Works matching DE "SUPER enhancers"

Results: 96

Systemic genome-epigenome analysis captures a lineage-specific super-enhancer for MYB in gastrointestinal adenocarcinoma.

Published in:

Molecular Systems Biology, 2025, v. 21, n. 6, p. 696, doi. 10.1038/s44320-025-00098-1

By:

Li, Fuyuan;
Wang, Shangzi;
Chen, Lian;
Jiang, Ning;
Chen, Xingdong;
Li, Jin

Publication type:

Article

A Non-Binary Approach to Super-Enhancer Identification and Clustering: A Dataset for Tumor- and Treatment-Associated Dynamics in Mouse Tissues.

Published in:

Data (2306-5729), 2025, v. 10, n. 5, p. 74, doi. 10.3390/data10050074

By:

Osintseva, Ekaterina D.;
Ashniev, German A.;
Orlov, Alexey V.;
Nikitin, Petr I.;
Zaitseva, Zoia G.;
Volkov, Vladimir V.;
Orlova, Natalia N.

Publication type:

Article

Engrailed 2 facilitates progression of triple-negative and HER2-enriched breast cancer by binding to enhancer region of Tenascin-C.

Published in:

Discover Oncology, 2024, v. 15, n. 1, p. 1, doi. 10.1007/s12672-024-01471-6

By:

Chen, Dandan;
Yin, Rongping

Publication type:

Article

Role of integrin β1 and tenascin C mediate TGF-SMAD2/3 signaling in chondrogenic differentiation of BMSCs induced by type I collagen hydrogel.

Published in:

Regenerative Biomaterials, 2024, v. 11, p. 1, doi. 10.1093/rb/rbae017

By:

Huang, Yuanjun;
Sun, Miao;
Lu, Zhenhui;
Zhong, Qiuling;
Tan, Manli;
Wei, Qingjun;
Zheng, Li

Publication type:

Article

Mapping the breakome reveals tight regulation on oncogenic super-enhancers.

Published in:

Molecular & Cellular Oncology, 2020, v. 7, n. 3, p. 1, doi. 10.1080/23723556.2019.1698933

By:

Oster, Sara;
Aqeilan, Rami I.

Publication type:

Article

Targeting complexes of super-enhancers is a promising strategy for cancer therapy.

Published in:

Oncology Letters, 2020, v. 20, n. 3, p. 2557, doi. 10.3892/ol.2020.11855

By:

Zheng, Chuqian;
Liu, Min;
Fan, Hong

Publication type:

Article

Phase separation and transcriptional regulation in cancer development.

Published in:

Journal of Biomedical Research, 2024, v. 38, n. 4, p. 307, doi. 10.7555/JBR.37.20230214

By:

Yan Gu;
Ke Wei;
Jun Wang

Publication type:

Article

Genetic variant in a BaP-activated super-enhancer increases prostate cancer risk by promoting AhR-mediated FAM227A expression.

Published in:

Journal of Biomedical Research, 2024, v. 38, n. 2, p. 149, doi. 10.7555/JBR.37.20230049

By:

Lulu Fan;
Hao Wang;
Shuai Ben;
Yifei Cheng;
Silu Chen;
Zhutao Ding;
Lingyan Zhao;
Shuwei Li;
Meilin Wang;
Gong Cheng

Publication type:

Article

The chromatin accessibility and transcriptomic landscape of the aging mice cochlea and the identification of potential functional super-enhancers in age-related hearing loss.

Published in:

Clinical Epigenetics, 2024, v. 16, n. 1, p. 1, doi. 10.1186/s13148-024-01702-1

By:

Zhang, Chanyuan;
Yang, Ting;
Luo, Xiaoqin;
Zhou, Xiaoqing;
Feng, Menglong;
Yuan, Wei

Publication type:

Article

Bioinformatics analysis of electroacupuncture treatment for ischemic stroke: exploring transcriptional regulatory mechanisms mediated by super-enhancers.

Published in:

Frontiers in Neuroscience, 2025, p. 1, doi. 10.3389/fnins.2025.1522466

By:

Wu, Chunxiao;
Wang, Qizhang;
Xu, Zhirui;
Deng, Chuyu;
Tang, Chunzhi

Publication type:

Article

Super enhancer lncRNAs: a novel hallmark in cancer.

Published in:

Cell Communication & Signaling, 2024, v. 22, n. 1, p. 1, doi. 10.1186/s12964-024-01599-6

By:

Song, Ping;
Han, Rongyan;
Yang, Fan

Publication type:

Article

Polycomb protein RYBP facilitates super-enhancer activity.

Published in:

Molecular Medicine, 2024, v. 30, n. 1, p. 1, doi. 10.1186/s10020-024-01006-3

By:

Hong, Yu;
Dai, Ranran;
Li, Xinlan;
Xu, He;
Wei, Chao

Publication type:

Article

Epigenetic regulation of key gene of PCK1 by enhancer and super-enhancer in the pathogenesis of fatty liver hemorrhagic syndrome.

Published in:

Animal Bioscience, 2024, v. 37, n. 8, p. 1317, doi. 10.5713/ab.23.0423

By:

Yi Wang;
Shuwen Chen;
Min Xue;
Jinhu Ma;
Xinrui Yi;
Xinyu Li;
Xuejin Lu;
Meizi Zhu;
Jin Peng;
Yunshu Tang;
Yaling Zhu

Publication type:

Article

Bleomycin-treated myoblasts undergo p21-associated cellular senescence and have severely impaired differentiation.

Published in:

GeroScience, 2024, v. 46, n. 2, p. 1843, doi. 10.1007/s11357-023-00929-9

By:

Kamal, Michael;
Joanisse, Sophie;
Parise, Gianni

Publication type:

Article

The Emerging Role and Clinical Significance of PI3K-Akt-mTOR in Rhabdomyosarcoma.

Published in:

Biomolecules (2218-273X), 2025, v. 15, n. 3, p. 334, doi. 10.3390/biom15030334

By:

Versari, Ilaria;
Salucci, Sara;
Bavelloni, Alberto;
Battistelli, Michela;
Traversari, Mirko;
Wang, Ashley;
Sampaolesi, Maurilio;
Faenza, Irene

Publication type:

Article

Pathogenic role of super-enhancers as potential therapeutic targets in lung cancer.

Published in:

Frontiers in Pharmacology, 2024, p. 1, doi. 10.3389/fphar.2024.1383580

By:

Zhiyuan Yao;
Peng Song;
Wenjie Jiao

Publication type:

Article

Liquid condensates: a new barrier to loop extrusion?

Published in:

Cellular & Molecular Life Sciences, 2025, v. 82, n. 1, p. 1, doi. 10.1007/s00018-024-05559-8

By:

Selivanovskiy, Arseniy V.;
Molodova, Maria N.;
Khrameeva, Ekaterina E.;
Ulianov, Sergey V.;
Razin, Sergey V.

Publication type:

Article

Phase-separated super-enhancers confer an innate radioresistance on genomic DNA.

Published in:

Journal of Radiation Research, 2024, v. 65, n. 4, p. 482, doi. 10.1093/jrr/rrae044

By:

Matsumoto, Koki;
Ikliptikawati, Dini Kurnia;
Makiyama, Kei;
Mochizuki, Kako;
Tobita, Maho;
Kobayashi, Isao;
Voon, Dominic Chih-Cheng;
Lim, Keesiang;
Ogawa, Kazuma;
Kashiwakura, Ikuo;
Suzuki, Hiroshi I;
Yoshino, Hironori;
Wong, Richard W;
Hazawa, Masaharu

Publication type:

Article

Identification and genetic validation of leukemia inhibitory factor super‐enhancers in acute respiratory distress syndrome and lung cancer.

Published in:

Cell Biochemistry & Function, 2024, v. 42, n. 4, p. 1, doi. 10.1002/cbf.4031

By:

Chen, Liuting;
Wang, Lu;
Shao, Yeling;
Guo, Xiaohong;
Li, Yanli;
Guo, Jinjing;
Tan, Fangzheng;
Shen, Haoliang;
Hu, Yunhong;
Huang, Lili;
Lu, Yang;
Fan, Yihui

Publication type:

Article

Erratum for the research article "The suppressive efficacy of THZ1 depends on KRAS mutation subtype and is associated with super‐enhancer activity and the PI3K/AKT/mTOR signalling in pancreatic ductal adenocarcinoma: A hypothesis‐generating study" by Huang et al

Published in:

2025

By:

Huang, Lei;
Yang, Hui;
Chen, Kaidi;
Yuan, Jing;
Li, Jie;
Dai, Guanghai;
Gu, Mancang;
Shi, Yan

Publication type:

Correction Notice

METTL3‐stabilized super enhancers‐lncRNA SUCLG2‐AS1 mediates the formation of a long‐range chromatin loop between enhancers and promoters of SOX2 in metastasis and radiosensitivity of nasopharyngeal carcinoma.

Published in:

Clinical & Translational Medicine, 2023, v. 13, n. 9, p. 1, doi. 10.1002/ctm2.1361

By:

Hu, Xinyu;
Wu, Jianfeng;
Feng, Yong;
Ma, Hongxia;
Zhang, Erbao;
Zhang, Chang;
Sun, Qi;
Wang, Tingting;
Ge, Yizhi;
Zong, Dan;
Chen, Wei;
He, Xia

Publication type:

Article

Doxorubicin, a DNA intercalator, inhibits transcription elongation.

Published in:

Biochemistry & Cell Biology, 2025, v. 103, p. 1, doi. 10.1139/bcb-2024-0264

By:

Tempel, Mathew;
Green, Kari;
Prajapati, Dhanvi;
Duaqui, Angela;
Norouzi, Mahboobeh;
Sattarifard, Hedieh;
Ashraf, Ahmed;
Wu, Elly;
Zovoilis, Athanasios;
Lakowski, Ted M.;
Davie, James R.

Publication type:

Article

Histone H4 asymmetrically dimethylated at arginine 3 (H4R3me2a), a mark of super-enhancers.

Published in:

Biochemistry & Cell Biology, 2024, v. 102, n. 2, p. 145, doi. 10.1139/bcb-2023-0211

By:

Sudhakar, Sadhana R.N.;
Wu, Li;
Patel, Shrinal;
Zovoilis, Athanasios;
Davie, James R.

Publication type:

Article

LINC01503/miR-342-3p facilitates malignancy in non-small-cell lung cancer cells via regulating LASP1.

Published in:

2020

By:

Shen, Qiming;
Sun, Yanbin;
Xu, Shun

Publication type:

journal article

Nuclear respiratory factor 1 regulates super enhancer-controlled SPIDR to protect hepatocellular carcinoma cells from oxidative stress.

Published in:

BMC Gastroenterology, 2024, v. 24, n. 1, p. 1, doi. 10.1186/s12876-024-03183-1

By:

Liu, Baowang;
Dou, Jian;
Cao, Jinglin

Publication type:

Article

Prediction of the 3D cancer genome from whole-genome sequencing using InfoHiC.

Published in:

Molecular Systems Biology, 2024, v. 20, n. 11, p. 1156, doi. 10.1038/s44320-024-00065-2

By:

Lee, Yeonghun;
Park, Sung-Hye;
Lee, Hyunju

Publication type:

Article

Androgen-dependent and DNA-binding-independent association of androgen receptor with chromatic regions coding androgen-induced noncoding RNAs.

Published in:

Bioscience, Biotechnology & Biochemistry, 2021, v. 85, n. 10, p. 2121, doi. 10.1093/bbb/zbab135

By:

Sawada, Takahiro;
Nishimura, Koichi;
Mori, Jinichi;
Kanemoto, Yoshiaki;
Kouzmenko, Alexander;
Amano, Rei;
Hayakawa, Akira;
Tokiwa, Suguru;
Shimmura, Hiroaki;
Kato, Shigeaki

Publication type:

Article

HIF1A facilitates hypoxia-induced changes in H3K27ac modification to promote myometrial contractility.

Published in:

Communications Biology, 2025, v. 8, n. 1, p. 1, doi. 10.1038/s42003-025-07880-9

By:

Ji, Kaiyuan;
Wen, Bolun;
Wang, Xiaodi;
Chen, Lina;
Chen, Yunshan;
Wang, Lele;
Bao, Junjie;
Pan, Xiuyu;
Zhang, Guozheng;
Jiang, Yanmin;
Liu, Huishu

Publication type:

Article

Multiscale 3D genome rewiring during PTF1A-mediated somatic cell reprogramming into neural stem cells.

Published in:

Communications Biology, 2024, v. 7, n. 1, p. 1, doi. 10.1038/s42003-024-07230-1

By:

Zhang, Rong;
Sun, Jun;
Liu, Shuting;
Ding, Junjun;
Xiang, Mengqing

Publication type:

Article

Functional characteristics and computational model of abundant hyperactive loci in the human genome.

Published in:

eLife, 2024, p. 1, doi. 10.7554/eLife.95170

By:

Hudaiberdiev, Sanjarbek;
Ovcharenko, Ivan

Publication type:

Article

Super-enhancers: a new frontier for epigenetic modifiers in cancer chemoresistance.

Published in:

Journal of Experimental & Clinical Cancer Research (17569966), 2021, v. 40, n. 1, p. 1, doi. 10.1186/s13046-021-01974-y

By:

Li, Guo-Hua;
Qu, Qiang;
Qi, Ting-Ting;
Teng, Xin-Qi;
Zhu, Hai-Hong;
Wang, Jiao-Jiao;
Lu, Qiong;
Qu, Jian

Publication type:

Article

Tracking Targets of Dynamic Super-Enhancers in Vitro to Better Characterize Osteoclastogenesis and to Evaluate the Effect of Diuron on the Maturation of Human Bone Cells.

Published in:

Environmental Health Perspectives, 2023, v. 131, n. 6, p. 067007-1, doi. 10.1289/EHP11690

By:

Tesfaye, Robel A.;
Lavaud, Melanie;
Charrier, Céline;
Brounais-Le Royer, Bénédicte;
Cartron, Pierre-François;
Verrecchia, Franck;
Baud'huin, Marc;
Lamoureux, François;
Georges, Steven;
Ory, Benjamin

Publication type:

Article

An Epigenomic fingerprint of human cancers by landscape interrogation of super enhancers at the constituent level.

Published in:

PLoS Computational Biology, 2024, v. 20, n. 2, p. 1, doi. 10.1371/journal.pcbi.1011873

By:

Liu, Xiang;
Gillis, Nancy;
Jiang, Chang;
McCofie, Anthony;
Shaw, Timothy I.;
Tan, Aik-Choon;
Zhao, Bo;
Wan, Lixin;
Duckett, Derek R.;
Teng, Mingxiang

Publication type:

Article

SEgene identifies links between super enhancers and gene expression across cell types.

Published in:

NPJ Systems Biology & Applications, 2025, v. 11, n. 1, p. 1, doi. 10.1038/s41540-025-00533-x

By:

Shinkai, Norio;
Asada, Ken;
Machino, Hidenori;
Takasawa, Ken;
Takahashi, Satoshi;
Kouno, Nobuji;
Komatsu, Masaaki;
Hamamoto, Ryuji;
Kaneko, Syuzo

Publication type:

Article

Effects of BRD4 inhibitor JQ1 on the expression profile of super-enhancer related lncRNAs and mRNAs in cervical cancer HeLa cells.

Published in:

PeerJ, 2024, p. 1, doi. 10.7717/peerj.17035

By:

Jianqing Zheng;
Bifen Huang;
Lihua Xiao;
Min Wu

Publication type:

Article

Differential Regulation of Male-Hormones-Related Enhancers Revealed by Chromatin Accessibility and Transcriptional Profiles in Pig Liver.

Published in:

Biomolecules (2218-273X), 2024, v. 14, n. 4, p. 427, doi. 10.3390/biom14040427

By:

Chan, Shuheng;
Wang, Yubei;
Luo, Yabiao;
Zheng, Meili;
Xie, Fuyin;
Xue, Mingming;
Yang, Xiaoyang;
Xue, Pengxiang;
Zha, Chengwan;
Fang, Meiying

Publication type:

Article

Sequence-Only Prediction of Super-Enhancers in Human Cell Lines Using Transformer Models.

Published in:

Biology (2079-7737), 2025, v. 14, n. 2, p. 172, doi. 10.3390/biology14020172

By:

Kravchuk, Ekaterina V.;
Ashniev, German A.;
Gladkova, Marina G.;
Orlov, Alexey V.;
Zaitseva, Zoia G.;
Malkerov, Juri A.;
Orlova, Natalia N.

Publication type:

Article

Effective Quality Breeding Directions—Comparison and Conservative Analysis of Hepatic Super-Enhancers between Chinese and Western Pig Breeds.

Published in:

Biology (2079-7737), 2022, v. 11, n. 11, p. 1631, doi. 10.3390/biology11111631

By:

Zhang, Yi;
Zhang, Jinbi;
Wang, Caixia;
Qin, Xinxin;
Zhang, Yuge;
Liu, Jingge;
Pan, Zengxiang

Publication type:

Article

BRD4 inhibitor GNE987 exerts anti-cancer effects by targeting super-enhancers in neuroblastoma.

Published in:

Cell & Bioscience, 2022, v. 12, n. 1, p. 1, doi. 10.1186/s13578-022-00769-8

By:

Chen, Yan-Ling;
Li, Xiao-Lu;
Li, Gen;
Tao, Yan-Fang;
Zhuo, Ran;
Cao, Hai-Bo;
Jiao, Wan-yan;
Li, Zhi-Heng;
Zhu, Zhen-Hong;
Fang, Fang;
Xie, Yi;
Liao, Xin-Mei;
Wu, Di;
Wang, Hai-Rong;
Yu, Juan-Juan;
Jia, Si-Qi;
Yang, Yang;
Feng, Chen-Xi;
Yang, Peng-Cheng;
Fei, Xiao-Dong

Publication type:

Article

EWSR1::ATF1 Orchestrates the Clear Cell Sarcoma Transcriptome in Human Tumors and a Mouse Genetic Model.

Published in:

Cancers, 2023, v. 15, n. 24, p. 5750, doi. 10.3390/cancers15245750

By:

Ozenberger, Benjamin B.;
Li, Li;
Wilson, Emily R.;
Lazar, Alexander J.;
Barrott, Jared J.;
Jones, Kevin B.

Publication type:

Article

A Combinatorial Regulatory Platform Determines Expression of RNA Polymerase III Subunit RPC7α (POLR3G) in Cancer.

Published in:

Cancers, 2023, v. 15, n. 20, p. 4995, doi. 10.3390/cancers15204995

By:

Cheng, Ruiying;
Zhou, Sihang;
K C, Rajendra;
Lizarazo, Simon;
Mouli, Leela;
Jayanth, Anshita;
Liu, Qing;
Van Bortle, Kevin

Publication type:

Article

The Promise of Retinoids in the Treatment of Cancer: Neither Burnt Out Nor Fading Away.

Published in:

Cancers, 2023, v. 15, n. 14, p. 3535, doi. 10.3390/cancers15143535

By:

Nagai, Yuya;
Ambinder, Alexander J.

Publication type:

Article

Genomic and Epigenetic Changes Drive Aberrant Skeletal Muscle Differentiation in Rhabdomyosarcoma.

Published in:

Cancers, 2023, v. 15, n. 10, p. 2823, doi. 10.3390/cancers15102823

By:

Pomella, Silvia;
Danielli, Sara G.;
Alaggio, Rita;
Breunis, Willemijn B.;
Hamed, Ebrahem;
Selfe, Joanna;
Wachtel, Marco;
Walters, Zoe S.;
Schäfer, Beat W.;
Rota, Rossella;
Shipley, Janet M.;
Hettmer, Simone

Publication type:

Article

Long Non-Coding RNAs as Epigenetic Regulators of Immune Checkpoints in Cancer Immunity.

Published in:

Cancers, 2023, v. 15, n. 1, p. 184, doi. 10.3390/cancers15010184

By:

Saadi, Wiam;
Fatmi, Ahlam;
Pallardó, Federico V.;
García-Giménez, José Luis;
Mena-Molla, Salvador

Publication type:

Article

Super Enhancer-Regulated LINC00094 (SERLOC) Upregulates the Expression of MMP-1 and MMP-13 and Promotes Invasion of Cutaneous Squamous Cell Carcinoma.

Published in:

Cancers, 2022, v. 14, n. 16, p. 3980, doi. 10.3390/cancers14163980

By:

Piipponen, Minna;
Riihilä, Pilvi;
Knuutila, Jaakko S.;
Kallajoki, Markku;
Kähäri, Veli-Matti;
Nissinen, Liisa

Publication type:

Article

Super-Enhancers, Phase-Separated Condensates, and 3D Genome Organization in Cancer.

Published in:

Cancers, 2022, v. 14, n. 12, p. 2866, doi. 10.3390/cancers14122866

By:

Tang, Seng Chuan;
Vijayakumar, Udhaya;
Zhang, Ying;
Fullwood, Melissa Jane

Publication type:

Article

Epigenetic Targeting of Mcl-1 Is Synthetically Lethal with Bcl-xL/Bcl-2 Inhibition in Model Systems of Glioblastoma.

Published in:

Cancers, 2020, v. 12, n. 8, p. 2137, doi. 10.3390/cancers12082137

By:

Shang, Enyuan;
Nguyen, Trang T. T.;
Shu, Chang;
Westhoff, Mike-Andrew;
Karpel-Massler, Georg;
Siegelin, Markus D.

Publication type:

Article

PIK3CA Cooperates with KRAS to Promote MYC Activity and Tumorigenesis via the Bromodomain Protein BRD9.

Published in:

Cancers, 2019, v. 11, n. 11, p. 1634, doi. 10.3390/cancers11111634

By:

Bell, Catherine M.;
Raffeiner, Philipp;
Hart, Jonathan R.;
Vogt, Peter K.

Publication type:

Article

Super-enhancer-hijacking RBBP7 potentiates metastasis and stemness of breast cancer via recruiting NuRD complex subunit LSD1.

Published in:

Journal of Translational Medicine, 2025, v. 23, n. 1, p. 1, doi. 10.1186/s12967-025-06270-3

By:

Xi, Yuanyin;
Wang, Ruoding;
Qu, Man;
Pan, Qinwen;
Wang, Minghao;
Ai, Xiang;
Sun, Zihan;
Zhang, Chao;
Tang, Peng;
Jiang, Jun;
Hu, Ying

Publication type:

Article

Enhanced transcriptional heterogeneity mediated by NF-κB super-enhancers.

Published in:

PLoS Genetics, 2022, v. 18, n. 6, p. 1, doi. 10.1371/journal.pgen.1010235

By:

Wibisana, Johannes N.;
Inaba, Takehiko;
Shinohara, Hisaaki;
Yumoto, Noriko;
Hayashi, Tetsutaro;
Umeda, Mana;
Ebisawa, Masashi;
Nikaido, Itoshi;
Sako, Yasushi;
Okada, Mariko

Publication type:

Article