Works matching DE "SYNUCLEIN structure"

Results: 30

Rapid and ultra-sensitive quantitation of disease-associated α-synuclein seeds in brain and cerebrospinal fluid by αSyn RT-QuIC.

Published in:

Acta Neuropathologica Communications, 2018, v. 6, p. 1, doi. 10.1186/s40478-018-0508-2

By:

Groveman, Bradley R.;
Orrù, Christina D.;
Hughson, Andrew G.;
Raymond, Lynne D.;
Zanusso, Gianluigi;
Ghetti, Bernardino;
Campbell, Katrina J.;
Safar, Jiri;
Galasko, Douglas;
Caughey, Byron

Publication type:

Article

Intrinsically Semi-disordered State and Its Role in Induced Folding and Protein Aggregation.

Published in:

Cell Biochemistry & Biophysics, 2013, v. 67, n. 3, p. 1193, doi. 10.1007/s12013-013-9638-0

By:

Zhang, Tuo;
Faraggi, Eshel;
Li, Zhixiu;
Zhou, Yaoqi

Publication type:

Article

Toll-like receptor 2 is increased in neurons in Parkinson's disease brain and may contribute to alpha-synuclein pathology.

Published in:

Acta Neuropathologica, 2017, v. 133, n. 2, p. 303, doi. 10.1007/s00401-016-1648-8

By:

Dzamko, Nicolas;
Gysbers, Amanda;
Perera, Gayathri;
Bahar, Anita;
Shankar, Amrita;
Gao, Jianqun;
Fu, YuHong;
Halliday, Glenda

Publication type:

Article

Structural insights from lipid-bilayer nanodiscs link α-Synuclein membrane-binding modes to amyloid fibril formation.

Published in:

Communications Biology, 2018, v. 1, n. 1, p. N.PAG, doi. 10.1038/s42003-018-0049-z

By:

Viennet, Thibault;
Wördehoff, Michael M.;
Uluca, Boran;
Poojari, Chetan;
Shaykhalishahi, Hamed;
Willbold, Dieter;
Strodel, Birgit;
Heise, Henrike;
Buell, Alexander K.;
Hoyer, Wolfgang;
Etzkorn, Manuel

Publication type:

Article

Metal ions shape α-synuclein.

Published in:

Scientific Reports, 2020, v. 10, n. 1, p. N.PAG, doi. 10.1038/s41598-020-73207-9

By:

Moons, Rani;
Konijnenberg, Albert;
Mensch, Carl;
Van Elzen, Roos;
Johannessen, Christian;
Maudsley, Stuart;
Lambeir, Anne-Marie;
Sobott, Frank

Publication type:

Article

Phase transitions and structure analysis in wild-type, A30P, E46K, and A53T mutants of α-synuclein.

Published in:

European Biophysics Journal, 2016, v. 45, n. 4, p. 355, doi. 10.1007/s00249-015-1103-0

By:

Healey, Mark;
Woodside, Michael;
Tuszynski, Jack

Publication type:

Article

Nigral injection of a proteasomal inhibitor, lactacystin, induces widespread glial cell activation and shows various phenotypes of Parkinson's disease in young and adult mouse.

Published in:

Experimental Brain Research, 2017, v. 235, n. 7, p. 2189, doi. 10.1007/s00221-017-4962-z

By:

Savolainen, Mari;
Albert, Katrina;
Airavaara, Mikko;
Myöhänen, Timo

Publication type:

Article

Co-existence of Two Different α-Synuclein Oligomers with Different Core Structures Determined by Hydrogen/Deuterium Exchange Mass Spectrometry.

Published in:

Angewandte Chemie International Edition, 2014, v. 53, n. 29, p. 7560, doi. 10.1002/anie.201400491

By:

Paslawski, Wojciech;
Mysling, Simon;
Thomsen, Karen;
Jørgensen, Thomas J. D.;
Otzen, Daniel E.

Publication type:

Article

Human Astrocytes Transfer Aggregated Alpha-Synuclein via Tunneling Nanotubes.

Published in:

Journal of Neuroscience, 2017, v. 37, n. 49, p. 11835, doi. 10.1523/JNEUROSCI.0983-17.2017

By:

Rostami, Jinar;
Holmqvist, Staffan;
Lindstrom, Veronica;
Sigvardson, Jessica;
Westermark, Gunilla T.;
Ingelsson, Martin;
Bergstrom, Joakim;
Roybon, Laurent;
Erlandsson, Anna

Publication type:

Article

The correlation between expression of synuclein-γ, glucose transporter-1, and survival outcomes in endometrioid endometrial carcinoma.

Published in:

European Journal of Gynaecological Oncology, 2013, v. 34, n. 2, p. 128

By:

Hong, D. G.;
Park, N. Y.;
Chong, G. O.;
Cho, Y. L.;
Park, L. S.;
Jeong, M. J.;
Park, J. Y.;
Lee, Y. S.

Publication type:

Article

α-Synuclein as a ferrireductase.

Published in:

Biochemical Society Transactions, 2013, v. 41, n. 6, p. 1513, doi. 10.1042/BST20130130

By:

Brown, David R.

Publication type:

Article

Rifampicin is a candidate preventive medicine against amyloid-β and tau oligomers.

Published in:

2016

By:

Tomohiro Umeda;
Ono, Kenjiro;
Ayumi Sakai;
Minato Yamashita;
Mineyuki Mizuguchi;
Klein, William L.;
Masahito Yamada;
Hiroshi Mori;
Takami Tomiyama;
Umeda, Tomohiro;
Sakai, Ayumi;
Yamashita, Minato;
Mizuguchi, Mineyuki;
Yamada, Masahito;
Mori, Hiroshi;
Tomiyama, Takami

Publication type:

journal article

Optical Structural Analysis of Individual α‐Synuclein Oligomers.

Published in:

Angewandte Chemie, 2018, v. 130, n. 18, p. 4980, doi. 10.1002/ange.201710779

By:

Varela, Juan A.;
Rodrigues, Margarida;
De, Suman;
Flagmeier, Patrick;
Gandhi, Sonia;
Dobson, Christopher M.;
Klenerman, David;
Lee, Steven F.

Publication type:

Article

Lysosomes and α-synuclein form a dangerous duet leading to neuronal cell death.

Published in:

Frontiers in Neuroanatomy, 2014, v. 8, p. 1, doi. 10.3389/fnana.2014.00083

By:

Bourdenx, Mathieu;
Bezard, Erwan;
Dehay, Benjamin

Publication type:

Article

Atypical multiple system atrophy is a new subtype of frontotemporal lobar degeneration: frontotemporal lobar degeneration associated with α-synuclein.

Published in:

Acta Neuropathologica, 2015, v. 130, n. 1, p. 93, doi. 10.1007/s00401-015-1442-z

By:

Aoki, Naoya;
Boyer, Philip;
Lund, Cheryl;
Lin, Wen-Lang;
Koga, Shunsuke;
Ross, Owen;
Weiner, Myron;
Lipton, Anne;
Powers, James;
White, Charles;
Dickson, Dennis

Publication type:

Article

Spinal cord lesions in sporadic Parkinson's disease.

Published in:

Acta Neuropathologica, 2012, v. 124, n. 5, p. 643, doi. 10.1007/s00401-012-1028-y

By:

Del Tredici, Kelly;
Braak, Heiko

Publication type:

Article

Molecular basis of Parkinsons's disease linked to LRRK2 mutations.

Published in:

Molecular Biology, 2014, v. 48, n. 1, p. 1, doi. 10.1134/S0026893314010117

By:

Pchelina, S.;
Emelyanov, A.;
Usenko, T.

Publication type:

Article

α-Synuclein lipoprotein nanoparticles.

Published in:

Nanotechnology Reviews, 2017, v. 6, n. 1, p. 105, doi. 10.1515/ntrev-2016-0062

By:

Eichmann, Cédric;
Bibow, Stefan;
Riek, Roland

Publication type:

Article

α-Synuclein binds to TOM20 and inhibits mitochondrial protein import in Parkinson’s disease.

Published in:

Science Translational Medicine, 2016, v. 8, n. 342, p. 1, doi. 10.1126/scitranslmed.aaf3634

By:

Di Maio, Roberto;
Barrett, Paul J.;
Hoffman, Eric K.;
Barrett, Caitlyn W.;
Zharikov, Alevtina;
Borah, Anupom;
Xiaoping Hu;
McCoy, Jennifer;
Chu, Charleen T.;
Burton, Edward A.;
Hastings, Teresa G.;
Greenamyre, J. Timothy

Publication type:

Article

Common structural features of toxic intermediates from α-synuclein and GroES fibrillogenesis detected using cryogenic coherent X-ray diffraction imaging.

Published in:

Journal of Biochemistry, 2017, v. 161, n. 1, p. 55, doi. 10.1093/jb/mvw052

By:

Hiroshi Kameda;
Sayaka Usugi;
Mana Kobayashi;
Naoya Fukui;
Seki Lee;
Kunihiro Hongo;
Tomohiro Mizobata;
Yuki Sekiguchi;
Yu Masaki;
Amane Kobayashi;
Tomotaka Oroguchi;
Masayoshi Nakasako;
Yuki Takayama;
Masaki Yamamoto;
Yasushi Kawata

Publication type:

Article

Secretion and Uptake of α-Synuclein Via Extracellular Vesicles in Cultured Cells.

Published in:

Cellular & Molecular Neurobiology, 2018, v. 38, n. 8, p. 1539, doi. 10.1007/s10571-018-0622-5

By:

Gustafsson, Gabriel;
Lööv, Camilla;
Persson, Emma;
Lázaro, Diana F.;
Takeda, Shuko;
Bergström, Joakim;
Erlandsson, Anna;
Sehlin, Dag;
Balaj, Leonora;
György, Bence;
Hallbeck, Martin;
Outeiro, Tiago F.;
Breakefield, Xandra O.;
Hyman, Bradley T.;
Ingelsson, Martin

Publication type:

Article

Kurtosis imaging reveals microstructural changes of late-stage α-synuclein accumulation in a mouse model of Parkinson's disease.

Published in:

2016

By:

Williams, Stephen

Publication type:

Editorial

The phosphorylation of α-synuclein: development and implication for the mechanism and therapy of the Parkinson's disease.

Published in:

Journal of Neurochemistry, 2015, v. 135, n. 1, p. 4, doi. 10.1111/jnc.13234

By:

Xu, Yan;
Deng, Yulin;
Qing, Hong

Publication type:

Article

Small-Molecule-Induced Soluble Oligomers of α-Synuclein with Helical Structure.

Published in:

Chemistry - A European Journal, 2017, v. 23, n. 53, p. 13010, doi. 10.1002/chem.201703001

By:

Fonseca‐Ornelas, Luis;
Schmidt, Carla;
Camacho‐Zarco, Aldo R.;
Fernandez, Claudio O.;
Becker, Stefan;
Zweckstetter, Markus

Publication type:

Article

Radiosynthesis and in Vivo Evaluation of Two PET Radioligands for Imaging α-Synuclein.

Published in:

Applied Sciences (2076-3417), 2014, v. 4, n. 1, p. 66, doi. 10.3390/app4010066

By:

Xiang Zhang;
Hongjun Jin;
Padakanti, Prashanth K.;
Junfeng Li;
Hao Yang;
Jinda Fan;
Mach, Robert H.;
Kotzbauer, Paul;
Zhude Tu

Publication type:

Article

Silencing Alpha Synuclein in Mature Nigral Neurons Results in Rapid Neuroinflammation and Subsequent Toxicity.

Published in:

Frontiers in Molecular Neuroscience, 2018, p. 1, doi. 10.3389/fnmol.2018.00036

By:

Benskey, Matthew J.;
Sellnow, Rhyomi C.;
Sandoval, Ivette M.;
Sortwell, Caryl E.;
Lipton, Jack W.;
Manfredsson, Fredric P.

Publication type:

Article

Diffusion Kurtosis Imaging Detects Microstructural Alterations in Brain of α-Synuclein Overexpressing Transgenic Mouse Model of Parkinson's Disease: A Pilot Study.

Published in:

Neurotoxicity Research, 2015, v. 28, n. 4, p. 281, doi. 10.1007/s12640-015-9537-9

By:

Khairnar, Amit;
Latta, Peter;
Drazanova, Eva;
Ruda-Kucerova, Jana;
Szabó, Nikoletta;
Arab, Anas;
Hutter-Paier, Birgit;
Havas, Daniel;
Windisch, Manfred;
Sulcova, Alexandra;
Starcuk, Zenon;
Rektorova, Irena

Publication type:

Article

Immunotherapy targeting toll-like receptor 2 alleviates neurodegeneration in models of synucleinopathy by modulating α-synuclein transmission and neuroinflammation.

Published in:

Molecular Neurodegeneration, 2018, v. 13, n. 1, p. N.PAG, doi. 10.1186/s13024-018-0276-2

By:

Kim, Changyoun;
Spencer, Brian;
Rockenstein, Edward;
Yamakado, Hodaka;
Mante, Michael;
Adame, Anthony;
Fields, Jerel Adam;
Masliah, Deborah;
Iba, Michiyo;
Lee, He-Jin;
Rissman, Robert A.;
Lee, Seung-Jae;
Masliah, Eliezer

Publication type:

Article

α-Synuclein accumulation and GBA deficiency due to L444P GBA mutation contributes to MPTP-induced parkinsonism.

Published in:

Molecular Neurodegeneration, 2018, v. 12, p. 1, doi. 10.1186/s13024-017-0233-5

By:

Yun, Seung Pil;
Kim, Donghoon;
Kim, Sangjune;
Kim, SangMin;
Karuppagounder, Senthilkumar S.;
Kwon, Seung-Hwan;
Lee, Saebom;
Kam, Tae-In;
Lee, Suhyun;
Ham, Sangwoo;
Park, Jae Hong;
Dawson, Valina L.;
Dawson, Ted M.;
Lee, Yunjong;
Ko, Han Seok

Publication type:

Article

Effects of Ginkgo Biloba Extract on A53T α-Synuclein Transgenic Mouse Models of Parkinson’s Disease.

Published in:

Canadian Journal of Neurological Sciences, 2018, v. 45, n. 2, p. 182, doi. 10.1017/cjn.2017.268

By:

Kuang, Shaosong;
Yang, Lin;
Rao, Ziliang;
Zhong, Zhiyong;
Li, Jinfeng;
Zhong, Haichao;
Dai, Lulu;
Tang, Xiaojiang

Publication type:

Article