AKT1 and CTNNB1 mutations as drivers of paclitaxel resistance in breast cancer cells.
- Published in:
- Oncology Letters, 2025, v. 30, n. 1, p. N.PAG, doi. 10.3892/ol.2025.15070
- By:
- Publication type:
- Article
Works matching DE "SITE-specific mutagenesis"
Results: 1382
1
2
Co-opted and canonical glycerol channels play a major role during anhydrobiosis of an extremophile crustacean.
- Published in:
- BMC Biology, 2025, v. 23, n. 1, p. 1, doi. 10.1186/s12915-025-02262-3
- By:
- Publication type:
- Article
3
Enhancing substrate specificity of microbial transglutaminase for precise nanobody labeling.
- Published in:
- Synthetic & Systems Biotechnology, 2025, v. 10, n. 1, p. 185, doi. 10.1016/j.synbio.2024.10.003
- By:
- Publication type:
- Article
4
Characterization of Terpene Synthases Reveals the Diversity of Terpenoids in Andrographis paniculata.
- Published in:
- Molecules, 2025, v. 30, n. 10, p. 2208, doi. 10.3390/molecules30102208
- By:
- Publication type:
- Article
5
Role of Tyrosine Phosphorylation in PEP1 Receptor 1(PEPR1) in Arabidopsis thaliana.
- Published in:
- Plants (2223-7747), 2025, v. 14, n. 10, p. 1515, doi. 10.3390/plants14101515
- By:
- Publication type:
- Article
6
Heterologous Overexpression of Cytochrome P450BM3 from Bacillus megaterium and Its Role in Gossypol Reduction.
- Published in:
- Toxins, 2025, v. 17, n. 5, p. 253, doi. 10.3390/toxins17050253
- By:
- Publication type:
- Article
7
ArcB initiates quorum sensing to regulate T3SS in Vibrio alginolyticus by recognizing bacterial and host-derived autoinducer-2 as a kinase.
- Published in:
- Cell Communication & Signaling, 2025, v. 23, n. 1, p. 1, doi. 10.1186/s12964-025-02258-0
- By:
- Publication type:
- Article
8
Amino acid residues in Rag1 crucial for DNA hairpin formation.
- Published in:
- Nature Structural & Molecular Biology, 2006, v. 13, n. 11, p. 1010, doi. 10.1038/nsmb1154
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- Publication type:
- Article
9
Mechanism of the receptor-catalyzed activation of heterotrimeric G proteins.
- Published in:
- Nature Structural & Molecular Biology, 2006, v. 13, n. 9, p. 772, doi. 10.1038/nsmb1129
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- Publication type:
- Article
10
Functional Characterisation of Highly Conserved and Structurally Prominent Residues of 2‐Methylisoborneol Synthase.
- Published in:
- Chemistry - A European Journal, 2023, v. 29, n. 32, p. 1, doi. 10.1002/chem.202300775
- By:
- Publication type:
- Article
11
Infrared Spectroscopy Elucidates the Inhibitor Binding Sites in a Metal‐Dependent Formate Dehydrogenase.
- Published in:
- Chemistry - A European Journal, 2022, v. 28, n. 54, p. 1, doi. 10.1002/chem.202201091
- By:
- Publication type:
- Article
12
Discovery of Homobivalent Bitopic Ligands of the Cannabinoid CB<sub>2</sub> Receptor**.
- Published in:
- Chemistry - A European Journal, 2020, v. 26, n. 68, p. 15839, doi. 10.1002/chem.202003389
- By:
- Publication type:
- Article
13
Site-Directed, On-Surface Assembly of DNA Nanostructures.
- Published in:
- Angewandte Chemie, 2015, v. 127, n. 41, p. 12207, doi. 10.1002/ange.201505553
- By:
- Publication type:
- Article
14
Dissecting the individual contribution of conserved cysteines to the redox regulation of RubisCO.
- Published in:
- Photosynthesis Research, 2018, v. 137, n. 2, p. 251, doi. 10.1007/s11120-018-0497-9
- By:
- Publication type:
- Article
15
Characterization of the copper-sensing transcriptional regulator CopR from the hyperthermophilic archeaon Thermococcus onnurineus NA1.
- Published in:
- BioMetals, 2019, v. 32, n. 6, p. 923, doi. 10.1007/s10534-019-00223-2
- By:
- Publication type:
- Article
16
The secondary substrate binding site of the Pseudoalteromonas haloplanktis GH8 xylanase is relevant for activity on insoluble but not soluble substrates.
- Published in:
- Applied Microbiology & Biotechnology, 2011, v. 92, n. 3, p. 539, doi. 10.1007/s00253-011-3343-y
- By:
- Publication type:
- Article
17
Tailor-made type II Pseudomonas PHA synthases and their use for the biosynthesis of polylactic acid and its copolymer in recombinant Escherichia coli.
- Published in:
- Applied Microbiology & Biotechnology, 2011, v. 90, n. 2, p. 603, doi. 10.1007/s00253-010-3077-2
- By:
- Publication type:
- Article
18
A new α-galactosidase from symbiotic Flavobacterium sp. TN17 reveals four residues essential for α-galactosidase activity of gastrointestinal bacteria.
- Published in:
- Applied Microbiology & Biotechnology, 2010, v. 88, n. 6, p. 1297, doi. 10.1007/s00253-010-2809-7
- By:
- Publication type:
- Article
19
Characterization of modification enzyme NukM and engineering of a novel thioether bridge in lantibiotic nukacin ISK-1.
- Published in:
- Applied Microbiology & Biotechnology, 2010, v. 86, n. 3, p. 891, doi. 10.1007/s00253-009-2334-8
- By:
- Publication type:
- Article
20
Improving the thermostability and activity of Melanocarpus albomyces cellobiohydrolase Cel7B.
- Published in:
- Applied Microbiology & Biotechnology, 2009, v. 83, n. 2, p. 261, doi. 10.1007/s00253-008-1848-9
- By:
- Publication type:
- Article
21
Molecular basis for thermal properties of Streptomyces thermovulgaris fumarase C hinge at hydrophilic amino acids R163, E170 and S347.
- Published in:
- Applied Microbiology & Biotechnology, 2007, v. 75, n. 2, p. 329, doi. 10.1007/s00253-006-0822-7
- By:
- Publication type:
- Article
22
Importance of Trp59 and Trp60 in chitin-binding, hydrolytic, and antifungal activities of Streptomyces griseus chitinase C.
- Published in:
- Applied Microbiology & Biotechnology, 2006, v. 72, n. 6, p. 1176, doi. 10.1007/s00253-006-0405-7
- By:
- Publication type:
- Article
23
Semi-rational design of L-amino acid deaminase for production of pyruvate and d-alanine by Escherichia coli whole-cell biocatalyst.
- Published in:
- Amino Acids, 2021, v. 53, n. 9, p. 1361, doi. 10.1007/s00726-021-03067-8
- By:
- Publication type:
- Article
24
Role of conserved active site tryptophan-101 in functional activity and stability of phosphoserine aminotransferase from an enteric human parasite.
- Published in:
- Amino Acids, 2012, v. 43, n. 1, p. 483, doi. 10.1007/s00726-011-1105-x
- By:
- Publication type:
- Article
25
Site-directed mutagenesis and feedback-resistant N-acetyl- L-glutamate kinase (NAGK) increase Corynebacterium crenatum L-arginine production.
- Published in:
- Amino Acids, 2012, v. 43, n. 1, p. 255, doi. 10.1007/s00726-011-1069-x
- By:
- Publication type:
- Article
26
Probing mammalian spermine oxidase enzyme-substrate complex through molecular modeling, site-directed mutagenesis and biochemical characterization.
- Published in:
- Amino Acids, 2011, v. 40, n. 4, p. 1115, doi. 10.1007/s00726-010-0735-8
- By:
- Publication type:
- Article
27
Site-directed mutagenesis and computational study of the Y366 active site in Bacillus subtilis protoporphyrinogen oxidase.
- Published in:
- Amino Acids, 2009, v. 37, n. 3, p. 523, doi. 10.1007/s00726-009-0256-5
- By:
- Publication type:
- Article
28
Comprehensive comparative assessment of the Arabidopsis thaliana MLO2--CALMODULIN2 interaction by various in vitro and in vivo protein--protein interaction assays.
- Published in:
- Biochemical Journal, 2023, v. 480, n. 20, p. 1615, doi. 10.1042/BCJ20230255
- By:
- Publication type:
- Article
29
In search for structural targets for engineering D-amino acid transaminase: modulation of pH optimum and substrate specificity.
- Published in:
- Biochemical Journal, 2023, v. 480, n. 16, p. 1267, doi. 10.1042/BCJ20230233
- By:
- Publication type:
- Article
30
Key allosteric and active site residues of SARS-CoV-2 3CLpro are promising drug targets.
- Published in:
- Biochemical Journal, 2023, v. 480, n. 11, p. 791, doi. 10.1042/BCJ20230027
- By:
- Publication type:
- Article
31
The hydrophobic residue Leu73 is crucial for the high stability and low aggregation properties of murine transthyretin.
- Published in:
- Biochemical Journal, 2022, v. 479, n. 18, p. 1999, doi. 10.1042/bcj20220203
- By:
- Publication type:
- Article
32
Thermodynamic analysis of Zα domain-nucleic acid interactions.
- Published in:
- Biochemical Journal, 2022, v. 479, n. 16, p. 1727, doi. 10.1042/BCJ20220200
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- Publication type:
- Article
33
Cryo-EM structures of the Synechocystis sp. PCC 6803 cytochrome b<sub>6</sub>f complex with and without the regulatory PetP subunit.
- Published in:
- Biochemical Journal, 2022, v. 479, n. 13, p. 1487, doi. 10.1042/BCJ20220124
- By:
- Publication type:
- Article
34
Characterization of subunit interactions in the hetero-oligomeric retinoid oxidoreductase complex.
- Published in:
- Biochemical Journal, 2021, v. 478, n. 19, p. 3597, doi. 10.1042/BCJ20210589
- By:
- Publication type:
- Article
35
Diversified amino acid-mediated allosteric regulation of phosphoglycerate dehydrogenase for serine biosynthesis in land plants.
- Published in:
- Biochemical Journal, 2021, v. 478, n. 12, p. 2217, doi. 10.1042/BCJ20210191
- By:
- Publication type:
- Article
36
Structural insights into histone chaperone Asf1 and its characterization from Plasmodium falciparum.
- Published in:
- Biochemical Journal, 2021, v. 478, n. 5, p. 1117, doi. 10.1042/BCJ20200891
- By:
- Publication type:
- Article
37
Unusual ring D fixation by three crucial residues promotes phycoviolobilin formation in the DXCFtype cyanobacteriochrome without the second Cys.
- Published in:
- Biochemical Journal, 2021, v. 478, n. 5, p. 1043, doi. 10.1042/BCJ20210013
- By:
- Publication type:
- Article
38
Structural insight into the catalytic mechanism and inhibitor binding of aminopeptidase A.
- Published in:
- Biochemical Journal, 2020, v. 477, n. 21, p. 4133, doi. 10.1042/BCJ20200307
- By:
- Publication type:
- Article
39
A structure model explaining the binding between a ubiquitous unconventional G-protein (OsYchF1) and a plant-specific C2-domain protein (OsGAP1) from rice.
- Published in:
- Biochemical Journal, 2020, v. 477, n. 20, p. 3935, doi. 10.1042/BCJ20200380
- By:
- Publication type:
- Article
40
Identifying key residues and key interactions for the binding of LEAP2 to receptor GHSR1a.
- Published in:
- Biochemical Journal, 2020, v. 477, n. 17, p. 3199, doi. 10.1042/BCJ20200228
- By:
- Publication type:
- Article
41
Structural and biochemical evidence of the glucose 6-phosphate-allosteric site of maize C<sup>4</sup>- phosphoenolpyruvate carboxylase: its importance in the overall enzyme kinetics.
- Published in:
- Biochemical Journal, 2020, v. 477, n. 11, p. 2095, doi. 10.1042/BCJ20200304
- By:
- Publication type:
- Article
42
FILTREST3D: discrimination of structural models using restraints from experimental data.
- Published in:
- Bioinformatics, 2010, v. 26, n. 23, p. 2986, doi. 10.1093/bioinformatics/btq582
- By:
- Publication type:
- Article
43
Direct Enzyme Engineering of B Family DNA Polymerases for Biotechnological Approaches.
- Published in:
- Bioengineering (Basel), 2023, v. 10, n. 10, p. 1150, doi. 10.3390/bioengineering10101150
- By:
- Publication type:
- Article
44
Atto488-Agitoxin 2—A Fluorescent Ligand with Increased Selectivity for Kv1.3 Channel Binding Site.
- Published in:
- Bioengineering (Basel), 2022, v. 9, n. 7, p. 295, doi. 10.3390/bioengineering9070295
- By:
- Publication type:
- Article
45
Engineering Novel Lentiviral Vectors for Labelling Tumour Cells and Oncogenic Proteins.
- Published in:
- Bioengineering (Basel), 2022, v. 9, n. 3, p. 91, doi. 10.3390/bioengineering9030091
- By:
- Publication type:
- Article
46
New insights into the structural characteristics and functional relevance of the human cytochrome P450 2D6 enzyme.
- Published in:
- Drug Metabolism Reviews, 2009, v. 41, n. 4, p. 573, doi. 10.1080/03602530903118729
- By:
- Publication type:
- Article
47
225. ALTERING CATALYTIC PROPERTIES OF P450 1A1 AND 1A2 BY SITE-DIRECTED MUTAGENESIS.
- Published in:
- 2002
- Publication type:
- Abstract
48
Hypothetical protein CuvA (Rv1422) from Mycobacterium tuberculosis H37Rv interacts with uridine diphosphate N-acetylglucosamine as a key precursor of cell wall.
- Published in:
- Applied Biological Chemistry, 2023, v. 66, n. 1, p. 1, doi. 10.1186/s13765-023-00840-z
- By:
- Publication type:
- Article
49
On the Biosynthesis of Bioactive Tryptamines in Black Cohosh (Actaea racemosa L.).
- Published in:
- Plants (2223-7747), 2025, v. 14, n. 2, p. 292, doi. 10.3390/plants14020292
- By:
- Publication type:
- Article
50
Site-Directed Mutations at Phosphorylation Sites in Zea mays PHO1 Reveal Modulation of Enzymatic Activity by Phosphorylation at S566 in the L80 Region.
- Published in:
- Plants (2223-7747), 2023, v. 12, n. 18, p. 3205, doi. 10.3390/plants12183205
- By:
- Publication type:
- Article