Works matching DE "PROTEASE-activated receptors"

Results: 481

Zebrafish sperm outsource activation to eggs' protease-activated receptors.

Published in:

PLoS Biology, 2025, v. 23, n. 6, p. 1, doi. 10.1371/journal.pbio.3003214

By:

Fissore, Rafael A.;
Lopes, Emily M.;
Carpentiero, Francesca

Publication type:

Article

Protease-mediated activation of Par2 elicits calcium waves during zebrafish egg activation and blastomere cleavage.

Published in:

PLoS Biology, 2025, v. 23, n. 6, p. 1, doi. 10.1371/journal.pbio.3003181

By:

Ma, Jiajia;
Carney, Tom J.

Publication type:

Article

Neuroprotection induced by protease-activated receptor 2 activation is independent of Gq signalling.

Published in:

Brain & Neuroscience Advances, 2025, p. 1, doi. 10.1177/23982128251345673

By:

Moudio, Serge;
Nuthall, Hugh N.;
Bushell, Trevor J.

Publication type:

Article

Thrombin receptor PAR4 drives canonical NLRP3 inflammasome signaling in the heart.

Published in:

Basic Research in Cardiology, 2020, v. 115, n. 2, p. 1, doi. 10.1007/s00395-019-0771-9

By:

Fender, Anke C.;
Kleeschulte, Sonja;
Stolte, Svenja;
Leineweber, Katja;
Kamler, Markus;
Bode, Johannes;
Li, Na;
Dobrev, Dobromir

Publication type:

Article

Proteinase-Activated Receptor 2 Is a Novel Regulator of TGF-β Signaling in Pancreatic Cancer.

Published in:

Journal of Clinical Medicine, 2016, v. 5, n. 12, p. 111, doi. 10.3390/jcm5120111

By:

Witte, David;
Zeeh, Franziska;
Gädeken, Thomas;
Gieseler, Frank;
Rauch, Bernhard H.;
Settmacher, Utz;
Kaufmann, Roland;
Lehnert, Hendrik;
Ungefroren, Hendrik

Publication type:

Article

The effect of exogenous activation of protease-activated receptor 2 on cutaneous vasodilatation and sweating in young males during rest and exercise in the heat.

Published in:

Temperature, 2018, v. 5, n. 3, p. 257, doi. 10.1080/23328940.2018.1506563

By:

Danquah, Mercy O.;
Meade, Robert D.;
Kenny, Glen P.;
Fujii, Naoto;
Nishiyasu, Takeshi

Publication type:

Article

Whitening effect of novel peptide mixture by regulating melanosome biogenesis, transfer and degradation.

Published in:

Korean Journal of Physiology & Pharmacology, 2021, v. 25, n. 1, p. 15, doi. 10.4196/kjpp.2021.25.1.15

By:

Eung-Ji Lee;
Jandi Kim;
Min Kyeong Jeong;
Young Min Lee;
Yong Ji Chung;
Eun Mi Kim

Publication type:

Article

Effects of silenced PAR-2 on cell proliferation, invasion and metastasis of esophageal cancer.

Published in:

Oncology Letters, 2017, v. 14, n. 4, p. 4115, doi. 10.3892/ol.2017.6711

By:

JINMEI CHEN;
LIQUN XIE;
YANMIN ZHENG;
CAIHONG LIU

Publication type:

Article

Platelet Protease Activated Receptor 1 Is Involved in the Hemostatic Effect of 20(S)-Protopanaxadiol by Regulating Calcium Signaling.

Published in:

Frontiers in Pharmacology, 2020, v. 11, p. N.PAG, doi. 10.3389/fphar.2020.549150

By:

Zhang, He;
Pan, Daian;
Wu, Xingquan;
Su, Wenjie;
Tang, Xiaolei;
Zhao, Daqing;
Sun, Liwei;
Song, Bailin;
Bai, Xueyuan;
Li, Xiangyan

Publication type:

Article

Interplay Between Angiotensin II Type 1 Receptor and Thrombin Receptor Revealed by Bioluminescence Resonance Energy Transfer Assay.

Published in:

Frontiers in Pharmacology, 2020, v. 11, p. N.PAG, doi. 10.3389/fphar.2020.01283

By:

Zamel, Isra Al;
Palakkott, Abdulrasheed;
Ashraf, Arshida;
Iratni, Rabah;
Ayoub, Mohammed Akli

Publication type:

Article

Pharmacological Inhibition of Serine Proteases to Reduce Cardiac Inflammation and Fibrosis in Atrial Fibrillation.

Published in:

Frontiers in Pharmacology, 2019, v. 10, p. 1, doi. 10.3389/fphar.2019.01420

By:

Coppini, Raffaele;
Santini, Lorenzo;
Palandri, Chiara;
Sartiani, Laura;
Cerbai, Elisabetta;
Raimondi, Laura

Publication type:

Article

Coagulation and Skin Autoimmunity.

Published in:

Frontiers in Immunology, 2019, p. N.PAG, doi. 10.3389/fimmu.2019.01407

By:

Cugno, Massimo;
Borghi, Alessandro;
Garcovich, Simone;
Marzano, Angelo Valerio

Publication type:

Article

Protease Activated Receptor 4 as a Novel Modulator of Regulatory T Cell Function.

Published in:

Frontiers in Immunology, 2019, p. N.PAG, doi. 10.3389/fimmu.2019.01311

By:

Peng, Qi;
Ratnasothy, Kulachelvy;
Boardman, Dominic A.;
Jacob, Jacinta;
Tung, Sim Lai;
McCluskey, Daniel;
Smyth, Lesley A.;
Lechler, Robert I.;
Dorling, Anthony;
Lombardi, Giovanna

Publication type:

Article

Newer agents in antiplatelet therapy: a review.

Published in:

Journal of Blood Medicine, 2012, v. 3, p. 33, doi. 10.2147/JBM.S25421

By:

Yeung, Jennifer;
Holinstat, Michael

Publication type:

Article

The role of protease-activated receptors in regulating other ion channels.

Published in:

2014

By:

Eisenhut, Michael

Publication type:

Letter to the Editor

Вплив пригнічення функції протеазаактивованих рецепторів 1 у латентний період розвитку скроневої епілепсії на депресивноподібну поведінку щурів

Published in:

Physiological Journal / Fiziologichnyi Zhurnal, 2020, v. 66, n. 5, p. 17

By:

Семеніхіна, М. О.;
Федорюк, М. П.;
Боговик, Р. І.

Publication type:

Article

Селективний антагоніст протеазоактивованих рецепторів 1 нормалізує рівень емоційної збудливості щурів у латентній стадії формування скроневої епілепсії.

Published in:

Physiological Journal / Fiziologichnyi Zhurnal, 2019, v. 65, n. 3, p. 7

By:

Semenikhina, M.;
Bogovik, R.;
Fedoryuk, M.;
Lunko, O.;
Savotchenko, A.;
Isaeva, E.

Publication type:

Article

The protease-activated receptor 1 inhibition during epileptogenesis does not alter behavioral excitability in rats.

Published in:

Physiological Journal / Fiziologichnyi Zhurnal, 2018, v. 64, n. 2, p. 12, doi. 10.15407/fz64.02.012

By:

Lunko, O. O.;
Bogovyk, R. I.;
Fedoriuk, M. P.;
Semenets, G. S.;
Isaeva, E. V.

Publication type:

Article

Host innate immune responses to sepsis.

Published in:

Virulence, 2014, v. 5, n. 1, p. 36, doi. 10.4161/viru.25436

By:

Wiersinga, Willem Joost;
Leopold, Stije J;
Cranendonk, Duncan R;
van der Poll, Tom

Publication type:

Article

Channel-mediated astrocytic glutamate modulates hippocampal synaptic plasticity by activating postsynaptic NMDA receptors.

Published in:

Molecular Brain, 2015, v. 8, n. 1, p. 1, doi. 10.1186/s13041-015-0097-y

By:

Hyungju Park;
Kyung-Seok Han;
Jinsoo Seo;
Jaekwang Lee;
Dravid, Shashank M.;
Junsung Woo;
Heejung Chun;
Sukhee Cho;
Jin Young Bae;
Heeyoung An;
Woohyun Koh;
Bo-Eun Yoon;
Berlinguer-Palmini, Rolando;
Mannaioni, Guido;
Traynelis, Stephen F.;
Yong Chul Bae;
Se-Young Choi;
Lee, C. Justin

Publication type:

Article

Protease activated receptor 1-induced glutamate release in cultured astrocytes is mediated by Bestrophin-1 channel but not by vesicular exocytosis.

Published in:

Molecular Brain, 2012, v. 5, n. 1, p. 38, doi. 10.1186/1756-6606-5-38

By:

Soo-Jin Oh;
Kyung-Seok Han;
Hyungju Park;
Dong ho Woo;
Hye Yun Kim;
Traynelis, Stephen F.;
Justin Lee, C.

Publication type:

Article

Protease signaling through protease activated receptor 1 mediate nerve activation by mucosal supernatants from irritable bowel syndrome but not from ulcerative colitis patients.

Published in:

PLoS ONE, 2018, v. 13, n. 3, p. 1, doi. 10.1371/journal.pone.0193943

By:

Buhner, Sabine;
Hahne, Hannes;
Hartwig, Kerstin;
Li, Qin;
Vignali, Sheila;
Ostertag, Daniela;
Meng, Chen;
Hörmannsperger, Gabriele;
Braak, Breg;
Pehl, Christian;
Frieling, Thomas;
Barbara, Giovanni;
De Giorgio, Roberto;
Demir, Ihsan Ekin;
Ceyhan, Güralp Onur;
Zeller, Florian;
Boeckxstaens, Guy;
Haller, Dirk;
Kuster, Bernhard;
Schemann, Michael

Publication type:

Article

Protease-activated receptor-1 impairs host defense in murine pneumococcal pneumonia: a controlled laboratory study.

Published in:

Critical Care, 2012, v. 16, n. 6, p. 1, doi. 10.1186/cc11910

By:

Schouten, Marcel;
van't Veer, Cornelis;
Roelofs, Joris J. T. H.;
Levi, Marcel;
van der Poll, Tom

Publication type:

Article

Role of the protease-activated receptor 1 in regulating the function of glial cells within central and peripheral nervous system.

Published in:

Journal of Neural Transmission, 2019, v. 126, n. 10, p. 1259, doi. 10.1007/s00702-019-02075-z

By:

Pompili, Elena;
Fabrizi, Cinzia;
Fornai, Francesco;
Fumagalli, Lorenzo

Publication type:

Article

Recombinant hirudin suppresses angiogenesis of diffuse large B‐cell lymphoma through regulation of the PAR‐1‐VEGF.

Published in:

Chemical Biology & Drug Design, 2024, v. 103, n. 5, p. 1, doi. 10.1111/cbdd.14533

By:

Zhao, Jingjing;
Li, Zihui;
Zhang, Haixi;
Qin, Tao;
Zhao, Juan;
Pei, Qiang

Publication type:

Article

Inhibition of melanin synthesis and melanosome transfer by chitosan biomaterials.

Published in:

Journal of Biomedical Materials Research, Part B: Applied Biomaterials, 2020, v. 108, n. 4, p. 1239, doi. 10.1002/jbm.b.34472

By:

Chen, Hsi‐Wen;
Chou, Ya‐Shuan;
Young, Tai‐Horng;
Cheng, Nai‐Chen

Publication type:

Article

Cell sheet produced from periodontal ligament stem cells activated by PAR1 improves osteogenic differentiation.

Published in:

Brazilian Oral Research, 2024, v. 38, p. 1, doi. 10.1590/1807-3107bor-2024.vol38.0079

By:

Miquelitto GASPARONI, Letícia;
ALVES, Tomaz;
Nunes de FRANÇA, Bruno;
BALZARINI, Danilo;
ALBUQUERQUE-SOUZA, Emmanuel;
Fagundes PEDRONI, Ana Clara;
da Silva ROVAI, Emanuel;
Huamán MENDOZA, Aldrin;
Renata SIPERT, Carla;
HOLZHAUSEN, Marinella

Publication type:

Article

Protease-activated receptor type 2 activation downregulates osteogenesis in periodontal ligament stem cells.

Published in:

Brazilian Oral Research, 2023, v. 37, p. 1, doi. 10.1590/1807-3107bor-2023.vol37.0002

By:

de FRANÇA, Bruno Nunes;
GASPARONI, Letícia Miquelitto;
ROVAI, Emanuel Silva;
AMBRÓSIO, Lucas Macedo Batitucci;
de MENDONÇA, Nathalia Felix;
HAGY, Marcos Hideki;
HUAMÁN MENDOZA, Aldrin;
SIPERT, Carla Renata;
HOLZHAUSEN, Marinella

Publication type:

Article

Protease-activated receptor type 1 (PAR1) increases CEMP1 gene expression through MAPK/ERK pathway.

Published in:

Brazilian Oral Research, 2022, v. 36, p. 1, doi. 10.1590/1807-3107bor-2022.vol36.0048

By:

ROVAI, Emanuel Silva;
ALVES, Tomaz;
GASPARONI, Letícia Miquelitto;
de FRANÇA, Bruno Nunes;
SIPERT, Carla Renata;
KANTARCI, Alpdogan;
HOLZHAUSEN, Marinella

Publication type:

Article

PAR2: The Cornerstone of Pancreatic Diseases.

Published in:

Physiological Research, 2022, v. 71, n. 5, p. 583, doi. 10.33549/physiolres.934931

By:

SUHAJ, Petr;
OLEJAR, Tomas;
Matej, Radoslav

Publication type:

Article

Role of Liver Kinase 1B in Platelet Activation and Host Defense During Klebsiella pneumoniae -Induced Pneumosepsis.

Published in:

International Journal of Molecular Sciences, 2025, v. 26, n. 8, p. 3714, doi. 10.3390/ijms26083714

By:

Chouchane, Osoul;
Léopold, Valentine;
van Linge, Christine C. A.;
de Vos, Alex F.;
Roelofs, Joris J. T. H.;
van 't Veer, Cornelis;
van der Poll, Tom

Publication type:

Article

PAR 2 Serves an Indispensable Role in Controlling PAR 4 Oncogenicity: The β-Catenin–p53 Axis.

Published in:

International Journal of Molecular Sciences, 2025, v. 26, n. 6, p. 2780, doi. 10.3390/ijms26062780

By:

Appasamy, Priyanga;
Nag, Jeetendra Kumar;
Malka, Hodaya;
Bar-Shavit, Rachel

Publication type:

Article

A New Strategy in Modulating the Protease-Activated Receptor 2 (Par2) in Autoimmune Diseases.

Published in:

2025

By:

Khoon, Lynn;
Piran, Ron

Publication type:

Literature Review

Atrial Fibrosis in Atrial Fibrillation: Mechanistic Insights, Diagnostic Challenges, and Emerging Therapeutic Targets.

Published in:

International Journal of Molecular Sciences, 2025, v. 26, n. 1, p. 209, doi. 10.3390/ijms26010209

By:

Karakasis, Paschalis;
Theofilis, Panagiotis;
Vlachakis, Panayotis K.;
Korantzopoulos, Panagiotis;
Patoulias, Dimitrios;
Antoniadis, Antonios P.;
Fragakis, Nikolaos

Publication type:

Article

Effect of chimeric antigen receptor T cells against protease-activated receptor 1 for treating pancreatic cancer.

Published in:

BMC Medicine, 2023, v. 21, n. 1, p. 1, doi. 10.1186/s12916-023-03053-9

By:

Hung, Hao-Chien;
Fan, Ming-Huei;
Wang, Daniel;
Miao, Carol H.;
Su, Pong;
Liu, Chao-Lien

Publication type:

Article

PAR2 Overexpression is Involved in the Occurrence of Hyperoxygen-Induced Bronchopulmonary Dysplasia in Rats.

Published in:

Fetal & Pediatric Pathology, 2023, v. 42, n. 3, p. 423, doi. 10.1080/15513815.2023.2166799

By:

Shao, Chunyan;
Lu, Liqun

Publication type:

Article

Attenuation of type-1 diabetes-induced cardiovascular dysfunctions by direct thrombin inhibitor in rats: a mechanistic study.

Published in:

Molecular & Cellular Biochemistry, 2019, v. 451, n. 1/2, p. 69, doi. 10.1007/s11010-018-3394-9

By:

Bulani, Yogesh;
Srinivasan, Krishnamoorthy;
Sharma, Shyam Sunder

Publication type:

Article

New insights into the mechanisms of itch: are pain and itch controlled by distinct mechanisms?

Published in:

Pflügers Archiv: European Journal of Physiology, 2013, v. 465, n. 12, p. 1671, doi. 10.1007/s00424-013-1284-2

By:

Liu, Tong;
Ji, Ru-Rong

Publication type:

Article

Allergic sensitization enhances anion current responsiveness of murine trachea to PAR-2 activation.

Published in:

Pflügers Archiv: European Journal of Physiology, 2012, v. 463, n. 3, p. 497, doi. 10.1007/s00424-011-1064-9

By:

Rievaj, Juraj;
Davidson, Courtney;
Nadeem, Ahmed;
Hollenberg, Morley;
Duszyk, Marek;
Vliagoftis, Harissios

Publication type:

Article

Effects of protease-activated receptors (PARs) on intracellular calcium dynamics of acinar cells in rat lacrimal glands.

Published in:

Histochemistry & Cell Biology, 2013, v. 140, n. 4, p. 463, doi. 10.1007/s00418-013-1082-0

By:

Oikawa, Makoto;
Saino, Tomoyuki;
Kimura, Katsura;
Kamada, Yuki;
Tamagawa, Yasunori;
Kurosaka, Daijiro;
Satoh, Yoh-ichi

Publication type:

Article

Serum from COVID-19 patients promotes endothelial cell dysfunction through protease-activated receptor 2.

Published in:

Inflammation Research, 2024, v. 73, n. 1, p. 117, doi. 10.1007/s00011-023-01823-y

By:

Vieceli Dalla Sega, Francesco;
Fortini, Francesca;
Licastro, Danilo;
Monego, Simeone Dal;
Degasperi, Margherita;
Ascierto, Alessia;
Marracino, Luisa;
Severi, Paolo;
D'Accolti, Maria;
Soffritti, Irene;
Brambilla, Marta;
Camera, Marina;
Tremoli, Elena;
Contoli, Marco;
Spadaro, Savino;
Campo, Gianluca;
Ferrari, Roberto;
Caselli, Elisabetta;
Rizzo, Paola

Publication type:

Article

Protease-activated receptor 2 enhances innate and inflammatory mechanisms induced by lipopolysaccharide in macrophages from C57BL/6 mice.

Published in:

Inflammation Research, 2022, v. 71, n. 4, p. 439, doi. 10.1007/s00011-022-01551-9

By:

Barra, Ayslan;
Brasil, Amanda Ferreira;
Ferreira, Thaís Lemos;
Fernandes-Braga, Weslley;
Marconato, Danielle Gomes;
Faria-Pinto, Priscila;
Alvarez-Leite, Jacqueline Isaura;
dos Santos Aggum Capettini, Luciano;
Klein, André

Publication type:

Article

Correction to: A role for mast cells and mast cell tryptase in driving neutrophil recruitment in LPS-induced lung inflammation via protease-activated receptor 2 in mice.

Published in:

2020

By:

de Almeida, Aline Dias;
Silva, Irismara Sousa;
Fernandes-Braga, Weslley;
LimaFilho, Antônio Carlos Melo;
Florentino, Rodrigo Machado;
Barra, Ayslan;
de Oliveira Andrade, Luciana;
Leite, M. Fátima;
Cassali, Geovanni Dantas;
Klein, André

Publication type:

Correction Notice

A role for mast cells and mast cell tryptase in driving neutrophil recruitment in LPS-induced lung inflammation via protease-activated receptor 2 in mice.

Published in:

Inflammation Research, 2020, v. 69, n. 10, p. 1059, doi. 10.1007/s00011-020-01376-4

By:

de Almeida, Aline Dias;
Silva, Irismara Sousa;
Fernandes-Braga, Weslley;
LimaFilho, Antônio Carlos Melo;
Florentino, R odrigo Machado;
Barra, Ayslan;
de Oliveira Andrade, Luciana;
Leite, M. Fátima;
Cassali, Geovanni Dantas;
Klein, André

Publication type:

Article

SCH79797 improves outcomes in experimental bacterial pneumonia by boosting neutrophil killing and direct antibiotic activity.

Published in:

2018

By:

Gupta, Naveen;
Liu, Roland;
Shin, Stephanie;
Sinha, Ranjeet;
Pogliano, Joseph;
Pogliano, Kit;
Griffin, John H;
Nizet, Victor;
Corriden, Ross

Publication type:

journal article

PARticularly Forceful: PAR1 Drives Glomerular Mesangial Cell Contractility.

Published in:

Function, 2024, v. 5, n. 6, p. 1, doi. 10.1093/function/zqae044

By:

Waller, Amanda P;
Muralidharan, Kaushik;
Kerlin, Bryce A

Publication type:

Article

PAR1-mediated Non-periodical Synchronized Calcium Oscillations in Human Mesangial Cells.

Published in:

Function, 2024, v. 5, n. 5, p. 1, doi. 10.1093/function/zqae030

By:

Stefanenko, Mariia;
Fedoriuk, Mykhailo;
Mamenko, Mykola;
Semenikhina, Marharyta;
Nowling, Tamara K;
Lipschutz, Joshua H;
Maximyuk, Oleksandr;
Staruschenko, Alexander;
Palygin, Oleg

Publication type:

Article

Platelet Apoptosis Can Be Triggered Bypassing the Death Receptors.

Published in:

Clinical & Applied Thrombosis/Hemostasis, 2019, v. 25, p. 1, doi. 10.1177/1076029619853641

By:

Leytin, Valery;
Gyulkhandanyan, Armen V.;
Freedman, John

Publication type:

Article

ALIX binds a YPX<sub>3</sub>L motif of the GPCR PAR1 and mediates ubiquitin-independent ESCRT-III/MVB sorting.

Published in:

Journal of Cell Biology, 2012, v. 197, n. 3, p. 407, doi. 10.1083/jcb.201110031

By:

Dores, Michael R.;
Buxin Chen;
Huilan Lin;
Soh, Unice J. K.;
Paing, May M.;
Montagne, William A.;
Meerloo, Timo;
Trejo, JoAnn

Publication type:

Article

The involvement of keratinocytes in pruritus of chronic inflammatory dermatosis.

Published in:

Experimental Dermatology, 2024, v. 33, n. 7, p. 1, doi. 10.1111/exd.15142

By:

Lin, Shiying;
Liu, Xin;
Jiang, Jian;
Ge, Wenqiang;
Zhang, Yinlian;
Li, Fei;
Tao, Qingxiao;
Liu, Suwen;
Li, Man;
Chen, Hongxiang

Publication type:

Article