Works about RHO-associated kinases

Results: 535

Upregulation of miR-183 inhibits the invasion and migration of endometrial stromal cells in endometriosis patients by downregulating Ezrin.

Published in:

Frontiers in Oncology, 2025, p. 1, doi. 10.3389/fonc.2025.1537528

By:

Shi, Jinmei;
Cai, Junbo;
Kong, Lin;
Ying, Lingxiao;
Liu, Xing;
Jiang, Mengting;
Pan, Dan

Publication type:

Article

RCAN1 in cardiovascular diseases: molecular mechanisms and a potential therapeutic target.

Published in:

Molecular Medicine, 2020, v. 26, n. 1, p. N.PAG, doi. 10.1186/s10020-020-00249-0

By:

Wang, Shuai;
Wang, Yuqing;
Qiu, Kaixin;
Zhu, Jin;
Wu, Yili

Publication type:

Article

Rho-kinase expression in Hirschsprung's disease.

Published in:

2015

By:

Coyle, David;
O'Donnell, Anne;
Corcionivoschi, Nicolae;
Gillick, John;
Puri, Prem;
O'Donnell, Anne Marie

Publication type:

journal article

Piezo1 regulates actin cytoskeleton remodeling to drive EMT in cervical cancer through the RhoA/ROCK1/PIP2 signaling pathway.

Published in:

Discover Oncology, 2025, v. 16, n. 1, p. 1, doi. 10.1007/s12672-025-02474-7

By:

Deng, Juexiao;
Li, Yang;
Zhang, Lanyue;
Liao, Wenxin;
Liu, Tingting;
Shen, Fujin

Publication type:

Article

Descemet Stripping Only for Symptomatic Fuchs Endothelial Dystrophy—A Retrospective Case Series Comparing ROCK-I vs. Hypertonic Sodium Chloride for Post-Surgical Adjuvant Therapy.

Published in:

2025

By:

Cohen, Eyal;
Din, Nizar;
Aldrees, Sultan;
Mimouni, Michael;
Trinh, Tanya;
Sorkin, Nir;
Gouvea, Larissa;
Chan, Clara C.;
Slomovic, Allan R.

Publication type:

Case Study

Therapeutic Advancements in Psoriasis and Psoriatic Arthritis.

Published in:

Journal of Clinical Medicine, 2025, v. 14, n. 4, p. 1312, doi. 10.3390/jcm14041312

By:

Yi, Robin C.;
Akbik, Maya;
Smith, Logan R.;
Klionsky, Yael;
Feldman, Steven R.

Publication type:

Article

Safety and Efficacy of the Rho-Kinase Inhibitor (Ripasudil) in Bleb Needling after Trabeculectomy: A Prospective Multicenter Study.

Published in:

Journal of Clinical Medicine, 2024, v. 13, n. 1, p. 75, doi. 10.3390/jcm13010075

By:

Mizuno, Yu;
Komatsu, Kaori;
Tokumo, Kana;
Okada, Naoki;
Onoe, Hiromitsu;
Okumichi, Hideaki;
Hirooka, Kazuyuki;
Aoki, Gaku;
Miura, Yukiko;
Kiuchi, Yoshiaki

Publication type:

Article

The Dual Effect of Rho-Kinase Inhibition on Trabecular Meshwork Cells Cytoskeleton and Extracellular Matrix in an In Vitro Model of Glaucoma.

Published in:

Journal of Clinical Medicine, 2022, v. 11, n. 4, p. N.PAG, doi. 10.3390/jcm11041001

By:

Buffault, Juliette;
Brignole-Baudouin, Françoise;
Reboussin, Élodie;
Kessal, Karima;
Labbé, Antoine;
Mélik Parsadaniantz, Stéphane;
Baudouin, Christophe

Publication type:

Article

Genetic Risk and Phenotype Correlation of Primary Open-Angle Glaucoma Based on Rho-Kinase Gene Polymorphisms.

Published in:

Journal of Clinical Medicine, 2021, v. 10, n. 9, p. 1953, doi. 10.3390/jcm10091953

By:

Kim, Yong-Woo;
Bak, Eunoo;
Wy, Seoyoung;
Lee, Seung-Chan;
Kim, Yu-Jeong;
Kim, Young-Kook;
Park, Ki-Ho;
Jeoung, Jin-Wook;
Grzybowski, Andrzej

Publication type:

Article

Effects of Netarsudil on Actin-Driven Cellular Functions in Normal and Glaucomatous Trabecular Meshwork Cells: A Live Imaging Study.

Published in:

Journal of Clinical Medicine, 2020, v. 9, n. 11, p. 3524, doi. 10.3390/jcm9113524

By:

Keller, Kate E.;
Kopczynski, Casey

Publication type:

Article

In Silico Drug Screening for Hepatitis C Virus Using QSAR-ML and Molecular Docking with Rho-Associated Protein Kinase 1 (ROCK1) Inhibitors.

Published in:

Computation, 2024, v. 12, n. 9, p. 175, doi. 10.3390/computation12090175

By:

De Borja, Joshua R.;
Cabrera, Heherson S.

Publication type:

Article

Inhibitors of Rho kinases (ROCK) induce multiple mitotic defects and synthetic lethality in BRCA2-deficient cells.

Published in:

eLife, 2023, p. 1, doi. 10.7554/eLife.80254

By:

Martino, Julieta;
Siri, Sebastián Omar;
Calzetta, Nicolás Luis;
Paviolo, Natalia Soledad;
Garro, Cintia;
Pansa, Maria F.;
Carbajosa, Sofía;
Brown, Aaron C.;
Bocco, José Luis;
Gloger, Israel;
Drewes, Gerard;
Madauss, Kevin P.;
Soria, Gastón;
Gottifredi, Vanesa

Publication type:

Article

SARS-CoV-2 S-protein expression drives syncytia formation in endothelial cells.

Published in:

Scientific Reports, 2025, v. 15, n. 1, p. 1, doi. 10.1038/s41598-025-86242-1

By:

Tieu, Katie V.;
Espey, Madaline;
Narayanan, Aarthi;
Heise, Rebecca L.;
Alem, Farhang;
Conway, Daniel E.

Publication type:

Article

Formation of Well-defined Embryoid Bodies from Dissociated Human Induced Pluripotent Stem Cells using Microfabricated Cell-repellent Microwell Arrays.

Published in:

Scientific Reports, 2014, p. 1, doi. 10.1038/srep07402

By:

Pettinato, Giuseppe;
Xuejun Wen;
Ning Zhang

Publication type:

Article

A Phase 1 Pharmacokinetic Drug Interaction Study of Belumosudil Coadministered With CYP3A4 Inhibitors and Inducers and Proton Pump Inhibitors.

Published in:

Clinical Pharmacology in Drug Development, 2022, v. 11, n. 7, p. 795, doi. 10.1002/cpdd.1082

By:

Schueller, Olivier;
Willson, Ashley;
Singh, Nand;
Lohmer, Lauren;
Alabanza, Anginelle;
Patel, Jeegar

Publication type:

Article

Corrigendum: Nonmuscle myosin heavy chain IIA-mediated exosome release via regulation of the rho-associated kinase 1/myosin light chains/actin pathway.

Published in:

2024

By:

Lv, Yanni;
Chen, Jin;
Hu, Jinfang;
Qian, Yisong;
Kong, Ying;
Fu, Longsheng

Publication type:

Correction Notice

Direct effects of Rho-kinase inhibitor on pial microvessels in rabbits.

Published in:

Journal of Anesthesia, 2015, v. 29, n. 2, p. 186, doi. 10.1007/s00540-014-1903-x

By:

Kotoda, Masakazu;
Ishiyama, Tadahiko;
Shintani, Noriyuki;
Matsukawa, Takashi

Publication type:

Article

Effect of Rho-kinase Inhibitor, Y27632, on Porcine Corneal Endothelial Cell Culture, Inflammation and Immune Regulation.

Published in:

2016

By:

Lee, Whayoung;
Miyagawa, Yuko;
Long, Cassandra;
Zhang, Matthew;
Cooper, David K. C.;
Hara, Hidetaka

Publication type:

journal article

The Latest Drugs in Development That Reduce Intraocular Pressure in Ocular Hypertension and Glaucoma.

Published in:

Journal of Experimental Pharmacology, 2020, v. 12, p. 539, doi. 10.2147/JEP.S281187

By:

Jayanetti, Viran;
Sandhu, Sartaj;
Lusthaus, Jed A

Publication type:

Article

Farnesyltransferase inhibition overcomes oncogene-addicted non-small cell lung cancer adaptive resistance to targeted therapies.

Published in:

Nature Communications, 2024, v. 15, n. 1, p. 1, doi. 10.1038/s41467-024-49360-4

By:

Figarol, Sarah;
Delahaye, Célia;
Gence, Rémi;
Doussine, Aurélia;
Cerapio, Juan Pablo;
Brachais, Mathylda;
Tardy, Claudine;
Béry, Nicolas;
Asslan, Raghda;
Colinge, Jacques;
Villemin, Jean-Philippe;
Maraver, Antonio;
Ferrer, Irene;
Paz-Ares, Luis;
Kessler, Linda;
Burrows, Francis;
Lajoie-Mazenc, Isabelle;
Dongay, Vincent;
Morin, Clara;
Florent, Amélie

Publication type:

Article

Natural Plant Compounds: Does Caffeine, Dipotassium Glycyrrhizinate, Curcumin, and Euphol Play Roles as Antitumoral Compounds in Glioblastoma Cell Lines?

Published in:

Frontiers in Neurology, 2022, v. 13, p. 1, doi. 10.3389/fneur.2021.784330

By:

Bonafé, Gabriel Alves;
Boschiero, Matheus Negri;
Sodré, André Rodrigues;
Ziegler, Jussara Vaz;
Rocha, Thalita;
Ortega, Manoela Marques

Publication type:

Article

Multi‐objective Optimization of Benzamide Derivatives as Rho Kinase Inhibitors.

Published in:

Molecular Informatics, 2018, v. 37, n. 3, p. 1, doi. 10.1002/minf.201700080

By:

Cardoso Gajo, Giovanna;
Rodrigues Silva, Daniela;
Barigye, Stephen J.;
da Cunha, Elaine Fontes Ferreira

Publication type:

Article

Derivation of Self-inhibitory Helical Peptides to Target Rho-kinase Dimerization in Cerebrovascular Malformation: Structural Bioinformatics Analysis and Peptide Binding Assay.

Published in:

Molecular Informatics, 2016, v. 35, n. 6/7, p. 262, doi. 10.1002/minf.201501022

By:

Wang, Xuyang;
Hou, Dianqi;
Dai, Weiwei;
Gao, Wenwei;
Ju, Shiming;
Cao, Heli;
Zhang, Lin;
Wang, Gan;
Guo, Yan;
Chen, Shiwen;
Tian, Hengli;
Li, Zhiqiang

Publication type:

Article

Affected primitive streak morphology does not inhibit primordial germ cell induction in rabbit.

Published in:

Anatomy: International Journal of Experimental & Clinical Anatomy, 2022, v. 16, p. S176

By:

Harre, Antonia;
Viebahn, Christoph;
Püschel, Bernd

Publication type:

Article

CID16020046, a GPR55 antagonist, attenuates sepsis-induced acute kidney injury.

Published in:

Molecular Medicine Reports, 2022, v. 25, n. 5, p. N.PAG, doi. 10.3892/mmr.2022.12671

By:

Chen, Rongxin;
Xu, Hailin;
Guo, Zebin;
Zhang, Peng;
Chen, Jianxia;
Chen, Zheng

Publication type:

Article

Phosphorylated-myosin light chain mediates the destruction of small intestinal epithelial tight junctions in mice with acute liver failure.

Published in:

Molecular Medicine Reports, 2021, v. 23, n. 5, p. N.PAG, doi. 10.3892/mmr.2021.12031

By:

Wu, Fan;
Li, Hui;
Zhang, Heng;
Liao, Yusheng;
Ren, Huanping;
Wu, Jie;
Zheng, Dan

Publication type:

Article

0.5-Gy X-ray irradiation induces reorganization of cytoskeleton and differentiation of osteoblasts.

Published in:

Molecular Medicine Reports, 2021, v. 23, n. 5, p. N.PAG, doi. 10.3892/mmr.2021.12018

By:

Huang, Qun;
Chai, Hao;
Wang, Shendong;
Sun, Yongming;
Xu, Wei

Publication type:

Article

Role of ROCK/NF-κB/AQP8 signaling in ethanol-induced intestinal epithelial barrier dysfunction.

Published in:

Molecular Medicine Reports, 2020, v. 22, n. 3, p. 2253, doi. 10.3892/mmr.2020.11318

By:

Zhao, Hang;
Sun, Xiaonan;
Tong, Jing

Publication type:

Article

lncRNA HAND2-AS1 mediates the downregulation of ROCK2 in hepatocellular carcinoma and inhibits cancer cell proliferation, migration and invasion.

Published in:

Molecular Medicine Reports, 2020, v. 21, n. 3, p. 1304, doi. 10.3892/mmr.2020.10928

By:

Jiang, Lijing;
He, Yunfen;
Shen, Guofeng;
Ni, Jindi;
Xia, Zhuye;
Liu, Hongjie;
Cao, Yunshan;
Li, Xiang

Publication type:

Article

MicroRNA-122 downregulates Rho-associated protein kinase 2 expression and inhibits the proliferation of prostate carcinoma cells.

Published in:

Molecular Medicine Reports, 2019, v. 19, n. 5, p. 3882

By:

Liu, Hong;
Hou, Teng;
Ju, Wen;
Xing, Yifei;
Zhang, Xiaoping;
Yang, Jun

Publication type:

Article

Salidroside prevents diabetes-induced cognitive impairment via regulating the Rho pathway.

Published in:

Molecular Medicine Reports, 2019, v. 19, n. 1, p. 678

By:

Hao, Xiuzhen;
Yuan, Jie;
Dong, Huixiao

Publication type:

Article

Silencing of URG11 expression inhibits the proliferation and epithelial-mesenchymal transition in benign prostatic hyperplasia cells via the RhoA/ROCK1 pathway.

Published in:

Molecular Medicine Reports, 2018, v. 18, n. 1, p. 391, doi. 10.3892/mmr.2018.8993

By:

Zhang, Guanying;
Zhu, Feng;
Han, Guangye;
Li, Zeyu;
Yu, Quanfeng;
Li, Zhenhui;
Li, Jianchang

Publication type:

Article

MicroRNA‑129‑5p suppresses cell proliferation, migration and invasion via targeting ROCK1 in osteosarcoma.

Published in:

Molecular Medicine Reports, 2018, v. 17, n. 3, p. 4777, doi. 10.3892/mmr.2018.8374

By:

Han, Chaofan;
Wang, WENbo

Publication type:

Article

MicroRNA‑195 inhibits cell proliferation, migration and invasion in laryngeal squamous cell carcinoma by targeting ROCK1.

Published in:

Molecular Medicine Reports, 2017, v. 16, n. 5, p. 7154, doi. 10.3892/mmr.2017.7460

By:

YANG LIU;
JIXIANG LIU;
LIN WANG;
XIANGLI YANG;
XIANG LIU

Publication type:

Article

Rho-kinase signaling pathway promotes the expression of PARP to accelerate cardiomyocyte apoptosis in ischemia/reperfusion.

Published in:

Molecular Medicine Reports, 2017, v. 16, n. 2, p. 2002, doi. 10.3892/mmr.2017.6826

By:

HONGJUN BIAN;
YI ZHOU;
BIN YU;
DEYA SHANG;
FULI LIU;
BIN LI;
JIANNI QI

Publication type:

Article

RhoA inhibits apoptosis and increases proliferation of cultured SPCA1 lung cancer cells.

Published in:

Molecular Medicine Reports, 2017, v. 15, n. 6, p. 3963, doi. 10.3892/mmr.2017.6545

By:

XUEYING YANG;
DABEI LIU;
XINGKE MEI;
LINLIN WANG

Publication type:

Article

Inhibition of Rho-associated protein kinase increases the ratio of formation of blastocysts from single human blastomeres.

Published in:

Molecular Medicine Reports, 2016, v. 13, n. 3, p. 2046, doi. 10.3892/mmr.2016.4766

By:

SUNXING HUANG;
CHENHUI DING;
QINGYUN MAI;
YANWEN XU;
CANQUAN ZHOU

Publication type:

Article

Inhibitory effects of fasudil on renal interstitial fibrosis induced by unilateral ureteral obstruction.

Published in:

Molecular Medicine Reports, 2015, v. 12, n. 6, p. 8010, doi. 10.3892/mmr.2015.4467

By:

ITSUKO BABA;
YASUHIRO EGI;
HIROYUKI UTSUMI;
TETSUHIRO KAKIMOTO;
KAZUO SUZUKI

Publication type:

Article

Rho-associated kinase inhibitor, Y-27632, inhibits the invasion and proliferation of T24 and 5367 bladder cancer cells.

Published in:

Molecular Medicine Reports, 2015, v. 12, n. 5, p. 7526, doi. 10.3892/mmr.2015.4404

By:

LEI JIANG;
JIAMING WEN;
WEI LUO

Publication type:

Article

Protection of photoreceptors by intravitreal injection of the Y-27632 Rho-associated protein kinase inhibitor in Royal College of Surgeons rats.

Published in:

Molecular Medicine Reports, 2015, v. 12, n. 3, p. 3655, doi. 10.3892/mmr.2015.3889

By:

TING ZHANG;
YANTAO WEI;
XINTONG JIANG;
JINGMING LI;
SUO QIU;
SHAOCHONG ZHANG

Publication type:

Article

Role of ROCK expression in gallbladder smooth muscle contraction.

Published in:

Molecular Medicine Reports, 2015, v. 12, n. 2, p. 2907, doi. 10.3892/mmr.2015.3726

By:

BIN WANG;
YOU-MING DING;
CHUN-TAO WANG;
WEI-XING WANG

Publication type:

Article

microRNA-145 inhibits osteosarcoma cell proliferation and invasion by targeting ROCK1.

Published in:

Molecular Medicine Reports, 2014, v. 10, n. 1, p. 155, doi. 10.3892/mmr.2014.2195

By:

PENGFEI LEI;
JIE XIE;
LONG WANG;
XUCHENG YANG;
ZIXUN DAI;
YIHE HU

Publication type:

Article

Y-27632 inhibits ethanol-induced increase in intestinal epithelial barrier permeability.

Published in:

Molecular Medicine Reports, 2014, v. 9, n. 6, p. 2357, doi. 10.3892/mmr.2014.2060

By:

JING TONG;
YING WANG;
BING CHANG;
DAI ZHANG;
BINGYUAN WANG

Publication type:

Article

ROCK1, a novel target of miR-145, promotes glioma cell invasion.

Published in:

Molecular Medicine Reports, 2014, v. 9, n. 5, p. 1877, doi. 10.3892/mmr.2014.1982

By:

XIN WAN;
QUAN CHENG;
RENJUN PENG;
ZHIMING MA;
ZIGUI CHEN;
YIQIANG CAO;
BING JIANG

Publication type:

Article

Establishment of Primary Transgenic Human Airway Epithelial Cell Cultures to Study Respiratory Virus–Host Interactions.

Published in:

Viruses (1999-4915), 2019, v. 11, n. 8, p. 747, doi. 10.3390/v11080747

By:

Jonsdottir, Hulda R.;
Marti, Sabrina;
Geerts, Dirk;
Rodriguez, Regulo;
Thiel, Volker;
Dijkman, Ronald

Publication type:

Article

Vanillic Acid Alleviates Right Ventricular Function in Rats With MCT-Induced Pulmonary Arterial Hypertension.

Published in:

Natural Product Communications, 2023, v. 18, n. 1, p. 1, doi. 10.1177/1934578X221148896

By:

Chen, Ju;
Huayu, Meiduo;
Su, Shanshan;
Wang, Shan;
Yang, Zhanting;
Nan, Xingmei;
Lu, Dianxiang;
Li, Zhanqiang

Publication type:

Article

Cooperative induction of apoptosis in NRAS mutant melanoma by inhibition of MEK and ROCK.

Published in:

Pigment Cell & Melanoma Research, 2015, v. 28, n. 3, p. 307, doi. 10.1111/pcmr.12364

By:

Vogel, Celia J.;
Smit, Marjon A.;
Maddalo, Gianluca;
Possik, Patricia A.;
Sparidans, Rolf W.;
Burg, Sjoerd H.;
Verdegaal, Els M.;
Heck, Albert J. R.;
Samatar, Ahmed A.;
Beijnen, Jos H.;
Altelaar, A. F. Maarten;
Peeper, Daniel S.

Publication type:

Article

Effect of Rho-Kinase and Autophagy on Remote Ischemic Conditioning-Induced Cardioprotection in Rat Myocardial Ischemia/Reperfusion Injury Model.

Published in:

Cardiovascular Therapeutics, 2022, p. 1, doi. 10.1155/2022/6806427

By:

Gao, Jie;
Min, Feng;
Wang, Shasha;
Lv, Heng;
Liang, Huan;
Cai, Ben;
Jia, Xianjie;
Gao, Qin;
Yu, Ying

Publication type:

Article

Rho-Kinase inhibitor fasudil suppresses high glucose-induced H9c2 cell apoptosis through activation of autophagy.

Published in:

Cardiovascular Therapeutics, 2016, v. 34, n. 5, p. 352, doi. 10.1111/1755-5922.12206

By:

Gao, Huikuan;
Hou, Fei;
Dong, Ruiqing;
Wang, Zefeng;
Zhao, Can;
Tang, Wurina;
Wu, Yongquan

Publication type:

Article

The non-selective Rho-kinase inhibitors Y-27632 and Y-33075 decrease contraction but increase migration in murine and human hepatic stellate cells.

Published in:

PLoS ONE, 2023, v. 18, n. 1, p. 1, doi. 10.1371/journal.pone.0270288

By:

Bachtler, Nadine;
Torres, Sandra;
Ortiz, Cristina;
Schierwagen, Robert;
Tyc, Olaf;
Hieber, Christoph;
Berres, Marie-Luise;
Meier, Caroline;
Kraus, Nico;
Zeuzem, Stefan;
Nijmeijer, Bart;
Pronk, Sebas;
Trebicka, Jonel;
Klein, Sabine

Publication type:

Article