Works about SECRETASES

Results: 311

Capillary electrophoresis integrated immobilized enzyme reactor for kinetic and inhibition assays of β‐secretase as the Alzheimer's disease drug target.

Published in:

Journal of Separation Science, 2019, v. 42, n. 5, p. 1067, doi. 10.1002/jssc.201800947

By:

Schejbal, Jan;
Šefraná, Šárka;
Řemínek, Roman;
Glatz, Zdeněk

Publication type:

Article

Gamma-secretase subunits associate in intracellular membrane compartments in Arabidopsis thaliana.

Published in:

Journal of Experimental Botany, 2014, v. 65, n. 12, p. 1, doi. 10.1093/jxb/eru147

By:

Smolarkiewicz, Michalina;
Skrzypczak, Tomasz;
Michalak, Michał;
Leśniewicz, Krzysztof;
Walker, J. Ross;
Ingram, Gwyneth;
Wojtaszek, Przemysław

Publication type:

Article

MicroRNA‑125b regulates Alzheimer's disease through SphK1 regulation.

Published in:

Molecular Medicine Reports, 2018, v. 18, n. 2, p. 2373, doi. 10.3892/mmr.2018.9156

By:

Jin, Yan;
Tu, Qiuyun;
Liu, Min

Publication type:

Article

Molecular cloning and characterization of presenilin gene in Bombyx mori.

Published in:

Molecular Medicine Reports, 2015, v. 12, n. 4, p. 5508, doi. 10.3892/mmr.2015.4019

By:

ZENG-ZHANG ZHENG;
MENG-LING CHAO;
ZONG-BIAO FAN;
YI-JIAO ZHAO;
HONG-SHENG SONG

Publication type:

Article

Attenuated ability of BACE1 to cleave the amyloid precursor protein via silencing long noncoding RNA BACE1-AS expression.

Published in:

Molecular Medicine Reports, 2014, v. 10, n. 3, p. 1275, doi. 10.3892/mmr.2014.2351

By:

TE LIU;
YONGYI HUANG;
JIULIN CHEN;
HUIYING CHI;
ZHIHUA YU;
JIAN WANG;
CHUAN CHEN

Publication type:

Article

β-Secretases, Alzheimer's Disease, and Down Syndrome.

Published in:

Current Gerontology & Geratrics Research, 2012, p. 1, doi. 10.1155/2012/362839

By:

Webb, Robin L.;
Paul Murphy, M.

Publication type:

Article

Activation of γ-Secretase Trimming Activity by Topological Changes of Transmembrane Domain 1 of Presenilin 1.

Published in:

Journal of Neuroscience, 2017, v. 37, n. 50, p. 12272, doi. 10.1523/JNEUROSCI.1628-17.2017

By:

Tetsuo Cai;
Masahiro Yonaga;
Taisuke Tomita

Publication type:

Article

SNX27 Deletion Causes Hydrocephalus by Impairing Ependymal Cell Differentiation and Ciliogenesis.

Published in:

Journal of Neuroscience, 2016, v. 36, n. 50, p. 12586, doi. 10.1523/JNEUROSCI.1620-16.2016

By:

Xin Wang;
Ying Zhou;
Jian Wang;
I-Chu Tseng;
Huang, Timothy;
Yingjun Zhao;
Qiuyang Zheng;
Yue Gao;
Hong Luo;
Xian Zhang;
Guojun Bu;
Wanjin Hong;
Huaxi Xu

Publication type:

Article

Conformational Changes in Transmembrane Domain 4 of Presenilin 1 Are Associated with Altered Amyloid-β 42 Production.

Published in:

Journal of Neuroscience, 2016, v. 36, n. 4, p. 1362, doi. 10.1523/JNEUROSCI.5090-14.2016

By:

Aya Tominaga;
Tetsuo Cai;
Shizuka Takagi-Niidome;
Takeshi Iwatsubo;
Taisuke Tomita

Publication type:

Article

Knock-In of Human BACE1 Cleaves Murine APP and Reiterates Alzheimer-like Phenotypes.

Published in:

Journal of Neuroscience, 2014, v. 34, n. 32, p. 10710, doi. 10.1523/JNEUROSCI.0433-14.2014

By:

Plucinska, Kaja;
Crouch, Barry;
Koss, David;
Robinson, Lianne;
Siebrecht, Michael;
Riedel, Gernot;
Platt, Bettina

Publication type:

Article

Proximity ligation assay reveals both pre- and postsynaptic localization of the APP-processing enzymes ADAM10 and BACE1 in rat and human adult brain.

Published in:

2020

By:

Lundgren, Jolanta L.;
Vandermeulen, Lina;
Sandebring-Matton, Anna;
Ahmed, Saheeb;
Winblad, Bengt;
Di Luca, Monica;
Tjernberg, Lars O.;
Marcello, Elena;
Frykman, Susanne

Publication type:

journal article

Astrocytes infected with Chlamydia pneumoniae demonstrate altered expression and activity of secretases involved in the generation of β-amyloid found in Alzheimer disease.

Published in:

2019

By:

Al-Atrache, Zein;
Lopez, Danielle B.;
Hingley, Susan T.;
Appelt, Denah M.

Publication type:

journal article

β-Secretase inhibition by C-methylisoflavones from Abronia nana.

Published in:

Natural Product Research, 2019, v. 33, n. 12, p. 1705, doi. 10.1080/14786419.2018.1431637

By:

Yang, Eun-Ju;
Lee, Taeho;
Song, Kyung-Sik

Publication type:

Article

The Nogo-66 receptor family in the intact and diseased CNS.

Published in:

Cell & Tissue Research, 2012, v. 349, n. 1, p. 105, doi. 10.1007/s00441-012-1332-9

By:

Borrie, Sarah;
Baeumer, Bastian;
Bandtlow, Christine

Publication type:

Article

The effects and interactions of APOE and APH-1A polymorphisms in Alzheimer disease.

Published in:

Turkish Journal of Medical Sciences, 2015, v. 45, n. 5, p. 1098, doi. 10.3906/sag-1407-19

By:

ACAR ÇİNLETİ, Burcu;
YARDIMCI, Nilgül;
AYTÜRK, Zübeyde;
İLHAN, Atilla;
KAYA, Gülhan;
ACAR, Muradiye;
KOÇ, Emine Rabia;
GÜNDÜZ, Esra;
GÜNDÜZ, Mehmet

Publication type:

Article

Expression analysis of beta-secretase 1 (BACE1) and its naturally occurring antisense (BACE1-AS) in blood of epileptic patients.

Published in:

2018

By:

Mazdeh, Mehrdokht;
Komaki, Alireza;
Omrani, Mir Davood;
Gharzi, Vajihe;
Sayad, Arezou;
Taheri, Mohammad;
Ghafouri-Fard, Soudeh

Publication type:

journal article

Hydrogen Sulfide Chemistry in Continuous Flow: Efficient Synthesis of 2-Oxopropanethioamide.

Published in:

Journal of Flow Chemistry, 2017, v. 7, n. 2, p. 29, doi. 10.1556/1846.2017.00006

By:

Cantillo, David;
Inglesby, Phillip A.;
Boyd, Alistair;
Kappe, C. Oliver

Publication type:

Article

Knockdown of BACE1-AS by siRNA improves memory and learning behaviors in Alzheimer's disease animal model.

Published in:

Experimental & Therapeutic Medicine, 2018, v. 16, n. 3, p. 2080, doi. 10.3892/etm.2018.6359

By:

Zhang, Wenting;
Zhao, Hao;
Wu, Qian;
Xu, Wenan;
Xia, Minwu

Publication type:

Article

Suppression of the amyloidogenic metabolism of APP and the accumulation of Aβ by alcadein α in the brain during aging.

Published in:

Scientific Reports, 2024, v. 14, n. 1, p. 1, doi. 10.1038/s41598-024-69400-9

By:

Honda, Keiko;
Takahashi, Hiroo;
Hata, Saori;
Abe, Ruriko;
Saito, Takashi;
Saido, Takaomi C.;
Taru, Hidenori;
Sobu, Yuriko;
Ando, Kanae;
Yamamoto, Tohru;
Suzuki, Toshiharu

Publication type:

Article

Alpha-Secretase ADAM10 Regulation: Insights into Alzheimer's Disease Treatment.

Published in:

Pharmaceuticals (14248247), 2018, v. 11, n. 1, p. 12, doi. 10.3390/ph11010012

By:

Peron, Rafaela;
Vatanabe, Izabela Pereira;
Manzine, Patricia Regina;
Camins, Antoni;
Cominetti, Márcia Regina

Publication type:

Article

Cancer and Alzheimer's disease: common starters, different roads.

Published in:

Cancer Therapy, 2011, v. 8, p. 118

By:

Israël, Maurice

Publication type:

Article

Retrospective molecular docking study of WY-25105 ligand to β-secretase and bias of the three-dimensional structure flexibility.

Published in:

Journal of Molecular Modeling, 2013, v. 19, n. 8, p. 2971, doi. 10.1007/s00894-013-1821-0

By:

Ghemtio, Leo;
Muzet, Nicolas

Publication type:

Article

Developing consensus 3D-QSAR and pharmacophore models for several beta-secretase, farnesyl transferase and histone deacetylase inhibitors.

Published in:

Journal of Molecular Modeling, 2012, v. 18, n. 2, p. 675, doi. 10.1007/s00894-011-1094-4

By:

Wei, Hsin-Yuan;
Chen, Guan-Ju;
Chen, Chih-Lun;
Lin, Thy-Hou

Publication type:

Article

Calsenilin Contributes to Neuronal Cell Death in Ischemic Stroke.

Published in:

Brain Pathology, 2013, v. 23, n. 4, p. 402, doi. 10.1111/bpa.12013

By:

Park, Jong‐Sung;
Manzanero, Silvia;
Chang, Jae‐Woong;
Choi, Yuri;
Baik, Sang‐Ha;
Cheng, Yi‐Lin;
Li, Yu‐I;
Gwon, A‐Ryeong;
Woo, Ha‐Na;
Jang, Jiyeon;
Choi, In‐Young;
Lee, Joo‐Yong;
Jung, Yong‐Keun;
Tang, Sung‐Chun;
Sobey, Christopher G.;
Arumugam, Thiruma V.;
Jo, Dong‐Gyu

Publication type:

Article

Involvement of the γ-Secretase-Mediated EphA4 Signaling Pathway in Synaptic Pathogenesis of Alzheimer's Disease.

Published in:

Brain Pathology, 2012, v. 22, n. 6, p. 776, doi. 10.1111/j.1750-3639.2012.00587.x

By:

Matsui, Chiyuki;
Inoue, Eiji;
Kakita, Akiyoshi;
Arita, Kohei;
Deguchi-Tawarada, Maki;
Togawa, Aki;
Yamada, Akio;
Takai, Yoshimi;
Takahashi, Hitoshi

Publication type:

Article

Overexpression of SNX3 Decreases Amyloid-β Peptide Production by Reducing Internalization of Amyloid Precursor Protein.

Published in:

Neurodegenerative Diseases, 2018, v. 18, n. 1, p. 26, doi. 10.1159/000486199

By:

Xu, Shaohua;
Nigam, Saket M.;
Brodin, Lennart

Publication type:

Article

Frontal Cortex and Hippocampal γ-Secretase Activating Protein Levels in Prodromal Alzheimer Disease.

Published in:

Neurodegenerative Diseases, 2017, v. 17, n. 6, p. 235, doi. 10.1159/000477937

By:

Perez, Sylvia E.;
Nadeem, Muhammad;
Malek-ahmadi, Michael H.;
He, Bin;
Mufson, Elliott J.

Publication type:

Article

The Effect of Aβ1-42 Oligomers on APP Processing and Aβ1-40 Generation in Cultured U-373 Astrocytes.

Published in:

Neurodegenerative Diseases, 2015, v. 15, n. 6, p. 361, doi. 10.1159/000438923

By:

Ourdev, Dimitar;
Foroutanpay, Bahram V.;
Wang, Yanlin;
Kar, Satyabrata

Publication type:

Article

Function and Dysfunction of Presenilin.

Published in:

Neurodegenerative Diseases, 2014, v. 13, n. 2/3, p. 61, doi. 10.1159/000354971

By:

Shen, Jie

Publication type:

Article

ADAM10 in Synaptic Physiology and Pathology.

Published in:

Neurodegenerative Diseases, 2014, v. 13, n. 2/3, p. 72, doi. 10.1159/000354233

By:

Musardo, Stefano;
Marcello, Elena;
Gardoni, Fabrizio;
Di Luca, Monica

Publication type:

Article

α-Secretase-Derived Cleavage of Cellular Prion Yields Biologically Active Catabolites with Distinct Functions.

Published in:

Neurodegenerative Diseases, 2012, v. 10, n. 1-4, p. 294, doi. 10.1159/000333804

By:

Guillot-Sestier, M.-V.;
Checler, F.

Publication type:

Article

Substrate processing in intramembrane proteolysis by γ-secretase - the role of protein dynamics.

Published in:

Biological Chemistry, 2017, v. 398, n. 4, p. 441, doi. 10.1515/hsz-2016-0269

By:

Langosch, Dieter;
Steiner, Harald

Publication type:

Article

Membrane trafficking and proteolytic activity of γ-secretase in Alzheimer's disease.

Published in:

Biological Chemistry, 2016, v. 397, n. 9, p. 827, doi. 10.1515/hsz-2016-0146

By:

Kanatsu, Kunihiko;
Tomita, Taisuke

Publication type:

Article

Processive proteolysis by γ-secretase and the mechanism of Alzheimer's disease.

Published in:

Biological Chemistry, 2012, v. 393, n. 9, p. 899, doi. 10.1515/hsz-2012-0140

By:

Wolfe, Michael S.

Publication type:

Article

Tmem27 dimerization, deglycosylation, plasma membrane depletion, and the extracellular Phe-Phe motif are negative regulators of cleavage by Bace2.

Published in:

Biological Chemistry, 2012, v. 393, n. 6, p. 473, doi. 10.1515/hsz-2012-0104

By:

Esterházy, Daria;
Akpinar, Pinar;
Stoffel, Markus

Publication type:

Article

Characterization of β-secretase inhibitory peptide purified from skate skin protein hydrolysate.

Published in:

European Food Research & Technology, 2015, v. 240, n. 1, p. 129, doi. 10.1007/s00217-014-2314-9

By:

Lee, Jung;
Li-Chan, Eunice;
Byun, Hee-Guk

Publication type:

Article

Genetic Association Between APP, ADAM10 Gene Polymorphism, and Sporadic Alzheimer's Disease in the Chinese Population.

Published in:

Neurotoxicity Research, 2015, v. 27, n. 3, p. 284, doi. 10.1007/s12640-015-9516-1

By:

Zeng, Fan;
Shen, Cheng;
Liu, Yu-Hui;
Li, Jing;
Zhu, Jie;
Wang, Ye-Ran;
Yan, Jia-Chuan;
Gao, Chang-Yue;
Zhou, Hua-Dong;
Deng, Juan;
Wang, Yan-Jiang

Publication type:

Article

Amyloid-β Production: Major Link Between Oxidative Stress and BACE1.

Published in:

Neurotoxicity Research, 2012, v. 22, n. 3, p. 208, doi. 10.1007/s12640-011-9283-6

By:

Tamagno, Elena;
Guglielmotto, Michela;
Monteleone, Debora;
Tabaton, Massimo

Publication type:

Article

Biological and computational evaluation of resveratrol inhibitors against Alzheimer’s disease.

Published in:

Journal of Enzyme Inhibition & Medicinal Chemistry, 2016, v. 31, n. 1, p. 67, doi. 10.3109/14756366.2014.1003928

By:

Koukoulitsa, Catherine;
Villalonga-Barber, Caroline;
Csonka, Robert;
Alexi, Xanthippi;
Leonis, Georgios;
Dellis, Dimitris;
Hamelink, Elizabeth;
Belda, Oscar;
Steele, Barry R.;
Micha-Screttas, Maria;
Alexis, Michael N.;
Papadopoulos, Manthos G.;
Mavromoustakos, Thomas

Publication type:

Article

The standardized Centella asiatica extract ECa 233 regulates the catalytic activities of βAPP-cleaving secretases in human cell lines.

Published in:

ScienceAsia, 2023, v. 49, n. 2, p. 256, doi. 10.2306/scienceasia1513-1874.2023.014

By:

Protha, Mehbuba Nur;
Therathep Srisutjarit;
Arpita Dey;
Maitra, Subhamita;
Hernandez, Jean-Francois;
Tantisira, Mayuree H.;
Yingrak Boondam;
Narawut Pakaprot;
Vincent, Bruno

Publication type:

Article

Targeting γ-secretase in breast cancer.

Published in:

Breast Cancer: Targets & Therapy, 2012, v. 4, p. 83, doi. 10.2147/BCTT.S26437

By:

Jianxun Han;
Qiang Shen

Publication type:

Article

BACE1 Inhibition Using 2'-OMePS Steric Blocking Antisense Oligonucleotides.

Published in:

Genes, 2019, v. 10, n. 9, p. 705, doi. 10.3390/genes10090705

By:

Chakravarthy, Madhuri;
Veedu, Rakesh N

Publication type:

Article

Nanoscale organization of Nicastrin, the substrate receptor of the γ-secretase complex, as independent molecular domains.

Published in:

Molecular Brain, 2021, v. 14, n. 1, p. 1, doi. 10.1186/s13041-021-00855-x

By:

Kedia, Shekhar;
Mandal, Kousik;
Netrakanti, Pallavi Rao;
Jose, Mini;
Sisodia, Sangram S.;
Nair, Deepak

Publication type:

Article

Correction: An Anti-Parkinson's Disease Drug via Targeting Adenosine A2A Receptor Enhances Amyloid-β Generation and γ-Secretase Activity.

Published in:

2017

By:

null, null

Publication type:

Correction Notice

The Polyherbal Wattana Formula Displays Anti-Amyloidogenic Properties by Increasing α-Secretase Activities.

Published in:

PLoS ONE, 2017, v. 12, n. 1, p. 1, doi. 10.1371/journal.pone.0170360

By:

Htoo, Htut Htut;
Limsuvan, Suveerawan;
Thamsermsang, Onusa;
Hernandez, Jean-François;
Checler, Frédéric;
Govitrapong, Piyarat;
Pakaprot, Narawut;
Akarasereenont, Pravit;
Vincent, Bruno

Publication type:

Article

Acute and Chronic Sustained Hypoxia Do Not Substantially Regulate Amyloid-β Peptide Generation In Vivo.

Published in:

PLoS ONE, 2017, v. 12, n. 1, p. 1, doi. 10.1371/journal.pone.0170345

By:

Serrano-Pozo, Alberto;
Sánchez-García, Manuel A.;
Heras-Garvín, Antonio;
March-Díaz, Rosana;
Navarro, Victoria;
Vizuete, Marisa;
López-Barneo, José;
Vitorica, Javier;
Pascual, Alberto

Publication type:

Article

Inhibition of Notch Signaling Attenuates Schistosomiasis Hepatic Fibrosis via Blocking Macrophage M2 Polarization.

Published in:

PLoS ONE, 2016, v. 11, n. 11, p. 1, doi. 10.1371/journal.pone.0166808

By:

Zheng, Shaoping;
Zhang, Peige;
Chen, Yixiong;
Zheng, Shaojiang;
Zheng, Liping;
Weng, Zhihong

Publication type:

Article

An Anti-Parkinson’s Disease Drug via Targeting Adenosine A2A Receptor Enhances Amyloid-β Generation and γ-Secretase Activity.

Published in:

PLoS ONE, 2016, v. 11, n. 11, p. 1, doi. 10.1371/journal.pone.0166415

By:

Lu, Jing;
Cui, Jin;
Li, Xiaohang;
Wang, Xin;
Zhou, Yue;
Yang, Wenjuan;
Chen, Ming;
Zhao, Jian;
Pei, Gang

Publication type:

Article

Correction: Gamma-Secretase-Dependent and -Independent Effects of Presenilin1 on β-Catenin·Tcf-4 Transcriptional Activity.

Published in:

PLoS ONE, 2016, v. 11, n. 8, p. 1, doi. 10.1371/journal.pone.0161515

By:

Raurell, Imma;
Codina, Montserrat;
Casagolda, David;
del Valle, Beatriz;
Baulida, Josep;
de Herreros, Antonio García;
Duñach, Mireia

Publication type:

Article

ABCG1 and ABCG4 Suppress γ-Secretase Activity and Amyloid β Production.

Published in:

PLoS ONE, 2016, v. 11, n. 5, p. 1, doi. 10.1371/journal.pone.0155400

By:

Sano, Osamu;
Tsujita, Maki;
Shimizu, Yuji;
Kato, Reiko;
Kobayashi, Aya;
Kioka, Noriyuki;
Remaley, Alan T.;
Michikawa, Makoto;
Ueda, Kazumitsu;
Matsuo, Michinori

Publication type:

Article