Works about SMAD proteins

Results: 686

CHIP mediates glucagon action on hepatic glucose production via regulating Smad3 ubiquitination.

Published in:

Diabetes, Obesity & Metabolism, 2025, v. 27, n. 8, p. 4499, doi. 10.1111/dom.16493

By:

Pan, Quan;
Ai, Weiqi;
Chen, Yunmei;
Shen, Zheng;
Yang, Wanbao;
Jiang, Wen;
Guo, Shaodong

Publication type:

Article

Anti-Mullerian hormone (AMH) protects ovarian follicle loss by downregulating granulosa cell function in in vitro and in vivo models.

Published in:

Journal of Assisted Reproduction & Genetics, 2025, v. 42, n. 6, p. 2029, doi. 10.1007/s10815-025-03473-x

By:

Detti, Laura;
Mari, Michael C.;
Diamond, Michael P.;
Saed, Ghassan M.

Publication type:

Article

SMAD dependent signaling plays a detrimental role in a fly model of SMARCB1-deficiency and the biology of atypical teratoid/rhabdoid tumors.

Published in:

Journal of Neuro-Oncology, 2017, v. 131, n. 3, p. 477, doi. 10.1007/s11060-016-2326-3

By:

Jeibmann, Astrid;
Schulz, Jacqueline;
Eikmeier, Kristin;
Johann, Pascal;
Thiel, Katharina;
Tegeder, Isabel;
Ambrée, Oliver;
Frühwald, Michael;
Pfister, Stefan;
Kool, Marcel;
Paulus, Werner;
Hasselblatt, Martin

Publication type:

Article

Identification and expression of Smads associated with TGF-β/activin/nodal signaling pathways in the rainbow trout ( Oncorhynchus mykiss).

Published in:

Fish Physiology & Biochemistry, 2012, v. 38, n. 5, p. 1233, doi. 10.1007/s10695-012-9611-7

By:

Gahr, Scott;
Weber, Gregory;
Rexroad, Caird

Publication type:

Article

Silencing of SCEL promotes progression of oral squamous cell carcinoma via activating TGF-β/Smad pathway.

Published in:

Discover Oncology, 2025, v. 16, n. 1, p. 1, doi. 10.1007/s12672-025-02423-4

By:

Li, Danping;
Li, Limei;
Wu, Shu;
Zhao, Jun;
Zhang, Haishan;
Chen, Qiaoli;
Mo, Yingxi;
Matskova, Liudmila;
Li, Ping;
Zhou, Xiaoying

Publication type:

Article

Pingxiao pian attenuate invasiveness and proliferation of lung adenocarcinoma through regulating miR-29b-3p/TGF-β1/Smad/EMT pathway.

Published in:

Discover Oncology, 2025, v. 16, n. 1, p. 1, doi. 10.1007/s12672-025-01959-9

By:

Feng, Jie-Ni;
Chen, Pei-Rui;
Yuan, Shao-Fei;
Dai, Qiang;
Zheng, Wei-E.;
Lin, Hua-Long

Publication type:

Article

耗牛SMADi基因SNPs检测及其与生长性状的关联分析.

Published in:

Journal of Northwest A & F University - Natural Science Edition, 2023, v. 51, n. 3, p. 1, doi. 10.13207/j.cnki.jnwafu.2023.03.001

By:

周建强;
祁增源;
韩银仓;
刘秀;
爲孙永刚

Publication type:

Article

The transcriptional regulators GATA6 and TET1 regulate the TGF-β pathway in cancer-associated fibroblasts to promote breast cancer progression.

Published in:

Cell Death Discovery, 2025, v. 11, n. 1, p. 1, doi. 10.1038/s41420-025-02438-4

By:

Ghazimoradi, Mohammad H.;
Babashah, Sadegh

Publication type:

Article

KDM5B promotes SMAD4 loss-driven drug resistance through activating DLG1/YAP to induce lipid accumulation in pancreatic ductal adenocarcinoma.

Published in:

Cell Death Discovery, 2024, v. 10, n. 1, p. 1, doi. 10.1038/s41420-024-02020-4

By:

Wang, Yumin;
Liu, Shiqian;
Wang, Yan;
Li, Baibei;
Liang, Jiaming;
Chen, Yu;
Tang, Bo;
Yu, Shuiping;
Wang, Hongquan

Publication type:

Article

Tyrosine hydroxylase inhibits HCC progression by downregulating TGFβ/Smad signaling.

Published in:

European Journal of Medical Research, 2024, v. 29, n. 1, p. 1, doi. 10.1186/s40001-024-01703-z

By:

Liu, Guoqian;
Li, Mengwei;
Zeng, Zimei;
Fan, Qi;
Ren, Xinxin;
Wang, Zhexin;
Sun, Yaoqi;
He, Yulin;
Sun, Lunquan;
Deng, Yuezhen;
Liu, Shupeng;
Zhong, Chenxi;
Gao, Jie

Publication type:

Article

SMAD4 promotes somatic-germline contact during murine oocyte growth.

Published in:

eLife, 2024, p. 1, doi. 10.7554/eLife.91798

By:

Granados-Aparici, Sofia;
Qin Yang;
Clarke, Hugh J.

Publication type:

Article

Trans-Resveratrol Attenuates Fibronectin Deposition via Downregulation of TGFβ1-SMAD Pathway in Dexamethasonetreated Human Trabecular Meshwork Cells.

Published in:

Malaysian Journal of Medicine & Health Sciences, 2024, v. 20, p. 78

By:

Abu Bakar, Amy Suzana;
Agarwal, Renu;
Iezhitsa, Igor;
Razali, Norhafiza

Publication type:

Article

Correction to: Bai et al., Melatonin promotes self-renewal of nestin-positive pancreatic stem cells through activation of the MT2/ERK/SMAD/nestin axis.

Published in:: 2018
Publication type:: Correction Notice

Smad4 and TGFβ1 dependent gene expression signatures in conditional intestinal adenoma, organoids and colorectal cancer.

Published in:

Scientific Reports, 2025, v. 15, n. 1, p. 1, doi. 10.1038/s41598-025-00908-4

By:

Surakhy, Mirvat;
Matheson, Julia;
Barnes, David J.;
Carter, Emma J.;
Hughes, Jennifer;
Bühnemann, Claudia;
Sanegre, Sabina;
Morreau, Hans;
Metz, Paul;
Imianowski, Charlotte J.;
Hassan, Andrew Bassim

Publication type:

Article

Guiding the osteogenic fate of mouse and human mesenchymal stem cells through feedback system control.

Published in:

Scientific Reports, 2013, p. 1, doi. 10.1038/srep03420

By:

Yoshitomo Honda;
Xianting Ding;
Mussano, Federico;
Wiberg, Akira;
Chih-ming Ho;
lchiro Nishimura

Publication type:

Article

GHK Peptide Inhibits Bleomycin-Induced Pulmonary Fibrosis in Mice by Suppressing TGFβ1/Smad-Mediated Epithelial-to-Mesenchymal Transition.

Published in:

Frontiers in Pharmacology, 2017, p. 1, doi. 10.3389/fphar.2017.00904

By:

Xiao-Ming Zhou;
Gui-Liang Wang;
Xiao-Bo Wang;
Li Liu;
Qin Zhang;
Yan Yin;
Qiu-Yue Wang;
Jian Kang;
Gang Hou

Publication type:

Article

Targeting TGF-β Mediated SMAD Signaling for the Prevention of Fibrosis.

Published in:

Frontiers in Pharmacology, 2017, p. 1, doi. 10.3389/fphar.2017.00461

By:

Walton, Kelly L.;
Johnson, Katharine E.;
Harrison, Craig A.

Publication type:

Article

Transforming growth factor-β1 and SMAD signalling pathway in the small airways of smokers and patients with COPD: potential role in driving fibrotic type-2 epithelial mesenchymal transition.

Published in:

Frontiers in Immunology, 2023, p. 1, doi. 10.3389/fimmu.2023.1216506

By:

Brake, Samuel James;
Wenying Lu;
Chia, Collin;
Haug, Greg;
Larby, Josie;
Hardikar, Ashutosh;
Singhera, Gurpreet K.;
Hackett, Tillie L.;
Eapen, Mathew Suji;
Sohal, Sukhwinder Singh

Publication type:

Article

The diverse effects of transforming growth factor-b and SMAD signaling pathways during the CTL response.

Published in:

Frontiers in Immunology, 2023, p. 1, doi. 10.3389/fimmu.2023.1199671

By:

Chandiran, Karthik;
Cauley, Linda S.

Publication type:

Article

Requirement of Smad4-mediated signaling in odontoblast differentiation and dentin matrix formation.

Published in:

Anatomy & Cell Biology, 2016, v. 49, n. 3, p. 199, doi. 10.5115/acb.2016.49.3.199

By:

Chi-Young Yun;
Hwajung Choi;
Young-Jae You;
Jin-Young Yang;
Jin-A Baek;
Eui-Sic Cho

Publication type:

Article

Rhus verniciflua Stokes attenuates cholestatic liver cirrhosis-induced interstitial fibrosis via Smad3 down-regulation and Smad7 up-regulation.

Published in:

Anatomy & Cell Biology, 2016, v. 49, n. 3, p. 189, doi. 10.5115/acb.2016.49.3.189

By:

Mi Na Gil;
Du Ri Choi;
Kwang Sik Yu;
Ji Heun Jeong;
Dong-Ho Bak;
Do-Kyung Kim;
Nam-Seob Lee;
Je-Hun Lee;
Young-Gil Jeong;
Chun Soo Na;
Dae Seung Na;
Ki-Hyun Ryu;
Seung Yun Han

Publication type:

Article

Author Correction: Dysregulation of MMP2-dependent TGF-ß2 activation impairs fibrous cap formation in type 2 diabetes-associated atherosclerosis.

Published in:

2025

By:

Singh, Pratibha;
Sun, Jiangming;
Cavalera, Michele;
Al-Sharify, Dania;
Matthes, Frank;
Barghouth, Mohammad;
Tengryd, Christoffer;
Dunér, Pontus;
Persson, Ana;
Sundius, Lena;
Nitulescu, Mihaela;
Bengtsson, Eva;
Rattik, Sara;
Engelbertsen, Daniel;
Orho-Melander, Marju;
Nilsson, Jan;
Monaco, Claudia;
Goncalves, Isabel;
Edsfeldt, Andreas

Publication type:

Correction Notice

A stepwise mode of TGFβ-SMAD signaling and DNA methylation regulates naïve-to-primed pluripotency and differentiation.

Published in:

Nature Communications, 2024, v. 15, n. 1, p. 1, doi. 10.1038/s41467-024-54433-5

By:

Zhao, Bingnan;
Yu, Xiuwei;
Shi, Jintong;
Ma, Shuangyu;
Li, Shizhao;
Shi, Haitao;
Xia, Shoubing;
Ye, Youqiong;
Zhang, Yongchun;
Du, Yanhua;
Wang, Qiong

Publication type:

Article

Low-frequency electromagnetic fields combined with tissue engineering techniques accelerate intervertebral fusion.

Published in:

Stem Cell Research & Therapy, 2021, v. 12, n. 1, p. 1, doi. 10.1186/s13287-021-02207-x

By:

Li, Weigang;
Huang, Chunwei;
Ma, Tian;
Wang, Jiachen;
Liu, Wenbin;
Yan, Jiyuan;
Sheng, Gaohong;
Zhang, Ruizhuo;
Wu, Hua;
Liu, Chaoxu

Publication type:

Article

Human placenta-derived mesenchymal stem cells stimulate ovarian function via miR-145 and bone morphogenetic protein signaling in aged rats.

Published in:

Stem Cell Research & Therapy, 2020, v. 11, n. 1, p. N.PAG, doi. 10.1186/s13287-020-01988-x

By:

Kim, Kyeoung-Hwa;
Kim, Eun-Young;
Kim, Gi Jin;
Ko, Jung-Jae;
Cha, Kwang Yul;
Koong, Mi Kyung;
Lee, Kyung-Ah

Publication type:

Article

Effects of overexpression of α-synuclein on mRNA expression levels of JUN, RELA, HMGA1, TP53, and SMAD3 in HEK293T culture.

Published in:

2022

By:

Keskin, Ebru;
Alaylıoğlu, Merve;
Yurttaş, Zuhal;
Çamoğlu, Tugay;
Şengül-Yediel, Büşra;
Sordu, Pelin;
Gezen-Ak, Duygu;
Dursun, Erdinç

Publication type:

Abstract

Di-(2-ethylhexyl) phthalate triggers proliferation, migration, stemness, and epithelial-mesenchymal transition in human endometrial and endometriotic epithelial cells via the transforming growth factor-β/ Smad signaling pathway.

Published in:

Anatomy: International Journal of Experimental & Clinical Anatomy, 2022, v. 16, p. S124

By:

Yeseon Lim;
Changyoung Lee;
Lata Rajbongshi;
Seonyeong Hwang;
Sik Yoon

Publication type:

Article

Distinct BMP-Smads signaling outputs confer diverse functions in the dental mesenchyme.

Published in:

Anatomy: International Journal of Experimental & Clinical Anatomy, 2022, v. 16, p. S96

By:

Liwen Li;
Qinghuang Tang;
Amy Wang;
Hua Li;
Linyan Wang;
Cong Gu;
Jung Mi Lee;
Hyukjae Kwon;
Yiping Chen

Publication type:

Article

STC1 regulates glioblastoma migration and invasion via the TGF-β/SMAD4 signaling pathway.

Published in:

Molecular Medicine Reports, 2019, v. 20, n. 4, p. 3055, doi. 10.3892/mmr.2019.10579

By:

Xiong, Yan;
Wang, Qibai

Publication type:

Article

MicroRNA-409 may function as a tumor suppressor in endometrial carcinoma cells by targeting Smad2.

Published in:

Molecular Medicine Reports, 2019, v. 19, n. 1, p. 622

By:

Zhang, Chunhua;
Wang, Bo;
Wu, Ling

Publication type:

Article

miR-486-5p is upregulated in osteoarthritis and inhibits chondrocyte proliferation and migration by suppressing SMAD2.

Published in:

Molecular Medicine Reports, 2018, v. 18, n. 1, p. 502, doi. 10.3892/mmr.2018.8931

By:

Shi, Junkai;
Guo, Kansuo;
Su, Shile;
Li, Jun;
Li, Chunhui

Publication type:

Article

Oxymatrine protects against the effects of cardiopulmonary resuscitation via modulation of the TGF-β1/Smad3 signaling pathway.

Published in:

Molecular Medicine Reports, 2018, v. 17, n. 3, p. 4747, doi. 10.3892/mmr.2018.8373

By:

Wang, Dawei;
Lou, Xiao Qian;
Jiang, Xiao-Ming;
Yang, ChENxi;
Liu, Xiao-Liang;
Zhang, Nan

Publication type:

Article

Mechanical stress affects the osteogenic differentiation of human ligamentum flavum cells via the BMP‑Smad1 signaling pathway.

Published in:

Molecular Medicine Reports, 2017, v. 16, n. 5, p. 7692, doi. 10.3892/mmr.2017.7543

By:

SHUNZHI YU;
NING YAN;
ZHONGHAI LI

Publication type:

Article

miR-203 inhibits the expression of collagen-related genes and the proliferation of hepatic stellate cells through a SMAD3-dependent mechanism.

Published in:

Molecular Medicine Reports, 2017, v. 16, n. 2, p. 1248, doi. 10.3892/mmr.2017.6702

By:

DANPING HU;
YIBING HU;
WANGWANG XU;
HUANHUAN YU;
NAIBIN YANG;
SHUNLAN NI;
RONGQUAN FU

Publication type:

Article

Identification and functional analysis of the risk microRNAs associated with cerebral low-grade glioma prognosis.

Published in:

Molecular Medicine Reports, 2017, v. 16, n. 2, p. 1173, doi. 10.3892/mmr.2017.6705

By:

XINRUI LIU;
BIN SONG;
SHANJI LI;
NAN WANG;
HONGFA YANG

Publication type:

Article

The protective role of vitamin D3 in a murine model of asthma via the suppression of TGF-β/Smad signaling and activation of the Nrf2/HO-1 pathway.

Published in:

Molecular Medicine Reports, 2016, v. 14, n. 3, p. 2389, doi. 10.3892/mmr.2016.5563

By:

ZHIHUI WANG;
HAITAO ZHANG;
XIAOHAN SUN;
LIHONG REN

Publication type:

Article

Involvement of epithelial-to-mesenchymal transition and associated transforming growth factor-β/Smad signaling in paraquat-induced pulmonary fibrosis.

Published in:

Molecular Medicine Reports, 2015, v. 12, n. 6, p. 7979, doi. 10.3892/mmr.2015.4454

By:

YING-YING HAN;
PENG SHEN;
WEN-XIU CHANG

Publication type:

Article

Astragaloside IV controls collagen reduction in photoaging skin by improving transforming growth factor-β/Smad signaling suppression and inhibiting matrix metalloproteinase-1.

Published in:

Molecular Medicine Reports, 2015, v. 11, n. 5, p. 3344, doi. 10.3892/mmr.2015.3212

By:

BIN CHEN;
RAN LI;
NING YAN;
GANG CHEN;
WEN QIAN;
HUI-LI JIANG;
CHAO JI;
ZHI-GANG BI

Publication type:

Article

Smad7 maintains epithelial phenotype of ovarian cancer stem-like cells and supports tumor colonization by mesenchymal-epithelial transition.

Published in:

Molecular Medicine Reports, 2015, v. 11, n. 1, p. 309, doi. 10.3892/mmr.2014.2714

By:

YIYING LI;
WENJIA GONG;
XIAOLING MA;
XIAOXI SUN;
HUA JIANG;
TONG CHEN

Publication type:

Article

miR-20a is an independent prognostic factor in colorectal cancer and is involved in cell metastasis.

Published in:

Molecular Medicine Reports, 2014, v. 10, n. 1, p. 283, doi. 10.3892/mmr.2014.2144

By:

GUANG-JUN ZHANG;
YU LI;
HE ZHOU;
HUA-XU XIAO;
TONG ZHOU

Publication type:

Article

JNK inhibitor SP600125 enhances TGF-β-induced apoptosis of RBE human cholangiocarcinoma cells in a Smad-dependent manner.

Published in:

Molecular Medicine Reports, 2013, v. 8, n. 6, p. 1623, doi. 10.3892/mmr.2013.1711

By:

YOUZHI LIN;
BINHAO ZHANG;
HUIFANG LIANG;
YULEI LU;
XI AI;
BIXIANG ZHANG;
XIAOPING CHEN

Publication type:

Article

Intraperitoneal injection of 17β‐estradiol increases ovarian smad2/3 expression in Yangtze sturgeon Acipenser dabryanus.

Published in:

Aquaculture Research, 2022, v. 53, n. 8, p. 3059, doi. 10.1111/are.15817

By:

Yue, Huamei;
Ye, Huan;
Ruan, Rui;
Du, Hao;
Wei, Qiwei;
Li, Chuangju

Publication type:

Article

The Drosophila functional Smad suppressing element fuss, a homologue of the human Skor genes, retains pro-oncogenic properties of the Ski/Sno family.

Published in:

PLoS ONE, 2022, v. 17, n. 1, p. 1, doi. 10.1371/journal.pone.0262360

By:

Rass, Mathias;
Gizler, Laura;
Bayersdorfer, Florian;
Irlbeck, Christoph;
Schramm, Matthias;
Schneuwly, Stephan

Publication type:

Article

Role of Hypothalamic Transforming Growth Factor-β (TGF-β)/Smad Signaling in Feeding Regulation in Chickens.

Published in:

Journal of Poultry Science, 2022, v. 59, n. 4, p. 357, doi. 10.2141/jpsa.0220040

By:

Takaoki Saneyasu;
Miku Ueda;
Kanami Nagata;
Jiawei Chai;
Kazuhisa Honda;
Hiroshi Kamisoyama

Publication type:

Article

Circ_0008529 Contributes to Renal Tubular Cell Dysfunction in High Glucose Stress via miR-185-5p/SMAD2 Pathway in Diabetic Nephropathy.

Published in:

Biochemical Genetics, 2023, v. 61, n. 3, p. 963, doi. 10.1007/s10528-022-10296-3

By:

Niu, Zheli;
Ren, Guangwei;
Huang, Lijing;
Mu, Liqin

Publication type:

Article

NS5ATP9 Suppresses Activation of Human Hepatic Stellate Cells, Possibly via Inhibition of Smad3/Phosphorylated-Smad3 Expression.

Published in:

Inflammation, 2015, v. 38, n. 1, p. 278, doi. 10.1007/s10753-014-0031-y

By:

Zhang, Mengran;
Zhang, Jinqian;
Liu, Shunai;
Wang, Qi;
Lin, Guoxian;
Qiu, Rongxian;
Quan, Min;
Cheng, Jun

Publication type:

Article

Superoxide dismutase 2 scavenges ROS to promote osteogenic differentiation of human periodontal ligament stem cells by regulating Smad3 in alveolar bone‐defective rats.

Published in:

Journal of Periodontology, 2024, v. 95, n. 5, p. 469, doi. 10.1002/JPER.23-0469

By:

Qiu, Wei;
Sun, Qian;
Li, Na;
Chen, Zehao;
Wu, Hongle;
Chen, Zhao;
Guo, Xiaolan;
Fang, Fuchun

Publication type:

Article

Role of Transforming Growth Factor-beta1 in Cyclosporine-Induced Epithelial-to-Mesenchymal Transition in Gingival Epithelium.

Published in:

Journal of Periodontology, 2015, v. 86, n. 1, p. 120, doi. 10.1902/jop.2014.130285

By:

Fu, Martin M.;
Chin, Yu‐Tang;
Fu, Earl;
Chiu, Hsien‐Chung;
Wang, Li‐Yu;
Chiang, Cheng‐Yang;
Tu, Hsiao‐Pei

Publication type:

Article

All-trans retinoic acid inhibits lipopolysaccharide-induced inflammatory responses in bovine adipocytes via TGFβ1/Smad3 signaling pathway.

Published in:

BMC Veterinary Research, 2019, v. 15, n. 1, p. N.PAG, doi. 10.1186/s12917-019-1791-2

By:

Xu, Qiushi;
Jia, Hongdou;
Ma, Li;
Liu, Guowen;
Li, Ying;
Li, Xinwei;
Li, Xiaobing;
Xu, Chuang

Publication type:

Article

TGF-β1/Smads and miR-21 in Renal Fibrosis and Inflammation.

Published in:

Mediators of Inflammation, 2016, p. 1, doi. 10.1155/2016/8319283

By:

Loboda, Agnieszka;
Sobczak, Mateusz;
Jozkowicz, Alicja;
Dulak, Jozef

Publication type:

Article