Works matching DE "SMAD proteins"

Results: 684

Notch and TGF?

Published in:

OncoImmunology, 2014, v. 3, n. 5, p. N.PAG, doi. 10.4161/onci.29029

By:

Ohnuki, Hidetaka;
Tosato, Giovanna

Publication type:

Article

Nuclear αB-Crystallin and SMAD4 Are Cooperatively Downregulated by Resistance Exercise-Induced Stress in Human Skeletal Muscle: A Potential Mechanism for Cellular Adaptation.

Published in:

German Journal of Sports Medicine / Deutsche Zeitschrift fur Sportmedizin, 2025, v. 76, n. 3, p. 91

By:

Jacko, D.;
Schaaf, K.;
Duda, C.;
Kostov, T.;
Bersiner, K.;
Zacher, J.;
Schiffer, T.;
Gehlert, S.;
Bloch, W.

Publication type:

Article

Inactivation of Notch1-TGF-β-Smads Signaling Pathway by Atorvastatin Improves Cardiac Function and Hemodynamic Performance in Acute Myocardial Infarction Rats.

Published in:

Journal of Vascular Research, 2025, v. 62, n. 3, p. 133, doi. 10.1159/000542728

By:

Kang, Qi;
Kang, Mei;
Yang, Mengyun;
Fernando, Taniya

Publication type:

Article

The Role of BMP2/4 in Intestinal Ischemia‐Reperfusion Injury: Bridging Smad1/5 and Notch Pathways via Smad6.

Published in:

Journal of Gastroenterology & Hepatology, 2025, v. 40, n. 6, p. 1548, doi. 10.1111/jgh.16944

By:

Luo, Binyu;
Zhang, Qin;
Qin, Long;
Kong, Xiangxin;
Song, Ke;
Yu, Zhenghang;
Ren, Yixing

Publication type:

Article

Probing the binding hypothesis of Smad3 modulators by molecular dynamic simulations for Atherosclerosis Cardiovascular Disease (ASCVD).

Published in:

PLoS ONE, 2025, v. 20, n. 6, p. 1, doi. 10.1371/journal.pone.0324677

By:

Aziz, Ubair;
Jabeen, Ishrat

Publication type:

Article

Low-dose irradiation of mouse embryos increases Smad-p21 pathway activity and preserves pluripotency.

Published in:

Journal of Assisted Reproduction & Genetics, 2018, v. 35, n. 6, p. 1061, doi. 10.1007/s10815-018-1156-y

By:

Hayashi, Masami;
Yoshida, Kayo;
Kitada, Kohei;
Kizu, Akane;
Tachibana, Daisuke;
Fukui, Mitsuru;
Morita, Takashi;
Koyama, Masayasu

Publication type:

Article

Oocyte maturation-related gene expression in the canine oviduct, cumulus cells, and oocytes and effect of co-culture with oviduct cells on in vitro maturation of oocytes.

Published in:

Journal of Assisted Reproduction & Genetics, 2017, v. 34, n. 7, p. 929, doi. 10.1007/s10815-017-0910-x

By:

Lee, Seok;
Oh, Hyun;
Kim, Min;
Kim, Geon;
Choi, Yoo;
Jo, Young;
Setyawan, Erif;
Lee, Byeong

Publication type:

Article

Effect of Anti-Müllerian hormone (AMH) and bone morphogenetic protein 15 (BMP-15) on steroidogenesis in primary-cultured human luteinizing granulosa cells through Smad5 signalling.

Published in:

Journal of Assisted Reproduction & Genetics, 2015, v. 32, n. 7, p. 1079, doi. 10.1007/s10815-015-0494-2

By:

Prapa, Ermioni;
Vasilaki, Anna;
Dafopoulos, Konstantinos;
Katsiani, Eleni;
Georgoulias, Panagiotis;
Messini, Christina;
Anifandis, George;
Messinis, Ioannis

Publication type:

Article

Downregulation of SMAD2 and SMAD4 is associated with poor prognosis and shorter survival in esophageal squamous cell carcinoma.

Published in:

Molecular Biology Reports, 2025, v. 52, n. 1, p. 1, doi. 10.1007/s11033-025-10390-w

By:

Talukdar, Jayasree;
Kataki, Kangkana;
Choudhury, Bikash Narayan;
Baruah, Munindra Narayan;
Bhattacharyya, Mallika;
Sarma, Manash Pratim;
Bhattacharjee, Minakshi;
Das, Partha Pratim;
Kalita, Simanta;
Medhi, Subhash

Publication type:

Article

Investigating the impact of SMAD2 and SMAD4 downregulation in colorectal cancer and their correlation with immune markers, prognosis, and drug resistance and sensitivity.

Published in:

Molecular Biology Reports, 2024, v. 51, n. 1, p. 1, doi. 10.1007/s11033-024-09697-x

By:

Amani, Melika Saadat;
Peymani, Maryam

Publication type:

Article

Introduction of miR-3613-3p as a regulator of transforming growth factor-β (TGF-β) signaling pathway in colorectal cancer.

Published in:

Molecular Biology Reports, 2024, v. 51, n. 1, p. 1, doi. 10.1007/s11033-024-09419-3

By:

Jafarian, Monireh;
Hasannia, Tabasom;
Badameh, Parisa;
Behmanesh, Mehrdad;
Soltani, Bahram M.

Publication type:

Article

The effect of saraglitazar on TGF-β-induced smad3 phosphorylation and expression of genes related to liver fibrosis in LX2 cell line.

Published in:

Molecular Biology Reports, 2024, v. 51, n. 1, p. 1, doi. 10.1007/s11033-024-09443-3

By:

Dinarvand, Negar;
Afarin, Reza;
Shakerian, Elham;
Bavarsad, Samaneh Salehipour;
Mohammadtaghvaei, Narges

Publication type:

Article

Correction: MicroRNA‑499‑5p inhibits transforming growth factor‑β1‑induced Smad2 signaling pathway and suppresses fibroblast proliferation and collagen synthesis in rat by targeting TGFβ‑R1.

Published in:

2024

By:

Zhao, Qing;
Yang, Wentao;
Li, Xiangdong;
Yuan, Hongtao;
Guo, Jianping;
Wang, Yutang;
Shan, Zhaoliang

Publication type:

Correction Notice

Silymarin and MSC-exosomes ameliorate thioacetamide-evoked renal fibrosis by inhibiting TGF-β/SMAD pathway in rats.

Published in:

Molecular Biology Reports, 2024, v. 51, n. 1, p. 1, doi. 10.1007/s11033-024-09343-6

By:

Mekawy, Dina Mohamed;
Sabry, Dina;
Sabry, Rania Mohamed;
Abozeid, Naglaa F.

Publication type:

Article

Colchicine Alleviates Steroid-Induced Hyperglycemia and Dyslipidemia: Targeting Pyroptosis and Oxidative Stress.

Published in:

Zagazig University Medical Journal, 2025, v. 31, n. 2, p. 695, doi. 10.21608/zumj.2024.333297.3674

By:

Nageeb, Mahitab M.;
Mahmoud, Samar Mortada;
Mohamed Ali, Shimaa Ali;
hendy awadallah, Nihal Ibrahim;
Ahmad, Marwa M.;
Hemead, Dalia A.

Publication type:

Article

Pingxiao pian attenuate invasiveness and proliferation of lung adenocarcinoma through regulating miR-29b-3p/TGF-β1/Smad/EMT pathway.

Published in:

Discover Oncology, 2025, v. 16, n. 1, p. 1, doi. 10.1007/s12672-025-01959-9

By:

Feng, Jie-Ni;
Chen, Pei-Rui;
Yuan, Shao-Fei;
Dai, Qiang;
Zheng, Wei-E.;
Lin, Hua-Long

Publication type:

Article

Integrated multi-omics characterization of SMAD4 mutant colorectal cancer.

Published in:

Discover Oncology, 2024, v. 15, n. 1, p. 1, doi. 10.1007/s12672-024-01268-7

By:

Zhao, Danyi;
Qu, Yanjun;
Gao, Na;
Wu, Tao

Publication type:

Article

Assessment of the Influence of 5-Fluorouracil on SMAD4 and TGFB1 Gene Expression, Apoptosis Induction and DNA Damage in Human Cell Lines.

Published in:

Bioengineering (Basel), 2023, v. 10, n. 5, p. 570, doi. 10.3390/bioengineering10050570

By:

Wosiak, Agnieszka;
Szmajda-Krygier, Dagmara;
Pietrzak, Jacek;
Boncela, Joanna;
Balcerczak, Ewa

Publication type:

Article

Carnosol attenuated atrophy of C2C12 myotubes induced by tumour‐derived exosomal miR‐183‐5p through inhibiting Smad3 pathway activation and keeping mitochondrial respiration.

Published in:

Basic & Clinical Pharmacology & Toxicology, 2022, v. 131, n. 6, p. 500, doi. 10.1111/bcpt.13795

By:

Kuang, Ji‐Xia;
Shen, Qiang;
Zhang, Rui‐Qin;
Fang, Qiao‐Yu;
Deng, Xue;
Fan, Meng;
Cheng, Chun‐Ru;
Zhang, Xiong‐Wen;
Liu, Xuan

Publication type:

Article

Stevioside inhibits experimental fibrosis by down‐regulating profibrotic Smad pathways and blocking hepatic stellate cell activation.

Published in:

Basic & Clinical Pharmacology & Toxicology, 2019, v. 124, n. 6, p. 670, doi. 10.1111/bcpt.13194

By:

Casas‐Grajales, Sael;
Alvarez‐Suarez, Diana;
Ramos‐Tovar, Erika;
Dayana Buendía‐Montaño, Laura;
Reyes‐Gordillo, Karina;
Camacho, Javier;
Tsutsumi, Víctor;
Lakshman, M. Raj;
Muriel, Pablo

Publication type:

Article

Magnolol Attenuates Concanavalin A-induced Hepatic Fibrosis, Inhibits CD4<sup>+</sup> T Helper 17 (Th17) Cell Differentiation and Suppresses Hepatic Stellate Cell Activation: Blockade of Smad3/Smad4 Signalling.

Published in:

Basic & Clinical Pharmacology & Toxicology, 2017, v. 120, n. 6, p. 560, doi. 10.1111/bcpt.12749

By:

Zhang, Hongjun;
Ju, Baoling;
Zhang, Xiaoli;
Zhu, Yanfei;
Nie, Ying;
Xu, Yuanhong;
Lei, Qiuxia

Publication type:

Article

Smads as muscle biomarkers in amyotrophic lateral sclerosis.

Published in:

Annals of Clinical & Translational Neurology, 2014, v. 1, n. 10, p. 778, doi. 10.1002/acn3.117

By:

Si, Ying;
Cui, Xianqin;
Kim, Soojin;
Wians, Robert;
Sorge, Robert;
Oh, Shin J.;
Kwan, Thaddeus;
AlSharabati, Mohammad;
Lu, Liang;
Claussen, Gwen;
Anderson, Tina;
Yu, Shaohua;
Morgan, Dylan;
Kazamel, Mohamed;
King, Peter H.

Publication type:

Article

Hydrogen sulfide alleviates hypothyroidism-induced myocardial fibrosis in rats through stimulating autophagy and inhibiting TGF-β1/Smad2 pathway.

Published in:

Korean Journal of Physiology & Pharmacology, 2023, v. 27, n. 1, p. 1, doi. 10.4196/kjpp.2023.27.1.1

By:

Xiong Song;
Liangui Nie;
Junrong Long;
Junxiong Zhao;
Xing Liu;
Liuyang Wang;
Da Liu;
Sen Wang;
Shengquan Liu;
Jun Yang

Publication type:

Article

FXR1 promotes proliferation, invasion and migration of hepatocellular carcinoma in vitro and in vivo.

Published in:

Oncology Letters, 2023, v. 25, n. 1, p. N.PAG

By:

Zhao, Kun;
Gao, Jie;
Shi, Jihua;
Shi, Chengcheng;
Pang, Chun;
Li, Jie;
Guo, Wenzhi;
Zhang, Shuijun

Publication type:

Article

SMOC1 silencing suppresses the angiotensin II‑induced myocardial fibrosis of mouse myocardial fibroblasts via affecting the BMP2/Smad pathway.

Published in:

Oncology Letters, 2018, v. 16, n. 3, p. 2903, doi. 10.3892/ol.2018.8989

By:

Wang, Yize;
Wu, Xianming

Publication type:

Article

Downregulation of FOXP2 promotes breast cancer migration and invasion through TGFβ/SMAD signaling pathway.

Published in:

Oncology Letters, 2018, v. 15, n. 6, p. 8582, doi. 10.3892/ol.2018.8402

By:

ChEN, MENg-Ting;
Sun, He-FEN;
Li, Liang-Dong;
Zhao, Yang;
Yang, Li-PENg;
Gao, Shui-Ping;
Jin, Wei

Publication type:

Article

miR-205 regulates the proliferation and invasion of ovarian cancer cells via suppressing PTEN/SMAD4 expression.

Published in:

Oncology Letters, 2018, v. 15, n. 5, p. 7571, doi. 10.3892/ol.2018.8313

By:

Chu, Ping;
Liang, Aihua;
Jiang, Aili;
Zong, Lu

Publication type:

Article

MMP‑2 silencing reduces the osteogenic transformation of fibroblasts by inhibiting the activation of the BMP/Smad pathway in ankylosing spondylitis.

Published in:

Oncology Letters, 2018, v. 15, n. 3, p. 3281, doi. 10.3892/ol.2017.7714

By:

Yuan, Bo;
Wu, Zhiming

Publication type:

Article

Dexamethasone induced apoptosis of A549 cells via the TGF‑β1/Smad2 pathway.

Published in:

Oncology Letters, 2018, v. 15, n. 3, p. 2801, doi. 10.3892/ol.2017.7696

By:

FENg, Xiao-Ling;
Fei, Hui-Zhi;
Hu, Ling

Publication type:

Article

The expression and underlying angiogenesis effect of DPC4 and VEGF on the progression of cervical carcinoma.

Published in:

Oncology Letters, 2018, v. 15, n. 2, p. 2534, doi. 10.3892/ol.2017.7580

By:

A, Yanni;
Li, Ying;
Zhao, Shuping

Publication type:

Article

Eupatolide inhibits the TGF-β1-induced migration of breast cancer cells via downregulation of SMAD3 phosphorylation and transcriptional repression of ALK5.

Published in:

Oncology Letters, 2017, v. 14, n. 5, p. 6031, doi. 10.3892/ol.2017.6957

By:

BOLDBAATAR, ARIUNDAVAA;
SUNYI LEE;
SORA HAN;
AE LEE JEONG;
HYE IN KA;
BUYANRAVJIKH, SUMIYASUREN;
JEONG HYUNG LEE;
JONG-SEOK LIM;
MYUNG SOK LEE;
YOUNG YANG

Publication type:

Article

Intestinal flora imbalance promotes alcohol-induced liver fibrosis by the TGFβ/smad signaling pathway in mice.

Published in:

Oncology Letters, 2017, v. 14, n. 4, p. 4511, doi. 10.3892/ol.2017.6762

By:

DONG ZHANG;
XIUXIAN HAO;
LILI XU;
JING CUI;
LI XUE;
ZIBIN TIAN

Publication type:

Article

miR-590 promotes the proliferation of HUMSCs and induces ECM synthesis by targeting Smad7.

Published in:

Oncology Letters, 2017, v. 14, n. 4, p. 3941, doi. 10.3892/ol.2017.6663

By:

TIANMING LIU;
YINGE WU;
TENGYI HUANG;
XUEXUAN ZHANG;
YINGMU CAI

Publication type:

Article

miRNA-708 functions as a tumour suppressor in hepatocellular carcinoma by targeting SMAD3.

Published in:

Oncology Letters, 2017, v. 14, n. 2, p. 2552, doi. 10.3892/ol.2017.6429

By:

QI LI;
SHENG LI;
YAOLU WU;
FENG GAO

Publication type:

Article

Maternal embryonic leucine zipper kinase inhibits epithelial-mesenchymal transition by regulating transforming growth factor-β signaling.

Published in:

Oncology Letters, 2017, v. 13, n. 6, p. 4794, doi. 10.3892/ol.2017.6081

By:

JIANJIAN CHENG;
BINYU QIN;
BAO LIU;
TAIBO HUANG;
YUGUANG LI;
LIJUN MA

Publication type:

Article

Upregulation of maspin expression in human cervical carcinoma cells by transforming growth factor β1 through the convergence of Smad and non-Smad signaling pathways.

Published in:

Oncology Letters, 2017, v. 13, n. 5, p. 3646, doi. 10.3892/ol.2017.5939

By:

ARIYAPHONG WONGNOPPAVICH;
NAHATHAI DUKAEW;
SIRINTHIP CHOONATE;
KONGTHAWAT CHAIRATVIT

Publication type:

Article

Smad3 mutant mice develop colon cancer with overexpression of COX-2.

Published in:

Oncology Letters, 2017, v. 13, n. 3, p. 1535, doi. 10.3892/ol.2017.5639

By:

YU-PING ZHU;
ZHUO LIU;
ZHI-XUAN FU;
DE-CHUAN LI

Publication type:

Article

miR-574-3p acts as a tumor promoter in osteosarcoma by targeting SMAD4 signaling pathway.

Published in:

Oncology Letters, 2016, v. 12, n. 6, p. 5247, doi. 10.3892/ol.2016.5355

By:

HAIDONG XU;
XIAOZHOU LIU;
JUAN ZHOU;
XIAOYUN CHEN;
JIANNING ZHAO

Publication type:

Article

Association between transforming growth factor-β1 expression and the clinical features of triple negative breast cancer.

Published in:

Oncology Letters, 2016, v. 11, n. 6, p. 4040, doi. 10.3892/ol.2016.4497

By:

MING-JIAN DING;
KE SU;
GUO-ZHONG CUI;
WEN-HUA YANG;
LIANG CHEN;
MENG YANG;
YAN-QING LIU;
DIAN-LU DAI

Publication type:

Article

Smad4 inhibits cell migration via suppression of JNK activity in human pancreatic carcinoma PANC-1 cells.

Published in:

Oncology Letters, 2016, v. 11, n. 5, p. 3465, doi. 10.3892/ol.2016.4427

By:

XUEYING ZHANG;
JUNXIA CAO;
YUJUN PEI;
JIYAN ZHANG;
QINGYANG WANG

Publication type:

Article

Genetic effects of multiple asthma loci identified by genomewide association studies on asthma and spirometric indices.

Published in:

Pediatric Allergy & Immunology, 2016, v. 27, n. 2, p. 185, doi. 10.1111/pai.12505

By:

Tang, Man Fung;
Sy, Hing Yee;
Kong, Alice Pik‐shan;
Ko, Fanny Wai‐san;
Wang, Susan Shuxin;
Liu, Tak Chi;
Chan, Wa Cheong;
Wong, Gary Wing‐kin;
Hon, Kam Lun;
Chan, Juliana Chung‐ngor;
Hui, David Shu‐cheong;
Leung, Ting Fan

Publication type:

Article

Loss-of-Function in SMAD4 Might Not Be Critical for Human Natural Killer Cell Responsiveness to TGF-β.

Published in:

Frontiers in Immunology, 2019, p. N.PAG, doi. 10.3389/fimmu.2019.00904

By:

Healy, Lachlan P.;
Rossi, Gustavo R.;
Rautela, Jai;
Slade, Charlotte A.;
Huntington, Nicholas D.;
Winship, Ingrid M.;
Souza-Fonseca-Guimaraes, Fernando

Publication type:

Article

Pin1 promotes degradation of Smad proteins and their interaction with phosphorylated tau in Alzheimer's disease.

Published in:

Neuropathology & Applied Neurobiology, 2014, v. 40, n. 7, p. 815, doi. 10.1111/nan.12163

By:

Ueberham, Uwe;
Rohn, Susanne;
Ueberham, Elke;
Wodischeck, Susanne;
Hilbrich, Isabel;
Holzer, Max;
Brückner, Martina K.;
Gruschka, Hildegard;
Arendt, Thomas

Publication type:

Article

SMAD4 exerts a tumor-promoting role in hepatocellular carcinoma.

Published in:

Oncogene, 2015, v. 34, n. 39, p. 5055, doi. 10.1038/onc.2014.425

By:

Hernanda, P Y;
Chen, K;
Das, A M;
Sideras, K;
Wang, W;
Li, J;
Cao, W;
Bots, S J A;
Kodach, L L;
de Man, R A;
Ijzermans, J N M;
Janssen, H L A;
Stubbs, A P;
Sprengers, D;
Bruno, M J;
Metselaar, H J;
ten Hagen, T L M;
Kwekkeboom, J;
Peppelenbosch, M P;
Pan, Q

Publication type:

Article

Cytoplasmic DRAK1 overexpressed in head and neck cancers inhibits TGF-β1 tumor suppressor activity by binding to Smad3 to interrupt its complex formation with Smad4.

Published in:

Oncogene, 2015, v. 34, n. 39, p. 5037, doi. 10.1038/onc.2014.423

By:

Park, Y;
Kim, W;
Lee, J-M;
Park, J;
Cho, J K;
Pang, K;
Lee, J;
Kim, D;
Park, S-W;
Yang, K-M;
Kim, S-J

Publication type:

Article

Ahnak functions as a tumor suppressor via modulation of TGFß/Smad signaling pathway.

Published in:

Oncogene, 2014, v. 33, n. 38, p. 4675, doi. 10.1038/onc.2014.69

By:

Lee, I. H.;
Sohn, M.;
Lim, H. J.;
Yoon, S.;
Oh, H.;
Shin, S.;
Shin, J. H.;
Oh, S.-H.;
Kim, J.;
Lee, D. K.;
Noh, D. Y.;
Bae, D. S.;
Seong, J. K.;
Bae, Y. S.

Publication type:

Article

Expression Patterns of TGF-β1 , TβR-I , TβR-II, and Smad2 Reveal Insights into Heterosis for Growth of Hybrid Offspring between Acanthopagrus schlegelii and Pagrus major.

Published in:

Genes, 2024, v. 15, n. 7, p. 945, doi. 10.3390/genes15070945

By:

Du, Xinran;
Zhao, Yue;
Li, Jingbo;
Xie, Wenli;
Lyu, Linna;
Chen, Shuyin;
Jia, Chaofeng;
Yan, Jie;
Li, Peng

Publication type:

Article

Expression and Polymorphisms of SMAD1 , SMAD2 and SMAD3 Genes and Their Association with Litter Size in Tibetan Sheep (Ovis aries).

Published in:

Genes, 2022, v. 13, n. 12, p. 2307, doi. 10.3390/genes13122307

By:

Li, Mingming;
He, Na;
Sun, Ruizhe;
Deng, Yuting;
Wen, Xiaocheng;
Zhang, Junxia

Publication type:

Article

Whole Genome Sequencing Applied in Familial Hamartomatous Polyposis Identifies Novel Structural Variations.

Published in:

2022

By:

Kariv, Revital;
Dahary, Dvir;
Yaron, Yuval;
Petel-Galil, Yael;
Malcov, Mira;
Rosner, Guy

Publication type:

Case Study

miR-152-3p Represses the Proliferation of the Thymic Epithelial Cells by Targeting Smad2.

Published in:

Genes, 2022, v. 13, n. 4, p. 576, doi. 10.3390/genes13040576

By:

Li, Ying;
Wang, Xintong;
Wu, Qingru;
Liu, Fenfen;
Yang, Lin;
Gong, Bishuang;
Zhang, Kaizhao;
Ma, Yongjiang;
Li, Yugu

Publication type:

Article