Works about STRUCTURE-activity relationship in pharmacology

Results: 398

ANALYZING MICROARRAY DATA WITH TRANSITIVE DIRECTED ACYCLIC GRAPHS.

Published in:

Journal of Bioinformatics & Computational Biology, 2009, v. 7, n. 1, p. 135, doi. 10.1142/S0219720009003972

By:

PHAN, VINHTHUY;
OLUSEGUN GEORGE, E.;
TRAN, QUYNH T.;
GOODWIN, SHIRLEAN;
BODREDDIGARI, SRIDEVI;
SUTTER, THOMAS R.

Publication type:

Article

Cell and tissue responses of a range of Urotensin II analogs at cloned and native urotensin II receptors. Evidence for coupling promiscuity.

Published in:

Naunyn-Schmiedeberg's Archives of Pharmacology, 2006, v. 373, n. 2, p. 148, doi. 10.1007/s00210-006-0057-2

By:

Song, Wei;
McDonald, John;
Camarda, Valeria;
Calo, Girolamo;
Guerrini, Remo;
Marzola, Erika;
Thompson, Jonathan;
Rowbotham, David;
Lambert, David

Publication type:

Article

Structure-activity relationships of alkylphosphocholine derivatives: antineoplastic action on brain tumor cell lines in vitro.

Published in:

Cancer Chemotherapy & Pharmacology, 2002, v. 50, n. 1, p. 71, doi. 10.1007/s00280-002-0440-8

By:

Jendrossek, Verena;
Hammersen, Kerstin;
Erdlenbruch, Bernhard;
Kugler, Wilfried;
Krügener, Regina;
Eibl, Hansjörg;
Lakomek, Max

Publication type:

Article

SAR study of tyrosine-chlorambucil hybrid regioisomers; synthesis and biological evaluation against breast cancer cell lines.

Published in:

Amino Acids, 2012, v. 43, n. 2, p. 923, doi. 10.1007/s00726-011-1152-3

By:

Descôteaux, Caroline;
Brasseur, Kevin;
Leblanc, Valérie;
Parent, Sophie;
Asselin, Éric;
Bérubé, Gervais

Publication type:

Article

Structural and functional insights into polymorphic enzymes of cytochrome P450 2C8.

Published in:

Amino Acids, 2011, v. 40, n. 4, p. 1195, doi. 10.1007/s00726-010-0743-8

By:

Jiang, Hualin;
Zhong, Fangfang;
Sun, Lu;
Feng, Weiyue;
Huang, Zhong-Xian;
Tan, Xiangshi

Publication type:

Article

Synthesis and adenosine receptors binding affinities of a series of 3-arylcoumarins.

Published in:

Journal of Pharmacy & Pharmacology, 2013, v. 65, n. 11, p. 1590, doi. 10.1111/jphp.12135

By:

Matos, Maria João;
Hogger, Veronika;
Gaspar, Alexandra;
Kachler, Sonja;
Borges, Fernanda;
Uriarte, Eugenio;
Santana, Lourdes;
Klotz, Karl-Norbert

Publication type:

Article

Structure activity relationship, acute toxicity and cytotoxicity of antimycobacterial neolignan analogues.

Published in:

Journal of Pharmacy & Pharmacology, 2011, v. 63, n. 7, p. 936, doi. 10.1111/j.2042-7158.2011.01290.x

By:

de Souza, Ana Olívia;
Alderete, Joel Bernabé;
Minarini, Paulo Roberto Regazi;
da Silva Melo, Patrícia;
Ferreira, Iasmin;
Barata, Lauro Euclides Soares;
Silva, Célio Lopes

Publication type:

Article

Synthesis and structure-activity relationships of carbohydrazides and 1,3,4-oxadiazole derivatives bearing an imidazolidine moiety against the yellow fever and dengue vector, Aedes aegypti.

Published in:

Pest Management Science, 2018, v. 74, n. 2, p. 413, doi. 10.1002/ps.4722

By:

Tok, Fatih;
Kocyigit‐Kaymakcioglu, Bedia;
Tabanca, Nurhayat;
Estep, Alden S.;
Gross, Aaron D.;
Geldenhuys, Werner J.;
Becnel, James J.;
Bloomquist, Jeffrey R.

Publication type:

Article

Evaluation of antifungal activities and structure-activity relationships of coumarin derivatives.

Published in:

Pest Management Science, 2017, v. 73, n. 1, p. 94, doi. 10.1002/ps.4422

By:

Song, Ping‐Ping;
Zhao, Jun;
Liu, Zong‐Liang;
Duan, Ya‐Bing;
Hou, Yi‐Ping;
Zhao, Chun‐Qing;
Wu, Min;
Wei, Min;
Wang, Nian‐He;
Lv, Ye;
Han, Zhao‐Jun

Publication type:

Article

Synthesis, Characterization, Antidepressant Activity and Docking Studies of Some Novel Indole Bearing Azetidinone Derivatives.

Published in:

Indian Journal of Pharmaceutical Education & Research, 2018, v. 52, n. 1, p. 110, doi. 10.5530/ijper.52.1.13

By:

Kerzare, Deweshri Rajendrakumar;
Menghani, Sunil Sugnomal;
Khedekar, Pramod Bhujangrao

Publication type:

Article

EXPLORING THE STRUCTURAL INSIGHTS OF INDOLE-7-CARBOXAMIDES AS ANTI-HIV AGENTS.

Published in:

Farmacia, 2016, v. 64, n. 5, p. 745

By:

RAVICHANDRAN, VEERASAMY;
SHALINI, SIVADASAN;
VENKATESKUMAR, KRISHNAMOORTHY;
DHANARAJ, SOKKALINGAM ARUMUGAM

Publication type:

Article

Reassessment of antioxidant activity of arbutin: Multifaceted evaluation using five antioxidant assay systems.

Published in:

Free Radical Research, 2010, v. 44, n. 4, p. 473, doi. 10.3109/10715761003610760

By:

Takebayashi, Jun;
Ishii, Rie;
Chen, Jianbin;
Matsumoto, Teruki;
Ishimi, Yoshiko;
Tai, Akihiro

Publication type:

Article

Anti-Cancer Potential of Benzophenone-Bis-Schiff bases on Human Pancreatic Cancer Cell Line.

Published in:

Journal of the Chemical Society of Pakistan, 2016, v. 38, n. 5, p. 954

By:

Khan, Khalid Mohammed;
Rasheed, Huma;
Fatima, Bibi;
Hayat, Muhammad;
Rahim, Fazal;
Ullah, Hayat;
Hameed, Abdul;
Taha, Muhammad;
Tahir, Affan;
Perveen, Shahnaz

Publication type:

Article

In Vitro Antileishmanial Activities of 2-Aryl-4(3H)-quinazolinones.

Published in:

Journal of the Chemical Society of Pakistan, 2016, v. 38, n. 2, p. 352

By:

Perveen, Shama;
Saad, Syed Muhammad;
Perveen, Shahnaz;
Hameed, Abdul;
Alam, Muhammad Tanveer;
Khan, Khalid Mohammed;
Choudhary, M. Iqbal

Publication type:

Article

Synthesis and antimicrobial evaluation of 2-hydroxynaphthalene-1,4-dione and 4 H-chromene conjugates.

Published in:

Research on Chemical Intermediates, 2016, v. 42, n. 10, p. 7285, doi. 10.1007/s11164-016-2536-5

By:

Rao, H.;
Tangeti, Venkata;
Adigopula, Lakshmi

Publication type:

Article

Design, synthesis, and evaluation of methoxylated resveratrol derivatives as potential antitumor agents.

Published in:

Research on Chemical Intermediates, 2015, v. 41, n. 5, p. 2725, doi. 10.1007/s11164-013-1382-y

By:

Chen, Yuanmou;
Hu, Fei;
Gao, Yinghao;
Jia, Shaolong;
Ji, Na;
Hua, Erbing

Publication type:

Article

Probing the chemical-biological relationship space with the Drug Target Explorer.

Published in:

Journal of Cheminformatics, 2018, v. 10, n. 1, p. 1, doi. 10.1186/s13321-018-0297-4

By:

Allaway, Robert J.;
La Rosa, Salvatore;
Guinney, Justin;
Gosline, Sara J. C.

Publication type:

Article

Generation of artificial neural networks models in anticancer study.

Published in:

Neural Computing & Applications, 2013, v. 23, n. 3/4, p. 577, doi. 10.1007/s00521-013-1404-0

By:

Sousa, Inês;
Padrón, José;
Fernandes, Miguel

Publication type:

Article

Evaluation of quinolone derivatives for antitrypanosomal activity.

Published in:

2001

By:

Keiser, J.;
Burri, C.

Publication type:

journal article

Medicinal compounds with antiepileptic/anticonvulsant activities.

Published in:

Epilepsia (Series 4), 2014, v. 55, n. 1, p. 3, doi. 10.1111/epi.12463

By:

Zhu, Hui‐Ling;
Wan, Jian‐Bo;
Wang, Yi‐Tao;
Li, Bao‐Cai;
Xiang, Cheng;
He, Jing;
Li, Peng

Publication type:

Article

How did phenobarbital's chemical structure affect the development of subsequent antiepileptic drugs (AEDs)?

Published in:

Epilepsia (Series 4), 2012, v. 53, p. 3, doi. 10.1111/epi.12024

By:

Bialer, Meir

Publication type:

Article

Structure-activity relationships of 3-substituted-5,5--diphenylhydantoins as potential antiproliferative and antimicrobial agents.

Published in:

Journal of the Serbian Chemical Society, 2011, v. 76, n. 12, p. 1597, doi. 10.2298/JSC110314143T

By:

TRIŠOVIĆ, NEMANJA;
BOŽIĆ, BOJAN;
OBRADOVIĆ, ANA;
STEFANOVIĆ, OLGICA;
MARKOVIĆ, SNEŽANA;
ČOMIĆ, LJILJANA;
BOŽIĆ, BILJANA;
UŠĆUMLIĆ, GORDANA

Publication type:

Article

Design, synthesis, and cytotoxic activity evaluation of new linear pyranoxanthone aminoderivatives.

Published in:

Journal of Heterocyclic Chemistry, 2011, v. 48, n. 4, p. 927, doi. 10.1002/jhet.670

By:

Kolokythas, George;
Daniilides, Konstantinos;
Pouli, Nicole;
Marakos, Panagiotis;
Pratsinis, Harris;
Kletsas, Dimitris

Publication type:

Article

Synthesis and in vitro antibacterial assessment of novel chromones featuring 1,2,4-oxadiazole.

Published in:

Journal of Heterocyclic Chemistry, 2011, v. 48, n. 4, p. 882, doi. 10.1002/jhet.656

By:

Diwakar, Santosh D.;
Joshi, Ratnadeep S.;
Gill, Charansing H.

Publication type:

Article

Production of new amilorides as potent inhibitors of mitochondrial respiratory complex I.

Published in:

Bioscience, Biotechnology & Biochemistry, 2015, v. 79, n. 7, p. 1061, doi. 10.1080/09168451.2015.1010479

By:

Masatoshi Murai;
Sayako Habu;
Sonomi Murakami;
Takeshi Ito;
Hideto Miyoshi

Publication type:

Article

A microcalorimetric method to determine antimicrobial effects of two bile acid derivatives on Staphylococcus aureus.

Published in:

Journal of Thermal Analysis & Calorimetry, 2012, v. 108, n. 3, p. 1293, doi. 10.1007/s10973-011-1436-6

By:

Li, Xingfeng;
Jin, Cheng;
Liu, Wei;
Zhou, Jian;
Kong, Weijun;
Dai, Bing;
Wang, Jiabo;
Yan, Dan;
Zhao, Yanling;
Luo, Yun;
Xiao, Xiaohe

Publication type:

Article

Investigation of ibuprofen drug using mass spectrometry, thermal analyses, and semi-empirical molecular orbital calculation.

Published in:

Journal of Thermal Analysis & Calorimetry, 2012, v. 108, n. 1, p. 315, doi. 10.1007/s10973-011-1876-z

By:

Zayed, Mohamed;
Hawash, M.;
Fahmey, M.;
El-Gizouli, Ali

Publication type:

Article

Solid-state mechanical properties of crystalline drugs and excipients.

Published in:

Journal of Thermal Analysis & Calorimetry, 2012, v. 108, n. 1, p. 283, doi. 10.1007/s10973-011-1859-0

By:

Thakur, Shravan;
Maheswaram, Manik;
Mantheni, Dhruthiman;
Kaza, Lakshmi;
Perara, Indika;
Ball, David;
Moran, John;
Riga, Alan

Publication type:

Article

Identification of Pinocembrin as an Anti-Glycation Agent and α-Glucosidase Inhibitor from Fingerroot (Boesenbergia rotunda): The Tentative Structure–Activity Relationship towards MG-Trapping Activity.

Published in:

Molecules, 2018, v. 23, n. 12, p. 3365, doi. 10.3390/molecules23123365

By:

Potipiranun, Thammatee;
Adisakwattana, Sirichai;
Worawalai, Wisuttaya;
Ramadhan, Rico;
Phuwapraisirisan, Preecha;
Epifano, Francesco

Publication type:

Article

Design, Synthesis and Antibacterial Evaluation of 3-Substituted Ocotillol-Type Derivatives.

Published in:

Molecules, 2018, v. 23, n. 12, p. 3320, doi. 10.3390/molecules23123320

By:

Wang, Kai-Yi;
Zhou, Zhi-Wen;
Zhang, Heng-Yuan;
Cao, Yu-Cheng;
Xu, Jin-Yi;
Ma, Cong;
Meng, Qing-Guo;
Bi, Yi

Publication type:

Article

Design of a Novel and Selective IRAK4 Inhibitor Using Topological Water Network Analysis and Molecular Modeling Approaches.

Published in:

Molecules, 2018, v. 23, n. 12, p. 3136, doi. 10.3390/molecules23123136

By:

Lee, Myeong Hwi;
Balupuri, Anand;
Jung, Ye-rim;
Choi, Sungwook;
Lee, Areum;
Cho, Young Sik;
Kang, Nam Sook

Publication type:

Article

A Chemical Genetics Strategy That Identifies Small Molecules Which Induce the Triple Response in Arabidopsis.

Published in:

Molecules, 2017, v. 22, n. 12, p. 2270, doi. 10.3390/molecules22122270

By:

Keimei Oh;
Tomoki Hoshi;
Sumiya Tomio;
Kenji Ueda;
Kojiro Hara

Publication type:

Article

Spiro[pyrrolidine-3,3'-oxindoles] and Their Indoline Analogues as New 5-HT6 Receptor Chemotypes.

Published in:

Molecules, 2017, v. 22, n. 12, p. 2221, doi. 10.3390/molecules22122221

By:

Kelemen, Ádám A.;
Satala, Grzegorz;
Bojarski, Andrzej J.;
Keserű, György M.

Publication type:

Article

Structure Modification of an Active Azo-Compound as a Route to New Antimicrobial Compounds.

Published in:

Molecules, 2017, v. 22, n. 6, p. 875, doi. 10.3390/molecules22060875

By:

Concilio, Simona;
Sessa, Lucia;
Petrone, Anna Maria;
Porta, Amalia;
Diana, Rosita;
Iannelli, Pio;
Piotto, Stefano

Publication type:

Article

New Mild and Simple Approach to Isothiocyanates: A Class of Potent Anticancer Agents.

Published in:

Molecules, 2017, v. 22, n. 6, p. 773, doi. 10.3390/molecules22060773

By:

Bingling Luo;
Jiankang Wang;
Xiaobing Li;
Wenhua Lu;
Jing Yang;
Yumin Hu;
Peng Huang;
Shijun Wen

Publication type:

Article

Design of New Benzo[h]chromene Derivatives: Antitumor Activities and Structure-Activity Relationships of the 2,3-Positions and Fused Rings at the 2,3-Positions.

Published in:

Molecules, 2017, v. 22, n. 3, p. 479, doi. 10.3390/molecules22030479

By:

Okasha, Rawda M.;
Alblewi, Fawzia F.;
Afifi, Tarek H.;
Naqvi, Arshi;
Fouda, Ahmed M.;
Al-Dies, Al-Anood M.;
El-Agrody, Ahmed M.

Publication type:

Article

N-Pyrrylarylsulfones with High Therapeutic Potential.

Published in:

Molecules, 2017, v. 22, n. 3, p. 434, doi. 10.3390/molecules22030434

By:

Valeria Famiglini;
Sabrina Castellano;
Romano Silvestri

Publication type:

Article

Biologic Stress, Oxidative Stress, and Resistance to Drugs: What Is Hidden Behind.

Published in:

Molecules, 2017, v. 22, n. 2, p. 307, doi. 10.3390/molecules22020307

By:

Pantelidou, Maria;
Tsiakitzis, Karyofyllis;
Rekka, Eleni A.;
Kourounakis, Panos N.

Publication type:

Article

Antiplasmodial Activity, Cytotoxicity and Structure-Activity Relationship Study of Cyclopeptide Alkaloids.

Published in:

Molecules, 2017, v. 22, n. 2, p. 224, doi. 10.3390/molecules22020224

By:

Tuenter, Emmy;
Segers, Karen;
Kyo Bin Kang;
Viaene, Johan;
Sang Hyun Sung;
Cos, Paul;
Maes, Louis;
Heyden, Yvan Vander;
Pieters, Luc

Publication type:

Article

Synthesis and Cytotoxic Activity Evaluation of Novel Arylpiperazine Derivatives on Human Prostate Cancer Cell Lines.

Published in:

Molecules, 2014, v. 19, n. 8, p. 12048, doi. 10.3390/molecules190812048

By:

Hong Chen;
Xue Liang;
Fang Xu;
Bingbing Xu;
Xuelan He;
Biyun Huang;
Mu Yuan

Publication type:

Article

Antiparasitic Activity of Natural and Semi-Synthetic Tirucallane Triterpenoids from Schinus terebinthifolius (Anacardiaceae): Structure/Activity Relationships.

Published in:

Molecules, 2014, v. 19, n. 5, p. 5761, doi. 10.3390/molecules19055761

By:

Morais, Thiago R.;
da Costa-Silva, Thais A.;
Tempone, Andre G.;
Borborema, Samanta Etel T.;
Scotti, Marcus T.;
de Sousa, Raquel Maria F.;
Araujo, Ana Carolina C.;
de Oliveira, Alberto;
de Morais, Sérgio Antônio L.;
Sartorelli, Patricia;
Lago, João Henrique G.

Publication type:

Article

Design, Synthesis, Biological Activities and 3D-QSAR of New N,N'-Diacylhydrazines Containing 2,4-Dichlorophenoxy Moieties.

Published in:

Molecules, 2013, v. 18, n. 12, p. 14876, doi. 10.3390/molecules181214876

By:

Guo-Xiang Sun;
Zhao-Hui Sun;
Ming-Yan Yang;
Xing-Hai Liu;
Yi Ma;
Yun-Yang Wei

Publication type:

Article

Cytochrome P450 Family 1 Inhibitors and Structure-Activity Relationships.

Published in:

Molecules, 2013, v. 18, n. 12, p. 14470, doi. 10.3390/molecules181214470

By:

Jiawang Liu;
Sridhar, Jayalakshmi;
Foroozesh, Maryam

Publication type:

Article

2-(Substituted phenyl)-3,4-dihydroisoquinolin-2-iums as Novel Antifungal Lead Compounds: Biological Evaluation and Structure-Activity Relationships.

Published in:

Molecules, 2013, v. 18, n. 9, p. 10413, doi. 10.3390/molecules180910413

By:

Zhe Hou;
Rui Yang;
Cen Zhang;
Li-Fei Zhu;
Fang Miao;
Xin-Juan Yang;
Le Zhou

Publication type:

Article

Cytotoxicity and Structure-Activity Relationships of Xanthone Derivatives from Mesua beccariana, Mesua ferrea and Mesua congestiflora towards Nine Human Cancer Cell Lines.

Published in:

Molecules, 2013, v. 18, n. 2, p. 1985, doi. 10.3390/molecules18021985

By:

Soek Sin Teh;
Gwendoline Cheng Lian Ee;
Siau Hui Mah;
Yang Mooi Lim;
Zuraini Ahmad

Publication type:

Article

Design, Synthesis and Hepatoprotective Activity of Analogs of the Natural Product Goodyeroside A.

Published in:

Molecules, 2013, v. 18, n. 2, p. 1933, doi. 10.3390/molecules18021933

By:

Feng Zhang;
Bei Han;
Peng Li;
Ziyun Lin;
Dali Yin;
Yan Li;
Jialiang Zhong;
Haihong Huang

Publication type:

Article

Synthesis and Structure-Activity Relationships of Novel Amino/Nitro Substituted 3-Arylcoumarins as Antibacterial Agents.

Published in:

Molecules, 2013, v. 18, n. 2, p. 1394, doi. 10.3390/molecules18021394

By:

Matos, Maria J.;
Vazquez-Rodriguez, Saleta;
Santana, Lourdes;
Uriarte, Eugenio;
Fuentes-Edfuf, Cristina;
Santos, Ysabel;
Muñoz-Crego, Angeles

Publication type:

Article

Substituted Benzamides Containing Azaspiro Rings as Upregulators of Apolipoprotein A-I Transcription.

Published in:

Molecules, 2012, v. 17, n. 6, p. 7379, doi. 10.3390/molecules17067379

By:

Yu Du;
Yuan Yang;
Wei Jiang;
Li Wang;
Xiao-Jian Jia;
Shu-Yi Si;
Xiao-Fang Chen;
Bin Hong

Publication type:

Article

Syntheses and Cell-Based Phenotypic Screen of Novel 7-Amino pyrido[2,3-d]pyrimidine-6-carbonitrile Derivatives as Potential Antiproliferative Agents.

Published in:

Molecules, 2012, v. 17, n. 3, p. 2351, doi. 10.3390/molecules17032351

By:

Tao Yang;
Hong He;
Wei Ang;
Ying-Hong Yang;
Jian-Zhong Yang;
Yan-Ni Lin;
Hua-Cheng Yang;
Wei-Yi Pi;
Zi-Cheng Li;
Ying-Lan Zhao;
You-Fu Luo;
Yuquan Wei

Publication type:

Article

Chemometric Studies on Natural Products as Potential Inhibitors of the NADH Oxidase from Trypanosoma cruzi Using the VolSurf Approach.

Published in:

Molecules, 2010, v. 15, n. 10, p. 7363, doi. 10.3390/molecules15107363

By:

Scotti, Luciana;
Ferreira, Elizabeth Igne;
da Silva, Marcelo Sobral;
Scotti, Marcus Tullius

Publication type:

Article