Works matching DE "RAS proteins"

Results: 1031

Optimizing drug design by merging generative AI with a physics-based active learning framework.

Published in:

Communications Chemistry, 2025, v. 8, n. 1, p. 1, doi. 10.1038/s42004-025-01635-7

By:

Filella-Merce, Isaac;
Molina, Alexis;
Díaz, Lucía;
Orzechowski, Marek;
Berchiche, Yamina A.;
Zhu, Yang Ming;
Vilalta-Mor, Júlia;
Malo, Laura;
Yekkirala, Ajay S.;
Ray, Soumya;
Guallar, Victor

Publication type:

Article

Inhibition of MLC Phosphorylation Downstream of Ca and RhoA: A Novel Mechanism Involving Phosphorylation of Myosin Phosphatase Interacting Protein (M-RIP) by PKG and Stimulation of MLC Phosphatase Activity.

Published in:

Cell Biochemistry & Biophysics, 2014, v. 68, n. 1, p. 1, doi. 10.1007/s12013-013-9677-6

By:

Mahavadi, Sunila;
Nalli, Ancydimpy;
Al-Shboul, Othman;
Murthy, Karnam

Publication type:

Article

S-Nitrosylation Decreases the Adsorption of H-Ras in Lipid Bilayer and Changes Intrinsic Catalytic Activity.

Published in:

Cell Biochemistry & Biophysics, 2011, v. 59, n. 3, p. 191, doi. 10.1007/s12013-010-9132-x

By:

Shanshiashvili, L.;
Narmania, N.;
Barbakadze, T.;
Zhuravliova, E.;
Natsvlishvili, N.;
Ramsden, J.;
Mikeladze, D. G.

Publication type:

Article

In vitro Scleroderma laeve and Eucalyptus grandis mycorrhization and analysis of atp6, 17S rDNA, and ras gene expression during ectomycorrhizal formation.

Published in:

Journal of Basic Microbiology, 2014, v. 54, n. 12, p. 1358, doi. 10.1002/jobm.201400253

By:

de Freitas Pereira, Maíra;
Betancourth, Blanca Mercedes Leguízamo;
Teixeira, Janaina Aparecida;
Zubieta, Mariane Paludetti;
de Queiroz, Marisa Vieira;
Kasuya, Maria Catarina Megumi;
Costa, Mauricio Dutra;
de Araújo, Elza Fernandes

Publication type:

Article

Letter to the Editor: Sequence-specific resonance assignment of the Ras-binding domain of AF6.

Published in:

Journal of Biomolecular NMR, 2000, v. 18, n. 1, p. 73, doi. 10.1023/A:1008373529242

By:

Steiner, G.;
Kremer, W.;
Linnemann, T.;
Herrmann, C.;
Geyer, M.;
Kalbitzer, H.R.

Publication type:

Article

Landscape of RAS Variations in 17,993 Pan-cancer Patients Identified by Next-generation Sequencing.

Published in:

2020

By:

Zhou, Shaoqiang;
Zhang, Ding;
Li, Junjie;
Zhao, Jing;
Wang, Guoqiang;
Zhang, Yuzi;
Bai, Yuezong;
Chen, Dedian;
Wu, Hao

Publication type:

Letter

Next Generation Lipophilic Bisphosphonate Shows Antitumor Effect in Colorectal Cancer In Vitro and In Vivo.

Published in:

Pathology & Oncology Research, 2020, v. 26, n. 3, p. 1957, doi. 10.1007/s12253-019-00789-9

By:

Baranyi, Marcell;
Rittler, Dominika;
Molnár, Eszter;
Shirasawa, Senji;
Jalsovszky, István;
Varga, Imre Károly;
Hegedűs, Luca;
Németh, Afrodíté;
Dank, Magdolna;
Aigner, Clemens;
Tóvári, József;
Tímár, József;
Hegedűs, Balázs;
Garay, Tamás

Publication type:

Article

EGFR Protein Expression of KRAS Wild-Type Colorectal Cancer: Predictive Value of the Sidedness for Efficacy of Anti-EGFR Therapy.

Published in:

Pathology & Oncology Research, 2020, v. 26, n. 3, p. 1429, doi. 10.1007/s12253-018-00572-2

By:

Uhlyarik, A.;
Piurko, V.;
Vizkeleti, L.;
Pápai, Zs;
Rásó, E.;
Lahm, E.;
Kiss, E.;
Sikter, M.;
Vachaja, J.;
Kenessey, I.;
Tímár, József

Publication type:

Article

Towards an Improvement of Anticancer Activity of Benzyl Adenosine Analogs.

Published in:

Molecules, 2021, v. 26, n. 23, p. 7146, doi. 10.3390/molecules26237146

By:

Covelli, Verdiana;
Grimaldi, Manuela;
Randino, Rosario;
Firoznezhad, Mohammad;
Proto, Maria Chiara;
Simone, Veronica De;
Matteoli, Gianluca;
Gazzerro, Patrizia;
Bifulco, Maurizio;
D'Ursi, Anna Maria;
Rodriquez, Manuela

Publication type:

Article

KRAS (G12D) Cooperates with AML1/ETO to Initiate a Mouse Model Mimicking Human Acute Myeloid Leukemia.

Published in:

Cellular Physiology & Biochemistry (Karger AG), 2014, v. 33, n. 1, p. 78, doi. 10.1159/000356651

By:

Zhao, Shanmin;
Zhang, Yuxia;
Sha, Kun;
Tang, Qiu;
Yang, Xiaohua;
Yu, Chenlin;
Liu, Zhixue;
Sun, Wei;
Cai, Liping;
Xu, Chen;
Cui, Shufang

Publication type:

Article

Overexpression of SYNGAP1 suppresses the proliferation of rectal adenocarcinoma via Wnt/β-Catenin signaling pathway.

Published in:

Discover Oncology, 2024, v. 15, n. 1, p. 1, doi. 10.1007/s12672-024-00997-z

By:

Xiao, Yun;
Zhu, Ying;
Chen, Jiaojiao;
Wu, Mei;
Wang, Lan;
Su, Li;
Feng, Fei;
Hou, Yanli

Publication type:

Article

Identification of an H-Ras nanocluster disrupting peptide.

Published in:

Communications Biology, 2024, v. 7, n. 1, p. 1, doi. 10.1038/s42003-024-06523-9

By:

Steffen, Candy Laura;
Manoharan, Ganesh babu;
Pavic, Karolina;
Yeste-Vázquez, Alejandro;
Knuuttila, Matias;
Arora, Neha;
Zhou, Yong;
Härmä, Harri;
Gaigneaux, Anthoula;
Grossmann, Tom N.;
Abankwa, Daniel Kwaku

Publication type:

Article

DIFFERENTIAL GENE EXPRESSION OF KRAS GENE IN COLON ADENOCARCINOMA CELL LINE (HT-29) TREATED WITH L. PLANTARUM (ATCC 804) DERIVED SCFA.

Published in:

Journal of Experimental Zoology India, 2024, v. 27, n. 2, p. 2257, doi. 10.51470/jez.2024.27.2.2257

By:

Antony Reneese, P. Joseph;
Kasilingam, S.;
Ragavi, M.;
Boominathan, Meganathan;
Muthukumar, Sivaramapillai;
Razia, M.;
Ramaiyan, Sankar

Publication type:

Article

Combining an FPTase inhibitor with cisplatin facilitates induction of apoptosis in human A549 lung cancer cells.

Published in:

Journal of Experimental Therapeutics & Oncology, 2011, v. 9, n. 1, p. 53

By:

Weber, Franziska;
Siska, Peter;
Kramer, Matthias;
Zulehner, Nora;
Hacki, Stefan;
Węsierska-Gądek, Józefa

Publication type:

Article

Characterization of Infiltrating Immune Cells and Secretory or Membrane-Associated Proteins in KRAS Lung Adenocarcinoma.

Published in:

Journal of Immunology Research, 2023, p. 1, doi. 10.1155/2023/4987832

By:

Bian, Yunyi;
Bi, Guoshu;
Shan, Guangyao;
Liang, Jiaqi;
Sui, Qihai;
Hu, Zhengyang;
Wang, Qun;
Zhang, Yi;
Fan, Hong

Publication type:

Article

Targeting oncogenic KRasG13C with nucleotide-based covalent inhibitors.

Published in:

eLife, 2023, p. 1, doi. 10.7554/eLife.82184

By:

Goebel, Lisa;
Kirschner, Tonia;
Koska, Sandra;
Rai, Amrita;
Janning, Petra;
Maffini, Stefano;
Vatheuer, Helge;
Czodrowski, Paul;
Goody, Roger S.;
Müller, Matthias P.;
Rauh, Daniel

Publication type:

Article

Inhibition of mutant RAS-RAF interaction by mimicking structural and dynamic properties of phosphorylated RAS.

Published in:

eLife, 2022, p. 1, doi. 10.7554/eLife.79747

By:

Ilter, Metehan;
Kasmer, Ramazan;
Jalalypour, Farzaneh;
Atilgan, Canan;
Topcu, Ozan;
Karakas, Nihal;
Sensoy, Ozge

Publication type:

Article

A saturation-mutagenesis analysis of the interplay between stability and activation in Ras.

Published in:

eLife, 2022, p. 1, doi. 10.7554/eLife.76595

By:

Hidalgo, Frank;
Nocka, Laura M.;
Shah, Neel H.;
Gorday, Kent;
Latorraca, Naomi R.;
Bandaru, Pradeep;
Templeton, Sage;
Lee, David;
Karandur, Deepti;
Pelton, Jeffrey G.;
Marqusee, Susan;
Wemmer, David;
Kuriyan, John

Publication type:

Article

Quantitative Systems Pharmacology Analysis of KRAS G12C Covalent Inhibitors.

Published in:

CPT: Pharmacometrics & Systems Pharmacology, 2018, v. 7, n. 5, p. 342, doi. 10.1002/psp4.12291

By:

Stites, Edward C.;
Shaw, Andrey S.

Publication type:

Article

STAT3–mediated up-regulation of DAB2 via SRC-YAP1 signaling axis promotes Helicobacter pylori-driven gastric tumorigenesis.

Published in:

Biomarker Research, 2024, v. 12, n. 1, p. 1, doi. 10.1186/s40364-024-00577-x

By:

Duan, Yantao;
Kong, Pengfei;
Huang, Mingzhu;
Yan, Yonghao;
Dou, Yi;
Huang, Binhao;
Guo, Jing;
Kang, Wei;
Zhu, Caixia;
Wang, Yuyan;
Zhou, Donglei;
Cai, Qiliang;
Xu, Dazhi

Publication type:

Article

R-Ras deficiency does not affect papain-induced IgE production in mice.

Published in:

Immunity, Inflammation & Disease, 2017, v. 5, n. 3, p. 280, doi. 10.1002/iid3.168

By:

Kummola, Laura;
Ortutay, Zsuzsanna;
Vähätupa, Maria;
Prince, Stuart;
Uusitalo‐Järvinen, Hannele;
Järvinen, Tero A.H.;
Junttila, Ilkka S.

Publication type:

Article

Unraveling novel variants in the NF1 gene and investigating potential therapeutic strategies.

Published in:

Scientific Reports, 2025, v. 15, n. 1, p. 1, doi. 10.1038/s41598-025-07318-6

By:

Huang, Jianmei;
Yang, Ke;
Wang, Yaoping;
Ma, Xinrui;
Yang, Wenke;
Huo, Xiaodong;
Bai, Jie;
Zhu, Hongjie;
Wang, Jinming;
Lv, Yibing;
Liao, Shixiu

Publication type:

Article

GRB2 promotes brain metastasis in HER2-positive breast cancer by regulating the Ras/MAPK pathway.

Published in:

Scientific Reports, 2025, v. 15, n. 1, p. 1, doi. 10.1038/s41598-025-99685-3

By:

Li, Hongyu;
Zhang, Yalin;
Han, Xiao;
Li, Bingyu;
Liu, Dan;
Sun, Gang

Publication type:

Article

Jorunnamycin A induces apoptosis in pancreatic ductal adenocarcinoma cells, spheroids, and patient-derived organoids by modulating KRAS-mediated survival pathways.

Published in:

Scientific Reports, 2025, v. 15, n. 1, p. 1, doi. 10.1038/s41598-025-95766-5

By:

Khine, Hnin Ei Ei;
Suriya, Utid;
Rungrotmongkol, Thanyada;
Chamni, Supakarn;
Lu, Yanxi;
Bénard, Alan;
Lan, Bin;
Mukhopadhyay, Debabrata;
Chang, David;
Biankin, Andrew;
Schneider-Stock, Regine;
Grützmann, Robert;
Sungthong, Rungroch;
Pilarsky, Christian;
Chaotham, Chatchai

Publication type:

Article

Network pharmacology and AI in cancer research uncovering biomarkers and therapeutic targets for RALGDS mutations.

Published in:

Scientific Reports, 2025, v. 15, n. 1, p. 1, doi. 10.1038/s41598-025-91568-x

By:

Zaidh, S. Mohammed;
Vengateswaran, Hariharan Thirumalai;
Habeeb, Mohammad;
Aher, Kiran Balasaheb;
Bhavar, Girija Balasaheb;
Irfan, N.;
Lakshmi, K N V Chenchu

Publication type:

Article

IRGM1 enhances B16 melanoma cell metastasis through PI3K-Rac1 mediated epithelial mesenchymal transition.

Published in:

Scientific Reports, 2015, p. 12357, doi. 10.1038/srep12357

By:

Tian, Linlu;
Xing, Wenjing;
Pei, Chunying;
Dong, Xiao;
Fu, Yanran;
Gu, Changcong;
Guo, Xize;
Li, Bo;
Ren, Huan;
Xu, Hongwei;
Li, Lixian;
Jia, Yulong;
Li, Rui;
Wang, Guangyou;
Wang, Jinghua

Publication type:

Article

Rap2B promotes proliferation, migration, and invasion of human breast cancer through calcium-related ERK1/2 signaling pathway.

Published in:

Scientific Reports, 2015, p. 12363, doi. 10.1038/srep12363

By:

Di, Jiehui;
Huang, Hui;
Qu, Debao;
Tang, Juangjuan;
Cao, Wenjia;
Lu, Zheng;
Cheng, Qian;
Yang, Jing;
Bai, Jin;
Zhang, Yanping;
Zheng, Junnian

Publication type:

Article

RhoA and Membrane Fluidity Mediates the Spatially Polarized Src/FAK Activation in Response to Shear Stress.

Published in:

Scientific Reports, 2014, p. 1, doi. 10.1038/srep07008

By:

Bo Liu;
Shaoying Lu;
Ying-li Hu;
Xiaoling Liao;
Mingxing Ouyang;
Yingxiao Wang

Publication type:

Article

Endothelial-Derived APT1-Mediated Macrophage-Endothelial Cell Interactions Participate in the Development of Atherosclerosis by Regulating the Ras/MAPK Signaling Pathway.

Published in:

Life (2075-1729), 2022, v. 12, n. 4, p. N.PAG, doi. 10.3390/life12040551

By:

Wang, Xinghua;
Cheng, Lijun;
Fu, Huaying;
Chan, Calista Zhuo Yi;
Tse, Gary;
Liu, Tong;
Li, Guangping

Publication type:

Article

Overexpression of Ras-GTPase-activating protein SH3 domain-binding protein 1 correlates with poor prognosis in gastric cancer patients.

Published in:

Histopathology, 2015, v. 67, n. 5, p. 677, doi. 10.1111/his.12695

By:

Min, Lingqiang;
Ruan, Yuanyuan;
Shen, Zhenbin;
Jia, Dongwei;
Wang, Xuefei;
Zhao, Junjie;
Sun, Yihong;
Gu, Jianxin

Publication type:

Article

The NFAT3/RERG Complex in Luminal Breast Cancers Is Required to Inhibit Cell Invasion and May Be Correlated With an Absence of Axillary Lymph Nodes Colonization.

Published in:

Frontiers in Oncology, 2022, v. 12, p. 1, doi. 10.3389/fonc.2022.804868

By:

Coillard, Lucie;
Guaddachi, Frédéric;
Ralu, Maëlle;
Brabencova, Eva;
Garbar, Christian;
Bensussan, Armand;
Le Bras, Morgane;
Lehmann-Che, Jacqueline;
Jauliac, Sébastien

Publication type:

Article

Mechanistic insights into the clinical Y96D mutation with acquired resistance to AMG510 in the KRASG12C.

Published in:

Frontiers in Oncology, 2022, v. 12, p. 1, doi. 10.3389/fonc.2022.915512

By:

Haiming Zhuang;
Jigang Fan;
Mingyu Li;
Hao Zhang;
Xiuyan Yang;
Ligen Lin;
Shaoyong Lu;
Qing Wang;
Yaqin Liu

Publication type:

Article

Concurrent inhibition of FAK/SRC and MEK overcomes MEK inhibitor resistance in Neurofibromatosis Type I related malignant peripheral nerve sheath tumors.

Published in:

Frontiers in Oncology, 2022, v. 12, p. 1, doi. 10.3389/fonc.2022.910505

By:

Yihui Gu;
Chengjiang Wei;
Manhon Chung;
Haibo Li;
Zizhen Guo;
Manmei Long;
Yuehua Li;
Wei Wang;
Aimaier, Rehanguli;
Qingfeng Li;
Zhichao Wang

Publication type:

Article

The NFAT3/RERG Complex in Luminal Breast Cancers Is Required to Inhibit Cell Invasion and May Be Correlated With an Absence of Axillary Lymph Nodes Colonization.

Published in:

Frontiers in Oncology, 2022, v. 12, p. 1, doi. 10.3389/fonc.2022.804868

By:

Coillard, Lucie;
Guaddachi, Frédéric;
Ralu, Maëlle;
Brabencova, Eva;
Garbar, Christian;
Bensussan, Armand;
Le Bras, Morgane;
Lehmann-Che, Jacqueline;
Jauliac, Sébastien

Publication type:

Article

Selective inhibition of canonical STAT3 signaling suppresses K-ras mutant lung tumorigenesis and reinvigorates anti-tumor immunity.

Published in:

Frontiers in Immunology, 2025, p. 1, doi. 10.3389/fimmu.2025.1575181

By:

Clowers, Michael J.;
Rahal, Zahraa;
Cho, Sung-Nam;
Krishna, Avantika;
Yuan, Bo;
Hamana Zorrilla, Leticia G.;
Eckols, T. Kris;
Kasembeli, Moses M.;
Liu, Samuel;
Peng, Stephen;
Ramos-Castaneda, Marco;
Thompson, Annamarie L.;
Rodriguez Reyna, Carlos Ignacio;
Larsen, Katherine E.;
Grimaldo, Maria T.;
Deng, Shanshan;
Karimi, Nastaran;
Chou, Cody;
Velasco, Walter V.;
Zarghooni, Melody

Publication type:

Article

Differential Expression and Bioinformatics Analysis of circRNA in Non-small Cell Lung Cancer.

Published in:

Frontiers in Genetics, 2020, v. 11, p. N.PAG, doi. 10.3389/fgene.2020.586814

By:

Sun, Qiuwen;
Li, Xia;
Xu, Muchen;
Zhang, Li;
Zuo, Haiwei;
Xin, Yong;
Zhang, Longzhen;
Gong, Ping

Publication type:

Article

The role of G-domain orientation and nucleotide state on the Ras isoform-specific membrane interaction.

Published in:

European Biophysics Journal, 2012, v. 41, n. 10, p. 801, doi. 10.1007/s00249-012-0841-5

By:

Kapoor, Shobhna;
Weise, Katrin;
Erlkamp, Mirko;
Triola, Gemma;
Waldmann, Herbert;
Winter, Roland

Publication type:

Article

CodeBreaK 200: Sotorasib (AMG510) Has Broken the KRAS G12C+ NSCLC Enigma Code.

Published in:

Lung Cancer: Targets & Therapy, 2023, v. 14, p. 31, doi. 10.2147/LCTT.S403614

By:

Brazel, Danielle;
Kim, Jennifer;
Ou, Sai-Hong Ignatius

Publication type:

Article

Rheb promotes cell growth as a component of the insulin/TOR signalling network.

Published in:

Nature Cell Biology, 2003, v. 5, n. 6, p. 566, doi. 10.1038/ncb996

By:

Saucedo, Leslie J.;
Gao, Xinsheng;
Chiarelli, Dominic A.;
Li, Ling;
Pan, Duoija;
Edgar, Bruce A.

Publication type:

Article

Tiam1 mediates Ras activation of Rac by a PI(3)K-independent mechanism.

Published in:

Nature Cell Biology, 2002, v. 4, n. 8, p. 621, doi. 10.1038/ncb833

By:

Lambert, John M.;
Lambert, Que T.;
Reuther, Gary W.;
Malliri, Angeliki;
Siderovski, David P.;
Sondek, John;
Collard, John G.;
Der, Channing J.

Publication type:

Article

Ras signalling on the endoplasmic reticulum and the Golgi.

Published in:

Nature Cell Biology, 2002, v. 4, n. 5, p. 343, doi. 10.1038/ncb783

By:

Chiu, Vi K.;
Bivona, Trever;
Hach, Angela;
Sajous, J. Bernard;
Silletti, Joseph;
Wiener, Heidi;
Johnson, Ronald L.;
Cox, Adrienne D.;
Philips, Mark R.

Publication type:

Article

Oncogenes in Ras signalling pathway dictate host-cell permissiveness to herpes simplex virus 1.

Published in:

Nature Cell Biology, 2001, v. 3, n. 8, p. 745, doi. 10.1038/35087061

By:

Farassati, Faris;
Yang, An-Dao;
Lee, Patrick W. K.

Publication type:

Article

Which Ras rides the raft?

Published in:

Nature Cell Biology, 2001, v. 3, n. 8, p. E172, doi. 10.1038/35087098

By:

White, Michael A.;
Anderson, Richard G. W.

Publication type:

Article

Which Ras rides the raft? - Reply.

Published in:

Nature Cell Biology, 2001, v. 3, n. 8, p. E172, doi. 10.1038/35087100

By:

Prior, Ian A;
Parton, Robert G;
Hancock, John F

Publication type:

Article

Tools of the trade: use of dominant-inhibitory mutants of Ras-family GTPases.

Published in:

Nature Cell Biology, 1999, v. 1, n. 2, p. E25, doi. 10.1038/10018

By:

Feig, Larry A.

Publication type:

Article

Anti-proteolytic regulation of KRAS by USP9X/NDRG3 in KRAS-driven cancer development.

Published in:

Nature Communications, 2025, v. 16, n. 1, p. 1, doi. 10.1038/s41467-024-54476-8

By:

Koo, Han;
Park, Kyung Chan;
Sohn, Hyun Ahm;
Kang, Minho;
Kim, Dong Joon;
Park, Zee-Yong;
Park, Sehoon;
Min, Sang Hyun;
Park, Seong-Hwan;
You, Yeon-Mi;
Han, Yohan;
Kim, Bo-Kyung;
Lee, Chul-Ho;
Kim, Yeon-Soo;
Chung, Sang J.;
Yeom, Young Il;
Lee, Dong Chul

Publication type:

Article

The small GTPase MRAS is a broken switch.

Published in:

Nature Communications, 2025, v. 16, n. 1, p. 1, doi. 10.1038/s41467-025-55967-y

By:

Bernal Astrain, Gabriela;
Strakhova, Regina;
Jo, Chang Hwa;
Teszner, Emma;
Killoran, Ryan C.;
Smith, Matthew J.

Publication type:

Article

Inhibition of DUSP18 impairs cholesterol biosynthesis and promotes anti-tumor immunity in colorectal cancer.

Published in:

Nature Communications, 2024, v. 15, n. 1, p. 1, doi. 10.1038/s41467-024-50138-x

By:

Zhou, Xiaojun;
Wang, Genxin;
Tian, Chenhui;
Du, Lin;
Prochownik, Edward V.;
Li, Youjun

Publication type:

Article

Inhibition of DUSP18 impairs cholesterol biosynthesis and promotes anti-tumor immunity in colorectal cancer.

Published in:

Nature Communications, 2024, v. 15, n. 1, p. 1, doi. 10.1038/s41467-024-50138-x

By:

Zhou, Xiaojun;
Wang, Genxin;
Tian, Chenhui;
Du, Lin;
Prochownik, Edward V.;
Li, Youjun

Publication type:

Article

Lipid-mediated intracellular delivery of recombinant bioPROTACs for the rapid degradation of undruggable proteins.

Published in:

Nature Communications, 2024, v. 15, n. 1, p. 1, doi. 10.1038/s41467-024-50235-x

By:

Chan, Alexander;
Haley, Rebecca M.;
Najar, Mohd Altaf;
Gonzalez-Martinez, David;
Bugaj, Lukasz J.;
Burslem, George M.;
Mitchell, Michael J.;
Tsourkas, Andrew

Publication type:

Article