Works matching DE "SECRETASE inhibitors"
Results: 229
β‐Sheet to Helical‐Sheet Evolution Induced by Topochemical Polymerization: Cross‐α‐Amyloid‐like Packing in a Pseudoprotein with Gly‐Phe‐Gly Repeats.
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- Angewandte Chemie, 2020, v. 132, n. 23, p. 8939, doi. 10.1002/ange.201914975
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Redox Stability Controls the Cellular Uptake and Activity of Ruthenium‐Based Inhibitors of the Mitochondrial Calcium Uniporter (MCU).
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- Angewandte Chemie, 2020, v. 132, n. 16, p. 6544, doi. 10.1002/ange.202000247
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Vanadium Oxygen Fuel Cell Utilising High Concentration Electrolyte.
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- Batteries, 2019, v. 5, n. 1, p. 1, doi. 10.3390/batteries5010024
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Novel harmine derivatives as potent acetylcholinesterase and amyloid beta aggregation dual inhibitors for management of Alzheimer's disease.
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- Journal of Enzyme Inhibition & Medicinal Chemistry, 2023, v. 38, n. 1, p. 1, doi. 10.1080/14756366.2023.2281893
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Structure–activity relationship, in vitro and in vivo evaluation of novel dienyl sulphonyl fluorides as selective BuChE inhibitors for the treatment of Alzheimer's disease.
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- Journal of Enzyme Inhibition & Medicinal Chemistry, 2021, v. 36, n. 1, p. 1860, doi. 10.1080/14756366.2021.1959571
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β-secretase inhibitory activity of phenolic acid conjugated chitooligosaccharides.
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- Journal of Enzyme Inhibition & Medicinal Chemistry, 2013, v. 28, n. 1, p. 214, doi. 10.3109/14756366.2011.629197
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Square Wave Voltammetric Determination of 8-Hydroxyquinoline-2-Carboxaldehyde Isonicotinoyl Hydrazone (INHHQ), a Promising Metal-Protein Attenuating Compound for the Treatment of Alzheimer's Disease, Using a Multiwalled Carbon Nanotube (MWCNT) Modified Glassy Carbon Electrode (GCE)
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- Analytical Letters, 2020, v. 53, n. 14, p. 2337, doi. 10.1080/00032719.2020.1741603
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Pursuing the Complexity of Alzheimer's Disease: Discovery of Fluoren-9-Amines as Selective Butyrylcholinesterase Inhibitors and N -Methyl-d-Aspartate Receptor Antagonists.
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- Biomolecules (2218-273X), 2021, v. 11, n. 1, p. 3, doi. 10.3390/biom11010003
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Non-canonical Notch Signaling Regulates Actin Remodeling in Cell Migration by Activating PI3K/AKT/Cdc42 Pathway.
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- Frontiers in Pharmacology, 2019, p. N.PAG, doi. 10.3389/fphar.2019.00370
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Regulation of osteoprotegerin expression by Notch signaling in human oral squamous cell carcinoma cell line.
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- Asian Pacific Journal of Tropical Biomedicine, 2016, v. 6, n. 8, p. 692, doi. 10.1016/j.apjtb.2016.06.012
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Control of intestinal stem cell fate: A novel approach to treating diabetes.
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- Journal of Diabetes Investigation, 2016, v. 7, n. 2, p. 166, doi. 10.1111/jdi.12390
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Current Research in Neuropathology and Pharmacotherapy of Alzheimer’s Disease: A Review.
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- Indian Journal of Public Health Research & Development, 2020, v. 11, n. 2, p. 427, doi. 10.37506/v11/i2/2020/ijphrd/194838
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Current Research in Neuropathology and Pharmacotherapy of Alzheimer’s Disease: A Review.
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- Indian Journal of Public Health Research & Development, 2020, v. 11, n. 1, p. 334, doi. 10.37506/v11/i1/2020/ijphrd/193840
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Blockade of Notch Signalling by γ-Secretase Inhibitor in Lung T Cells of Asthmatic Mice Affects T Cell Differentiation and Pulmonary Inflammation.
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- Inflammation, 2015, v. 38, n. 3, p. 1281, doi. 10.1007/s10753-014-0098-5
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Combined Treatment with a BACE Inhibitor and Anti-Aβ Antibody Gantenerumab Enhances Amyloid Reduction in APP<sub>London</sub> Mice.
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- Journal of Neuroscience, 2014, v. 34, n. 35, p. 11621, doi. 10.1523/JNEUROSCI.1405-14.2014
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Genetic Modulation of Soluble Aβ Rescues Cognitive and Synaptic Impairment in a Mouse Model of Alzheimer's Disease.
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- Journal of Neuroscience, 2014, v. 34, n. 23, p. 7871, doi. 10.1523/JNEUROSCI.0572-14.2014
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Genetic Suppression of Transgenic APP Rescues Hypersynchronous Network Activity in a Mouse Model of Alzeimer's Disease.
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- Journal of Neuroscience, 2014, v. 34, n. 11, p. 3826, doi. 10.1523/JNEUROSCI.5171-13.2014
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Alzheimer's Disease: Presenilin 2-Sparing γ-Secretase Inhibition Is a Tolerable Aβ Peptide-Lowering Strategy.
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- Journal of Neuroscience, 2012, v. 32, n. 48, p. 17297, doi. 10.1523/JNEUROSCI.1451-12.2012
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Functional gamma-secretase inhibitors reduce beta-amyloid peptide levels in brain.
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- Journal of Neurochemistry, 2001, v. 76, n. 1, p. 173
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- Article
Kinetics and Thermodynamic Study of Corrosion Inhibition of Mild Steel in 1.5M HCl Medium using Cocoa Leaf Extract as Inhibitor.
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- Journal of Applied Sciences & Environmental Management, 2020, v. 24, n. 1, p. 37, doi. 10.4314/jasem.v24i1.6
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Therapeutic potential of a gamma-secretase inhibitor for hearing restoration in a guinea pig model with noise-induced hearing loss.
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- BMC Neuroscience, 2014, v. 15, n. 1, p. 1, doi. 10.1186/1471-2202-15-66
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γ-Secretase inhibitor DAPT sensitizes t-AUCB-induced apoptosis of human glioblastoma cells in vitro via blocking the p38 MAPK/MAPKAPK2/Hsp27 pathway.
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- Acta Pharmacologica Sinica, 2014, v. 35, n. 6, p. 825, doi. 10.1038/aps.2013.195
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L655,240, acting as a competitive BACE1 inhibitor, efficiently decreases β-amyloid peptide production in HEK293-APPswe cells.
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- Acta Pharmacologica Sinica, 2012, v. 33, n. 12, p. 1459, doi. 10.1038/aps.2012.74
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Stereoselective yeast-mediated reduction of trans-5-(1′-oxo-3′-methylbutyl)-3-methyldihydrofuran-2-one: production of chiral intermediates for the synthesis of β-secretase inhibitors.
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- Biotechnology Letters, 2016, v. 38, n. 1, p. 103, doi. 10.1007/s10529-015-1954-6
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Nonclinical Safety Assessment of the γ-Secretase Inhibitor Avagacestat.
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- Toxicological Sciences, 2018, v. 163, n. 2, p. 525, doi. 10.1093/toxsci/kfy048
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Prostaglandin EP2 receptor downstream of Notch signaling inhibits differentiation of human skeletal muscle progenitors in differentiation conditions.
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- Communications Biology, 2020, v. 3, n. 1, p. 1, doi. 10.1038/s42003-020-0904-6
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Perspectives on Precision Medicine in Chronic Lymphocytic Leukemia: Targeting Recurrent Mutations—NOTCH1, SF3B1, MYD88, BIRC3.
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- Journal of Clinical Medicine, 2021, v. 10, n. 16, p. 3735, doi. 10.3390/jcm10163735
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[<sup>3</sup>H]-L685,458 Binding Sites are Abundant in Multiple Peripheral Organs in Rats: Implications for Safety Assessment of Putative γ-Secretase Targeting Drugs.
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- Basic & Clinical Pharmacology & Toxicology, 2014, v. 115, n. 6, p. 518, doi. 10.1111/bcpt.12271
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Expression of Amyloid Precursor Protein, Caveolin-1, Alpha-, Beta-, and Gamma-Secretases in Penumbra Cells after Photothrombotic Stroke and Evaluation of Neuroprotective Effect of Secretase and Caveolin-1 Inhibitors.
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- Biomedicines, 2022, v. 10, n. 10, p. N.PAG, doi. 10.3390/biomedicines10102655
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Tongluo Xingnao effervescent tablet reverses memory deficit and reduces plaque load in APPswe/PS1dE9 mice.
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- Experimental & Therapeutic Medicine, 2018, v. 15, n. 4, p. 4005, doi. 10.3892/etm.2018.5897
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Experimental and Theoretical Approaches in the Study of Phenanthroline‐Tetrahydroquinolines for Alzheimer's Disease.
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- ChemistryOpen, 2019, v. 8, n. 5, p. 627, doi. 10.1002/open.201900073
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Gliotoxin Targets Nuclear NOTCH2 in Human Solid Tumor Derived Cell Lines In Vitro and Inhibits Melanoma Growth in Xenograft Mouse Model.
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- Frontiers in Pharmacology, 2017, p. 1, doi. 10.3389/fphar.2017.00319
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Docking Studies and Biological Evaluation of a Potential β-Secretase Inhibitor of 3-Hydroxyhericenone F from Hericium erinaceus.
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- Frontiers in Pharmacology, 2017, v. 8, p. 1, doi. 10.3389/fphar.2017.00219
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Neuroprotective Effect of Ligustilide through Induction of α-Secretase Processing of Both APP and Klotho in a Mouse Model of Alzheimer's Disease.
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- Frontiers in Aging Neuroscience, 2017, p. 1, doi. 10.3389/fnagi.2017.00353
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Per-Residue Energy Footprints-Based Pharmacophore Modeling as an Enhanced In Silico Approach in Drug Discovery: A Case Study on the Identification of Novel β-Secretase1 (BACE1) Inhibitors as Anti-Alzheimer Agents.
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- Cellular & Molecular Bioengineering, 2016, v. 9, n. 1, p. 175, doi. 10.1007/s12195-015-0421-8
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Nirogacestat and its potential impact on desmoid tumor.
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- Rare Tumors, 2023, p. 1, doi. 10.1177/20363613231182485
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- Article
Nirogacestat and its potential impact on desmoid tumor.
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- Rare Tumors, 2023, v. 15, p. 1, doi. 10.1177/20363613231182485
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- Article
Discovery of Tryptophan‐tetrahydroisoquinoline Derivatives as Multifunctional Agents for Treatment of Alzheimer's Disease.
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- Chinese Journal of Chemistry, 2022, v. 40, n. 15, p. 1821, doi. 10.1002/cjoc.202200096
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Inhibition of the Numb/Notch signaling pathway increases radiation sensitivity in human nasopharyngeal carcinoma cells.
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- Kaohsiung Journal of Medical Sciences, 2019, v. 35, n. 8, p. 474, doi. 10.1002/kjm2.12087
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The Binding Mechanisms and Inhibitory Effect of Intravenous Anesthetics on AChE In Vitro and In Vivo: Kinetic Analysis and Molecular Docking.
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- Neurochemical Research, 2019, v. 44, n. 9, p. 2147, doi. 10.1007/s11064-019-02852-y
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ALDH<sup>+</sup> tumor-initiating cells exhibiting gain in NOTCH1 gene copy number have enhanced regrowth sensitivity to a γ-secretase inhibitor and irinotecan in colorectal cancer
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- Molecular Oncology, 2012, v. 6, n. 3, p. 370, doi. 10.1016/j.molonc.2012.03.004
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Intermittent Oral Coadministration of a Gamma Secretase Inhibitor with Dexamethasone Mitigates Intestinal Goblet Cell Hyperplasia in Rats.
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- Toxicologic Pathology, 2014, v. 42, n. 2, p. 422, doi. 10.1177/0192623313486315
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Dimensionality-reduction techniques for complex mass spectrometric datasets: application to laboratory atmospheric organic oxidation experiments.
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- Atmospheric Chemistry & Physics, 2020, v. 20, n. 2, p. 1021, doi. 10.5194/acp-20-1021-2020
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Loss of Notch dimerization perturbs intestinal homeostasis by a mechanism involving HDAC activity.
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- PLoS Genetics, 2024, v. 20, n. 12, p. 1, doi. 10.1371/journal.pgen.1011486
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A β-Secretase (BACE1)-inhibiting C-Methylrotenoid Induced by Yeast Elicitation in Abronia nana Suspension Cultures.
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- Applied Biochemistry & Biotechnology, 2014, v. 172, n. 7, p. 3529, doi. 10.1007/s12010-014-0762-0
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Inhibition of Notch signaling facilitates the differentiation of human-induced pluripotent stem cells into neural stem cells.
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- Molecular & Cellular Biochemistry, 2014, v. 395, n. 1/2, p. 291, doi. 10.1007/s11010-014-2130-3
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Deal watch: Lilly buys back into the BACE race for Alzheimer's disease.
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- Nature Reviews Drug Discovery, 2014, v. 13, n. 11, p. 804, doi. 10.1038/nrd4469
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The BACE race is on.
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- Nature Reviews Drug Discovery, 2014, v. 13, n. 3, p. 165, doi. 10.1038/nrd4274
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- Article
Neurodegenerative diseases: New kinase targets for Alzheimer's disease.
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- Nature Reviews Drug Discovery, 2013, v. 12, n. 10, p. 739, doi. 10.1038/nrd4132
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Active site geometry stabilization of a presenilin homolog by the lipid bilayer promotes intramembrane proteolysis.
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- eLife, 2022, p. 1, doi. 10.7554/eLife.76090
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- Article