myeloma.

Published in:

Journal of Clinical Medicine, 2025, v. 14, n. 12, p. 4071, doi. 10.3390/jcm14124071

By:

Khouri, Jack;
Sborov, Douglas;
Rossi, Adriana;
Martin, Thomas;
Kashyap, Trinayan;
Mark, Tomer;
Baljevic, Muhamed

Publication type:

Article

Ivy Leaf Dry Extract EA 575 ® Is a Potent Immunomodulator Acting on Dendritic Cells.

Published in:

Pharmaceutics, 2025, v. 17, n. 6, p. 773, doi. 10.3390/pharmaceutics17060773

By:

Čolić, Miodrag;
Tomić, Sergej;
Bekić, Marina;
Dubovina, Anđela;
Häberlein, Hanns;
Rademaekers, André;
Mašić, Srđan;
Bokonjić, Dejan

Publication type:

Article

Single‐Cell RNA Sequencing Reveals Functional Exhaustion of T Cells in Oral Lichen Planus.

Published in:

Molecular Oral Microbiology, 2025, v. 40, n. 4, p. 147, doi. 10.1111/omi.12495

By:

Chen, Xin;
Wu, Xin‐Wen;
Zhao, Ruo‐Wen;
Xu, Pan;
Zhu, Ping‐Yi;
Tang, Kai‐Lin;
He, Yuan

Publication type:

Article

HIV, Inflammation, and Immunometabolism: A Model of the Inflammatory Theory of Disease.

Published in:

Viruses (1999-4915), 2025, v. 17, n. 6, p. 839, doi. 10.3390/v17060839

By:

Teer, Eman;
Mukonowenzou, Nyasha C.;
Essop, M. Faadiel

Publication type:

Article

Finetuning Type I Interferon Signaling to Enhance T Cell Immunity in HIV Infection.

Published in:

Viruses (1999-4915), 2025, v. 17, n. 6, p. 774, doi. 10.3390/v17060774

By:

Mu, Wenli;
Kedia, Nandita;
Zhen, Anjie

Publication type:

Article

Placental growth factor alleviates hyperglycemia‐induced trophoblast pyroptosis by regulating mitophagy.

Published in:

Journal of Obstetrics & Gynaecology Research, 2024, v. 50, n. 10, p. 1813, doi. 10.1111/jog.16050

By:

Tao, Jun;
Rao, Yuzhu;
Wang, Jingjing;
Tan, Shiming;
Zhao, Jinli;
Cao, Zitong;
He, Lu;
Meng, Jun;
Wu, Peng;
Wang, Zuo

Publication type:

Article

Chronic non-bacterial osteomyelitis and immune checkpoint molecules.

Published in:

Clinical Rheumatology, 2024, v. 43, n. 1, p. 553, doi. 10.1007/s10067-023-06761-y

By:

Kaya Akca, Ummusen;
Sag, Erdal;
Aydın, Busra;
Tasdemir, Nur Kubra;
Kasap Cuceoglu, Muserref;
Basaran, Ozge;
Batu, Ezgi Deniz;
Bilginer, Yelda;
Ozen, Seza

Publication type:

Article

Effects of co-infection with Clonorchis sinensis on T cell exhaustion levels in patients with chronic hepatitis B.

Published in:: Journal of Helminthology, 2024, v. 98, p. 1, doi. 10.1017/S0022149X23000871
Publication type:: Article

Senolytic compounds reduce epigenetic age of blood samples in vitro.

Published in:

NPJ Aging, 2025, v. 11, n. 1, p. 1, doi. 10.1038/s41514-025-00199-z

By:

Tharmapalan, Vithurithra;
Du Marchie Sarvaas, Miriam;
Bleichert, Michael;
Wessiepe, Martina;
Wagner, Wolfgang

Publication type:

Article

An integrated single-cell atlas of blood immune cells in aging.

Published in:

NPJ Aging, 2024, v. 10, n. 1, p. 1, doi. 10.1038/s41514-024-00185-x

By:

Filippov, Igor;
Schauser, Leif;
Peterson, Pärt

Publication type:

Article

Senolytics: from pharmacological inhibitors to immunotherapies, a promising future for patients' treatment.

Published in:

NPJ Aging, 2024, v. 10, n. 1, p. 1, doi. 10.1038/s41514-024-00138-4

By:

Lelarge, V.;
Capelle, R.;
Oger, F.;
Mathieu, T.;
Le Calvé, B.

Publication type:

Article

Identification of biomarkers associated with exhausted CD8 + T cells in the tumor microenvironment of intrahepatic cholangiocarcinoma based on Mendelian randomization and bioinformatics analysis.

Published in:

Discover Oncology, 2025, v. 16, n. 1, p. 1, doi. 10.1007/s12672-025-02970-w

By:

Feng, LiuXing;
Yuan, Quan;
Yu, Hao;
Ye, RongJie;
Xie, ZhenHao;
Xu, JiaHuan;
Li, XiuDong;
Wang, ShuangJia

Publication type:

Article

Stereotactic body radiation therapy (SBRT) increases anti-PD-1 antitumor activity by enhancing the tumor immune microenvironment in mice with metastatic hepatocellular carcinoma.

Published in:

Discover Oncology, 2025, v. 16, n. 1, p. 1, doi. 10.1007/s12672-025-02914-4

By:

Xu, Ke;
Gu, Tao;
Su, Ke;
Liu, Xin;
He, Bingsheng;
He, Jie;
Chi, Hao;
Zhou, Xuancheng;
Liu, Hanlin;
Xiao, Rui;
Tang, Xue;
Ye, Qinni;
Zhou, Xue;
Liu, Yingpeng;
Xiong, Jie;
Wang, Pan;
Li, Han;
He, Kun;
Guo, Lu;
Han, Yunwei

Publication type:

Article

Multi-omics analysis of tumor necrosis factor superfamily 4 reveals its prognostic value with T cell exhaustion feature in cancer.

Published in:

Discover Oncology, 2025, v. 16, n. 1, p. 1, doi. 10.1007/s12672-025-02666-1

By:

Lei, Kai;
Chen, Weiqing;
Wang, Anqi;
Zeng, Anyu;
Ding, Yun;
Luo, Tianqi;
Zhou, Qi

Publication type:

Article

Butyrate confers colorectal cancer cell resistance to anti-PD-1 therapy by promoting CPT1A-mediated fatty acid oxidation.

Published in:

Discover Oncology, 2025, v. 16, n. 1, p. 1, doi. 10.1007/s12672-025-02686-x

By:

Zhu, Ran;
Gu, Shujiang;
Tao, Yuan;
Zhang, Yan

Publication type:

Article

Construction of a novel CD8T cell-related index for predicting clinical outcomes and immune landscape in ovarian cancer by combined single-cell and RNA-sequencing analysis.

Published in:

Discover Oncology, 2025, v. 16, n. 1, p. 1, doi. 10.1007/s12672-025-02582-4

By:

Zhang, Yu;
Wan, Peng;
Wang, Liangliang;
Ren, Ruiping

Publication type:

Article