Works about SECRETASE inhibitors

Results: 232

Nirogacestat in Desmoid Tumor Management: Painful to Painless?

Published in:

Indian Journal of Medical & Paediatric Oncology, 2025, v. 46, n. 3, p. 347, doi. 10.1055/s-0045-1802635

By:

Jain, Himanshi Avinash;
Bagri, Puneet Kumar;
Tripathy, Amruta;
Chaudhary, Kiran G.

Publication type:

Article

Stereoselective yeast-mediated reduction of trans-5-(1′-oxo-3′-methylbutyl)-3-methyldihydrofuran-2-one: production of chiral intermediates for the synthesis of β-secretase inhibitors.

Published in:

Biotechnology Letters, 2016, v. 38, n. 1, p. 103, doi. 10.1007/s10529-015-1954-6

By:

Gładkowski, Witold;
Mituła, Paweł

Publication type:

Article

Developing Novel Beta‐Secretase Inhibitors in a Computer Model as a Possible Treatment for Alzheimer's Disease.

Published in:

Advances in Pharmacological & Pharmaceutical Sciences, 2025, p. 1, doi. 10.1155/adpp/5528793

By:

Ongtanasup, Tassanee;
Eawsakul, Komgrit;
Elmaaiden, Ezzouhra

Publication type:

Article

Auditory system: turn it up a notch.

Published in:

2013

By:

Flight, Monica Hoyos

Publication type:

journal article

VEGF combined with DAPT promotes tissue regeneration and remodeling in vascular grafts.

Published in:

Regenerative Biomaterials, 2023, v. 10, p. 1, doi. 10.1093/rb/rbad088

By:

Yang, Tao;
Li, Guangxu;
Li, Xifeng;
Wei, Boyang;
Su, Hengxian;
Liu, Wenchao;
Guo, Shenquan;
Yang, Nan;
Xu, Tao;
Duan, Chuanzhi

Publication type:

Article

Impact of Drying Processes on Phenolics and In Vitro Health-Related Activities of Indigenous Plants in Thailand.

Published in:

Plants (2223-7747), 2022, v. 11, n. 3, p. 294, doi. 10.3390/plants11030294

By:

Sirichai, Pandaree;
Kittibunchakul, Suwapat;
Thangsiri, Sirinapa;
On-Nom, Nattira;
Chupeerach, Chaowanee;
Temviriyanukul, Piya;
Inthachat, Woorawee;
Nuchuchua, Onanong;
Aursalung, Amornrat;
Sahasakul, Yuraporn;
Charoenkiatkul, Somsri;
Suttisansanee, Uthaiwan

Publication type:

Article

PRECISE RADIONUCLIDE LOCALIZATION USING UAV-BASED LIDAR AND GAMMA PROBE WITH REAL-TIME PROCESSING.

Published in:

International Archives of the Photogrammetry, Remote Sensing & Spatial Information Sciences, 2019, v. XLII-3/W8, p. 503, doi. 10.5194/isprs-archives-XLII-3-W8-503-2019

By:

Schraml, S.;
Hinterhofer, T.;
Pfennigbauer, M.;
Hofstätter, M.

Publication type:

Article

Super-resolution microscopy reveals γ- secretase at both sides of the neuronal synapse.

Published in:

Acta Neuropathologica Communications, 2016, v. 4, p. 1, doi. 10.1186/s40478-016-0296-5

By:

Schedin-Weiss, Sophia;
Caesar, Ina;
Winblad, Bengt;
Blom, Hans;
Tjernberg, Lars O.

Publication type:

Article

Evaluation of the anticancer activity of RIN-1, a Notch signaling modulator, in head and neck squamous cell carcinoma.

Published in:

Scientific Reports, 2023, v. 13, n. 1, p. 1, doi. 10.1038/s41598-023-39472-0

By:

Czerwonka, Arkadiusz;
Kałafut, Joanna;
Wang, Shaoxia;
Anameric, Alinda;
Przybyszewska-Podstawka, Alicja;
Mattsson, Jesse;
Karbasian, Mahtab;
Le Manach, Doriane;
Toriseva, Mervi;
Nees, Matthias

Publication type:

Article

Evaluation of the anticancer activity of RIN-1, a Notch signaling modulator, in head and neck squamous cell carcinoma.

Published in:

Scientific Reports, 2023, v. 13, n. 1, p. 1, doi. 10.1038/s41598-023-39472-0

By:

Czerwonka, Arkadiusz;
Kałafut, Joanna;
Wang, Shaoxia;
Anameric, Alinda;
Przybyszewska-Podstawka, Alicja;
Mattsson, Jesse;
Karbasian, Mahtab;
Le Manach, Doriane;
Toriseva, Mervi;
Nees, Matthias

Publication type:

Article

Gliotoxin Targets Nuclear NOTCH2 in Human Solid Tumor Derived Cell Lines In Vitro and Inhibits Melanoma Growth in Xenograft Mouse Model.

Published in:

Frontiers in Pharmacology, 2017, p. 1, doi. 10.3389/fphar.2017.00319

By:

Hubmann, Rainer;
Sieghart, Wolfgang;
Schnabl, Susanne;
Araghl, Mohammad;
Hilgarth, Martin;
Reiter, Marlies;
Demirtas, Dita;
Valent, Peter;
Zielinski, Christoph;
Jäger, Ulrich;
Shehata, Medhat

Publication type:

Article

Docking Studies and Biological Evaluation of a Potential β-Secretase Inhibitor of 3-Hydroxyhericenone F from Hericium erinaceus.

Published in:

Frontiers in Pharmacology, 2017, v. 8, p. 1, doi. 10.3389/fphar.2017.00219

By:

Chen Diling;
Yong Tianqiao;
Yang Jian;
Zheng Chaoqun;
Shuai Ou;
Xie Yizhen

Publication type:

Article

The Interplay of Notch Signaling and STAT3 in TLR-Activated Human Primary Monocytes.

Published in:

Frontiers in Cellular & Infection Microbiology, 2018, v. 8, p. N.PAG, doi. 10.3389/fcimb.2018.00241

By:

Hildebrand, Dagmar;
Uhle, Florian;
Sahin, Delal;
Krauser, Ute;
Weigand, Markus Alexander;
Heeg, Klaus

Publication type:

Article

β-secretase inhibitor; a promising novel therapeutic drug in Alzheimer's disease.

Published in:

Frontiers in Aging Neuroscience, 2014, v. 6, p. 1, doi. 10.3389/fnagi.2014.00165

By:

Willemijn Menting, Kelly;
Claassen, Jurgen A. H. R.

Publication type:

Article

Control of intestinal stem cell fate: A novel approach to treating diabetes.

Published in:

Journal of Diabetes Investigation, 2016, v. 7, n. 2, p. 166, doi. 10.1111/jdi.12390

By:

Yamane, Shunsuke;
Inagaki, Nobuya

Publication type:

Article

The β-carboline analogs as a potent inhibitor for Alzheimer's Disease, molecular docking and dynamics simulation study.

Published in:

Arabian Journal of Chemistry, 2023, v. 16, n. 12, p. N.PAG, doi. 10.1016/j.arabjc.2023.105300

By:

Taha, Muhammad;
Rahim, Fazal;
Khan, Azmat Ali;
Adalat, Bushra;
Imran, Syahrul;
Alshehri, Jamilah M.;
Ahmad, Asrar;
Khan, Khalid Mohammed;
Shah, Syed Adnan Ali;
Uddin, Nizam

Publication type:

Article

MAO-B Inhibitor (2E)-3-(4-Bromophenyl)-1-(1H-indol-3-yl) prop-2-en-1-one as a Neuroprotective Agent Against Alzheimer's Disease.

Published in:

Neurochemical Research, 2024, v. 49, n. 6, p. 1518, doi. 10.1007/s11064-023-04031-6

By:

Sasidharan, Rani;
Mohanan, Ratheesh;
Kukreti, Neelima;
Raj, Praveen;
Abdelgawad, Mohamed A.;
Ghoneim, Mohammed M.;
Manju, Sreedharannair L.;
Mathew, Bijo

Publication type:

Article

The Binding Mechanisms and Inhibitory Effect of Intravenous Anesthetics on AChE In Vitro and In Vivo: Kinetic Analysis and Molecular Docking.

Published in:

Neurochemical Research, 2019, v. 44, n. 9, p. 2147, doi. 10.1007/s11064-019-02852-y

By:

Işık, Mesut

Publication type:

Article

ALDH<sup>+</sup> tumor-initiating cells exhibiting gain in NOTCH1 gene copy number have enhanced regrowth sensitivity to a γ-secretase inhibitor and irinotecan in colorectal cancer

Published in:

Molecular Oncology, 2012, v. 6, n. 3, p. 370, doi. 10.1016/j.molonc.2012.03.004

By:

Arcaroli, John J.;
Powell, Rebecca W.;
Varella-Garcia, Marileila;
McManus, Martine;
Tan, Aik Choon;
Quackenbush, Kevin S.;
Pitts, Todd M.;
Gao, Dexiang;
Spreafico, Anna;
Dasari, Arvind;
Touban, Basel M.;
Messersmith, Wells A.

Publication type:

Article

In silico study of tacrine and acetylcholine binding profile with human acetylcholinesterase: docking and electronic structure.

Published in:

Journal of Molecular Modeling, 2022, v. 28, n. 9, p. 1, doi. 10.1007/s00894-022-05252-2

By:

Nascimento, Letícia A.;
Nascimento, Érica C. M.;
Martins, João B. L.

Publication type:

Article

Inhibitory mechanism of 17β-aminoestrogens in the formation of Aβ aggregates.

Published in:

Journal of Molecular Modeling, 2019, v. 25, n. 8, p. N.PAG, doi. 10.1007/s00894-019-4128-y

By:

Noriega, Lisset;
Díaz, Alfonso;
Limón, Daniel;
Castro, María Eugenia;
Caballero, Norma A.;
Ramírez, Ramsés E.;
Perez-Aguilar, Jose Manuel;
Melendez, Francisco J.

Publication type:

Article

Investigation of naphthofuran moiety as potential dual inhibitor against BACE-1 and GSK-3β: molecular dynamics simulations, binding energy, and network analysis to identify first-in-class dual inhibitors against Alzheimer's disease.

Published in:

Journal of Molecular Modeling, 2017, v. 23, n. 8, p. 1, doi. 10.1007/s00894-017-3396-7

By:

Kumar, Akhil;
Srivastava, Gaurava;
Srivastava, Swati;
Verma, Seema;
Negi, Arvind;
Sharma, Ashok

Publication type:

Article

Differential activation of NOTCH1 pathway in HNSCC cell lines of different anatomical sites.

Published in:

Indian Journal of Experimental Biology, 2023, v. 61, n. 4, p. 244, doi. 10.56042/ijeb.v61i04.171

By:

Mukhopadhyay, Debalina;
Chakroborty, Balark;
Basu, Mukta;
Ghosh, Supratim;
Panda, Chinmay Kumar

Publication type:

Article

Strong therapeutic potential of γ-secretase inhibitor MRK003 for CD44-high and CD133-low glioblastoma initiating cells.

Published in:

Journal of Neuro-Oncology, 2015, v. 121, n. 2, p. 239, doi. 10.1007/s11060-014-1630-z

By:

Tanaka, Shingo;
Nakada, Mitsutoshi;
Yamada, Daisuke;
Nakano, Ichiro;
Todo, Tomoki;
Ino, Yasushi;
Hoshii, Takayuki;
Tadokoro, Yuko;
Ohta, Kumiko;
Ali, Mohamed;
Hayashi, Yutaka;
Hamada, Jun-ichiro;
Hirao, Atsushi

Publication type:

Article

Preparation, Purification and Characterization of Antibacterial and ACE Inhibitory Peptides from Head Protein Hydrolysate of Kuruma Shrimp, Marsupenaeus japonicus.

Published in:

Molecules, 2023, v. 28, n. 2, p. 894, doi. 10.3390/molecules28020894

By:

Zhou, Jie;
Han, Qiuyu;
Koyama, Tomoyuki;
Ishizaki, Shoichiro

Publication type:

Article

Synthesis of Isomeric 3-Benzazecines Decorated with Endocyclic Allene Moiety and Exocyclic Conjugated Double Bond and Evaluation of Their Anticholinesterase Activity.

Published in:

Molecules, 2022, v. 27, n. 19, p. 6276, doi. 10.3390/molecules27196276

By:

Titov, Alexander A.;
Purgatorio, Rosa;
Obydennik, Arina Y.;
Listratova, Anna V.;
Borisova, Tatiana N.;
de Candia, Modesto;
Catto, Marco;
Altomare, Cosimo D.;
Varlamov, Alexey V.;
Voskressensky, Leonid G.

Publication type:

Article

Assessing the Role of a Malonamide Linker in the Design of Potent Dual Inhibitors of Factor Xa and Cholinesterases.

Published in:

Molecules, 2022, v. 27, n. 13, p. 4269, doi. 10.3390/molecules27134269

By:

Purgatorio, Rosa;
Gambacorta, Nicola;
Samarelli, Francesco;
Lopopolo, Gianfranco;
de Candia, Modesto;
Catto, Marco;
Nicolotti, Orazio;
Altomare, Cosimo D.

Publication type:

Article

In Silico Screening of Novel TMPRSS2 Inhibitors for Treatment of COVID-19.

Published in:

Molecules, 2022, v. 27, n. 13, p. 4210, doi. 10.3390/molecules27134210

By:

Wang, Shuo;
Fang, Xuexun;
Wang, Ye

Publication type:

Article

Role of Natural Compounds and Target Enzymes in the Treatment of Alzheimer's Disease.

Published in:

Molecules, 2022, v. 27, n. 13, p. 4175, doi. 10.3390/molecules27134175

By:

Wang, Shanshan;
Kong, Xianbo;
Chen, Zhangjing;
Wang, Guopin;
Zhang, Juan;
Wang, Jing

Publication type:

Article

First-in-Class Isonipecotamide-Based Thrombin and Cholinesterase Dual Inhibitors with Potential for Alzheimer Disease.

Published in:

Molecules, 2021, v. 26, n. 17, p. 5208, doi. 10.3390/molecules26175208

By:

Purgatorio, Rosa;
Gambacorta, Nicola;
de Candia, Modesto;
Catto, Marco;
Rullo, Mariagrazia;
Pisani, Leonardo;
Nicolotti, Orazio;
Altomare, Cosimo D.

Publication type:

Article

New Hybrids of 4-Amino-2,3-polymethylene-quinoline and p-Tolylsulfonamide as Dual Inhibitors of Acetyl- and Butyrylcholinesterase and Potential Multifunctional Agents for Alzheimer's Disease Treatment.

Published in:

Molecules, 2020, v. 25, n. 17, p. 3915, doi. 10.3390/molecules25173915

By:

Makhaeva, Galina F.;
Kovaleva, Nadezhda V.;
Boltneva, Natalia P.;
Lushchekina, Sofya V.;
Astakhova, Tatiana Yu.;
Rudakova, Elena V.;
Proshin, Alexey N.;
Serkov, Igor V.;
Radchenko, Eugene V.;
Palyulin, Vladimir A.;
Bachurin, Sergey O.;
Richardson, Rudy J.;
Kovarik, Zrinka

Publication type:

Article

Design of Curcumin and Flavonoid Derivatives with Acetylcholinesterase and Beta-Secretase Inhibitory Activities Using in Silico Approaches.

Published in:

Molecules, 2020, v. 25, n. 16, p. 3644, doi. 10.3390/molecules25163644

By:

Tran, Thai-Son;
Le, Minh-Tri;
Tran, Thanh-Dao;
Tran, The-Huan;
Thai, Khac-Minh;
Coy-Barrera, Ericsson;
Ferrari, Erika

Publication type:

Article

Study of Caspase 8 Inhibition for the Management of Alzheimer's Disease: A Molecular Docking and Dynamics Simulation.

Published in:

Molecules, 2020, v. 25, n. 9, p. 2071, doi. 10.3390/molecules25092071

By:

Ahmad, Syed Sayeed;
Sinha, Meetali;
Ahmad, Khurshid;
Khalid, Mohammad;
Choi, Inho

Publication type:

Article

Targeted Radionuclide Therapy of Prostate Cancer—From Basic Research to Clinical Perspectives.

Published in:

Molecules, 2020, v. 25, n. 7, p. 1743, doi. 10.3390/molecules25071743

By:

Czerwińska, Malwina;
Bilewicz, Aleksander;
Kruszewski, Marcin;
Wegierek-Ciuk, Aneta;
Lankoff, Anna

Publication type:

Article

Design, Synthesis, and In Vitro Evaluation of Hydroxybenzimidazole-Donepezil Analogues as Multitarget-Directed Ligands for the Treatment of Alzheimer's Disease.

Published in:

Molecules, 2020, v. 25, n. 4, p. 985, doi. 10.3390/molecules25040985

By:

Chaves, Sílvia;
Resta, Simonetta;
Rinaldo, Federica;
Costa, Marina;
Josselin, Romane;
Gwizdala, Karolina;
Piemontese, Luca;
Capriati, Vito;
Pereira-Santos, A. Raquel;
Cardoso, Sandra M.;
Santos, M. Amélia;
Muñoz-Torrero, Diego

Publication type:

Article

Deep Eutectic Solvents as Effective Reaction Media for the Synthesis of 2-Hydroxyphenylbenzimidazole-Based Scaffolds en Route to Donepezil-Like Compounds.

Published in:

Molecules, 2020, v. 25, n. 3, p. 574, doi. 10.3390/molecules25030574

By:

Piemontese, Luca;
Sergio, Roberta;
Rinaldo, Federica;
Brunetti, Leonardo;
Perna, Filippo M.;
Santos, M. Amélia;
Capriati, Vito;
Branco, Paula Sério

Publication type:

Article

Development and Validation of Analytical Method for SH-1242 in the Rat and Mouse Plasma by Liquid Chromatography/Tandem Mass Spectrometry.

Published in:

Molecules, 2020, v. 25, n. 3, p. 531, doi. 10.3390/molecules25030531

By:

Jeong, Yoo-Seong;
Baek, Minjeong;
Lee, Seungbeom;
Kim, Min-Soo;
Maeng, Han-Joo;
Lee, Jong-Hwa;
Suh, Young-Ger;
Chung, Suk-Jae

Publication type:

Article

A Novel Dual Fluorochrome Near-Infrared Imaging Probe for Potential Alzheimer's Enzyme Biomarkers-BACE1 and Cathepsin D.

Published in:

Molecules, 2020, v. 25, n. 2, p. 274, doi. 10.3390/molecules25020274

By:

Tam, Jenny M.;
Josephson, Lee;
Pilozzi, Alexander R.;
Huang, Xudong;
Christine, Goze

Publication type:

Article

Future Therapeutic Perspectives into the Alzheimer's Disease Targeting the Oxidative Stress Hypothesis.

Published in:

Molecules, 2019, v. 24, n. 23, p. 4410, doi. 10.3390/molecules24234410

By:

Teixeira, Jéssika P.;
de Castro, Alexandre A.;
Soares, Flávia V.;
da Cunha, Elaine F. F.;
Ramalho, Teodorico C.;
Kuča, Kamil;
Franca, Tanos Celmar Costa

Publication type:

Article

Multifunctional Donepezil Analogues as Cholinesterase and BACE1 Inhibitors.

Published in:

Molecules, 2018, v. 23, n. 12, p. 3252, doi. 10.3390/molecules23123252

By:

Green, Keith D.;
Fosso, Marina Y.;
Garneau-Tsodikova, Sylvie;
Muñoz-Torrero, Diego;
Decker, Michael

Publication type:

Article

Design, Synthesis and Evaluation of 3-(2-Aminoheterocycle)-4-benzyloxyphenylbenzamide Derivatives as BACE-1 Inhibitors.

Published in:

Molecules, 2013, v. 18, n. 3, p. 3577, doi. 10.3390/molecules18033577

By:

Shangguan, Shihao;
Fei Wang;
Yong Liao;
Haiping Yu;
Jia Li;
Wenhai Huang;
Haihong Hu;
Lushan Yu;
Yongzhou Hu;
Rong Sheng

Publication type:

Article

γ-Secretase Inhibitors Selected by Molecular Docking, to Develop a New Drug Against Alzheimer's Disease.

Published in:

Reports of Biochemistry & Molecular Biology, 2023, v. 12, n. 2, p. 340, doi. 10.61186/rbmb.12.2.340

By:

Humberto Trasviña-Arenas, Carlos;
Ayala Medina, Luis Alejandro;
Luis Vique-Sánchez, José

Publication type:

Article

Expression of Amyloid Precursor Protein, Caveolin-1, Alpha-, Beta-, and Gamma-Secretases in Penumbra Cells after Photothrombotic Stroke and Evaluation of Neuroprotective Effect of Secretase and Caveolin-1 Inhibitors.

Published in:

Biomedicines, 2022, v. 10, n. 10, p. N.PAG, doi. 10.3390/biomedicines10102655

By:

Sharifulina, Svetlana;
Khaitin, Andrey;
Guzenko, Valeria;
Kalyuzhnaya, Yuliya;
Dzreyan, Valentina;
Logvinov, Alexandr;
Dobaeva, Natalia;
Li, Yan;
Chen, Lei;
He, Bin;
Demyanenko, Svetlana

Publication type:

Article

The genetic landscape for amyloid beta fibril nucleation accurately discriminates familial Alzheimer's disease mutations.

Published in:

eLife, 2021, p. 1, doi. 10.7554/eLife.63364

By:

Seuma, Mireia;
Faure, Andre J.;
Badia, Marta;
Lehner, Ben;
Bolognesi, Benedetta

Publication type:

Article

Dynamic Evaluation of Notch Signaling-Mediated Angiogenesis in Ischemic Rats Using Magnetic Resonance Imaging.

Published in:

Behavioural Neurology, 2018, p. 1, doi. 10.1155/2018/8351053

By:

Tian, Jia-qi;
Zheng, Jia-jun;
Hao, Xiao-zhu;
Yin, Le-kang;
Zhang, Xiao-xue;
Li, Chan-chan;
Feng, Xiao-yuan;
Jiang, Min;
Sun, Hua-ping;
Zheng, Kang;
Yang, Yan-mei

Publication type:

Article

Innovation in BCMA CAR-T therapy: Building beyond the Model T.

Published in:

Frontiers in Oncology, 2022, v. 12, p. 1, doi. 10.3389/fonc.2022.1070353

By:

Banerjee, Rahul;
Lee, Sarah S.;
Cowan, Andrew J.

Publication type:

Article

The protein–surfactant stoichiometry governs the conformational switching and amyloid nucleation kinetics of tau K18.

Published in:

European Biophysics Journal, 2020, v. 49, n. 6, p. 425, doi. 10.1007/s00249-020-01447-8

By:

Kaur, Jaspreet;
Giri, Anjali;
Bhattacharya, Mily

Publication type:

Article

Plasma membrane-derived extracellular microvesicles mediate non-canonical intercellular NOTCH signaling.

Published in:

Nature Communications, 2017, v. 8, n. 1, p. 1, doi. 10.1038/s41467-017-00767-2

By:

Qiyu Wang;
Quan Lu

Publication type:

Article

The importance of Notch signaling in peripheral T-cell lymphomas.

Published in:

Leukemia & Lymphoma, 2014, v. 55, n. 3, p. 639, doi. 10.3109/10428194.2013.807510

By:

Kamstrup, Maria Rørbæk;
Biskup, Edyta;
Gjerdrum, Lise Mette Rahbek;
Ralfkiaer, Elizabeth;
Niazi, Omid;
Gniadecki, Robert

Publication type:

Article

Nirogacestat and its potential impact on desmoid tumor.

Published in:

Rare Tumors, 2023, p. 1, doi. 10.1177/20363613231182485

By:

Rohail, Samia;
fareed, Areeba;
Taimuri, Muskan Asim;
Adnan, Alisbha

Publication type:

Article