Works matching DE "SHIKONIN"

Results: 278

Shikonin attenuates blood-brain barrier injury and oxidative stress in rats with subarachnoid hemorrhage by activating Sirt1/Nrf2/HO-1 signaling.

Published in:

Korean Journal of Physiology & Pharmacology, 2025, v. 29, n. 3, p. 283, doi. 10.4196/kjpp.24.182

By:

Guanghu Li;
Yang'e Yi;
Sheng Qian;
Xianping Xu;
Hao Min;
Jianpeng Wang;
Pan Guo;
Tingting Yu;
Zhiqiang Zhang

Publication type:

Article

Assessment of Skin Photoallergy Risk in Cosmetics Containing Herbal Extract Ingredients.

Published in:

Skin Pharmacology & Physiology, 2021, v. 34, n. 5, p. 253, doi. 10.1159/000515470

By:

Pan, Nannan;
Xia, Yue;
Hou, Wenyi;
Zhu, Gouxing;
Zhang, Jie;
Lai, Wei;
Zheng, Yue

Publication type:

Article

The inhibitory effects of shikonin and β,β-dimethylacrylshikonin on tramadol metabolism in vitro and in vivo.

Published in:

Journal of Pharmacy & Pharmacology, 2021, v. 73, n. 11, p. 1232, doi. 10.1111/jphp.13288

By:

Mi Jin;
Dawei Shi;
Hui Jin;
Ziye Zhou;
Chenxiang Wang

Publication type:

Article

Shikonin ameliorates experimental autoimmune encephalomyelitis (EAE) via immunomodulatory, anti‐apoptotic and antioxidative activity.

Published in:

Journal of Pharmacy & Pharmacology, 2020, v. 72, n. 12, p. 1970, doi. 10.1111/jphp.13364

By:

Nasrollahzadeh Sabet, Mehrdad;
Biglari, Sajjad;
Khorram Khorshid, Hamid Reza;
Esmaeilzadeh, Emran

Publication type:

Article

Shikonin inhibits the cell viability, adhesion, invasion and migration of the human gastric cancer cell line MGC-803 via the Toll-like receptor 2/nuclear factor-kappa B pathway.

Published in:

Journal of Pharmacy & Pharmacology, 2015, v. 67, n. 8, p. 1143, doi. 10.1111/jphp.12402

By:

Liu, Ji Ping;
Liu, Dan;
Gu, Jun Fei;
Zhu, Mao Mao;
Cui, Li

Publication type:

Article

Enhancement of NK cells proliferation and function by Shikonin.

Published in:

Immunopharmacology & Immunotoxicology, 2017, v. 39, n. 3, p. 124, doi. 10.1080/08923973.2017.1299174

By:

Li, Yan;
Lu, Hailin;
Gu, Yongchun;
Ning, Zhiqiang;
Cao, Tinghua;
Chen, Chao;
Hu, Chengru;
Tao, Min

Publication type:

Article

The effects of acetyl shikonin isolated from Onosma armeniacum on oxidative stress in ethanol-induced ulcer model of rats.

Published in:

Turkish Journal of Medical Sciences, 2013, v. 43, n. 2, p. 315, doi. 10.3906/sag-1203-89

By:

TOKER, Aysun;
AKÇAY, Fatih;
AKSOY, Hülya;
SÜLEYMAN, Halis;
ÖZGEN, Ufuk;
ERDEM, Havva

Publication type:

Article

Shikonin alleviates doxorubicin-induced cardiotoxicity via Mst1/Nrf2 pathway in mice.

Published in:

Scientific Reports, 2024, v. 14, n. 1, p. 1, doi. 10.1038/s41598-024-51675-7

By:

Tuo, Hu;
Li, Wenjing;
Zhao, Wei;
Zhao, Juan;
Li, Danni;
Jin, Lin

Publication type:

Article

The anti-leukemia activity and mechanisms of shikonin: a mini review.

Published in:

Frontiers in Pharmacology, 2023, p. 1, doi. 10.3389/fphar.2023.1271252

By:

Han Dong;
Chun-Di Chang;
Fei Gao;
Na Zhang;
Xing-Jian Yan;
Xue Wu;
Yue-Hui Wang

Publication type:

Article

Bacterial responses to plant antimicrobials: the case of alkannin and shikonin derivatives.

Published in:

Frontiers in Pharmacology, 2023, p. 1, doi. 10.3389/fphar.2023.1244270

By:

Rat, Angélique;
Koletti, Antigoni E.;
Rodić, Nebojša;
Papageorgiou, Vassilios P.;
Willems, Anne;
Assimopoulou, Andreana N.

Publication type:

Article

Emodin and shikonin (quinones): an overview of their chemistry, plant sources, pharmacology and cytotoxic activities against lung cancer.

Published in:

Journal of Chinese Pharmaceutical Sciences, 2020, v. 29, n. 1, p. 1, doi. 10.5246/jcps.2020.01.001

By:

Wei Chiang Chan, Eric;
Chen Wai Wong;
Siu Kuin Wong;
Yew Woh Hui;
Ban Lee Tan, Joash

Publication type:

Article

Shikonin enhances efficacy of a gene-based cancer vaccine via induction of RANTES.

Published in:: Journal of Biomedical Science, 2012, v. 19, n. 1, p. 42, doi. 10.1186/1423-0127-19-42
Publication type:: Article

Regulating lactate-related immunometabolism and EMT reversal for colorectal cancer liver metastases using shikonin targeted delivery.

Published in:

Journal of Experimental & Clinical Cancer Research (17569966), 2023, v. 42, n. 1, p. 1, doi. 10.1186/s13046-023-02688-z

By:

Long, Li;
Xiong, Wei;
Lin, Fenwang;
Hou, Jiazhen;
Chen, Guihua;
Peng, Taoxing;
He, Yihao;
Wang, Rui;
Xu, Qin;
Huang, Yongzhuo

Publication type:

Article

Protective Effect of Shikonin in Experimental Ischemic Stroke: Attenuated TLR4, p-p38MAPK, NF-κB, TNF-α and MMP-9 Expression, Up-Regulated Claudin-5 Expression, Ameliorated BBB Permeability.

Published in:

Neurochemical Research, 2014, v. 39, n. 1, p. 97, doi. 10.1007/s11064-013-1194-x

By:

Wang, Lina;
Li, Zhenzhong;
Zhang, Xiangjian;
Wang, Sheng;
Zhu, Chunhua;
Miao, Jiangyong;
Chen, Linyu;
Cui, Lili;
Qiao, Huimin

Publication type:

Article

Shikonin Protects Dopaminergic Cell Line PC12 Against 6-Hydroxydopamine-Mediated Neurotoxicity Via Both Glutathione-Dependent and Independent Pathways and by Inhibiting Apoptosis.

Published in:

Neurochemical Research, 2013, v. 38, n. 8, p. 1590, doi. 10.1007/s11064-013-1061-9

By:

Esmaeilzadeh, Emran;
Gardaneh, Mossa;
Gharib, Ehsan;
Sabouni, Farzaneh

Publication type:

Article

Effects of Shikonin on the Functions of Myeloid Dendritic Cells in a Mouse Model of Severe Aplastic Anemia.

Published in:

Mediators of Inflammation, 2020, p. 1, doi. 10.1155/2020/9025705

By:

Zheng, Mengying;
Liu, Bingnan;
Shao, Yuanyuan;
Hua, Luogang;
Fu, Rong;
Wang, Huaquan;
Wang, Ting;
Qi, Weiwei;
Shao, Zonghong;
Liu, Chunyan

Publication type:

Article

Reactive oxygen species enhance rAAV transduction by promoting its escape from late endosomes.

Published in:

Virology Journal, 2023, v. 20, n. 1, p. 1, doi. 10.1186/s12985-023-01964-w

By:

Huang, Xiaoping;
Wang, Xiao;
Ren, Yanxuan;
Gao, Pingzhang;
Xu, Wentao;
Xie, Xiaolan;
Diao, Yong

Publication type:

Article

Mechanisms Behind the Inhibition of Lung Adenocarcinoma Cell by Shikonin.

Published in:

Cell Biochemistry & Biophysics, 2014, v. 70, n. 2, p. 1459, doi. 10.1007/s12013-014-0083-5

By:

Lan, Wenjing;
Wan, Shengbang;
Gu, Weiqing;
Wang, Heyong;
Zhou, Songwen

Publication type:

Article

MrgX2-SNAP-tag/cell membrane chromatography model coupled with liquid chromatography-mass spectrometry for anti-pseudo-allergic compound screening in Arnebiae Radix.

Published in:

Analytical & Bioanalytical Chemistry, 2022, v. 414, n. 19, p. 5741, doi. 10.1007/s00216-022-04167-4

By:

Jia, Qianqian;
Fu, Jia;
Gao, Chunlei;
Wang, Hong;
Wang, Saisai;
Liang, Peida;
Han, Shengli;
Lv, Yanni;
He, Langchong

Publication type:

Article

Shikonin potentiates therapeutic efficacy of oxaliplatin through reactive oxygen species‐mediated intrinsic apoptosis and endoplasmic reticulum stress in oxaliplatin‐resistant colorectal cancer cells.

Published in:

Drug Development Research, 2023, v. 84, n. 3, p. 542, doi. 10.1002/ddr.22044

By:

Zhang, Zhengguang;
Shen, Cunsi;
Zhou, Fuqiong;
Zhang, Yajie

Publication type:

Article

Shikonin attenuates kidney tubular epithelial cells apoptosis, oxidative stress, and inflammatory response through nicotinamide adenine dinucleotide phosphate oxidase 4/PTEN pathway in acute kidney injury of sepsis model.

Published in:

Drug Development Research, 2022, v. 83, n. 5, p. 1111, doi. 10.1002/ddr.21936

By:

Peng, Yanqin;
Li, Yuan;
Li, Hao;
Yu, Junhua

Publication type:

Article

Correction: Li et al. Shikonin Attenuates Acetaminophen-Induced Hepatotoxicity by Upregulation of Nrf2 through Akt/GSK3β Signaling. Molecules 2019, 24 , 110.

Published in:

2023

By:

Li, Huachao;
Chen, Yueming;
Zhang, Jiahao;
Chen, Xiangcui;
Li, Zheng;
Liu, Bing;
Zhang, Luyong

Publication type:

Correction Notice

Shikonin as a WT1 Inhibitor Promotes Promyeloid Leukemia Cell Differentiation.

Published in:

Molecules, 2022, v. 27, n. 23, p. 8264, doi. 10.3390/molecules27238264

By:

Guo, Zhenzhen;
Sun, Luyao;
Xia, Haojie;
Tian, Shibin;
Liu, Mengyue;
Hou, Jiejie;
Li, Jiahuan;
Lin, Haihong;
Du, Gangjun

Publication type:

Article

Natural Compound Shikonin Is a Novel PAK1 Inhibitor and Enhances Efficacy of Chemotherapy against Pancreatic Cancer Cells.

Published in:

Molecules, 2022, v. 27, n. 9, p. 2747, doi. 10.3390/molecules27092747

By:

Ji, Wenjing;
Sun, Xiaoyan;
Gao, Yang;
Lu, Man;
Zhu, Lingxia;
Wang, Dawei;
Hu, Chunping;
Chen, Jiao;
Cao, Peng

Publication type:

Article

Assessment of Antidiabetic Activity of the Shikonin by Allosteric Inhibition of Protein-Tyrosine Phosphatase 1B (PTP1B) Using State of Art: An In Silico and In Vitro Tactics.

Published in:

Molecules, 2021, v. 26, n. 13, p. 3996, doi. 10.3390/molecules26133996

By:

Saeed, Mohd;
Shoaib, Ambreen;
Tasleem, Munazzah;
Alabdallah, Nadiyah M.;
Alam, Md Jahoor;
Asmar, Zeina El;
Jamal, Qazi Mohammad Sajid;
Bardakci, Fevzi;
Alqahtani, Saad S.;
Ansari, Irfan Ahmad;
Badraoui, Riadh

Publication type:

Article

Biological Effects of Shikonin in Human Gingival Fibroblasts via ERK 1/2 Signaling Pathway.

Published in:

Molecules, 2019, v. 24, n. 19, p. 3542, doi. 10.3390/molecules24193542

By:

Imai, Kazutaka;
Kato, Hirohito;
Taguchi, Yoichiro;
Umeda, Makoto

Publication type:

Article

Shikonin Attenuates Acetaminophen-Induced Hepatotoxicity by Upregulation of Nrf2 through Akt/GSK3β Signaling.

Published in:

Molecules, 2019, v. 24, n. 1, p. 110, doi. 10.3390/molecules24010110

By:

Li, Huachao;
Chen, Yueming;
Zhang, Jiahao;
Chen, Xiangcui;
Li, Zheng;
Liu, Bing;
Zhang, Luyong

Publication type:

Article

Synthesis of Novel Shikonin Derivatives and Pharmacological Effects of Cyclopropylacetylshikonin on Melanoma Cells.

Published in:

Molecules, 2018, v. 23, n. 11, p. 2820, doi. 10.3390/molecules23112820

By:

Durchschein, Christin;
Hufner, Antje;
Rinner, Beate;
Stallinger, Alexander;
Deutsch, Alexander;
Lohberger, Birgit;
Bauer, Rudolf;
Kretschmer, Nadine

Publication type:

Article

Anticancer Efficacy of Targeted Shikonin Liposomes Modified with RGD in Breast Cancer Cells.

Published in:

Molecules, 2018, v. 23, n. 2, p. 268, doi. 10.3390/molecules23020268

By:

Wen, Xianchun;
Li, Jiping;
Cai, Defu;
Yue, Liling;
Wang, Qi;
Zhou, Li;
Fan, Li;
Sun, Jianwen;
Wu, Yonghui

Publication type:

Article

Use of Ultrasonication Technology for the Increased Production of Plant Secondary Metabolites.

Published in:

Molecules, 2017, v. 22, n. 7, p. 1046, doi. 10.3390/molecules22071046

By:

Hasan, Md. Mohidul;
Bashir, Tufail;
Hanhong Bae

Publication type:

Article

Metabolic Profiling and Identification of Shikonins in Root Periderm of Two Invasive Echium spp. Weeds in Australia.

Published in:

Molecules, 2017, v. 22, n. 2, p. 330, doi. 10.3390/molecules22020330

By:

Skoneczny, Dominik;
Weston, Paul A.;
Xiaocheng Zhu;
Gurr, Geoff M.;
Callaway, Ragan M.;
Barrow, Russel A.;
Weston, Leslie A.

Publication type:

Article

Shikonin Inhibits the Proliferation of Human Lens Epithelial Cells by Inducing Apoptosis through ROS and Caspase-Dependent Pathway.

Published in:

Molecules, 2014, v. 19, n. 6, p. 7785, doi. 10.3390/molecules19067785

By:

Wan-Rong Huang;
Yue Zhang;
Xin Tang

Publication type:

Article

Optimization of Shikonin Homogenate Extraction from Arnebia euchroma Using Response Surface Methodology.

Published in:

Molecules, 2013, v. 18, n. 1, p. 466, doi. 10.3390/molecules18010466

By:

Tingting Liu;
Chunhui Ma;
Lei Yang;
Wenjie Wang;
Xiaoyu Sui;
Chunjian Zhao;
Yuangang Zu

Publication type:

Article

紫草素提取工艺及应用研究.

Published in:

Feed Research, 2022, v. 45, n. 17, p. 147, doi. 10.13557/j.cnki.issn1002-2813.2022.17.032

By:

巨婷婷;
李小东;
刘蕊娜;
张煜;
李刚刚;
效碧亮

Publication type:

Article

Sterically stabilized liposomes as a potent carrier for shikonin.

Published in:

Journal of Liposome Research, 2014, v. 24, n. 3, p. 230, doi. 10.3109/08982104.2014.891233

By:

Kontogiannopoulos, K. N.;
Tsermentseli, S. K.;
Assimopoulou, A. N.;
Papageorgiou, V. P.

Publication type:

Article

Echium plantagineum L. hairy root cultures for the production of anticancer shikonin derivatives.

Published in:

Biotechnologia, 2018, v. 99, n. 3, p. 321

By:

JEZIOREK, MAŁGORZATA;
MAZUR, PAULINA;
GÜRCÜ, SELIN;
KASZTELAN, ADRIAN;
SYKŁOWSKA-BARANEK, KATARZYNA;
PIETROSIUK, AGNIESZKA

Publication type:

Article

紫草素对四氯化碳诱导的肝纤维化大鼠TGF-β1的影响.

Published in:

Journal of Pharmaceutical Practice & Service, 2018, v. 36, n. 5, p. 453, doi. 10.3969/j.issn.1006-0111.2018.05.016

By:

鲁明霞;
王红岗;
胡仁标

Publication type:

Article

Shikonin inhibits ER stress in vascular endothelial cells, when induced by H<sub>2</sub> O<sub>2</sub>, and promotes vascular regeneration.

Published in:

ScienceAsia, 2023, v. 49, n. 4, p. 497, doi. 10.2306/scienceasia1513-1874.2023.041

By:

Lili Guo;
Yinling Li;
Shuang Wen;
Wen jun Liu;
Lei Yang;
Yu Wan;
Jia xin Liu;
Wen e Zhao;
Shu-Wei Li

Publication type:

Article

Differential microbial assemblages associated with shikonin-producing Borage species in two distinct soil types.

Published in:

Scientific Reports, 2021, v. 11, n. 1, p. 1, doi. 10.1038/s41598-021-90251-1

By:

Fazal, Aliya;
Yang, Minkai;
Wen, Zhongling;
Ali, Farman;
Ren, Ran;
Hao, Chenyu;
Chen, Xingyu;
Fu, Jiangyan;
Wang, Xuan;
Jie, Wencai;
Yin, Tongming;
Lu, Guihua;
Qi, Jinliang;
Yang, Yonghua

Publication type:

Article

Integrated proteomics and metabolomics reveals the comprehensive characterization of antitumor mechanism underlying Shikonin on colon cancer patient-derived xenograft model.

Published in:

Scientific Reports, 2020, v. 10, n. 1, p. N.PAG, doi. 10.1038/s41598-020-71116-5

By:

Chen, Yang;
Ni, Juan;
Gao, Yun;
Zhang, Jinghui;
Liu, Xuesong;
Chen, Yong;
Chen, Zhongjian;
Wu, Yongjiang

Publication type:

Article

Apple latent spherical virus (ALSV)-induced gene silencing in a medicinal plant, Lithospermum erythrorhizon.

Published in:

Scientific Reports, 2020, v. 10, n. 1, p. 1, doi. 10.1038/s41598-020-70469-1

By:

Izuishi, Yuki;
Isaka, Natsumi;
Li, Hao;
Nakanishi, Kohei;
Kageyama, Joji;
Ishikawa, Kazuya;
Shimada, Tomoo;
Masuta, Chikara;
Yoshikawa, Nobuyuki;
Kusano, Hiroaki;
Yazaki, Kazufumi

Publication type:

Article

Shikonin induces ferroptosis in multiple myeloma via GOT1-mediated ferritinophagy.

Published in:

Frontiers in Oncology, 2022, v. 12, p. 1, doi. 10.3389/fonc.2022.1025067

By:

Wenxia Li;
Hangjie Fu;
Liuyuan Fang;
Hui Chai;
Tianwen Gao;
Zhenzhen Chen;
Shenxian Qian

Publication type:

Article

Shikonin ameliorates oxidative stress and neuroinflammation via the Akt/ERK/JNK/NF‐κB signalling pathways in a model of Parkinson's disease.

Published in:

Clinical & Experimental Pharmacology & Physiology, 2022, v. 49, n. 11, p. 1221, doi. 10.1111/1440-1681.13709

By:

Guo, Lei;
Li, Yuanyuan;
Li, Wenna;
Qiu, Jiaoxue;
Du, Juan;
Wang, Lingling;
Zhang, Ting

Publication type:

Article

Shikonin Exerts an Antileukemia Effect against FLT3-ITD Mutated Acute Myeloid Leukemia Cells via Targeting FLT3 and Its Downstream Pathways.

Published in:

Acta Haematologica, 2024, v. 147, n. 3, p. 310, doi. 10.1159/000534101

By:

Zhao, Mu-Nan;
Su, Long;
Song, Fei;
Wei, Zhi-Feng;
Qin, Tian-Xue;
Zhang, Yun-Wei;
Li, Wei;
Gao, Su-Jun

Publication type:

Article

Onosma L.: A review of phytochemistry and ethnopharmacology.

Published in:

Pharmacognosy Reviews, 2013, v. 7, n. 14, p. 140, doi. 10.4103/0973-7847.120513

By:

Kumar, Neeraj;
Kumar, Rajnish;
Kishore1, Kamal

Publication type:

Article

The Anti-tumor Function of Shikonin by Targeting EGFR/AKT/mTOR Signaling in Human Osteosarcoma Cells.

Published in:

Pharmacognosy Magazine, 2024, v. 20, n. 2, p. 553, doi. 10.1177/09731296231215938

By:

Zhu, Rui-Dan;
Zhang, Jia-Jia;
Yao, Xiao-Bin;
Wang, Zhang-Jiao;
Du, Zhi-Ling;
Xu, Qing-Xia

Publication type:

Article

Anti-cancer effect shikonin on ferric nitrilotriacetate-induced renal cancer rats apoptosis mediating PEG2/NF-κB signaling pathway.

Published in:

Pharmacognosy Magazine, 2022, v. 18, n. 80, p. 1170, doi. 10.4103/pm.pm_517_21

By:

Wang, Dong;
Lu, Yahong;
Meng, Wenjing;
Shu, Tao;
Yang, Zengyue

Publication type:

Article

Shikonin induces apoptosis in the human gastric cancer cells HGC-27 through mitochondria-mediated pathway.

Published in:

Pharmacognosy Magazine, 2015, v. 11, n. 42, p. 250, doi. 10.4103/0973-1296.153074

By:

Yue Hou;
Jinghua Xu;
Xia Liu;
Xichun Xia;
Ning Li;
Xiuli Bi

Publication type:

Article

Shikonin-enhanced cell immunogenicity of tumor vaccine is mediated by the differential effects of DAMP components.

Published in:

Molecular Cancer, 2015, v. 14, n. 1, p. 1, doi. 10.1186/s12943-015-0435-9

By:

Tien-Jen Lin;
Hsin-Ting Lin;
Wei-Ting Chang;
Mitapalli, Pradeep S.;
Pei-Wen Hsiao;
Shu-Yi Yin;
Ning-Sun Yang

Publication type:

Article

Shikonin derivatives as potent xanthine oxidase inhibitors: in-vitro study.

Published in:

Natural Product Research, 2023, v. 37, n. 16, p. 2795, doi. 10.1080/14786419.2022.2132499

By:

Kumar, Nitish;
Rajput, Ankita;
Kaur, Harmandeep;
Sharma, Anchal;
Bhagat, Kavita;
Singh, Jatinder Vir;
Arora, Saroj;
Bedi, Preet Mohinder Singh

Publication type:

Article