Works about PROTEASE-activated receptors

Results: 481

Protease-Activated Receptor 1 Contributes to Angiotensin II-Induced Cardiovascular Remodeling and Inflammation.

Published in:

Cardiology, 2017, v. 136, n. 4, p. 258, doi. 10.1159/000452269

By:

antoniak, Silvio;
Cardenas, Jessica C.;
Buczek, Laura J.;
Church, Frank C.;
Mackman, Nigel;
Pawlinski, Rafal

Publication type:

Article

L-asparaginase is a PAR2 N-terminal protease that unmasks the PAR2 tethered ligand.

Published in:

Cell Death Discovery, 2025, v. 11, n. 1, p. 1, doi. 10.1038/s41420-025-02467-z

By:

Lee, Jung Kwon;
Riabowol, Karl;
Wang, Xidi;
Lee, Ki-Young

Publication type:

Article

The Influence of Anti-PAR 1 and Anti-ACE 2 Antibody Levels on the Course of Specific Glomerulonephritis Types.

Published in:

Journal of Clinical Medicine, 2025, v. 14, n. 9, p. 3178, doi. 10.3390/jcm14093178

By:

Szymczak, Maciej;
Heidecke, Harald;
Żabińska, Marcelina;
Janek, Łucja;
Wronowicz, Jakub;
Kujawa, Krzysztof;
Schulze-Forster, Kai;
Marek-Bukowiec, Karolina;
Gołębiowski, Tomasz;
Banasik, Mirosław

Publication type:

Article

Non-HLA Antibodies in Hand Transplant Recipients Are Connected to Multiple Acute Rejection Episodes and Endothelial Activation.

Published in:

Journal of Clinical Medicine, 2022, v. 11, n. 3, p. 833, doi. 10.3390/jcm11030833

By:

Sikorska, Dorota;
Kamińska, Dorota;
Catar, Rusan;
Banasik, Mirosław;
Heidecke, Harald;
Schulze-Forster, Kai;
Korybalska, Katarzyna;
Rutkowski, Rafał;
Łuczak, Joanna;
Jabłecki, Jerzy;
Oko, Andrzej;
Daroszewski, Przemysław;
Kusztal, Mariusz;
Samborski, Włodzimierz

Publication type:

Article

Many Good Reasons to Switch from Vitamin K Antagonists to Non-Vitamin K Antagonists in Patients with Non-Valvular Atrial Fibrillation.

Published in:

Journal of Clinical Medicine, 2021, v. 10, n. 13, p. 2866, doi. 10.3390/jcm10132866

By:

Botto, Giovanni Luca;
Ameri, Pietro;
De Caterina, Raffaele

Publication type:

Article

Proteinase-Activated Receptor 2 Is a Novel Regulator of TGF-β Signaling in Pancreatic Cancer.

Published in:

Journal of Clinical Medicine, 2016, v. 5, n. 12, p. 111, doi. 10.3390/jcm5120111

By:

Witte, David;
Zeeh, Franziska;
Gädeken, Thomas;
Gieseler, Frank;
Rauch, Bernhard H.;
Settmacher, Utz;
Kaufmann, Roland;
Lehnert, Hendrik;
Ungefroren, Hendrik

Publication type:

Article

Activación concertada de los receptores transmembranales: Repercusiones fisiológicas.

Published in:

TIP Revista Especializada en Ciencias Químico-Biológicas, 2023, v. 26, p. 1, doi. 10.22201/fesz.23958723e.2023.572

By:

Lee-Rivera, Irene;
López, Edith;
López Colomé, Ana María

Publication type:

Article

IL-32-PAR2 axis is an innate immunity sensor providing alternative signaling for LPS-TRIF axis.

Published in:

Scientific Reports, 2013, p. 1, doi. 10.1038/srep02960

By:

Masanori Nakayama;
Yasuo Niki;
Toshiki Kawasaki;
Yuki Takeda;
Hiroyasu Ikegami;
Yoshiaki Toyama;
Takeshi Miyamoto

Publication type:

Article

Vorapaxar, an oral PAR-1 receptor antagonist, does not affect the pharmacokinetics of rosiglitazone.

Published in:

Clinical Pharmacology in Drug Development, 2015, v. 4, n. 1, p. 56, doi. 10.1002/cpdd.133

By:

Kosoglou, Teddy;
Kumar, Bharath;
Statkevich, Paul;
Schiller, James E.;
Kantesaria, Bhavna;
Hanson, Mary E.;
Sisk, Christine McCrary;
Cutler, David L.

Publication type:

Article

Protease-Activated Receptor-2 Deficiency Attenuates Atherosclerotic Lesion Progression and Instability in Apolipoprotein E-Deficient Mice.

Published in:

Frontiers in Pharmacology, 2017, p. 1, doi. 10.3389/fphar.2017.00647

By:

Pengfei Zuo;
Zhi Zuo;
Yueyue Zheng;
Xin Wang;
Qianxing Zhou;
Long Chen;
Genshan Ma

Publication type:

Article

Cathepsin S Is Involved in Th17 Differentiation Through the Upregulation of IL-6 by Activating PAR-2 after Systemic Exposure to Lipopolysaccharide from Porphyromonas gingivalis.

Published in:

Frontiers in Pharmacology, 2017, p. 1, doi. 10.3389/fphar.2017.00470

By:

Masato Dekita;
Zhou Wu;
Junjun Ni;
Xinwen Zhang;
Yicong Liu;
Xu Yan;
Hiroshi Nakanishi;
Ichiro Takahashi

Publication type:

Article

Tissue Factor-Expressing Tumor- Derived Extracellular Vesicles Activate Quiescent Endothelial Cells via Protease-Activated Receptor-1.

Published in:

Frontiers in Oncology, 2017, p. 1, doi. 10.3389/fonc.2017.00261

By:

Che, Sara P. Y.;
Park, Jeannie Y.;
Stokol, Tracy

Publication type:

Article

Association of EPCR Polymorphism rs867186-GG With Severity of Human Malaria.

Published in:

Frontiers in Genetics, 2020, v. 11, p. 1, doi. 10.3389/fgene.2020.00056

By:

Cespedes, Juan Carlos;
Hibbert, Jacqueline;
Krishna, Sri;
Yan, Fengxia;
Bharti, Praveen K.;
Stiles, Jonathan K.;
Liu, Mingli

Publication type:

Article

Newer agents in antiplatelet therapy: a review.

Published in:

Journal of Blood Medicine, 2012, v. 3, p. 33, doi. 10.2147/JBM.S25421

By:

Yeung, Jennifer;
Holinstat, Michael

Publication type:

Article

A scoping review: What are the cellular mechanisms that drive the allergic inflammatory response to fungal allergens in the lung epithelium?

Published in:

Clinical & Translational Allergy, 2023, v. 13, n. 6, p. 1, doi. 10.1002/clt2.12252

By:

Goode, Emma‐Jane;
Marczylo, Emma

Publication type:

Article

Vorapaxar: A new class of drug.

Published in:

International Journal of Pharmacy & Life Sciences, 2014, v. 5, n. 8, p. 3725

By:

RaoVinay Rajan, Kattula;
Sathish Sreenivas, Pasam;
Surya Durga Devi, Pilla Sree;
Vineela, Penugonda;
Kalluri, Satish;
Govind Raj, Polla

Publication type:

Article

EXTRACTION AND UTILIZATION OF PAPAYA EXTRACT AS MEAT TENDERIZER AND ANTIMICROBIAL ACTIVITY AGAINST Salmonella typhimurium.

Published in:

Pakistan Journal of Agricultural Sciences, 2017, v. 54, n. 1, p. 153, doi. 10.21162/PAKJAS/17.5032

By:

Saeed, Muhammad;
ur Rahman, Sajjad;
Shabbir, Muhammad Asim;
Khan, Nassrulla;
Shakeel, Azam

Publication type:

Article

The association between the expression of PAR2 and TMEM16A and neuropathic pain.

Published in:

Molecular Medicine Reports, 2018, v. 17, n. 3, p. 3744, doi. 10.3892/mmr.2017.8295

By:

Zhang, MENg;
Gao, Cun-Xiang;
Wang, Yan-Ping;
Ma, Ke-Tao;
Li, Li;
Yin, Jiang-WEN;
Dai, Zhi-Gang;
Wang, ShENg;
Si, Jun-Qiang

Publication type:

Article

PAR1-mediated c-Jun activation promotes heat stress-induced early stage apoptosis of human umbilical vein endothelial cells.

Published in:

Molecular Medicine Reports, 2017, v. 15, n. 5, p. 2595, doi. 10.3892/mmr.2017.6303

By:

SHUANG ZHANG;
YANAN LIU;
ZHENGLIAN WANG;
JINGXIAN LIU;
ZHENGTAO GU;
QIULIN XU;
LEI SU

Publication type:

Article

Activation of protease-activated receptor-2 is associated with increased expression of inflammatory factors in the adipose tissues of obese mice.

Published in:

Molecular Medicine Reports, 2015, v. 12, n. 4, p. 6227, doi. 10.3892/mmr.2015.4179

By:

MENGMENG LI;
XIAOMING YANG;
YADONG ZHANG;
LIANG CHEN;
HANYU LU;
XIAOBO LI;
LIANHUA YIN;
XIULING ZHI

Publication type:

Article

Effects of calcium signaling on coagulation factor VIIa-induced proliferation and migration of the SW620 colon cancer cell line.

Published in:

Molecular Medicine Reports, 2014, v. 10, n. 6, p. 3021, doi. 10.3892/mmr.2014.2665

By:

YING WU;
JING WANG;
HONG ZHOU;
XIAOYAN YU;
LICHAO HU;
FANLU MENG;
SHUANGHONG JIANG

Publication type:

Article

Targeting A549 lung adenocarcinoma cell growth and invasion with protease-activated receptor-1 siRNA.

Published in:

Molecular Medicine Reports, 2014, v. 9, n. 5, p. 1787, doi. 10.3892/mmr.2014.2023

By:

ZHUO WU;
YANYAN ZENG;
MINGKANG ZHONG;
BIN WANG

Publication type:

Article

Molecular Mechanisms Involved in the B Cell Growth and Clonogenic Activity of HIV-1 Matrix Protein p17 Variants.

Published in:

Viruses (1999-4915), 2024, v. 16, n. 7, p. 1048, doi. 10.3390/v16071048

By:

D'Ursi, Pasqualina;
Rondina, Alessandro;
Zani, Alberto;
Uggeri, Matteo;
Messali, Serena;
Caruso, Arnaldo;
Caccuri, Francesca

Publication type:

Article

Protease-Activated Receptor Type 1 Activation Enhances Osteogenic Activity in Human Periodontal Ligament Stem Cells.

Published in:

Stem Cells International, 2019, p. 1, doi. 10.1155/2019/6857386

By:

Rovai, Emanuel Silva;
Ambrósio, Lucas Macedo Batitucci;
de França, Bruno Nunes;
de Oliveira, Letícia Rodrigues;
Gasparoni, Letícia Miquelitto;
Sipert, Carla Renata;
Holzhausen, Marinella

Publication type:

Article

Trypsin may be associated with duodenal eosinophils through the expression of PAR2 in early chronic pancreatitis and functional dyspepsia with pancreatic enzyme abnormalities.

Published in:

PLoS ONE, 2022, v. 17, n. 10, p. 1, doi. 10.1371/journal.pone.0275341

By:

Agawa, Shuhei;
Futagami, Seiji;
Yamawaki, Hiroshi;
Tsushima, Rina;
Higuchi, Kazutoshi;
Habiro, Mayu;
Kawawa, Rie;
Kodaka, Yasuhiro;
Ueki, Nobue;
Watanabe, Yoshiyuki;
Gudis, Katya;
Ohashi, Rhuji;
Iwakiri, Katsuhiko

Publication type:

Article

Granzyme K initiates IL-6 and IL-8 release from epithelial cells by activating protease-activated receptor 2.

Published in:

PLoS ONE, 2022, v. 17, n. 7, p. 1, doi. 10.1371/journal.pone.0270584

By:

Kaiserman, Dion;
Zhao, Peishen;
Rowe, Caitlin Lorraine;
Leong, Andrea;
Barlow, Nicholas;
Joeckel, Lars Thomas;
Hitchen, Corinne;
Stewart, Sarah Elizabeth;
Hollenberg, Morley D.;
Bunnett, Nigel;
Suhrbier, Andreas;
Bird, Phillip Ian

Publication type:

Article

Protease-Activated Receptor 4: A Critical Participator in Inflammatory Response.

Published in:

Inflammation, 2015, v. 38, n. 2, p. 886, doi. 10.1007/s10753-014-9999-6

By:

Fu, Qiang;
Cheng, Jing;
Gao, Yebo;
Zhang, Yonglei;
Chen, Xiaobing;
Xie, Jianguo

Publication type:

Article

First-in-human study to assess the safety, pharmacokinetics, and pharmacodynamics of BMS-986141, a novel, reversible, small-molecule, PAR4 agonist in non-Japanese and Japanese healthy participants.

Published in:

Platelets, 2023, v. 34, n. 1, p. 1, doi. 10.1080/09537104.2023.2222846

By:

Merali, Samira;
Zhaoqing Wang;
Frost, Charles;
Meadows-Shropshire, Stephanie;
Hawthorne, Dara;
Jing Yang;
Seiffert, Dietmar

Publication type:

Article

New oral protease-activated receptor 4 antagonist BMS-986120: tolerability, pharmacokinetics, pharmacodynamics, and gene variant effects in humans.

Published in:

Platelets, 2022, v. 33, n. 7, p. 969, doi. 10.1080/09537104.2022.2088719

By:

Merali, Samira;
Wang, Zhaoqing;
Frost, Charles;
Callejo, Mario;
Hedrick, Michael;
Hui, Lester;
Meadows Shropshire, Stephanie;
Xu, Ke;
Bouvier, Michel;
DeSouza, Mary M.;
Yang, Jing

Publication type:

Article

An optimized agonist peptide of protease-activated receptor 4 and its use in a validated platelet-aggregation assay.

Published in:

Platelets, 2022, v. 33, n. 7, p. 979, doi. 10.1080/09537104.2022.2053091

By:

Yang, Jing;
Mapelli, Claudio;
Wang, Zhaoqing;
Sum, Chi Shing;
Hua, Ji;
Lawrence, R. Michael;
Ni, Yan;
Seiffert, Dietmar A.

Publication type:

Article

Does hsa-miR-223-3p from platelet-derived extracellular vesicles regulate tissue factor expression in monocytic cells?

Published in:

Platelets, 2022, v. 33, n. 7, p. 1031, doi. 10.1080/09537104.2022.2027903

By:

Collier, Mary E. W.;
Ambrose, Ashley R.;
Goodall, Alison H.

Publication type:

Article

Signaling mechanisms of the platelet glycoprotein Ib-IX complex.

Published in:

Platelets, 2022, v. 33, n. 6, p. 823, doi. 10.1080/09537104.2022.2071852

By:

Zhang, Yaping;
Ehrlich, Samuel M;
Zhu, Cheng;
Du, Xiaoping

Publication type:

Article

Determination of PAR4 numbers on the surface of human platelets: no effect of the single nucleotide polymorphism rs773902.

Published in:

Platelets, 2021, v. 32, n. 7, p. 988, doi. 10.1080/09537104.2020.1810654

By:

Li, Simeng;
Tarlac, Volga;
Christanto, Roberto B. I.;
French, Shauna L.;
Hamilton, Justin R.

Publication type:

Article

Protease-activated receptor 4 causes Akt phosphorylation independently of PI3 kinase pathways.

Published in:

Platelets, 2021, v. 32, n. 6, p. 832, doi. 10.1080/09537104.2020.1802415

By:

Dangelmaier, Carol;
Kunapuli, Satya P

Publication type:

Article

Factor Xa and thrombin induce endothelial progenitor cell activation. The effect of direct oral anticoagulants.

Published in:

Platelets, 2021, v. 32, n. 6, p. 807, doi. 10.1080/09537104.2020.1802413

By:

Papadaki, Styliani;
Sidiropoulou, Sofia;
Moschonas, Iraklis C.;
Tselepis, Alexandros D.

Publication type:

Article

Novel antiplatelet targets in the treatment of acute coronary syndromes.

Published in:

Platelets, 2021, v. 32, n. 1, p. 15, doi. 10.1080/09537104.2020.1763731

By:

Alenazy, Fawaz O.;
Thomas, Mark R.

Publication type:

Article

Assessment of neonatal, cord, and adult platelet granule trafficking and secretion.

Published in:

Platelets, 2020, v. 31, n. 1, p. 68, doi. 10.1080/09537104.2019.1573314

By:

Ngo, Anh T. P.;
Sheriff, Jawaad;
Rocheleau, Anne D.;
Bucher, Matthew;
Jones, Kendra R.;
Sepp, Anna-Liisa I.;
Malone, Lisa E.;
Zigomalas, Amanda;
Maloyan, Alina;
Bahou, Wadie F.;
Bluestein, Danny;
McCarty, Owen J. T.;
Haley, Kristina M.

Publication type:

Article

Protease-activated receptor 4 activity promotes platelet granule release and platelet-leukocyte interactions.

Published in:

Platelets, 2019, v. 30, n. 1, p. 126, doi. 10.1080/09537104.2017.1406076

By:

Rigg, Rachel A.;
Chu, Tiffany T.;
Ngo, Anh T. P.;
Mitrugno, Annachiara;
Zilberman-Rudenko, Jevgenia;
Hinds, Monica T.;
McCarty, Owen J. T.;
Gruber, András;
Healy, Laura D.;
Aslan, Joseph E.;
Vecchiarelli, Lisa Dirling;
Morgan, Terry K.;
Duvernay, Matthew T.;
Hamm, Heidi E.;
Temple, Kayla J.;
Lindsley, Craig W.

Publication type:

Article

Perinatal lethality of Par4<sup>-/-</sup> mice delivered by primiparous dams reveals spontaneous bleeding in mice without platelet thrombin receptor function.

Published in:

Platelets, 2018, v. 29, n. 2, p. 196, doi. 10.1080/09537104.2017.1349310

By:

French, Shauna L.;
Hamilton, Justin R.

Publication type:

Article

Molecular requirements involving the human platelet protease-activated receptor-4 mechanism of activation by peptide analogues of its tethered-ligand.

Published in:

Platelets, 2017, v. 28, n. 8, p. 812, doi. 10.1080/09537104.2017.1282607

By:

Moschonas, I. C.;
Kellici, T. F.;
Mavromoustakos, T.;
Stathopoulos, P.;
Tsikaris, V.;
Magafa, V.;
Tzakos, A. G.;
Tselepis, A. D.

Publication type:

Article

In Vivo and protease-activated receptor-1-mediated platelet activation in patients presenting for cardiac catheterization.

Published in:

Platelets, 2016, v. 27, n. 4, p. 308, doi. 10.3109/09537104.2015.1095876

By:

Gremmel, Thomas;
Michelson, Alan D.;
Frelinger III, Andrew L.

Publication type:

Article

Stimulation of PAR-1 or PAR-4 promotes similar pattern of VEGF and endostatin release and pro-angiogenic responses mediated by human platelets.

Published in:

Platelets, 2015, v. 26, n. 8, p. 799, doi. 10.3109/09537104.2015.1051953

By:

Etulain, J.;
Mena, H. A.;
Negrotto, S.;
Schattner, M.

Publication type:

Article

Specific activation, signalling and secretion profiles of human platelets following PAR-1 and PAR-4 stimulation.

Published in:

Platelets, 2015, v. 26, n. 8, p. 795, doi. 10.3109/09537104.2015.1050585

By:

Nguyen, Kim Anh;
Hamzeh-Cognasse, Hind;
Laradi, Sandrine;
Pozzetto, Bruno;
Garraud, Olivier;
Cognasse, Fabrice

Publication type:

Article

Characterization of UBO-QIC as a G α q inhibitor in platelets.

Published in:

Platelets, 2015, v. 26, n. 8, p. 771, doi. 10.3109/09537104.2014.998993

By:

Inamdar, Vaishali;
Patel, Akruti;
Manne, Bhanu Kanth;
Dangelmaier, Carol;
Kunapuli, Satya P

Publication type:

Article

Megakaryocytic emperipolesis and platelet function abnormalities in five patients with gray platelet syndrome.

Published in:

Platelets, 2015, v. 26, n. 8, p. 751, doi. 10.3109/09537104.2014.994093

By:

Larocca, Luigi M.;
Heller, Paula G.;
Podda, Gianmarco;
Pujol-Moix, Nuria;
Glembotsky, Ana C.;
Pecci, Alessandro;
Alberelli, Maria Adele;
Balduini, Carlo L.;
Landolfi, Raffaele;
Cattaneo, Marco;
De Candia, Erica

Publication type:

Article

PAR1 antagonists inhibit thrombin-induced platelet activation whilst leaving the PAR4-mediated response intact.

Published in:

Platelets, 2015, v. 26, n. 3, p. 236, doi. 10.3109/09537104.2014.902924

By:

Judge, Heather M.;
Jennings, Lisa K.;
Moliterno, David J.;
Hord, Edward;
Ecob, Rosemary;
Tricoci, Pierluigi;
Rorick, Tyrus;
Kotha, Jayaprakash;
Storey, Robert F.

Publication type:

Article

New PAR1 Agonist Peptide Demonstrates Protective Action in a Mouse Model of Photothrombosis-Induced Brain Ischemia.

Published in:

Frontiers in Neuroscience, 2020, v. 14, p. 1, doi. 10.3389/fnins.2020.00335

By:

Galkov, Maksim;
Kiseleva, Ekaterina;
Gulyaev, Mikhail;
Sidorova, Maria;
Gorbacheva, Liubov

Publication type:

Article

Expression of Protease Activated Receptor-1 in Chronic Periodontitis.

Published in:

Journal of Periodontology, 2014, v. 85, n. 12, p. 1763, doi. 10.1902/jop.2014.140172

By:

Bueno da Silva, Henrique Aparecido;
Euzebio Alves, Vanessa Tubero;
Spolidório, Luis Carlos;
César Neto, João Batista;
Eichler, Rosangela Santos;
Catelli de Carvalho, Maria Helena;
Holzhausen, Marinella

Publication type:

Article

Porphyromonas Gingivalis is Associated With Protease-Activated Receptor-2 Upregulation in Chronic Periodontitis.

Published in:

Journal of Periodontology, 2011, v. 82, n. 11, p. 1596, doi. 10.1902/jop.2011.110073

By:

Fagundes, José Américo G.;
Monoo, Letícia D.;
Alves, Vanessa Tubero Euzébio;
Pannuti, Cláudio Mendes;
Cortelli, Sheila Cavalca;
Cortelli, José Roberto;
Holzhausen, Marinella

Publication type:

Article

Clinically uninvolved but not healthy—The skin of patients with atopic dermatitis is primed for itch and inflammation.

Published in:

Journal of the European Academy of Dermatology & Venereology, 2024, v. 38, n. 6, p. 1089, doi. 10.1111/jdv.19694

By:

Moon, S.;
Stasikowska‐Kanicka, O.;
Wągrowska‐Danilewicz, M.;
Hawro, M.;
Metz, M.;
Maurer, M.;
Hawro, T.

Publication type:

Article