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Amitriptyline inhibits NLRP3 inflammasome activation via the ASM/CE pathway in a cell model of NAFLD.
- Published in:
- Biocell, 2024, v. 48, n. 5, p. 759, doi. 10.32604/biocell.2024.048551
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- Article
Anti-Nociceptive Effects of Sphingomyelinase and Methyl-Beta-Cyclodextrin in the Icilin-Induced Mouse Pain Model.
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- International Journal of Molecular Sciences, 2024, v. 25, n. 9, p. 4637, doi. 10.3390/ijms25094637
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- Article
Neutral Sphingomyelinase 2 Inhibition Limits Hepatic Steatosis and Inflammation.
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- Cells (2073-4409), 2024, v. 13, n. 5, p. 463, doi. 10.3390/cells13050463
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- Article
Molecular docking as a tool for the discovery of novel insight about the role of acid sphingomyelinase inhibitors in SARS- CoV-2 infectivity.
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- BMC Public Health, 2024, v. 24, n. 1, p. 1, doi. 10.1186/s12889-024-17747-z
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- Article
The Genetic Basis, Lung Involvement, and Therapeutic Options in Niemann–Pick Disease: A Comprehensive Review.
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- Biomolecules (2218-273X), 2024, v. 14, n. 2, p. 211, doi. 10.3390/biom14020211
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- Article
The Acid Sphingomyelinase Inhibitor Amitriptyline Ameliorates TNF-α-Induced Endothelial Dysfunction.
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- Cardiovascular Drugs & Therapy, 2024, v. 38, n. 1, p. 43, doi. 10.1007/s10557-022-07378-0
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- Article
Novel insight into the lipid network of plasma extracellular vesicles reveal sex-based differences in the lipidomic profile of alcohol use disorder patients.
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- Biology of Sex Differences, 2024, v. 15, n. 1, p. 1, doi. 10.1186/s13293-024-00584-5
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- Article
Effects of Nutraceuticals on Cisplatin-Induced Cytotoxicity in HEI-OC1 Cells.
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- International Journal of Molecular Sciences, 2023, v. 24, n. 24, p. 17416, doi. 10.3390/ijms242417416
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- Article
Role of ErbB and IL-1 signaling pathways in the dermonecrotic lesion induced by Loxosceles sphingomyelinases D.
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- Archives of Toxicology, 2023, v. 97, n. 12, p. 3285, doi. 10.1007/s00204-023-03602-4
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- Publication type:
- Article
Identification of a Novel Acid Sphingomyelinase Activity Associated with Recombinant Human Acid Ceramidase.
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- Biomolecules (2218-273X), 2023, v. 13, n. 11, p. 1623, doi. 10.3390/biom13111623
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- Publication type:
- Article
The anti‐cancer effect of epigallocatechin‐3‐O‐gallate against multiple myeloma cells is potentiated by 5,7‐dimethoxyflavone.
- Published in:
- FEBS Open Bio, 2023, v. 13, n. 11, p. 2147, doi. 10.1002/2211-5463.13708
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- Article
SMPDL3B contributes to gastric adenocarcinoma cells progression by promoting the infiltration of M2 macrophages.
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- Turkish Journal of Medical Sciences, 2023, v. 53, n. 6, p. 1635, doi. 10.55730/1300-0144.5732
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- Article
Neutral sphingomyelinase inhibition promotes local and network degeneration in vitro and in vivo.
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- Cell Communication & Signaling, 2023, v. 21, n. 1, p. 1, doi. 10.1186/s12964-023-01291-1
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- Publication type:
- Article
Regulation of NLRP3 Inflammasome Activation and Inflammatory Exosome Release in Podocytes by Acid Sphingomyelinase During Obesity.
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- Inflammation, 2023, v. 46, n. 5, p. 2037, doi. 10.1007/s10753-023-01861-y
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- Publication type:
- Article
Acid sphingomyelinase mediates ferroptosis induced by high glucose via autophagic degradation of GPX4 in type 2 diabetic osteoporosis.
- Published in:
- Molecular Medicine, 2023, v. 29, n. 1, p. 1, doi. 10.1186/s10020-023-00724-4
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- Article
Inhibition of acid sphingomyelinase reduces reactive astrocyte secretion of mitotoxic extracellular vesicles and improves Alzheimer's disease pathology in the 5xFAD mouse.
- Published in:
- Acta Neuropathologica Communications, 2023, v. 11, n. 1, p. 1, doi. 10.1186/s40478-023-01633-7
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- Article
Virtual screening reveals aprepitant to be a potent inhibitor of neutral sphingomyelinase 2: implications in blockade of exosome release in cancer therapy.
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- Journal of Cancer Research & Clinical Oncology, 2023, v. 149, n. 10, p. 7207, doi. 10.1007/s00432-023-04674-6
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- Publication type:
- Article
The relevance of acid sphingomyelinase as a potential target for therapeutic intervention in hepatic disorders: current scenario and anticipated trends.
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- Archives of Toxicology, 2023, v. 97, n. 8, p. 2069, doi. 10.1007/s00204-023-03529-w
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- Publication type:
- Article
Medications Modulating the Acid Sphingomyelinase/Ceramide System and 28-Day Mortality among Patients with SARS-CoV-2: An Observational Study.
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- Pharmaceuticals (14248247), 2023, v. 16, n. 8, p. 1107, doi. 10.3390/ph16081107
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- Article
Genomic Regions and Candidate Genes Associated with Milk Production Traits in Holstein and Its Crossbred Cattle: A Review.
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- International Journal of Genomics, 2023, p. 1, doi. 10.1155/2023/8497453
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- Publication type:
- Article
Acid sphingomyelinase expression is associated with survival in resectable pancreatic ductal adenocarcinoma.
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- Journal of Molecular Medicine, 2023, v. 101, n. 7, p. 891, doi. 10.1007/s00109-023-02331-6
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- Publication type:
- Article
Effects of Polygonatum cyrtonema Hua polysaccharide on C2C12 cells with cisplatin-induced myotube atrophy based on TMT proteomics.
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- Journal of Beijing University of Traditional Chinese Medicine, 2023, v. 46, n. 6, p. 790, doi. 10.3969/j.issn.1006-2157.2023.06.009
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- Article
Multi-omic modeling of antidepressant response implicates dynamic immune and inflammatory changes in individuals who respond to treatment.
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- PLoS ONE, 2023, v. 17, n. 5, p. 1, doi. 10.1371/journal.pone.0285123
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- Article
Náhodný nález splenomegalie jako hlavní příznak vedoucí k diagnóze Niemann-Pickovy choroby typu B u dospělého pacienta.
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- Medicina Pro Praxi, 2023, v. 20, n. 2, p. 112, doi. 10.36290/med.2023.016
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- Article
Donkey Colostrum and Milk: How Dietary Probiotics Can Affect Metabolomic Profile, Alkaline Sphingomyelinase and Alkaline Phosphatase Activity.
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- Metabolites (2218-1989), 2023, v. 13, n. 5, p. 622, doi. 10.3390/metabo13050622
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- Publication type:
- Article
Acid sphingomyelinase (ASM) and COVID‐19: A review of the potential use of ASM inhibitors against SARS‐CoV‐2.
- Published in:
- Cell Biochemistry & Function, 2023, v. 41, n. 3, p. 284, doi. 10.1002/cbf.3789
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- Publication type:
- Article
SMPD1 gene variants in patients with β-Thalassemia major.
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- Molecular Biology Reports, 2023, v. 50, n. 4, p. 3355, doi. 10.1007/s11033-023-08275-x
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- Publication type:
- Article
Repurposing FIASMAs against Acid Sphingomyelinase for COVID-19: A Computational Molecular Docking and Dynamic Simulation Approach.
- Published in:
- Molecules, 2023, v. 28, n. 7, p. 2989, doi. 10.3390/molecules28072989
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- Article
SMPD1 expression profile and mutation landscape help decipher genotype–phenotype association and precision diagnosis for acid sphingomyelinase deficiency.
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- Hereditas, 2023, v. 160, n. 1, p. 1, doi. 10.1186/s41065-023-00272-1
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- Article
Simultaneous targeting of mitochondrial Kv1.3 and lysosomal acid sphingomyelinase amplifies killing of pancreatic ductal adenocarcinoma cells in vitro and in vivo.
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- Journal of Molecular Medicine, 2023, v. 101, n. 3, p. 295, doi. 10.1007/s00109-023-02290-y
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- Article
Mechanisms of Arachidonic Acid In Vitro Tumoricidal Impact.
- Published in:
- Molecules, 2023, v. 28, n. 4, p. 1727, doi. 10.3390/molecules28041727
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- Article
Digestive enzymes and sphingomyelinase D in spiders without venom (Uloboridae).
- Published in:
- Scientific Reports, 2023, v. 13, n. 1, p. 1, doi. 10.1038/s41598-023-29828-x
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- Article
Acid sphingomyelinase promotes diabetic cardiomyopathy via NADPH oxidase 4 mediated apoptosis.
- Published in:
- Cardiovascular Diabetology, 2023, v. 22, n. 1, p. 1, doi. 10.1186/s12933-023-01747-1
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- Article
Inhibition of Neutral Sphingomyelinase 2 by Novel Small Molecule Inhibitors Results in Decreased Release of Extracellular Vesicles by Vascular Smooth Muscle Cells and Attenuated Calcification.
- Published in:
- International Journal of Molecular Sciences, 2023, v. 24, n. 3, p. 2027, doi. 10.3390/ijms24032027
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- Article
Characterization of a Neutral Sphingomyelinase Activity in Human Serum and Plasma.
- Published in:
- International Journal of Molecular Sciences, 2023, v. 24, n. 3, p. 2467, doi. 10.3390/ijms24032467
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- Article
Abnormalities of Sphingolipids Metabolic Pathways in the Pathogenesis of Psoriasis.
- Published in:
- Metabolites (2218-1989), 2023, v. 13, n. 2, p. 291, doi. 10.3390/metabo13020291
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- Publication type:
- Article
Sph2 (176–191) and Sph2 (446–459) : Identification of B-Cell Linear Epitopes in Sphingomyelinase 2 (Sph2), Naturally Recognized by Patients Infected by Pathogenic Leptospires.
- Published in:
- Vaccines, 2023, v. 11, n. 2, p. 359, doi. 10.3390/vaccines11020359
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- Article
Alkaline sphingomyelinase (NPP7) impacts the homeostasis of intestinal T lymphocyte populations.
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- Frontiers in Immunology, 2023, v. 13, p. 1, doi. 10.3389/fimmu.2022.1050625
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- Article
A rare case of intermediate phenotype Niemann-Pick disease with a rare pathogenic variant of 1624C>T in SMPD1 gene.
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- Journal of Neurosciences in Rural Practice, 2023, v. 14, n. 1, p. 189, doi. 10.25259/JNRP-2022-6-43
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- Publication type:
- Article
Systemic Loxoscelism, Less Frequent but More Deadly: The Involvement of Phospholipases D in the Pathophysiology of Envenomation.
- Published in:
- Toxins, 2023, v. 15, n. 1, p. 17, doi. 10.3390/toxins15010017
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- Article
Acid Sphingomyelinase Inhibitor, Imipramine, Reduces Hippocampal Neuronal Death after Traumatic Brain Injury.
- Published in:
- International Journal of Molecular Sciences, 2022, v. 23, n. 23, p. 14749, doi. 10.3390/ijms232314749
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- Article
Correction: Probiotic Sonicates Selectively Induce Mucosal Immune Cells Apoptosis through Ceramide Generation via Neutral Sphingomyelinase.
- Published in:
- 2022
- Publication type:
- Correction Notice
Metagenomic characterization of sphingomyelinase C in the microbiome of humans and environments.
- Published in:
- Frontiers in Cellular & Infection Microbiology, 2022, v. 12, p. 1, doi. 10.3389/fcimb.2022.1015706
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- Article
Allosteric Inhibition of Neutral Sphingomyelinase 2 (nSMase2) by DPTIP: From Antiflaviviral Activity to Deciphering Its Binding Site through In Silico Studies and Experimental Validation.
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- International Journal of Molecular Sciences, 2022, v. 23, n. 22, p. 13935, doi. 10.3390/ijms232213935
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- Article
Selective immunocapture reveals neoplastic human mast cells secrete distinct microvesicle‐ and exosome‐like populations of KIT‐containing extracellular vesicles.
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- Journal of Extracellular Vesicles, 2022, v. 11, n. 10, p. 1, doi. 10.1002/jev2.12272
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- Article
Stress induces major depressive disorder by a neutral sphingomyelinase 2-mediated accumulation of ceramide-enriched exosomes in the blood plasma.
- Published in:
- Journal of Molecular Medicine, 2022, v. 100, n. 10, p. 1493, doi. 10.1007/s00109-022-02250-y
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- Publication type:
- Article
Molecular Bases of Serotonin Reuptake Inhibitor Antidepressant-Attributed Effects in COVID-19: A New Insight on the Role of Bradykinins.
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- Journal of Personalized Medicine, 2022, v. 12, n. 9, p. N.PAG, doi. 10.3390/jpm12091487
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- Article
Vascular Smooth Muscle Cell Neutral Sphingomyelinase 2 in the Release of Exosomes and Vascular Calcification.
- Published in:
- International Journal of Molecular Sciences, 2022, v. 23, n. 16, p. 9178, doi. 10.3390/ijms23169178
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- Article
Increased acid sphingomyelinase levels in pediatric patients with obesity.
- Published in:
- Scientific Reports, 2022, v. 12, n. 1, p. 1, doi. 10.1038/s41598-022-14687-9
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- Article
Case Report: Novel Biallelic Null Variants of SMPD4 Confirm Its Involvement in Neurodevelopmental Disorder With Microcephaly, Arthrogryposis, and Structural Brain Anomalies.
- Published in:
- Frontiers in Genetics, 2022, v. 13, p. 1, doi. 10.3389/fgene.2022.872264
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- Article