Works about SHIKONIN

Results: 286

Shikonin inhibits migration and invasion of triplenegative breast cancer cells by suppressing epithelialmesenchymal transition via miR-17-5p/PTEN/Akt pathway.

Published in:

Journal of Cancer, 2021, v. 12, n. 1, p. 76, doi. 10.7150/jca.47553

By:

Chang Bao;
Tao Liu;
Lingbo Qian;
Chi Xiao;
Xinru Zhou;
Heng Ai;
Jue Wang;
Weimin Fan;
Jie Pan

Publication type:

Article

Shikonin inhibits epithelial-mesenchymal transition in glioblastoma cells by upregulating p53 and promoting miR-361-5p level to suppress ZEB1 expression.

Published in:

BMC Neuroscience, 2025, v. 26, n. 1, p. 1, doi. 10.1186/s12868-025-00956-6

By:

Zhang, Fengying;
Liu, Zhiyi;
Wang, Yingbin;
Zuo, Lin;
Xu, Sicong;
Liu, Yin;
Liang, Hao;
Xue, Yixue

Publication type:

Article

Electrochemical Determination of the Anticancer Herbal Drug Shikonin at a Nanostructured Poly(hydroxymethylated-3,4-ethylenedioxythiophene) Modified Electrode.

Published in:

Electroanalysis, 2013, v. 25, n. 9, p. 2244, doi. 10.1002/elan.201300247

By:

Wu, Liping;
Lu, Limin;
Zhang, Long;
Xu, Jingkun;
Zhang, Kaixin;
Wen, Yangping;
Duan, Xuemin;
Yang, Fan

Publication type:

Article

Shikonin Induces ROS-Dependent Apoptosis Via Mitochondria Depolarization and ER Stress in Adult T Cell Leukemia/Lymphoma.

Published in:

Antioxidants, 2023, v. 12, n. 4, p. 864, doi. 10.3390/antiox12040864

By:

Boonnate, Piyanard;
Kariya, Ryusho;
Okada, Seiji

Publication type:

Article

Shikonin induces the apoptosis and pyroptosis of EGFR-T790M-mutant drug-resistant non-small cell lung cancer cells via the degradation of cyclooxygenase-2.

Published in:

European Journal of Medical Research, 2024, v. 29, p. 1, doi. 10.1186/s40001-024-02187-7

By:

Cao, Shaoyi;
Li, Huaqiu;
Ye, Xiaoyan;
Xing, Xinxing;
Xie, Yonghuan;
Zeng, Xiangfeng;
Liu, Hongjiao;
Zhong, Xing;
Yang, Xinyi;
Xing, Wenxiu;
Zhu, Cairong;
Wu, Xiaoping

Publication type:

Article

Expression of Concern: Shikonin inhibits proliferation, migration, invasion and promotes apoptosis in NCI-N87 cells via inhibition of PI3K/AKT signal pathway.

Published in:: 2020
Publication type:: Correction Notice

Shikonin inhibits proliferation, migration, invasion and promotes apoptosis in NCI-N87 cells via inhibition of PI3K/AKT signal pathway.

Published in:

Artificial Cells, Nanomedicine & Biotechnology, 2019, v. 47, n. 1, p. 2662, doi. 10.1080/21691401.2019.1632870

By:

Jia, Liushun;
Zhu, Zhen;
Li, Hongbo;
Li, Yaofeng

Publication type:

Article

Shikonin induces apoptosis and prosurvival autophagy in human melanoma A375 cells via ROS-mediated ER stress and p38 pathways.

Published in:

Artificial Cells, Nanomedicine & Biotechnology, 2019, v. 47, n. 1, p. 626, doi. 10.1080/21691401.2019.1575229

By:

Liu, Yongkang;
Kang, Xing;
Niu, Geng;
He, Senlin;
Zhang, Tingting;
Bai, Yuwei;
Li, Yi;
Hao, Houyan;
Chen, Chao;
Shou, Zhexing;
Li, Bin

Publication type:

Article

Molecular mechanism of shikonin inhibiting tumor growth and potential application in cancer treatment.

Published in:

Toxicology Research, 2021, v. 10, n. 6, p. 1077, doi. 10.1093/toxres/tfab107

By:

Wang, Qiang;
Wang, Jing;
Wang, Jiayou;
Ju, Xiaoli;
Zhang, Heng

Publication type:

Article

Expression of concern: Shikonin-mediated up-regulation of miR-34a and miR-202 inhibits retinoblastoma proliferation.

Published in:: Toxicology Research, 2021, v. 10, n. 3, p. 665, doi. 10.1093/toxres/tfab033
Publication type:: Article

Shikonin-mediated up-regulation of miR-34a and miR-202 inhibits retinoblastoma proliferation.

Published in:

Toxicology Research, 2018, v. 7, n. 5, p. 907, doi. 10.1039/c8tx00079d

By:

Su, Yan;
Lu, Shiyou;
Li, Jincun;
Deng, Liya

Publication type:

Article

Shikonin inhibits NLRP3 inflammasome activation and controls inflammatory disease.

Published in:

Scientific Reports, 2025, v. 15, n. 1, p. 1, doi. 10.1038/s41598-025-03512-8

By:

Huang, Jing;
Dai, Mengmeng;
Huang, Xinyu;
Qi, Wenqing;
Jing, Jing;
He, Jiayi;
Lu, Zhizhuo;
Zhang, Chaofang;
Wang, Guiling;
Ma, Yuanfang;
Zhang, Hailong;
Cao, Run

Publication type:

Article

Shikonin suppresses proliferation of osteosarcoma cells by inducing ferroptosis through promoting Nrf2 ubiquitination and inhibiting the xCT/GPX4 regulatory axis.

Published in:

Frontiers in Pharmacology, 2024, p. 1, doi. 10.3389/fphar.2024.1490759

By:

Huang, Rui;
Chu, Dawei;
Shi, Jiandang;
Xu, Ruiqing;
Wang, Kun

Publication type:

Article

Development of a Porcine Full-Thickness Burn Hypertrophic Scar Model and Investigation of the Effects of Shikonin on Hypertrophic Scar Remediation.

Published in:

Frontiers in Pharmacology, 2018, p. 1, doi. 10.3389/fphar.2018.00590

By:

Xingwang Deng;
Qian Chen;
Lijuan Qiang;
Mingwei Chi;
Nan Xie;
Yinsheng Wu;
Ming Yao;
Dan Zhao;
Jiaxiang Ma;
Ning Zhang;
Yan Xie

Publication type:

Article

Identification of a novel combination treatment strategy in clear cell renal cell carcinoma stem cells with shikonin and ipilimumab.

Published in:

Frontiers in Immunology, 2023, p. 01, doi. 10.3389/fimmu.2023.1186388

By:

Chen Lyu;
Stadlbauer, Birgit;
Wang, Lili;
Buchner, Alexander;
Pohla, Heike

Publication type:

Article

Shikonin improves pulmonary vascular remodeling in monocrotaline‑induced pulmonary arterial hypertension via regulation of PKM2.

Published in:

Molecular Medicine Reports, 2023, v. 27, n. 3, p. 1, doi. 10.3892/mmr.2023.12947

By:

WENFENG LI;
WENJUAN CHEN;
HONGYAN PENG;
ZHENGHUI XIAO;
JINQIAO LIU;
YUNHONG ZENG;
TING HUANG;
QINGQING SONG;
XUN WANG;
YUNBIN XIAO

Publication type:

Article

Shikonin inhibits the Warburg effect, cell proliferation, invasion and migration by downregulating PFKFB2 expression in lung cancer.

Published in:

Molecular Medicine Reports, 2021, v. 24, n. 2, p. N.PAG, doi. 10.3892/mmr.2021.12199

By:

Sha, Liying;
Lv, Zhiqiang;
Liu, Yujun;
Zhang, Yun;
Sui, Xin;
Wang, Teng;
Zhang, Hui

Publication type:

Article

Shikonin ameliorates lipoteichoic acid-induced acute lung injury via promotion of neutrophil apoptosis.

Published in:

Molecular Medicine Reports, 2021, v. 23, n. 2, p. N.PAG

By:

Zhang, Yong;
Zhang, Haibo;
Wang, Muqun;
Gao, Shan;
Hong, Lei;
Hou, Tingting;
Zhang, Yaoyao;
Zhu, Yuling;
Qian, Feng

Publication type:

Article

Shikonin inhibits CEBPD downregulation in IL-17-treated HaCaT cells and in an imiquimod-induced psoriasis model.

Published in:

Molecular Medicine Reports, 2020, v. 22, n. 3, p. 2263, doi. 10.3892/mmr.2020.11315

By:

Lan, Xiao-Ou;
Wang, He-Xiao;
Qi, Rui-Qun;
Xu, Yuan-Yuan;
Yu, Ya-Jie;
Yang, Yang;
Guo, Hao;
Gao, Xing-Hua;
Geng, Long

Publication type:

Article

Shikonin inhibits proliferation and induces apoptosis in glioma cells via downregulation of CD147.

Published in:

Molecular Medicine Reports, 2019, v. 19, n. 5, p. 4335

By:

Guo, Na;
Miao, Rui;
Gao, Xingchun;
Huang, Dong;
Hu, Zhifang;
Ji, Naichun;
Nan, Ying;
Jiang, Fengliang;
Gou, Xingchun

Publication type:

Article

Shikonin-mediated inhibition of nestin affects hypoxia-induced proliferation of pulmonary artery smooth muscle cells.

Published in:

Molecular Medicine Reports, 2018, v. 18, n. 3, p. 3476, doi. 10.3892/mmr.2018.9333

By:

He, Susu;
Lin, Jian;
Lin, Ling;
Xu, Youzu;
Feng, Jiaxi

Publication type:

Article

Shikonin suppresses proliferation and induces apoptosis in human leukemia NB4 cells through modulation of MAPKs and c‑Myc.

Published in:

Molecular Medicine Reports, 2017, v. 16, n. 3, p. 3055, doi. 10.3892/mmr.2017.6965

By:

ZHI‑LING SHAN;
LIANG ZHONG;
CHU‑LAN XIAO;
LIU‑GEN GAN;
TING XU;
HAO SONG;
RONG YANG;
LIU LI;
BEI‑ZHONG LIU

Publication type:

Article

Shikonin promotes adriamycin-induced apoptosis by upregulating caspase-3 and caspase-8 in osteosarcoma.

Published in:

Molecular Medicine Reports, 2017, v. 16, n. 2, p. 1347, doi. 10.3892/mmr.2017.6729

By:

QING YANG;
SUOYUAN LI;
ZEZE FU;
BINHUI LIN;
ZIFEI ZHOU;
ZHUOYING WANG;
YINGQI HUA;
ZHENGDONG CAI

Publication type:

Article

Shikonin stimulates MC3T3-E1 cell proliferation and differentiation via the BMP-2/Smad5 signal transduction pathway.

Published in:

Molecular Medicine Reports, 2016, v. 14, n. 2, p. 1269, doi. 10.3892/mmr.2016.5363

By:

TAO FANG;
QIANQIAN WU;
SHUAI MU;
LIYU YANG;
SHENGYE LIU;
QIN FU

Publication type:

Article

Apoptosis is induced by shikonin through the mitochondrial signaling pathway.

Published in:

Molecular Medicine Reports, 2016, v. 13, n. 4, p. 3668, doi. 10.3892/mmr.2016.4967

By:

XUXIA TANG;
CHEN ZHANG;
JIONGZHOU WEI;
YUTING FANG;
RONGXIANG ZHAO;
JIANXIN YU

Publication type:

Article

Shikonin induces apoptosis of HaCaT cells via the mitochondrial, Erk and Akt pathways.

Published in:

Molecular Medicine Reports, 2016, v. 13, n. 4, p. 3009, doi. 10.3892/mmr.2016.4917

By:

HUILING JING;
WENYAN SUN;
JINGHUA FAN;
YANMIN ZHANG;
JIAO YANG;
JINJING JIA;
JICHANG LI;
JIAQI GUO;
SUJU LUO;
YAN ZHENG

Publication type:

Article

Cbl participates in shikonin-induced apoptosis by negatively regulating phosphoinositide 3-kinase/protein kinase B signaling.

Published in:

Molecular Medicine Reports, 2015, v. 12, n. 1, p. 1305, doi. 10.3892/mmr.2015.3510

By:

DAN QU;
XIAO-MAN XU;
MENG ZHANG;
TING-SHU JIANG;
YI ZHANG;
SHENG-QI LI

Publication type:

Article

Structural Basis for the Inhibition of SARS-CoV-2 M pro D48N Mutant by Shikonin and PF-07321332.

Published in:

Viruses (1999-4915), 2024, v. 16, n. 1, p. 65, doi. 10.3390/v16010065

By:

Zhao, Zhenyu;
Zhu, Qinyao;
Zhou, Xuelan;
Li, Wenwen;
Yin, Xiushan;
Li, Jian

Publication type:

Article

Shikonin Controls the Differentiation of CD4<sup>+</sup>CD25<sup>+</sup> Regulatory T Cells by Inhibiting AKT/mTOR Pathway.

Published in:

Inflammation, 2019, v. 42, n. 4, p. 1215, doi. 10.1007/s10753-019-00982-7

By:

Zhang, Xiaolan;
Li, Jianping;
Yu, Yajie;
Lian, Peng;
Gao, Xinghua;
Xu, Yuanyuan;
Geng, Long

Publication type:

Article

Shikonin Inhibits Inflammatory Cytokine Production in Human Periodontal Ligament Cells.

Published in:

Inflammation, 2016, v. 39, n. 3, p. 1124, doi. 10.1007/s10753-016-0344-0

By:

Shindo, Satoru;
Hosokawa, Yoshitaka;
Hosokawa, Ikuko;
Ozaki, Kazumi;
Matsuo, Takashi

Publication type:

Article

A review on improving the sensitivity and color stability of naturally sourced pH‐sensitive indicator films.

Published in:

Comprehensive Reviews in Food Science & Food Safety, 2024, v. 23, n. 4, p. 1, doi. 10.1111/1541-4337.13390

By:

Guo, Chang;
Li, Ying;
Zhang, Hao;
Zhang, Quanyu;
Wu, Xiaodan;
Wang, Ying;
Sun, Fangda;
Shi, Shuo;
Xia, Xiufang

Publication type:

Article

Increased Growth Rate, Lignin, and Shikonin Levels in Onosma dichroantha Bioss. as Affected by Silicon Treatment.

Published in:

Journal of Agricultural Science & Technology, 2019, v. 21, n. 3, p. 671

By:

Koolabadi, Z.;
Najjar, M. B. Bagherieh;
Abdolzadeh, A.

Publication type:

Article

Shikonin Attenuates Concanavalin A-Induced Acute Liver Injury in Mice via Inhibition of the JNK Pathway.

Published in:

Mediators of Inflammation, 2016, p. 1, doi. 10.1155/2016/2748367

By:

Liu, Tong;
Xia, Yujing;
Li, Jingjing;
Li, Sainan;
Feng, Jiao;
Wu, Liwei;
Zhang, Rong;
Xu, Shizan;
Cheng, Keran;
Zhou, Yuqing;
Zhou, Shunfeng;
Dai, Weiqi;
Chen, Kan;
Wang, Fan;
Lu, Jie;
Zhou, Yingqun;
Guo, Chuanyong

Publication type:

Article

Rapid and sensitive determination of shikonin and its derivatives in the roots of Arnebia euchroma (Royle) Johnst using matrix solid-phase dispersion extraction and ultrahigh-performance liquid chromatography with photodiode array detector.

Published in:

Journal of Liquid Chromatography & Related Technologies, 2018, v. 41, n. 9, p. 489, doi. 10.1080/10826076.2018.1467836

By:

Zhang, Qi;
Cai, Defu;
Wang, Liang;
Yang, Xueting;
Fan, Songjie;
Zhang, Keyong

Publication type:

Article

Determination of Shikonin and Rosmarinic Acid in Echium vulgare L. and Echium russicum J.F. Gmel. by Capillary Electrophoresis.

Published in:

Journal of Liquid Chromatography & Related Technologies, 2015, v. 38, n. 6, p. 698, doi. 10.1080/10826076.2014.951767

By:

Dresler, Sławomir;
Kubrak, Tomasz;
Bogucka-Kocka, Anna;
Szymczak, Grażyna

Publication type:

Article

Shikonin Suppresses High Glucose-Induced Cardiomyocyte Damage by Down-Regulating circ_0000491.

Published in:

Indian Journal of Pharmaceutical Sciences, 2023, v. 85, n. 6, p. 1725, doi. 10.36468/pharmaceutical-sciences.1229

By:

LE ZHOU;
XIAOHONG GENG;
QIAN HU;
JIANI GU;
YI CHEN

Publication type:

Article

Shikonin Induces Oxidative Damage and Promotes Cell Senescence in Lung Cancer Cells through p53/p21WAF Signaling Pathway.

Published in:

Indian Journal of Pharmaceutical Sciences, 2022, v. 84, n. 4, p. 832, doi. 10.36468/pharmaceutical-sciences.978

By:

LIWEN RONG;
YUXIN HE;
MENGZHEN YUAN;
ZHENG, L.;
TINGTING ZHAN;
HUA LING;
JUN ZHANG

Publication type:

Article

Involvement of LeMDR, an ATP-binding cassette protein gene, in shikonin transport and biosynthesis in Lithospermum erythrorhizon.

Published in:

BMC Plant Biology, 2017, v. 17, p. 1, doi. 10.1186/s12870-017-1148-6

By:

Yu Zhu;
Gui-Hua Lu;
Zhuo-Wu Bian;
Feng-Yao Wu;
Yan-Jun Pang;
Xiao-Ming Wang;
Rong-Wu Yang;
Cheng-Yi Tang;
Jin-Liang Qi;
Yong-Hua Yang

Publication type:

Article

Transgenic studies reveal the positive role of LeEIL-1 in regulating shikonin biosynthesis in Lithospermum erythrorhizon hairy roots.

Published in:

BMC Plant Biology, 2016, v. 16, p. 1, doi. 10.1186/s12870-016-0812-6

By:

Rongjun Fang;
Ailan Zou;
Hua Zhao;
Fengyao Wu;
Yu Zhu;
Hu Zhao;
Yonghui Liao;
Ren-Jie Tang;
Yanjun Pang;
Rongwu Yang;
Xiaoming Wang;
Jinliang Qi;
Guihua Lu;
Yonghua Yang

Publication type:

Article

Shikonin promotes rat periodontal bone defect repair and osteogenic differentiation of BMSCs by p38 MAPK pathway.

Published in:

Odontology, 2023, v. 111, n. 3, p. 649, doi. 10.1007/s10266-022-00774-w

By:

Lin, Xiaoxin;
Wang, Yuxin;
Guo, Xiaoli;
Li, Chen;
Wu, Kuaifeng;
Wang, Siya;
Yu, Xijiao;
Du, Yi

Publication type:

Article

Optimization of shikonin production in Onosma dichroantha callus using response surface methodology.

Published in:

Plant Cell, Tissue & Organ Culture, 2016, v. 126, n. 3, p. 399, doi. 10.1007/s11240-016-1009-2

By:

Bagherieh-Najjar, Mohammad;
Nezamdoost, Tahereh

Publication type:

Article

Different secondary metabolic responses to MeJA treatment in shikonin-proficient and shikonin-deficient cell lines from Arnebia euchroma (Royle) Johnst.

Published in:

Plant Cell, Tissue & Organ Culture, 2014, v. 119, n. 3, p. 587, doi. 10.1007/s11240-014-0558-5

By:

Wang, Sheng;
Guo, Lan;
Xie, Teng;
Yang, Jian;
Tang, Jin;
Li, Xuan;
Wang, Xiao;
Huang, Lu

Publication type:

Article

Shikonin and its Esters from Buglossoides arvensis and Other Species of the Family Boraginaceae.

Published in:

Chemistry of Natural Compounds, 2020, v. 56, n. 4, p. 713, doi. 10.1007/s10600-020-03127-7

By:

Olennikov, D. N.;
Kruglov, D. S.;
Daironas, Zh. V.;
Zilfikarov, I. N.

Publication type:

Article

Shikonin and Rosmarinic-Acid Derivatives from Echium russicum Roots.

Published in:

Chemistry of Natural Compounds, 2017, v. 53, n. 5, p. 953, doi. 10.1007/s10600-017-2166-1

By:

Olennikov, D.;
Daironas, Zh.;
Zilfikarov, I.

Publication type:

Article

Effect of l-phenylalanine on PAL activity and production of naphthoquinone pigments in suspension cultures of Arnebia euchroma (Royle) Johnst.

Published in:

In Vitro Cellular & Developmental Biology Plant, 2012, v. 48, n. 5, p. 555, doi. 10.1007/s11627-012-9443-2

By:

Sykłowska-Baranek, Katarzyna;
Pietrosiuk, Agnieszka;
Naliwajski, Marcin;
Kawiak, Anna;
Jeziorek, Małgorzata;
Wyderska, Sylwia;
Łojkowska, Ewa;
Chinou, Ioanna

Publication type:

Article

紫草素纳米结构脂质载体制备与质量评价研究.

Published in:

Experimental Technology & Management, 2019, v. 36, n. 1, p. 96, doi. 10.16791/j.cnki.sjg.2019.01.023

By:

史凡;
杨红

Publication type:

Article

Induction of Ferroptosis by Shikonin in Gastric Cancer via the DLEU1/mTOR/GPX4 Axis.

Published in:

Cell Biology International, 2025, v. 49, n. 7, p. 757, doi. 10.1002/cbin.70018

By:

Wang, Yiying;
Xu, Midie;
Liu, Cheng;
Wang, Xin;
Zhang, Xiaoyan;
Sheng, Weiqi;
Wang, Xiaoyu

Publication type:

Article

Shikonin protects skin cells against oxidative stress and cellular dysfunction induced by fine particulate matter.

Published in:

Cell Biology International, 2024, v. 48, n. 12, p. 1836, doi. 10.1002/cbin.12233

By:

Shilnikova, Kristina;
Kang, Kyoung Ah;
Piao, Mei Jing;
Herath, Herath Mudiyanselage Udari Lakmini;
Fernando, Pincha Devage Sameera Madushan;
Boo, Hye‐Jin;
Yoon, Sang Pil;
Hyun, Jin Won

Publication type:

Article

Shikonin suppresses progression and epithelial–mesenchymal transition in hepatocellular carcinoma (HCC) cells by modulating miR‐106b/SMAD7/TGF‐β signaling pathway.

Published in:

Cell Biology International, 2020, v. 44, n. 2, p. 467, doi. 10.1002/cbin.11247

By:

Li, Xiaojing;
Zeng, Xianpeng

Publication type:

Article

Sterically stabilized liposomes as a potent carrier for shikonin.

Published in:

Journal of Liposome Research, 2014, v. 24, n. 3, p. 230, doi. 10.3109/08982104.2014.891233

By:

Kontogiannopoulos, K. N.;
Tsermentseli, S. K.;
Assimopoulou, A. N.;
Papageorgiou, V. P.

Publication type:

Article