Works matching DE "SYNAPTOTAGMINS"

Results: 133

Synaptotagmin-1 and -7 Are Redundantly Essential for Maintaining the Capacity of the Readily-Releasable Pool of Synaptic Vesicles.

Published in:

PLoS Biology, 2015, v. 13, n. 10, p. 1, doi. 10.1371/journal.pbio.1002267

By:

Bacaj, Taulant;
Wu, Dick;
Burré, Jacqueline;
Malenka, Robert C.;
Liu, Xinran;
Südhof, Thomas C.

Publication type:

Article

Dual-Function Exocytosis Regulator Has Yet Another Job.

Published in:

PLoS Biology, 2015, v. 13, n. 10, p. 1, doi. 10.1371/journal.pbio.1002268

By:

Robinson, Richard

Publication type:

Article

Neurotransmission: The second sensor.

Published in:

Nature Reviews Neuroscience, 2014, v. 15, n. 1, p. 5, doi. 10.1038/nrn3663

By:

Yates, Darran

Publication type:

Article

Synaptotagmin-1 binds to PIP2-containing membrane but not to SNAREs at physiological ionic strength.

Published in:

Nature Structural & Molecular Biology, 2015, v. 22, n. 10, p. 815, doi. 10.1038/nsmb.3097

By:

Park, Yongsoo;
Seo, Jong Bae;
Fraind, Alicia;
Pérez-Lara, Angel;
Yavuz, Halenur;
Han, Kyungreem;
Jung, Seung-Ryoung;
Kattan, Iman;
Walla, Peter Jomo;
Choi, MooYoung;
Cafiso, David S;
Koh, Duk-Su;
Jahn, Reinhard

Publication type:

Article

Dynamic binding mode of a Synaptotagmin-1-SNARE complex in solution.

Published in:

Nature Structural & Molecular Biology, 2015, v. 22, n. 7, p. 555, doi. 10.1038/nsmb.3035

By:

Brewer, Kyle D;
Bacaj, Taulant;
Cavalli, Andrea;
Camilloni, Carlo;
Swarbrick, James D;
Liu, Jin;
Zhou, Amy;
Zhou, Peng;
Barlow, Nicholas;
Xu, Junjie;
Seven, Alpay B;
Prinslow, Eric A;
Voleti, Rashmi;
Häussinger, Daniel;
Bonvin, Alexandre M J J;
Tomchick, Diana R;
Vendruscolo, Michele;
Graham, Bim;
Südhof, Thomas C;
Rizo, Josep

Publication type:

Article

Phosphatidylinositol 4,5-bisphosphate clusters act as molecular beacons for vesicle recruitment.

Published in:

Nature Structural & Molecular Biology, 2013, v. 20, n. 6, p. 679, doi. 10.1038/nsmb.2570

By:

Honigmann, Alf;
van den Bogaart, Geert;
Iraheta, Emilio;
Risselada, H Jelger;
Milovanovic, Dragomir;
Mueller, Veronika;
Müllar, Stefan;
Diederichsen, Ulf;
Fasshauer, Dirk;
Grubmüller, Helmut;
Hell, Stefan W;
Eggeling, Christian;
Kühnel, Karin;
Jahn, Reinhard

Publication type:

Article

Controlling synaptotagmin activity by electrostatic screening.

Published in:

Nature Structural & Molecular Biology, 2012, v. 19, n. 10, p. 991, doi. 10.1038/nsmb.2375

By:

Park, Yongsoo;
Hernandez, Javier M;
van den Bogaart, Geert;
Ahmed, Saheeb;
Holt, Matthew;
Riedel, Dietmar;
Jahn, Reinhard

Publication type:

Article

Synaptotagmin-7 places dense-core vesicles at the cell membrane to promote Munc13-2- and Ca2+-dependent priming.

Published in:

eLife, 2021, p. 1, doi. 10.7554/eLife.64527

By:

Tawfik, Bassam;
Martins, Joana S.;
Houy, Sébastien;
Imig, Cordelia;
Pinheiro, Paulo S.;
Wojcik, Sonja M.;
Brose, Nils;
Cooper, Benjamin H.;
Sørensen, Jakob Balslev

Publication type:

Article

Synaptotagmin 7 switches short-term synaptic plasticity from depression to facilitation by suppressing synaptic transmission.

Published in:

Scientific Reports, 2021, v. 11, n. 1, p. 1, doi. 10.1038/s41598-021-83397-5

By:

Fujii, Takaaki;
Sakurai, Akira;
Littleton, J. Troy;
Yoshihara, Motojiro

Publication type:

Article

Species-specific differences in synaptic transmission and plasticity.

Published in:

Scientific Reports, 2020, v. 10, n. 1, p. N.PAG, doi. 10.1038/s41598-020-73547-6

By:

Beed, Prateep;
Ray, Saikat;
Velasquez, Laura Moreno;
Stumpf, Alexander;
Parthier, Daniel;
Swaminathan, Aarti;
Nitzan, Noam;
Breustedt, Jörg;
Las, Liora;
Brecht, Michael;
Schmitz, Dietmar

Publication type:

Article

The short isoform of extended synaptotagmin-2 controls Ca2+ dynamics in T cells via interaction with STIM1.

Published in:

Scientific Reports, 2020, v. 10, n. 1, p. N.PAG, doi. 10.1038/s41598-020-71489-7

By:

Woo, Jin Seok;
Sun, Zuoming;
Srikanth, Sonal;
Gwack, Yousang

Publication type:

Article

Synaptotagmin-like proteins control the formation of a single apical membrane domain in epithelial cells.

Published in:

Nature Cell Biology, 2012, v. 14, n. 8, p. 838, doi. 10.1038/ncb2541

By:

Gálvez-Santisteban, Manuel;
Rodriguez-Fraticelli, Alejo E.;
Bryant, David M.;
Vergarajauregui, Silvia;
Yasuda, Takao;
Bañón-Rodríguez, Inmaculada;
Bernascone, Ilenia;
Datta, Anirban;
Spivak, Natalie;
Young, Kitty;
Slim, Christiaan L.;
Brakeman, Paul R.;
Fukuda, Mitsunori;
Mostov, Keith E.;
Martín-Belmonte, Fernando

Publication type:

Article

A Stimulation Function of Synaptotagmin-1 in Ternary SNARE Complex Formation Dependent on Munc18 and Munc13.

Published in:

Frontiers in Molecular Neuroscience, 2017, p. 1, doi. 10.3389/fnmol.2017.00256

By:

Yun Li;
Shen Wang;
Tianzhi Li;
Le Zhu;
Yuanyuan Xu;
Cong Ma

Publication type:

Article

Identification of the novel activity-driven interaction between synaptotagmin 1 and presenilin 1 links calcium, synapse, and amyloid beta.

Published in:

BMC Biology, 2016, v. 14, p. 1, doi. 10.1186/s12915-016-0248-3

By:

Kuzuya, Akira;
Zoltowska, Katarzyna M.;
Post, Kathryn L.;
Arimon, Muriel;
Xuejing Li;
Svirsky, Sarah;
Maesako, Masato;
Muzikansky, Alona;
Gautam, Vivek;
Kovacs, Dora;
Hyman, Bradley T.;
Berezovska, Oksana

Publication type:

Article

A Sequential Vesicle Pool Model with a Single Release Sensor and a Ca2+-Dependent Priming Catalyst Effectively Explains Ca2+-Dependent Properties of Neurosecretion.

Published in:

PLoS Computational Biology, 2013, v. 9, n. 12, p. 1, doi. 10.1371/journal.pcbi.1003362

By:

Walter, Alexander M.;
Pinheiro, Paulo S.;
Verhage, Matthijs;
Sørensen, Jakob B.

Publication type:

Article

Molecular machines governing exocytosis of synaptic vesicles.

Published in:

Nature, 2012, v. 490, n. 7419, p. 201, doi. 10.1038/nature11320

By:

Jahn, Reinhard;
Fasshauer, Dirk

Publication type:

Article

The synaptotagmin juxtamembrane domain is involved in neuroexocytosis.

Published in:

FEBS Open Bio, 2015, v. 5, p. 388, doi. 10.1016/j.fob.2015.04.013

By:

Caccin, Paola;
Scorzeto, Michele;
Damiano, Nunzio;
Marin, Oriano;
Megighian, Aram;
Montecucco, Cesare

Publication type:

Article

Variations in the Botulinum Neurotoxin Binding Domain and the Potential for Novel Therapeutics.

Published in:

Toxins, 2018, v. 10, n. 10, p. 421, doi. 10.3390/toxins10100421

By:

Davies, Jonathan R.;
Acharya, K. Ravi;
Liu, Sai Man

Publication type:

Article

Botulinum Neurotoxin Serotype A Recognizes Its Protein Receptor SV2 by a Different Mechanism than Botulinum Neurotoxin B Synaptotagmin.

Published in:

Toxins, 2016, v. 8, n. 5, p. 154, doi. 10.3390/toxins8050154

By:

Weisemann, Jasmin;
Stern, Daniel;
Mahrhold, Stefan;
Dorner, Brigitte G.;
Rummel, Andreas

Publication type:

Article

Extended Synaptotagmin (ESyt) Triple Knock-Out Mice Are Viable and Fertile without Obvious Endoplasmic Reticulum Dysfunction.

Published in:

PLoS ONE, 2016, v. 11, n. 6, p. 1, doi. 10.1371/journal.pone.0158295

By:

Sclip, Alessandra;
Bacaj, Taulant;
Giam, Louise R.;
Südhof, Thomas C.

Publication type:

Article

Regulation of BDNF Release by ARMS/Kidins220 through Modulation of Synaptotagmin-IV Levels.

Published in:

Journal of Neuroscience, 2018, v. 38, n. 23, p. 5415, doi. 10.1523/JNEUROSCI.1653-17.2018

By:

López-Benito, Saray;
Sánchez-Sánchez, Julia;
Brito, Verónica;
Calvo, Laura;
Lisa, Silvia;
Torres-Valle, María;
Palko, Mary E.;
Vicente-García, Cristina;
Fernández-Fernández, Seila;
Bolaños, Juan P.;
Ginés, Silvia;
Tessarollo, Lino;
Arévalo, Juan C.

Publication type:

Article

SNT-1 Functions as the Ca2+ Sensor for Tonic and Evoked Neurotransmitter Release in Caenorhabditis Elegans.

Published in:

Journal of Neuroscience, 2018, v. 38, n. 23, p. 5313, doi. 10.1523/JNEUROSCI.3097-17.2018

By:

Lei Li;
Haowen Liu;
Wei Wang;
Chandra, Mintu;
Collins, Brett M.;
Zhitao Hu

Publication type:

Article

Synaptotagmin 7 Mediates Both Facilitation and Asynchronous Release at Granule Cell Synapses.

Published in:

Journal of Neuroscience, 2018, v. 38, n. 13, p. 3240, doi. 10.1523/JNEUROSCI.3207-17.2018

By:

Turecek, Josef;
Regehr, Wade G.

Publication type:

Article

Interactions Between SNAP-25 and Synaptotagmin-1 Are Involved in Vesicle Priming, Clamping Spontaneous and Stimulating Evoked Neurotransmission.

Published in:

Journal of Neuroscience, 2016, v. 36, n. 47, p. 11865, doi. 10.1523/JNEUROSCI.1011-16.2016

By:

Schupp, Melanie;
Malsam, Jörg;
Ruiter, Marvin;
Scheutzow, Andrea;
Wierda, Keimpe D. B.;
Söllner, Thomas H.;
Sørensen, Jakob B.

Publication type:

Article

Upregulating Synaptotagmin 10 Protects Neurons.

Published in:

Journal of Neuroscience, 2016, v. 36, n. 9, p. i

By:

Esch, Teresa

Publication type:

Article

A Post-Docking Role of Synaptotagmin 1-C2B Domain Bottom Residues R398/399 in Mouse Chromaffin Cells.

Published in:

Journal of Neuroscience, 2015, v. 35, n. 42, p. 14172, doi. 10.1523/JNEUROSCI.1911-15.2015

By:

Kedar, Girish H.;
Munch, Anders S.;
van Weering, Jan R. T.;
Malsam, Jõrg;
Scheutzow, Andrea;
de Wit, Heidi;
Houy, Sébastien;
Tawfik, Bassam;
Söllner, Thomas H.;
Sørensen, Jakob B.;
Verhage, Matthijs

Publication type:

Article

An Engineered Metal Sensor Tunes the Kinetics of Synaptic Transmission.

Published in:

Journal of Neuroscience, 2015, v. 35, n. 34, p. 11769, doi. 10.1523/JNEUROSCI.1694-15.2015

By:

Evans, Chantell S.;
Ruhl, David A.;
Chapman, Edwin R.

Publication type:

Article

Synaptotagmin-7 Is Essential for Ca2+-Triggered Delayed Asynchronous Release But Not for Ca2+-Dependent Vesicle Priming in Retinal Ribbon Synapses.

Published in:

Journal of Neuroscience, 2015, v. 35, n. 31, p. 11024, doi. 10.1523/JNEUROSCI.0759-15.2015

By:

Fujun Luo;
Bacaj, Taulant;
Südhof, Thomas C.

Publication type:

Article

Spontaneous Vesicle Release Is Not Tightly Coupled to Voltage-Gated Calcium Channel-Mediated Ca2+ Influx and Is Triggered by a Ca2+ Sensor Other Than Synaptotagmin-2 at the Juvenile Mice Calyx of Held Synapses.

Published in:

Journal of Neuroscience, 2015, v. 35, n. 26, p. 9632, doi. 10.1523/JNEUROSCI.0457-15.2015

By:

inye Dai;
Peihua Chen;
Hao Tian;
Jianyuan Sun

Publication type:

Article

Phosphorylation of Synaptic Vesicle Protein 2A at Thr84 by Casein Kinase 1 Family Kinases Controls the Specific Retrieval of Synaptotagmin-1.

Published in:

Journal of Neuroscience, 2015, v. 35, n. 6, p. 2492, doi. 10.1523/JNEUROSCI.4248-14.2015

By:

Ning Zhang;
Gordon, Sarah L.;
Fritsch, Maximilian J.;
Esoof, Noor;
Campbell, David G.;
Gourlay, Robert;
Velupillai, Srikannathasan;
Macartney, Thomas;
Peggie, Mark;
van Aalten, Daan M. F.;
Cousin, Michael A.;
Alessi, Dario R.

Publication type:

Article

Peptidergic Cell-Specific Synaptotagmins in Drosophila: Localization to Dense-Core Granules and Regulation by the bHLH Protein DIMMED.

Published in:

Journal of Neuroscience, 2014, v. 34, n. 39, p. 13195, doi. 10.1523/JNEUROSCI.2075-14.2014

By:

Park, Dongkook;
Li, Peiyao;
Dani, Adish;
Taghert, Paul H.

Publication type:

Article

An Alien Divalent Ion Reveals a Major Role for Ca2+ Buffering in Controlling Slow Transmitter Release.

Published in:

Journal of Neuroscience, 2014, v. 34, n. 38, p. 12622, doi. 10.1523/JNEUROSCI.1990-14.2014

By:

Babai, Norbert;
Kochubey, Olexiy;
Keller, Daniel;
Schneggenburger, Ralf

Publication type:

Article

Innervation by a GABAergic Neuron Depresses Spontaneous Release in Glutamatergic Neurons and Unveils the Clamping Phenotype of Synaptotagmin-1.

Published in:

Journal of Neuroscience, 2014, v. 34, n. 6, p. 2100, doi. 10.1523/JNEUROSCI.3934-13.2014

By:

Wierda, Keimpe D. B.;
Sørensen, Jakob B.

Publication type:

Article

Doc2b Synchronizes Secretion from Chromaffin Cells by Stimulating Fast and Inhibiting Sustained Release.

Published in:

Journal of Neuroscience, 2013, v. 33, n. 42, p. 16459, doi. 10.1523/JNEUROSCI.2656-13.2013

By:

Pinheiro, Paulo S.;
de Wit, Heidi;
Walter, Alexander M.;
Groffen, Alexander J.;
Verhage, Matthijs;
Sørensen, Jakob B.

Publication type:

Article

Synaptotagmin Interaction with SNAP-25 Governs Vesicle Docking, Priming, and Fusion Triggering.

Published in:

Journal of Neuroscience, 2013, v. 33, n. 36, p. 14417, doi. 10.1523/JNEUROSCI.1236-13.2013

By:

Mohrmann, Ralf;
De Wit, Heidi;
Connell, Emma;
Pinheiro, Paulo S.;
Leese, Charlotte;
Bruns, Dieter;
Davletov, Bazbek;
Verhage, Matthijs;
Sørensen, Jakob B.

Publication type:

Article

Synaptotagmin-12 Phosphorylation by cAMP-Dependent Protein Kinase Is Essential for Hippocampal Mossy Fiber LTP.

Published in:

Journal of Neuroscience, 2013, v. 33, n. 23, p. 9769, doi. 10.1523/JNEUROSCI.5814-12.2013

By:

Kaeser-Woo, Yea Jin;
Younts, Thomas J.;
Xiaofei Yang;
Peng Zhou;
Dick Wu;
Castillo, Pablo E.;
Südhof, Thomas C.

Publication type:

Article

Dance of the SNAREs: Assembly and Rearrangements Detected with FRET at Neuronal Synapses.

Published in:

Journal of Neuroscience, 2013, v. 33, n. 13, p. 5507, doi. 10.1523/JNEUROSCI.2337-12.2013

By:

Degtyar, Vadim;
Hafez, Ismail M.;
Bray, Christopher;
Zucker, Robert S.

Publication type:

Article

Complexin Activates Exocytosis of Distinct Secretory Vesicles Controlled by Different Synaptotagmins.

Published in:

Journal of Neuroscience, 2013, v. 33, n. 4, p. 1714, doi. 10.1523/JNEUROSCI.4087-12.2013

By:

Peng Cao;
Xiaofei Yang;
Südhof, Thomas C.

Publication type:

Article

Complexin Controls Spontaneous and Evoked Neurotransmitter Release by Regulating the Timing and Properties of Synaptotagmin Activity.

Published in:

Journal of Neuroscience, 2012, v. 32, n. 50, p. 18234, doi. 10.1523/JNEUROSCI.3212-12.2012

By:

Jorquera, Ramon A.;
Huntwork-Rodriguez, Sarah;
Akbergenova, Yulia;
Cho, Richard W.;
Littleton, J. Troy

Publication type:

Article

Control of Synaptotagmin‐1 Trafficking by SV2A—Mechanism and Consequences for Presynaptic Function and Dysfunction.

Published in:

Journal of Neurochemistry, 2025, v. 169, n. 1, p. 1, doi. 10.1111/jnc.16308

By:

Hogg, James A.;
Cousin, Michael A.

Publication type:

Article

Multiscale Structural Analysis of Plant ER-PM Contact Sites.

Published in:

Plant & Cell Physiology, 2017, v. 58, n. 3, p. 478, doi. 10.1093/pcp/pcw224

By:

McFarlane, Heather E.;
Eun Kyoung Lee;
van Bezouwen, Laura S.;
Ross, Bradford;
Rosado, Abel;
Samuels, A. Lacey

Publication type:

Article

Synaptotagmin 1 Negatively Controls the Two Distinct Immune Secretory Pathways to Powdery Mildew Fungi in Arabidopsis.

Published in:

Plant & Cell Physiology, 2016, v. 57, n. 6, p. 1133, doi. 10.1093/pcp/pcw061

By:

Hyeran Kim;
Hyeokjin Kwon;
Soohong Kim;
Mi Kyung Kim;
Botella, Miguel A.;
Hye Sup Yun;
Chian Kwon

Publication type:

Article

The release of inhibition model reproduces kinetics and plasticity of neurotransmitter release in central synapses.

Published in:

Communications Biology, 2023, v. 6, n. 1, p. 1, doi. 10.1038/s42003-023-05445-2

By:

Norman, Christopher A.;
Krishnakumar, Shyam S.;
Timofeeva, Yulia;
Volynski, Kirill E.

Publication type:

Article

Regulation of munc18-1 and syntaxin-1A interactive partners in schizophrenia prefrontal cortex: down-regulation of munc18-1a isoform and 75 kDa SNARE complex after antipsychotic treatment.

Published in:

International Journal of Neuropsychopharmacology, 2012, v. 15, n. 4, p. 573, doi. 10.1017/S1461145711000861

By:

Gil-Pisa, Itziar;
Munarriz-Cuezva, Eva;
Ramos-Miguel, Alfredo;
Urigüen, Leyre;
Meana, J. Javier;
García-Sevilla, Jesús A.

Publication type:

Article

Extended Synaptotagmin Localizes to Presynaptic ER and Promotes Neurotransmission and Synaptic Growth in Drosophila.

Published in:

Genetics, 2017, v. 207, n. 3, p. 993, doi. 10.1534/genetics.117.300261

By:

Koto Kikuma;
Xiling Li;
Daniel Kim;
Sutter, David;
Dickman, Dion K.

Publication type:

Article

Synaptotagmin 1 and Ca2+ drive trans SNARE zippering.

Published in:

Scientific Reports, 2014, p. 1, doi. 10.1038/srep04575

By:

Ying Lai;
Xiaochu Lou;
Chuqi Wang;
Tian Xia;
Jiansong Tong

Publication type:

Article

Synaptotagmin 1 clamps synaptic vesicle fusion in mammalian neurons independent of complexin.

Published in:

Nature Communications, 2019, v. 10, n. 1, p. N.PAG, doi. 10.1038/s41467-019-12015-w

By:

Courtney, Nicholas A.;
Bao, Huan;
Briguglio, Joseph S.;
Chapman, Edwin R.

Publication type:

Article

SGIP1α functions as a selective endocytic adaptor for the internalization of synaptotagmin 1 at synapses.

Published in:

Molecular Brain, 2019, v. 12, n. 1, p. N.PAG, doi. 10.1186/s13041-019-0464-1

By:

Lee, Sang-Eun;
Jeong, Soomin;
Lee, Unghwi;
Chang, Sunghoe

Publication type:

Article

SYT1-associated neurodevelopmental disorder: a case series.

Published in:

2018

By:

Baker, Kate;
Gordon, Sarah L;
Melland, Holly;
Bumbak, Fabian;
Scott, Daniel J;
Jiang, Tess J;
Owen, David;
Turner, Bradley J;
Boyd, Stewart G;
Rossi, Mari;
Al-Raqad, Mohammed;
Elpeleg, Orly;
Peck, Dawn;
Mancini, Grazia M S;
Wilke, Martina;
Zollino, Marcella;
Marangi, Giuseppe;
Weigand, Heike;
Borggraefe, Ingo;
Haack, Tobias

Publication type:

journal article

A molecular machine for neurotransmitter release: synaptotagmin and beyond.

Published in:

Nature Medicine, 2013, v. 19, n. 10, p. 1227, doi. 10.1038/nm.3338

By:

Südhof, Thomas C

Publication type:

Article