Works matching DE "PYRIMIDINES"

Results: 3323

Reaction of 5,7-Dihydroxycoumarins with Pyrimidines.

Published in:

Russian Journal of Organic Chemistry, 2025, v. 61, n. 7, p. 1296, doi. 10.1134/S1070428025602134

By:

Fatykhov, R. F.;
Khalymbadzha, I. A.;
Potapova, A. P.;
Melekhin, V. V.;
Paramonova, A.V.;
Kopchuk, D. S.;
Slepukhin, P. A.;
Kartsev, V. G.;
Chupakhin, O. N.

Publication type:

Article

Comparative genomic analysis reveals the adaptive traits of Ralstonia spp. in aquatic environments.

Published in:

Frontiers in Microbiology, 2025, p. 1, doi. 10.3389/fmicb.2025.1625651

By:

Liu, Gaopeng;
Mao, Chengzhi;
Li, Qi;
Huo, Da;
Li, Tao

Publication type:

Article

C-type natriuretic peptide attenuates enhanced glycolysis and de novo pyrimidine synthesis in pericytes of patients with pulmonary arterial hypertension.

Published in:

Communications Biology, 2025, v. 8, n. 1, p. 1, doi. 10.1038/s42003-025-08661-0

By:

Noh, Minhee;
Mitra, Ankita;
Krebes, Lisa;
Schmitz, Werner;
Dudek, Jan;
Agarwal, Stuti;
Maack, Christoph;
Arias-Loza, Paula;
Higuchi, Takahiro;
Aleksic, Ivan;
de Jesus Perez, Vinicio A.;
Kuhn, Michaela;
Dabral, Swati

Publication type:

Article

Revisiting Tautomerism and Rotamerism of 1,2-Dyhidro-N-(2-hydroxyethyl)-4,6-dimethyl-2-oxopyrimidine (Drug Xymedon) in Aqueous and Lipophilic Media.

Published in:

Russian Journal of General Chemistry, 2025, v. 95, n. 7, p. 1882, doi. 10.1134/S1070363225603527

By:

Katsyuba, S. A.;
Gerasimova, T. P.;
Burganov, T. I.;
Semenov, V. E.

Publication type:

Article

Skeletal editing of 4-arylpyrimidines into diverse nitrogen heteroaromatics via four-atom synthons.

Published in:

Nature Communications, 2025, v. 16, n. 1, p. 1, doi. 10.1038/s41467-025-62547-7

By:

Li, Shun;
Shi, Yonglin;
Tang, Juan;
Yan, Meixin;
Huang, Shunyao;
Dou, Tingying;
Wang, Shenxiang;
Jin, Xinchao;
Su, Zhishan;
Jiang, Weidong;
Xu, Jiaqi;
Zheng, Xueli;
Li, Ruixiang;
Chen, Hua;
Xue, Weichao;
Fu, Haiyan

Publication type:

Article

Untargeted Metabolomics Revealed Metabolomic Profile in Patients with Primary Systemic Sclerosis.

Published in:

Applied Biochemistry & Biotechnology, 2025, v. 197, n. 7, p. 4516, doi. 10.1007/s12010-025-05249-6

By:

Tang, Jinling;
Ruan, Pinglang;
Wei, Zhu

Publication type:

Article

Влияние пиридо [1,2-a]пиримидина и роль ряда н&#1077...

Published in:

National Academy of Sciences of Armenia Reports / Doklady Nacionalnaâ Akademiâ Nauk Armenii, 2025, v. 125, n. 1, p. 108, doi. 10.54503/0321-1339-2025.125.1-108

By:

Григорян, А. С.

Publication type:

Article

Site-specific binding of chelerythrine and sanguinarine to single pyrimidine bulges in hairpin DNA.

Published in:

Analytical & Bioanalytical Chemistry, 2008, v. 392, n. 4, p. 709, doi. 10.1007/s00216-008-2302-7

By:

Li-Ping Bai;
Zongwei Cai;
Zhong-Zhen Zhao;
Nakatani, Kazuhiko;
Zhi-Hong Jiang

Publication type:

Article

Mass-analyzed threshold ionization spectroscopy of pyrimidine: determining the geometry in the first excited and the ionic ground states.

Published in:

Analytical & Bioanalytical Chemistry, 2006, v. 386, n. 1, p. 59, doi. 10.1007/s00216-006-0567-2

By:

Riese, M.;
Grotemeyer, J.

Publication type:

Article

Study of a toxin–alkaline phosphatase conjugate for the development of an immunosensor for tetrodotoxin determination.

Published in:

Analytical & Bioanalytical Chemistry, 2006, v. 385, n. 6, p. 1068, doi. 10.1007/s00216-006-0522-2

By:

Neagu, D.;
Micheli, L.;
Palleschi, G.

Publication type:

Article

Eftect of carbon source on pyrimidine biosynthesis in Pseudomonas oryzihabitans.

Published in:

Journal of Basic Microbiology, 2010, v. 50, n. 4, p. 397, doi. 10.1002/jobm.201000022

By:

West, Thomas P.

Publication type:

Article

Regulation of the pyrimidine biosynthetic pathway in a pyrD knockout mutant of Pseudomonas aeruginosa.

Published in:

Journal of Basic Microbiology, 2007, v. 47, n. 2, p. 165

By:

Avinash C. Srivastava;
Gerard O'Donovan

Publication type:

Article

Residue Specific Ribose and Nucleobase Dynamics of the cUUCGg RNA Tetraloop Motif by MNMR 13C Relaxation.

Published in:

Journal of Biomolecular NMR, 2005, v. 32, n. 4, p. 295, doi. 10.1007/s10858-005-0659-x

By:

Duchardt, Elke;
Schwalbe, Harald

Publication type:

Article

Solution Structure of the Mouse Enhancer of Rudimentary Protein Reveals a Novel Fold.

Published in:

Journal of Biomolecular NMR, 2005, v. 32, n. 4, p. 329, doi. 10.1007/s10858-005-7959-z

By:

Hua Li;
Inoue, Makoto;
Yabuki, Takashi;
Aoki, Masaaki;
Seki, Eiko;
Matsuda, Takayoshi;
Nunokawa, Emi;
Motoda, Yoko;
Kobayashi, Atsuo;
Terada, Takaho;
Shirouzu, Mikako;
Koshiba, Seizo;
Yi-Jan Lin;
Güntert, Peter;
Suzuki, Harukazu;
Hayashizaki, Yoshihide;
Kigawa, Takanori;
Yokoyama, Shigeyuki

Publication type:

Article

Triple resonance experiments for the simultaneous correlation of H6/H5 and exchangeable protons of pyrimidine nucleotides in 13C,15N-labeled RNA applicable to larger RNA molecules.

Published in:

Journal of Biomolecular NMR, 2003, v. 26, n. 1, p. 79, doi. 10.1023/A:1023040520291

By:

Wöhnert, Jens;
Görlach, Matthias;
Schwalbe, Harald

Publication type:

Article

Measurement of small scalar and dipolar couplings in purine and pyrimidine bases*.

Published in:

Journal of Biomolecular NMR, 2001, v. 21, n. 2, p. 153, doi. 10.1023/a:1012435106858

By:

Žídek, Lukáš;
Wu, Haihong;
Feigon, Juli;
Sklená&icaron;, Vladimír

Publication type:

Article

Enhanced loop DNA folding induced by thymine-CH3 group contact and perpendicular guanine-thymine interaction.

Published in:

Journal of Biomolecular NMR, 2001, v. 19, n. 1, p. 33, doi. 10.1023/A:1008372701261

By:

Shan-Ho Chou;
Ko-Hsin Chin;
Carton W. Chen

Publication type:

Article

Redor in IS1S2 systems.

Published in:

Journal of Biomolecular NMR, 2000, v. 18, n. 2, p. 153, doi. 10.1023/A:1008318530946

By:

Leppert, Jörg;
Heise, Bert;
Ramachandran, Ramadurai

Publication type:

Article

Diel Patterns of UVBR-Induced DNA Damage in Picoplankton Size Fractions from the Gulf of Aqaba, Red Sea.

Published in:

Microbial Ecology, 2002, v. 44, n. 2, p. 164, doi. 10.1007/s00248-002-1002-7

By:

Boelen, P.;
Post, A. F.;
Veldhuis, M. J. W.;
Buma, A. G. J.

Publication type:

Article

Design, Synthesis, Pharmacodynamic and In Silico Pharmacokinetic Evaluation of Some Novel Biginelli-Derived Pyrimidines and Fused Pyrimidines as Calcium Channel Blockers.

Published in:

Molecules, 2022, v. 27, n. 7, p. 2240, doi. 10.3390/molecules27072240

By:

Farghaly, Ahmed M.;
Rizk, Ola H.;
Darwish, Inas;
Hamza, Manal;
Altowyan, Mezna Saleh;
Barakat, Assem;
Teleb, Mohamed

Publication type:

Article

Design, Synthesis of New 1,2,4-Triazole/1,3,4-Thiadiazole with Spiroindoline, Imidazo[4,5-b]quinoxaline and Thieno[2,3-d]pyrimidine from Isatin Derivatives as Anticancer Agents.

Published in:

Molecules, 2022, v. 27, n. 3, p. 835, doi. 10.3390/molecules27030835

By:

Abu-Hashem, Ameen Ali;
Al-Hussain, Sami A.

Publication type:

Article

Insights into Structure and Biological Activity of Copper(II) and Zinc(II) Complexes with Triazolopyrimidine Ligands.

Published in:

Molecules, 2022, v. 27, n. 3, p. 765, doi. 10.3390/molecules27030765

By:

Argăseală, Aura;
Maxim, Cătălin;
Badea, Mihaela;
Ioniță, Larisa;
Chifiriuc, Mariana Carmen;
Rostas, Arpad Mihai;
Bacalum, Mihaela;
Răileanu, Mina;
Ruţă, Lavinia L.;
Farcaşanu, Ileana C.;
Iorgulescu, Emilia Elena;
Olar, Rodica

Publication type:

Article

DFT, ADMET and Molecular Docking Investigations for the Antimicrobial Activity of 6,6′-Diamino-1,1′,3,3′-tetramethyl-5,5′-(4-chlorobenzylidene)bis[pyrimidine-2,4(1H,3H)-dione].

Published in:

Molecules, 2022, v. 27, n. 3, p. 620, doi. 10.3390/molecules27030620

By:

El-Shamy, Nesreen T.;
Alkaoud, Ahmed M.;
Hussein, Rageh K.;
Ibrahim, Moez A.;
Alhamzani, Abdulrahman G.;
Abou-Krisha, Mortaga M.

Publication type:

Article

Computational Estimation of the Acidities of Pyrimidines and Related Compounds †.

Published in:

Molecules, 2022, v. 27, n. 2, p. 385, doi. 10.3390/molecules27020385

By:

Holt, Rachael A.;
Seybold, Paul G.

Publication type:

Article

Azolo[1,5- a ]pyrimidines and Their Condensed Analogs with Anticoagulant Activity.

Published in:

Molecules, 2022, v. 27, n. 1, p. 274, doi. 10.3390/molecules27010274

By:

Savateev, Konstantin V.;
Fedotov, Victor V.;
Rusinov, Vladimir L.;
Kotovskaya, Svetlana K.;
Spasov, Alexandr A.;
Kucheryavenko, Aida F.;
Vasiliev, Pavel M.;
Kosolapov, Vadim A.;
Sirotenko, Victor S.;
Gaidukova, Kseniya A.;
Uskov, Georgiy M.

Publication type:

Article

Novel Substituted Purine Isosteres: Synthesis, Structure-Activity Relationships and Cytotoxic Activity Evaluation.

Published in:

Molecules, 2022, v. 27, n. 1, p. 247, doi. 10.3390/molecules27010247

By:

Dimitrakis, Spyridon;
Gavriil, Efthymios-Spyridon;
Pousias, Athanasios;
Lougiakis, Nikolaos;
Marakos, Panagiotis;
Pouli, Nicole;
Gioti, Katerina;
Tenta, Roxane

Publication type:

Article

Metal Coordination Properties of a Chromophoric Desferrioxamine (DFO) Derivative: Insight on the Coordination Stoichiometry and Thermodynamic Stability of Zr 4+ Complexes.

Published in:

Molecules, 2022, v. 27, n. 1, p. 184, doi. 10.3390/molecules27010184

By:

Savastano, Matteo;
Boscaro, Francesca;
Bianchi, Antonio

Publication type:

Article

Design and Synthesis of New Thiophene/Thieno[2,3- d ]pyrimidines along with Their Cytotoxic Biological Evaluation as Tyrosine Kinase Inhibitors in Addition to Their Apoptotic and Autophagic Induction.

Published in:

Molecules, 2022, v. 27, n. 1, p. 123, doi. 10.3390/molecules27010123

By:

Elmongy, Elshaymaa I.;
Attallah, Nashwah G. M.;
Altwaijry, Najla;
AlKahtani, Manal Mubarak;
Henidi, Hanan Ali

Publication type:

Article

Biological Activity of Triazolopyrimidine Copper(II) Complexes Modulated by an Auxiliary N-N-Chelating Heterocycle Ligands.

Published in:

Molecules, 2021, v. 26, n. 22, p. 6772, doi. 10.3390/molecules26226772

By:

Ruta, Lavinia L.;
Farcasanu, Ileana C.;
Bacalum, Mihaela;
Răileanu, Mina;
Rostas, Arpad Mihai;
Daniliuc, Constantin;
Chifiriuc, Mariana Carmen;
Măruțescu, Luminița;
Popa, Marcela;
Badea, Mihaela;
Iorgulescu, Emilia Elena;
Olar, Rodica

Publication type:

Article

Computational Approaches for the Design of Novel Anticancer Compounds Based on Pyrazolo[3,4-d]pyrimidine Derivatives as TRAP1 Inhibitor.

Published in:

Molecules, 2021, v. 26, n. 19, p. 5932, doi. 10.3390/molecules26195932

By:

Ali, Amena;
Abdellattif, Magda H.;
Ali, Abuzer;
AbuAli, Ola;
Shahbaaz, Mohd;
Ahsan, Mohamed Jawed;
Hussien, Mostafa A.

Publication type:

Article

Oxazinethione Derivatives as a Precursor to Pyrazolone and Pyrimidine Derivatives: Synthesis, Biological Activities, Molecular Modeling, ADME, and Molecular Dynamics Studies.

Published in:

Molecules, 2021, v. 26, n. 18, p. 5482, doi. 10.3390/molecules26185482

By:

Abdellattif, Magda H.;
Shahbaaz, Mohd;
Arief, M. M. H.;
Hussien, Mostafa A.

Publication type:

Article

Design, Synthesis and SAR in 2,4,7-Trisubstituted Pyrido[3,2- d ]Pyrimidine Series as Novel PI3K/mTOR Inhibitors.

Published in:

Molecules, 2021, v. 26, n. 17, p. 5349, doi. 10.3390/molecules26175349

By:

Buron, Frédéric;
Rodrigues, Nuno;
Saurat, Thibault;
Hiebel, Marie Aude;
Bourg, Stéphane;
Bonnet, Pascal;
Nehmé, Reine;
Morin, Philippe;
Percina, Nathalie;
Corret, Justine;
Vallée, Béatrice;
le Guevel, Remy;
Jourdan, Marie-Lise;
Bénédetti, Hélène;
Routier, Sylvain

Publication type:

Article

Studies of Interaction Mechanism between Pyrido [3,4- d ] Pyrimidine Inhibitors and Mps1.

Published in:

Molecules, 2021, v. 26, n. 16, p. 5075, doi. 10.3390/molecules26165075

By:

Xing, Cheng;
Zhou, Xiaoping;
Chen, Chengjuan;
Sun, Wei;
Zheng, Qingchuan;
Liang, Di

Publication type:

Article

Nitrogen-Containing Heterocycles as Significant Molecular Scaffolds for Medicinal and Other Applications.

Published in:

2021

By:

Frank, Éva;
Szőllősi, György

Publication type:

Editorial

Design, Synthesis and Biological Evaluation of Novel Pyrazolo[1,2,4]triazolopyrimidine Derivatives as Potential Anticancer Agents.

Published in:

Molecules, 2021, v. 26, n. 13, p. 4065, doi. 10.3390/molecules26134065

By:

Aliwaini, Saeb;
Abu Thaher, Bassam;
Al-Masri, Ihab;
Shurrab, Nabil;
El-Kurdi, Said;
Schollmeyer, Dieter;
Qeshta, Basem;
Ghunaim, Mariam;
Csuk, René;
Laufer, Stefan;
Kaiser, Lars;
Deigner, Hans-Peter

Publication type:

Article

4,7-Disubstituted 7 H -Pyrrolo[2,3-d]pyrimidines and Their Analogs as Antiviral Agents against Zika Virus.

Published in:

Molecules, 2021, v. 26, n. 13, p. 3779, doi. 10.3390/molecules26133779

By:

Soto-Acosta, Ruben;
Jung, Eunkyung;
Qiu, Li;
Wilson, Daniel J.;
Geraghty, Robert J.;
Chen, Liqiang

Publication type:

Article

Novel Bis- and Mono-Pyrrolo[2,3- d ]pyrimidine and Purine Derivatives: Synthesis, Computational Analysis and Antiproliferative Evaluation.

Published in:

Molecules, 2021, v. 26, n. 11, p. 3334, doi. 10.3390/molecules26113334

By:

Bistrović Popov, Andrea;
Vianelo, Robert;
Grbčić, Petra;
Sedić, Mirela;
Pavelić, Sandra Kraljević;
Pavelić, Krešimir;
Raić-Malić, Silvana

Publication type:

Article

Synthesis and Neurotropic Activity of New Heterocyclic Systems: Pyridofuro[3,2- d ]pyrrolo[1,2- a ]pyrimidines, Pyridofuro[3,2- d ]pyrido[1,2- a ]pyrimidines and Pyridofuro[3′,2′:4,5]pyrimido[1,2- a ]azepines.

Published in:

Molecules, 2021, v. 26, n. 11, p. 3320, doi. 10.3390/molecules26113320

By:

Sirakanyan, Samvel N.;
Spinelli, Domenico;
Geronikaki, Athina;
Kartsev, Victor;
Hakobyan, Elmira K.;
Petrou, Anthi;
Paronikyan, Ruzanna G.;
Nazaryan, Ivetta M.;
Akopyan, Hasmik H.;
Hovakimyan, Anush A.

Publication type:

Article

Design, Synthesis, and Anticancer Screening for Repurposed Pyrazolo[3,4-d]pyrimidine Derivatives on Four Mammalian Cancer Cell Lines.

Published in:

Molecules, 2021, v. 26, n. 10, p. 2961, doi. 10.3390/molecules26102961

By:

Othman, Eman M.;
Bekhit, Amany A.;
Anany, Mohamed A.;
Dandekar, Thomas;
Ragab, Hanan M.;
Wahid, Ahmed;
Brindisi, Margherita

Publication type:

Article

Functional Pyrazolo[1,5- a ]pyrimidines: Current Approaches in Synthetic Transformations and Uses As an Antitumor Scaffold.

Published in:

Molecules, 2021, v. 26, n. 9, p. 2708, doi. 10.3390/molecules26092708

By:

Arias-Gómez, Andres;
Godoy, Andrés;
Portilla, Jaime;
Silva, Vera L. M.;
Silva, Artur M. S.

Publication type:

Article

Nitrogenous Compounds from the Antarctic Fungus Pseudogymnoascus sp. HSX2#-11.

Published in:

Molecules, 2021, v. 26, n. 9, p. 2636, doi. 10.3390/molecules26092636

By:

Shi, Ting;
Zheng, Li;
Li, Xiang-Qian;
Dai, Jia-Jia;
Zhang, Yi-Ting;
Yu, Yan-Yan;
Hu, Wen-Peng;
Shi, Da-Yong;
Tormo, Rubén

Publication type:

Article

Promising Antidiabetic and Antimicrobial Agents Based on Fused Pyrimidine Derivatives: Molecular Modeling and Biological Evaluation with Histopathological Effect.

Published in:

Molecules, 2021, v. 26, n. 8, p. 2370, doi. 10.3390/molecules26082370

By:

Bassyouni, Fatma;
Tarek, Mohammad;
Salama, Abeer;
Ibrahim, Bassant;
Salah El Dine, Sawsan;
Yassin, Nemat;
Hassanein, Amina;
Moharam, Maysa;
Abdel-Rehim, Mohamed

Publication type:

Article

A New Pyrimidine Schiff Base with Selective Activities against Enterococcus faecalis and Gastric Adenocarcinoma.

Published in:

Molecules, 2021, v. 26, n. 8, p. 2296, doi. 10.3390/molecules26082296

By:

Stolarczyk, Marcin;
Wolska, Aleksandra;
Mikołajczyk, Aleksandra;
Bryndal, Iwona;
Cieplik, Jerzy;
Lis, Tadeusz;
Matera-Witkiewicz, Agnieszka

Publication type:

Article

Design, Synthesis and Biological Evaluation of New Pyrimidine Derivatives as Anticancer Agents.

Published in:

Molecules, 2021, v. 26, n. 3, p. 771, doi. 10.3390/molecules26030771

By:

Madia, Valentina Noemi;
Nicolai, Alice;
Messore, Antonella;
De Leo, Alessandro;
Ialongo, Davide;
Tudino, Valeria;
Saccoliti, Francesco;
De Vita, Daniela;
Scipione, Luigi;
Artico, Marco;
Taurone, Samanta;
Taglieri, Ludovica;
Di Santo, Roberto;
Scarpa, Susanna;
Costi, Roberta

Publication type:

Article

Bicyclic Basic Merbarone Analogues as Antiproliferative Agents.

Published in:

Molecules, 2021, v. 26, n. 3, p. 557, doi. 10.3390/molecules26030557

By:

Spallarossa, Andrea;
Lusardi, Matteo;
Caneva, Chiara;
Profumo, Aldo;
Rosano, Camillo;
Ponassi, Marco;
Chemat, Farid

Publication type:

Article

Recent Trends in Enzyme Inhibition and Activation in Drug Design.

Published in:

2021

By:

Geronikaki, Athina

Publication type:

Editorial

Hybrides of Alkaloid Lappaconitine with Pyrimidine Motif on the Anthranilic Acid Moiety: Design, Synthesis, and Investigation of Antinociceptive Potency.

Published in:

Molecules, 2020, v. 25, n. 23, p. 5578, doi. 10.3390/molecules25235578

By:

Cheremnykh, Kirill P.;
Savelyev, Victor A.;
Borisov, Sergey A.;
Ivanov, Igor D.;
Baev, Dmitry S.;
Tolstikova, Tatyana G.;
Vavilin, Valentin A.;
Shults, Elvira E.;
Skarzewski, Jacek;
FRSC, Jóhannes Reynisson

Publication type:

Article

Synthesis of Novel 2-(Pyridin-2-yl) Pyrimidine Derivatives and Study of Their Anti-Fibrosis Activity.

Published in:

Molecules, 2020, v. 25, n. 22, p. 5226, doi. 10.3390/molecules25225226

By:

Gu, Yi-Fei;
Zhang, Yue;
Yue, Feng-li;
Li, Shao-tong;
Zhang, Zhuo-qi;
Li, Jing;
Bai, Xu

Publication type:

Article

Synthesis, In Silico Prediction and In Vitro Evaluation of Antitumor Activities of Novel Pyrido[2,3- d ]pyrimidine, Xanthine and Lumazine Derivatives.

Published in:

Molecules, 2020, v. 25, n. 21, p. 5205, doi. 10.3390/molecules25215205

By:

El-Kalyoubi, Samar;
Agili, Fatimah;
Keglevich, György;
Moreau, Pascale

Publication type:

Article

Design of Anticancer 2,4-Diaminopyrimidines as Novel Anoctamin 1 (ANO1) Ion Channel Blockers.

Published in:

Molecules, 2020, v. 25, n. 21, p. 5180, doi. 10.3390/molecules25215180

By:

Kim, Taewoo;
Cho, Sinyoung;
Oh, Haejun;
Hur, Joonseong;
Kim, Haedong;
Choi, Young-Ho;
Jeon, Seongho;
Yang, Young Duk;
Kim, Seok-Ho;
Massa, Antonio

Publication type:

Article