Works matching DE "SECRETASES"

Results: 311

Characterization of β-secretase inhibitory peptide purified from skate skin protein hydrolysate.

Published in:

European Food Research & Technology, 2015, v. 240, n. 1, p. 129, doi. 10.1007/s00217-014-2314-9

By:

Lee, Jung;
Li-Chan, Eunice;
Byun, Hee-Guk

Publication type:

Article

Effects of lipids on the activity and structural dynamics of gamma secretase: A study using coarse-grained molecular dynamics simulations.

Published in:

ChemPhysMater, 2024, v. 3, n. 3, p. 303, doi. 10.1016/j.chphma.2024.03.005

By:

Sajjad, Ahmad;
Jinfei Mei;
Chuanbo Wang;
Hongqi Ai

Publication type:

Article

The PSEN1 E280G mutation leads to increased amyloid-β43 production in induced pluripotent stem cell neurons and deposition in brain tissue.

Published in:

Brain Communications, 2023, v. 5, n. 1, p. 1, doi. 10.1093/braincomms/fcac321

By:

Willumsen, Nanet;
Arber, Charles;
Lovejoy, Christopher;
Toombs, Jamie;
Alatza, Argyro;
Weston, Philip S. J.;
Chávez-Gutiérrez, Lucia;
Hardy, John;
Zetterberg, Henrik;
Fox, Nick C.;
Ryan, Natalie S.;
Lashley, Tammaryn;
Wray, Selina

Publication type:

Article

Gene expression: Converging pathways.

Published in:

Nature Reviews Neuroscience, 2015, v. 16, n. 6, p. 314, doi. 10.1038/nrn3968

By:

Carr, Fiona

Publication type:

Article

The effects and interactions of APOE and APH-1A polymorphisms in Alzheimer disease.

Published in:

Turkish Journal of Medical Sciences, 2015, v. 45, n. 5, p. 1098, doi. 10.3906/sag-1407-19

By:

ACAR ÇİNLETİ, Burcu;
YARDIMCI, Nilgül;
AYTÜRK, Zübeyde;
İLHAN, Atilla;
KAYA, Gülhan;
ACAR, Muradiye;
KOÇ, Emine Rabia;
GÜNDÜZ, Esra;
GÜNDÜZ, Mehmet

Publication type:

Article

Corrigendum.

Published in:: Experimental Dermatology, 2017, v. 26, n. 5, p. 467, doi. 10.1111/exd.13351
Publication type:: Article

Impaired Notch- MKP-1 signalling in hidradenitis suppurativa: an approach to pathogenesis by evidence from translational biology.

Published in:

Experimental Dermatology, 2013, v. 22, n. 3, p. 172, doi. 10.1111/exd.12098

By:

Melnik, Bodo C.;
Plewig, Gerd

Publication type:

Article

Retraction Note: Protective effects of gingerol on streptozotocin-induced sporadic Alzheimer's disease: emphasis on inhibition of β-amyloid, COX-2, alpha-, beta - secretases and APH1a.

Published in:

Scientific Reports, 2023, v. 13, n. 1, p. 1, doi. 10.1038/s41598-023-36652-w

By:

El Halawany, Ali M.;
EL Sayed, Nesrine S.;
Abdallah, Hossam M.;
El Dine, Riham Salah

Publication type:

Article

An approach to design potent anti-Alzheimer’s agents by 3D-QSAR studies on fused 5,6-bicyclic heterocycles as γ-secretase modulators using kNN–MFA methodology.

Published in:

Arabian Journal of Chemistry, 2014, v. 7, n. 6, p. 924, doi. 10.1016/j.arabjc.2013.02.002

By:

Bhadoriya, Kamlendra Singh;
Sharma, Mukesh C.;
Sharma, Smita;
Jain, Shailesh V.;
Avchar, Mandar H.

Publication type:

Article

Dysfunctional γ-Secretase in Familial Alzheimer's Disease.

Published in:

Neurochemical Research, 2019, v. 44, n. 1, p. 5, doi. 10.1007/s11064-018-2511-1

By:

Wolfe, Michael S.

Publication type:

Article

Hydrogen Sulfide Selectively Inhibits γ-Secretase Activity and Decreases Mitochondrial Aβ Production in Neurons from APP/PS1 Transgenic Mice.

Published in:

Neurochemical Research, 2016, v. 41, n. 5, p. 1145, doi. 10.1007/s11064-015-1807-7

By:

Zhao, Feng-li;
Qiao, Pei-feng;
Yan, Ning;
Gao, Dan;
Liu, Meng-jie;
Yan, Yong

Publication type:

Article

MH84: A Novel γ-Secretase Modulator/PPARγ Agonist-Improves Mitochondrial Dysfunction in a Cellular Model of Alzheimer's Disease.

Published in:

Neurochemical Research, 2016, v. 41, n. 1/2, p. 231, doi. 10.1007/s11064-015-1765-0

By:

Pohland, Maximilian;
Hagl, Stephanie;
Pellowska, Maren;
Wurglics, Mario;
Schubert-Zsilavecz, Manfred;
Eckert, Gunter

Publication type:

Article

Effects of Aluminium on β-Amyloid (1-42) and Secretases (APP-Cleaving Enzymes) in Rat Brain.

Published in:

Neurochemical Research, 2014, v. 39, n. 7, p. 1338, doi. 10.1007/s11064-014-1317-z

By:

Wang, Linping;
Hu, Jiali;
Zhao, Yue;
Lu, Xiaoting;
Zhang, Qinli;
Niu, Qiao

Publication type:

Article

Calsenilin Contributes to Neuronal Cell Death in Ischemic Stroke.

Published in:

Brain Pathology, 2013, v. 23, n. 4, p. 402, doi. 10.1111/bpa.12013

By:

Park, Jong‐Sung;
Manzanero, Silvia;
Chang, Jae‐Woong;
Choi, Yuri;
Baik, Sang‐Ha;
Cheng, Yi‐Lin;
Li, Yu‐I;
Gwon, A‐Ryeong;
Woo, Ha‐Na;
Jang, Jiyeon;
Choi, In‐Young;
Lee, Joo‐Yong;
Jung, Yong‐Keun;
Tang, Sung‐Chun;
Sobey, Christopher G.;
Arumugam, Thiruma V.;
Jo, Dong‐Gyu

Publication type:

Article

Involvement of the γ-Secretase-Mediated EphA4 Signaling Pathway in Synaptic Pathogenesis of Alzheimer's Disease.

Published in:

Brain Pathology, 2012, v. 22, n. 6, p. 776, doi. 10.1111/j.1750-3639.2012.00587.x

By:

Matsui, Chiyuki;
Inoue, Eiji;
Kakita, Akiyoshi;
Arita, Kohei;
Deguchi-Tawarada, Maki;
Togawa, Aki;
Yamada, Akio;
Takai, Yoshimi;
Takahashi, Hitoshi

Publication type:

Article

New tricks from an old dog: Another synaptotoxic fragment from APP.

Published in:

Cell Research, 2015, v. 25, n. 11, p. 1185, doi. 10.1038/cr.2015.125

By:

Tyan, Sheue-Houy;
Koo, Edward H

Publication type:

Article

Cutting in on a secretase pas de deux.

Published in:

Cell Research, 2015, v. 25, n. 10, p. 1091, doi. 10.1038/cr.2015.106

By:

Wolfe, Michael S

Publication type:

Article

Substrate processing in intramembrane proteolysis by γ-secretase - the role of protein dynamics.

Published in:

Biological Chemistry, 2017, v. 398, n. 4, p. 441, doi. 10.1515/hsz-2016-0269

By:

Langosch, Dieter;
Steiner, Harald

Publication type:

Article

Membrane trafficking and proteolytic activity of γ-secretase in Alzheimer's disease.

Published in:

Biological Chemistry, 2016, v. 397, n. 9, p. 827, doi. 10.1515/hsz-2016-0146

By:

Kanatsu, Kunihiko;
Tomita, Taisuke

Publication type:

Article

Processive proteolysis by γ-secretase and the mechanism of Alzheimer's disease.

Published in:

Biological Chemistry, 2012, v. 393, n. 9, p. 899, doi. 10.1515/hsz-2012-0140

By:

Wolfe, Michael S.

Publication type:

Article

Tmem27 dimerization, deglycosylation, plasma membrane depletion, and the extracellular Phe-Phe motif are negative regulators of cleavage by Bace2.

Published in:

Biological Chemistry, 2012, v. 393, n. 6, p. 473, doi. 10.1515/hsz-2012-0104

By:

Esterházy, Daria;
Akpinar, Pinar;
Stoffel, Markus

Publication type:

Article

Effects of super-hard rice bread blended with black rice bran on amyloid β peptide production and abrupt increase in postprandial blood glucose levels in mice.

Published in:

Bioscience, Biotechnology & Biochemistry, 2017, v. 81, n. 2, p. 323, doi. 10.1080/09168451.2016.1240605

By:

Nakamura, Sumiko;
Hara, Takashi;
Joh, Toshio;
Kobayashi, Atsushi;
Yamazaki, Akira;
Kasuga, Kensaku;
Ikeuchi, Takeshi;
Ohtsubo, Ken'ichi

Publication type:

Article

New Flurbiprofen Derivatives: Synthesis, Membrane Affinity and Evaluation of in Vitro Effect on β-Amyloid Levels.

Published in:

Molecules, 2013, v. 18, n. 9, p. 10747, doi. 10.3390/molecules180910747

By:

Sozio, Piera;
Marinelli, Lisa;
Cacciatore, Ivana;
Fontana, Antonella;
Türkez, Hasan;
Giorgioni, Gianfabio;
Ambrosini, Dario;
Barbato, Francesco;
Grumetto, Lucia;
Pacella, Stephanie;
Cataldi, Amelia;
Di Stefano, Antonio

Publication type:

Article

Inhibitory Evaluation of Sulfonamide Chalcones on β-Secretase and Acylcholinesterase.

Published in:

Molecules, 2013, v. 18, n. 1, p. 140, doi. 10.3390/molecules18010140

By:

Jae Eun Kang;
Jung Keun Cho;
Curtis-Long, Marcus J.;
Hyung Won Ryu;
Jin Hyo Kim;
Hye Jin Kim;
Heung Joo Yuk;
Dae Wook Kim;
Ki Hun Park

Publication type:

Article

Risk factor SORL1: from genetic association to functional validation in Alzheimer's disease.

Published in:

Acta Neuropathologica, 2016, v. 132, n. 5, p. 653, doi. 10.1007/s00401-016-1615-4

By:

Andersen, Olav;
Rudolph, Ina-Maria;
Willnow, Thomas

Publication type:

Article

Intraneuronal aggregation of the β-CTF fragment of APP (C99) induces Aβ-independent lysosomal-autophagic pathology.

Published in:

Acta Neuropathologica, 2016, v. 132, n. 2, p. 257, doi. 10.1007/s00401-016-1577-6

By:

Lauritzen, Inger;
Pardossi-Piquard, Raphaëlle;
Bourgeois, Alexandre;
Pagnotta, Sophie;
Biferi, Maria-Grazia;
Barkats, Martine;
Lacor, Pascale;
Klein, William;
Bauer, Charlotte;
Checler, Frederic

Publication type:

Article

Proteins interacting with γ-secretase subunits -- on the way to elucidate functions of the proteolytic complex in Arabidopsis thaliana.

Published in:

Biotechnologia, 2018, v. 99, n. 3, p. 271

By:

KWIATKOWSKI, WOJCIECH;
SKRZYPCZAK, TOMASZ;
WOJTASZEK, PRZEMYSŁAW

Publication type:

Article

The standardized Centella asiatica extract ECa 233 regulates the catalytic activities of βAPP-cleaving secretases in human cell lines.

Published in:

ScienceAsia, 2023, v. 49, n. 2, p. 256, doi. 10.2306/scienceasia1513-1874.2023.014

By:

Protha, Mehbuba Nur;
Therathep Srisutjarit;
Arpita Dey;
Maitra, Subhamita;
Hernandez, Jean-Francois;
Tantisira, Mayuree H.;
Yingrak Boondam;
Narawut Pakaprot;
Vincent, Bruno

Publication type:

Article

An evaluation of the self-assembly enhancing properties of cell-derived hexameric amyloid-β.

Published in:

Scientific Reports, 2021, v. 11, n. 1, p. 1, doi. 10.1038/s41598-021-90680-y

By:

Vadukul, Devkee M.;
Vrancx, Céline;
Burguet, Pierre;
Contino, Sabrina;
Suelves, Nuria;
Serpell, Louise C.;
Quinton, Loïc;
Kienlen-Campard, Pascal

Publication type:

Article

Angiotensin converting enzyme 2 is a novel target of the γ-secretase complex.

Published in:

Scientific Reports, 2021, v. 11, n. 1, p. 1, doi. 10.1038/s41598-021-89379-x

By:

Bartolomé, Alberto;
Liang, Jiani;
Wang, Pengfei;
Ho, David D.;
Pajvani, Utpal B.

Publication type:

Article

Class II phosphatidylinositol 3-kinase-C2α is essential for Notch signaling by regulating the endocytosis of γ-secretase in endothelial cells.

Published in:

Scientific Reports, 2021, v. 11, n. 1, p. 1, doi. 10.1038/s41598-021-84548-4

By:

Shimizu, Shota;
Yoshioka, Kazuaki;
Aki, Sho;
Takuwa, Yoh

Publication type:

Article

Author Correction: Amylin and pramlintide modulate γ-secretase level and APP processing in lipid rafts.

Published in:

2020

By:

Mousa, Youssef M.;
Abdallah, Ihab M.;
Hwang, Misako;
Martin, Douglas R.;
Kaddoumi, Amal

Publication type:

Correction Notice

Matriptase processing of APLP1 ectodomain alters its homodimerization.

Published in:

Scientific Reports, 2020, v. 10, n. 1, p. 1, doi. 10.1038/s41598-020-67005-6

By:

Lanchec, Erwan;
Désilets, Antoine;
Béliveau, François;
Fontaine-Carbonneau, Cloé;
Laniel, Andréanne;
Leduc, Richard;
Lavoie, Christine

Publication type:

Article

Concurrent hidradenitis suppurativa and Dowling–Degos disease taken down a ‘Notch’.

Published in:

British Journal of Dermatology, 2018, v. 178, n. 2, p. 328, doi. 10.1111/bjd.16068

By:

McGrath, J. A.

Publication type:

Article

A systematic review and critical evaluation of reported pathogenic sequence variants in hidradenitis suppurativa.

Published in:

British Journal of Dermatology, 2017, v. 177, n. 4, p. 987, doi. 10.1111/bjd.15441

By:

Frew, J.W.;
Vekic, D.A.;
Woods, J.;
Cains, G.D.

Publication type:

Article

Presenilin 1/γ-secretase modulates P-cadherin processing and influences cell adhesion in oral squamous cell carcinoma cell lines.

Published in:

Carcinogenesis, 2013, v. 34, n. 11, p. 2622, doi. 10.1093/carcin/bgt211

By:

Bauer, Karin;
Gosau, Martin;
Reinders, Jörg;
Oefner, Peter;
Reichert, Torsten E.;
Bauer, Richard

Publication type:

Article

β-Secretases, Alzheimer's Disease, and Down Syndrome.

Published in:

Current Gerontology & Geratrics Research, 2012, p. 1, doi. 10.1155/2012/362839

By:

Webb, Robin L.;
Paul Murphy, M.

Publication type:

Article

Inhibition of ADAM-17 more effectively down-regulates the Notch pathway than that of γ-secretase in renal carcinoma.

Published in:

Journal of Experimental & Clinical Cancer Research (17569966), 2013, v. 32, n. 1, p. 1, doi. 10.1186/1756-9966-32-26

By:

Zhen Guo;
Xunbo Jin;
Haiyan Jia

Publication type:

Article

Alzheimer's Transgenic Model Is Characterized by Very Early Brain Network Alterations and β-CTF Fragment Accumulation: Reversal by β-Secretase Inhibition.

Published in:

Frontiers in Cellular Neuroscience, 2018, p. 1, doi. 10.3389/fncel.2018.00121

By:

Mondragón-Rodríguez, Siddhartha;
Gu, Ning;
Manseau, Frederic;
Williams, Sylvain

Publication type:

Article

The Metalloprotease Meprin β Is an Alternative β-Secretase of APP.

Published in:

Frontiers in Molecular Neuroscience, 2017, v. 9, p. 1, doi. 10.3389/fnmol.2016.00159

By:

Becker-Pauly, Christoph;
Pietrzik, Claus U.

Publication type:

Article

Multi-compartmental modeling of SORLA's influence on amyloidogenic processing in Alzheimer's disease.

Published in:

BMC Systems Biology, 2012, v. 6, n. 1, p. 74, doi. 10.1186/1752-0509-6-74

By:

Lao, Angelyn;
Schmidt, Vanessa;
Schmitz, Yvonne;
Willnow, Thomas E.;
Wolkenhauer, Olaf

Publication type:

Article

Mitochondrial γ-secretase participates in the metabolism of mitochondria-associated amyloid precursor protein.

Published in:

FASEB Journal, 2011, v. 25, n. 1, p. 78, doi. 10.1096/fj.10-157230

By:

Pavlov, Pavel F.;
Wiehager, Birgitta;
Sakai, Jun;
Frykman, Susanne;
Behbahani, Homira;
Winblad, Bengt;
Ankarcrona, Maria

Publication type:

Article

The influence of BACE1 on macrophage recruitment and activity in the injured peripheral nerve.

Published in:

2021

By:

Fissel, John A.;
Farah, Mohamed H.

Publication type:

journal article

DOGS: Reaction-Driven de novo Design of Bioactive Compounds.

Published in:

PLoS Computational Biology, 2012, v. 8, n. 2, p. 1, doi. 10.1371/journal.pcbi.1002380

By:

Hartenfeller, Markus;
Zettl, Heiko;
Walter, Miriam;
Rupp, Matthias;
Reisen, Felix;
Proschak, Ewgenij;
Weggen, Sascha;
Stark, Holger;
Schneider, Gisbert

Publication type:

Article

β-Secretase inhibition by C-methylisoflavones from Abronia nana.

Published in:

Natural Product Research, 2019, v. 33, n. 12, p. 1705, doi. 10.1080/14786419.2018.1431637

By:

Yang, Eun-Ju;
Lee, Taeho;
Song, Kyung-Sik

Publication type:

Article

Alzheimer's disease: A protective mutation.

Published in:

Nature, 2012, v. 488, n. 7409, p. 38, doi. 10.1038/488038a

By:

De Strooper, Bart;
Voet, Thierry

Publication type:

Article

Delta Secretase and BDNF Signalling in Alzheimer's Disease.

Published in:

Experimed, 2023, v. 13, n. 1, p. 1, doi. 10.26650/experimed.1231893

By:

Unlu, Buse;
Ildiz, Sumeyra;
Ak, Duygu Gezen;
Dursun, Erdinc

Publication type:

Article

CSF beta-amyloid levels are altered in narcolepsy: a link with the inflammatory hypothesis?

Published in:

Journal of Sleep Research, 2014, v. 23, n. 4, p. 420, doi. 10.1111/jsr.12130

By:

Liguori, Claudio;
Placidi, Fabio;
Albanese, Maria;
Nuccetelli, Marzia;
Izzi, Francesca;
Marciani, Maria Grazia;
Mercuri, Nicola Biagio;
Bernardini, Sergio;
Romigi, Andrea

Publication type:

Article

Polypharmacology of Berberine Based on Multi-Target Binding Motifs.

Published in:

Frontiers in Pharmacology, 2018, p. N.PAG, doi. 10.3389/fphar.2018.00801

By:

Chu, Ming;
Chen, Xi;
Wang, Jing;
Guo, Likai;
Wang, Qianqian;
Gao, Zirui;
Kang, Jiarui;
Zhang, Mingbo;
Feng, Jinqiu;
Guo, Qi;
Li, Binghua;
Zhang, Chengrui;
Guo, Xueyuan;
Chu, Zhengyun;
Wang, Yuedan

Publication type:

Article

Immunohistochemical characterization of γ-secretase activating protein expression in Alzheimer's disease brains.

Published in:

Neuropathology & Applied Neurobiology, 2012, v. 38, n. 2, p. 132, doi. 10.1111/j.1365-2990.2011.01206.x

By:

Satoh, J.;
Tabunoki, H.;
Ishida, T.;
Saito, Y.;
Arima, K.

Publication type:

Article